Human adipose tissue. Medical search. Frequent questions

Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
Compared with mesenchymal stem cells (MSCs) derived from other tissues such as umbilical cord and bone marrow, isolation of ASCs from human white adipose tissue (WAT) has great advantages due to its rich tissue source and simple surgical procedure. (edu.au)
Differentiation of mesenchymal stem cells derived from human bone marrow and subcutaneous adipose tissue into pancreatic islet-like clusters in vitro. (bvsalud.org)
The results reveal that mesenchymal stem cells (MSC) derived from bone marrow and subcutaneous adipose tissue can differentiate into pancreatic islet -like clusters, as evidenced by their islet-like morphology, positive dithizone staining and expression of genes such as Nestin , PDX1, Isl 1, Ngn 3, Pax 4 and Insulin . (bvsalud.org)
Differentiation was compared to mesenchymal stem cells derived from human bone marrow, which is known to differentiate into adipocyte, osteocyte, and chondrocyte lineages. (jove.com)
Tissue bioengineering is a new branch of Science aiming to investigate and integrate techniques of tissue regeneration thorugh new biomaterials including natural markers (growth factors) and tissue and cellular components (mesenchymal stem cells). (bvsalud.org)
Mesenchymal stem cells have the ability to differentiate in osteoblasts with potential implications for the engineering of human bone tissue 11 . (bvsalud.org)
The stem cells coming from the adipose tissue can be an important source of progenitor mesenchymal stem cells which can be employed in tissue engineering for bone repairing 8 . (bvsalud.org)
Given this, the ALINE MANICA2 cryopreservation of adipose tissue-derived mesenchymal stem cells (ADMSCs) could be a JULIANA CRISTINA SCHMIDT2 way to collect them in one surgical procedure and after performing fractional fat grafting. (bvsalud.org)

In mammals, two types of adipose tissue have been observed: White Adipose Tissue, (WAT), which stores excess energy as triglycerides, and Brown Adipose Tissue (BAT), which dissipates stored energy as heat. (news-medical.net)
Brown adipose tissue (BAT) or brown fat makes up the adipose organ together with white adipose tissue (or white fat). (wikipedia.org)
Brown adipose tissue is found in almost all mammals. (wikipedia.org)
Brown adipose tissue is especially abundant in newborns and in hibernating mammals. (wikipedia.org)
In addition to heat produced by shivering muscle, brown adipose tissue produces heat by non-shivering thermogenesis. (wikipedia.org)
The presence of brown adipose tissue in adult humans was discovered in 2003 during FDG-PET scans to detect metastatic cancers. (wikipedia.org)
Using these scans and data from human autopsies, several brown adipose tissue deposits have been identified. (wikipedia.org)
It remains to be determined whether these deposits are 'classical' brown adipose tissue or beige/brite fat. (wikipedia.org)

Finally, a causal mediation analysis provided support for adipose tissue DNA methylation as a partial mediating factor between circulating triglycerides and insulin resistance. (lu.se)

However, the results indicate that bone marrow -derived MSCs are superior to those from subcutaneous adipose tissue in terms of differentiation into pancreatic islet -like clusters. (bvsalud.org)
Human platelet lysate represents an efficient alternative to fetal bovine serum for clinical-scale expansion of MSCs. (biomedcentral.com)
However, bone marrow-derived MSCs and adipose tissue-derived MSCs have not yet been directly compared with each other under human platelet lysate conditions. (biomedcentral.com)
This study aims to conduct a direct head-to-head comparison of the biological characteristics of the two types of MSCs under human platelet lysate-supplemented culture conditions for their ability to be used in regenerative medicine applications. (biomedcentral.com)
The bone marrow- and adipose tissue-derived MSCs were cultured under human platelet lysate conditions and their biological characteristics evaluated for cell therapy (morphology, immunophenotype, colony-forming unit-fibroblast efficiency, proliferation capacity, potential for mesodermal differentiation, secreted proteins, and immunomodulatory effects). (biomedcentral.com)
Under human platelet lysate-supplemented culture conditions, bone marrow- and adipose tissue-derived MSCs exhibited similar fibroblast-like morphology and expression patterns of surface markers. (biomedcentral.com)
Adipose tissue-derived MSCs had greater proliferative potential than bone marrow-derived MSCs, while no significantly difference in colony efficiency were observed between the two types of cells. (biomedcentral.com)
However, bone marrow-derived MSCs possessed higher capacity toward osteogenic and chondrogenic differentiation compared with adipose tissue-derived MSCs, while similar adipogenic differentiation potential wase observed between the two types of cells. (biomedcentral.com)
There were some differences between bone marrow- and adipose tissue-derived MSCs for several secreted proteins, such as cytokine (interferon-γ), growth factors (basic fibroblast growth factor, hepatocyte growth factor, and insulin-like growth factor-1), and chemokine (stem cell-derived factor-1). (biomedcentral.com)
Adipose tissue-derived MSCs had more potent immunomodulatory effects than bone marrow-derived MSCs. (biomedcentral.com)
Over the past decade, MSCs which are isolated from the umbilical cord, umbilical cord blood, bone marrow (BM), adipose tissue (AT) and many other adult tissues have been explored as potential therapeutic strategies for a number of diseases [ 2 ], but AT and BM are the most widely used sources of MSC, especially in autologous cell-based therapies due to ease of harvest and potential autologous application [ 3 ]. (biomedcentral.com)
Therefore, this study aimed to investigate the effects of hypoxia-preconditioned MSCs from human adipose tissue-derived MSCs (AT-MSCs) and from human umbilical cord-derived MSCs (UC-MSCs). (minervamedica.it)
Previous studies have proven that rodent and human MSCs can differentiate into HLCs in vitro and in vivo , which is one of the mechanisms of MSCs in the treatment of liver failure. (springer.com)

The resulting cell-scaffold constructs were either enzymatically treated to extract and characterize the cells or subcutaneously implanted in nude mice for 8 weeks to assess the capacity to form bone tissue and blood vessels. (nih.gov)
Importantly, constructs generated under 3D perfusion, and not those based on 2D-expanded cells, reproducibly formed bone tissue. (nih.gov)
Although stem cells are present in various adult tissues and body fluids , bone marrow has been the most popular source of stem cells for treatment of a wide range of diseases . (bvsalud.org)
In conclusion, bone marrow -derived MSC might serve as a better alternative in the treatment of diabetes mellitus than those from adipose tissue . (bvsalud.org)
In humans, bone mass gradually increases and peaks in the 30s and starts to decline again in the 40s ( 6 ). (frontiersin.org)
The adipose tissue is an important reservoir of adult stem cells which have capacity of differentiating in osteoblasts with potential implication in reaching bone regeneration. (bvsalud.org)
To evaluate the immunoexpression of BMP-2 protein on the bone repairing of critical size defects (CSD) surgically created in rat calvaria and treated by autogenous macerated adipose tissue. (bvsalud.org)
In group AT, both at 7 and 90 post-operative days, the main healing type was the presence of dense conjunctive tissue exhibiting bundles of collagen fibers disposed in beams permeating the remaining adipose tissue with rare heterotopic bone formation associated to fibrosis and different types of tissue necrosis. (bvsalud.org)
Within the limits of this present study, it can be concluded that the adipose tissue grafting did not favor bone neoformation in critical size defects and BMP-2 signaling was not observed. (bvsalud.org)
Despite of the great potential of repair by bone tissue, in some situations, according to the proportion of defects, the regeneration cannot be complete because the defect can be invaded by the surrounding conjunctive tissue which has a proliferation and cellular migration speed faster than those of bone tissue. (bvsalud.org)
13 verified that stromal cells (CD 34+) derived from the adipose tissue has the potential of osteogenic differentiation both in vitro and in vivo, being considered as a promising cellular therapy for the healing of bone defects. (bvsalud.org)
Currently, there are little studies evaluating whether the adipose tissue is really a safe option to reach bone repairing. (bvsalud.org)

In addition, CD11c + ATMs were enriched for mitochondria and for RNA transcripts encoding mitochondrial, proteasomal, and lysosomal proteins, fatty acid metabolism enzymes, and T-cell chemoattractants, whereas CD11c − ATMs were enriched for transcripts involved in tissue maintenance and repair. (diabetesjournals.org)
Despite the central role of adipose tissue in metabolism, little is known about the evolution of white adipose tissue in primates. (anthropogeny.org)
We find that many regions that have decreased accessibility in humans are enriched for promoter and enhancer sequences, are depleted for signatures of negative selection, are located near genes involved with lipid metabolism, and contain a short sequence motif involved in the beigeing of fat, the process in which lipid-storing white adipocytes are transdifferentiated into thermogenic beige adipocytes. (anthropogeny.org)
The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. (elifesciences.org)
We studied the effects of estradiol in vivo and in vitro on human adipose tissue metabolism and found that estradiol directly increases the number of antilipolytic alpha2A-adrenergic receptors in sc adipocytes. (indexindex.com)
We studied changes in lipid metabolism in adipose tissue in 24 healthy adults during early starvation (14-20 h) by cannulating the venous drainage of the subcutaneous adipose tissue of the anterior abdominal wall. (edu.au)
Lipodystrophies: windows on adipose biology and metabolism. (medscape.com)

5 , - , 9 This loose connective tissue is composed of extracellular matrix and various types of cells: fat cells-named adipocytes, and the non-fat cells of the stromal vascular fraction that contains preadipocytes, capillary endothelial cells, infiltrating leucocytes and multipotent stem cells. (bmj.com)
Human Adipose-derived Stem/Stromal Cells (ASCs) have been widely used in stem cell and obesity research, as well as clinical applications including cell-based therapies, tissue engineering and reconstruction. (edu.au)
Recent results for stem cells from adipose tissue have put it in a position to compete for being the leading therapeutic source. (bvsalud.org)
Human adipose tissue-derived stem cells (hASCs) are attractive cells for therapeutic applications and are currently being evaluated in multiple clinical trials. (biomedcentral.com)
The use of hASCs for therapeutic applications has grown substantially in the last years, because the use of stem cells from adult tissues circumvent some ethical issues associated with the application of embryonic stem cells, and because of their accessibility via isolation from lipoaspirates, a disposable byproduct of cosmetic surgery. (biomedcentral.com)
bioceramics and bioglasses, raising great interest in the research with adipose tissue as a reservoir of adult stem cells, generating good results. (bvsalud.org)
Adachi M, Asakura Y, Muroya K, Goto H, Kigasawa H. Abnormal adipose tissue distribution with unfavorable metabolic profile in five children following hematopoietic stem cell transplantation: a new etiology for acquired partial lipodystrophy. (medscape.com)

Adipose cell size (lipid per cell) was determined in three different subcutaneous and deep fat depots in each patient and the total number of adipose cells in the body estimated by division of total body fat by various combinations of the adipose cell sizes at six different sites. (jci.org)
The postdoctoral project will investigate the factors driving senescence in human adipose tissue and why specific adipose depots are protected from senescence. (varbi.com)
Recently, we and others have demonstrated fibrotic depots in white adipose tissue of obese subjects. (springer.com)
Very little is known about the maintenance of fat cells (adipocytes) in humans, how different fat depots are maintained and how (or if) this is altered in obesity. (europa.eu)

Tissue culture medium conditioned by CD11c + ATMs, but not CD11c − ATMs or other stromovascular cells, impaired insulin-stimulated glucose uptake by human adipocytes. (diabetesjournals.org)
In contrast to white adipocytes, which contain a single lipid droplet, brown adipocytes contain numerous smaller droplets and a much higher number of (iron-containing) mitochondria, which gives the tissue its color. (wikipedia.org)
Both adipocytes and brown adipocyte may be derived from pericytes, the cells which surround the blood vessels that run through white fat tissue. (wikipedia.org)
Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy demands, and secrete factors (lipids, peptides, cytokines, and adipokines) to regulate other metabolic tissues. (frontiersin.org)
The presence of various types of adipocytes (white, brown, and beige) characterized by the number/size of lipid droplets, mitochondrial density, and thermogenic capacity, further highlights how intricate is the communication of these cell-types with other metabolic tissues to sense nutrients. (frontiersin.org)
In humans the generation of fat cells (adipocytes) is a major factor behind the growth of adipose tissue during childhood. (europa.eu)
OBJECTIVES: We have therefore compared the impact of short- (24 h) and long-term (7 days) GC administration on insulin signalling in differentiated human adipocytes in the presence of low or high concentrations of insulin. (ox.ac.uk)
This study examined adipose and muscle inflammatory markers after treatment of humans with FOs and measured the effects of ω-3 fatty acids on adipocytes and macrophages in vitro. (uky.edu)

In obesity the inherent capacity of adipose tissue to store and sense nutrients is compromised, causing spillover of the intermediate lipid metabolites into circulation and resulting in their ectopic deposition in tissues not suitable for lipid storage, a phenomenon known as lipotoxicity. (frontiersin.org)

This protocol provides researchers with the tools to culture and assess purity and adipogenic differentiation capacity of human ASCs, which can then be utilized for required downstream in vitro applications. (edu.au)
The isolated human ASCs show high purity and demonstrate adipogenic differentiation capacity in vitro. (edu.au)
The adult unilocular subcutaneous adipose cells have the potential in vitro to redifferentiate in osteoblast (transdifferentiation). (bvsalud.org)

Adipose tissue was obtained from lean and obese women undergoing bariatric surgery. (diabetesjournals.org)
The current proposal aims to determine the dynamics of human adipose tissue maintenance and investigate any differences in regulation of the fat mass in lean and obese individuals. (europa.eu)

In all participants, dual-energy X-ray absorptiometry (DXA) and echocardiography were used to measure visceral adipose tissue (VAT)(g) and cardiac function, respectively. (nih.gov)
visceral adipose tissue. (nih.gov)
This protocol has been utilized to isolate and characterize human ASCs from both subcutaneous and visceral WAT. (edu.au)

In the first one, local adipose tissue hypoxia could induce fibrosis accumulation which in turn through adipocyte dysfunctions might provoke adipose tissue inflammation. (springer.com)
The microenvironment within tumors differs from that of healthy tissues, especially oxygen delivery is poor leading to hypoxia. (lu.se)

iXCells Biotechnologies provides SVF from human subcutaneous white fat tissue by enzymatic isolation and cryopreserved at P0, with ≥ 1.0 million cells/vial (Normal) or 0.5 million cells/vial (Diseased). (ixcellsbiotech.com)
A transcriptomic research revealed a rise in LOX manifestation in subcutaneous white adipose cells from obese topics, but its pathophysiological relevance continues to be unclear (Henegar et al. (exposed-skin-care.net)

SVF cells from human lipoaspirates were seeded and cultured for 5 days in porous hydroxyapatite scaffolds by alternate perfusion through the scaffold pores, eliminating standard monolayer (two-dimensional [2D]) culture. (nih.gov)
In conclusion, direct perfusion of human adipose-derived cells through ceramic scaffolds establishes a 3D culture system for osteoprogenitor and endothelial cells and generates osteogenic-vasculogenic constructs. (nih.gov)
In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. (karger.com)
Regulatory T cells (Tregs) are specifically reduced in adipose tissue of obese animals. (diabetesjournals.org)
BAPN also ameliorated the upsurge in collagen content material that was seen in adipose cells from obese pets and improved many metabolic guidelines C it ameliorated blood sugar and insulin amounts, reduced homeostasis model evaluation (HOMA) index and decreased plasma triglyceride amounts. (exposed-skin-care.net)
Furthermore, in white adipose cells from obese pets, BAPN avoided the downregulation of adiponectin and blood sugar transporter 4 (GLUT4), aswell as the upsurge in suppressor of cytokine signaling 3 (SOCS3) and dipeptidyl peptidase 4 (DPP4) amounts, triggered from the HFD. (exposed-skin-care.net)
Consequently, our data offer proof that LOX takes on a pathologically relevant part in the metabolic dysfunction induced by weight problems and emphasise the eye of book pharmacological interventions that focus on adipose cells fibrosis and LOX activity for the medical management of the disease. (exposed-skin-care.net)
2008). Consequently, the purpose of this research was to explore the part of LOX activity in adipose cells remodelling and in the metabolic disruptions associated with weight problems. (exposed-skin-care.net)
Lately, fibrosis continues to be recognised as an essential participant in adipose cells dysfunction in weight problems. (exposed-skin-care.net)
Nevertheless, its contribution to adipose cells dysfunction in weight problems is not clearly established. (exposed-skin-care.net)
Outcomes This research analyses the part of LOX in adipose cells remodelling through the use of three experimental systems: adipose cells examples from obese people that had been known for bariatric medical procedures (weight loss operation), an pet style of diet-induced weight problems and cell-based research. (exposed-skin-care.net)
The writers demonstrate that LOX may be the primary lysyl oxidase isoenzyme indicated in Rabbit polyclonal to ZFP161 human being adipose cells and that it's upregulated in examples from both obese people and rats given a high-fat diet plan. (exposed-skin-care.net)
In obese rats, the inhibition of LOX activity through -aminopropionitrile (BAPN, a particular inhibitor of LOX activity) decreases adipose cells fibrosis, partly corrects the adipocyte-size distribution design (moving it toward smaller sized sizes) and attenuates the upsurge in bodyweight and extra fat mass. (exposed-skin-care.net)
Also, in these pets, BAPN ameliorates the disruptions in the adipose cells manifestation of adiponectin, blood sugar transporter 4 (GLUT4), buy 76584-70-8 suppressor of cytokine signaling 3 (SOCS3) and dipeptidyl peptidase 4, all protein mixed up in control of insulin level of sensitivity. (exposed-skin-care.net)
and (2) through the paracrine release of trophic factors to induce tissue repair by endogenous cells [ 6 ]. (biomedcentral.com)
Through presentations and discussions, we hope to encourage further investigation of cells from families with rare single gene or syndromic obesity disorders to learn about unknown biological pathways regulating energy balance, and to encourage further human research to shed light on why obesity occurs in some individuals with the "same" syndrome but not in others. (nih.gov)
The goal of this protocol is to test the ability of progenitor cells derived from human perivascular adipose tissue to differentiate into multiple cell lineages. (jove.com)
Adipose progenitor cells vary according to their anatomical location. (jove.com)
The human body is more than a mere collection of 50 trillion individual cells because our cells work together. (ejnet.org)
Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells. (lu.se)

Initial studies of bariatric surgery patients by the Ruderman laboratory established (1) that they could be subdivided into insulin resistant (75%) and insulin sensitive (25%) subgroups and (2) that these subgroups were distinguished by differences in AMPK activity, oxidative stress and the expression of inflammatory, mitochondrial and other genes in their adipose tissue. (bu.edu)
Studies of rare disorders affecting the amount and distribution of body fat provide opportunities to define previously unidentified genes and biological pathways involved in appetite regulation, adipose tissue biology, and energy homeostasis, and to provide novel insights into the myriad of mechanisms potentially contributing to obesity and its adverse consequences. (nih.gov)
Downregulated adipose tissue expression of browning genes with increased environmental temperatures. (medscape.com)

The high prevalence of vitamin D deficiency in obese subjects [ 3 ] suggests that adipose tissue (AT) has a major role in the body distribution of vitamin D, but the causal relationship between obesity and low levels of circulating 25(OH)D has not been completely elucidated yet. (medscape.com)

Metabolic markers were measured in fasting serum and ATMs characterized by immunohistology, flow cytometry, and tissue culture studies. (diabetesjournals.org)
In humans, ceramides predict the occurrence of major adverse cardiac events, such that the numerous clinics have started to offer serum ceramide tests as prognostic measures of cardiovascular risk ( 24 , 25 ). (frontiersin.org)
hASCs were expanded in Dulbecco's modified Eagle's medium supplemented with pooled allogeneic human serum or fetal bovine serum to enable a side-by-side comparison. (biomedcentral.com)
The hASCs expanded in medium with pooled allogeneic human serum did not show remarkable differences in morphology, viability, differentiation capacity or immunophenotype. (biomedcentral.com)
The main difference observed was a significantly higher proliferative effect on hASCs cultured in pooled allogeneic human serum. (biomedcentral.com)
however, C-MYC protein expression was enhanced in pooled allogeneic human serum cultures compared to fetal bovine serum cultures. (biomedcentral.com)
Moreover, the hASCs presented normal karyotype undergoing senescence, and did not form in vivo tumors, eliminating the possibility that spontaneous immortalization of hASCs had occurred with pooled allogeneic human serum. (biomedcentral.com)
This complete characterization of hASCs cultivated in pooled allogeneic human serum, a suitable xeno-free approach, shows that pooled allogeneic human serum provides a high proliferation rate, which can be attributed for the first time to C-MYC protein expression, and showed cell stability for safe clinical applications in compliance with good manufacturing practice. (biomedcentral.com)
[ 5 , 6 ] An alternative hypothesis considers low serum 25(OH)D in obese as a result of volumetric dilution of vitamin D in the large adipose stores. (medscape.com)

Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. (diabetesjournals.org)
Experiments performed in mice and humans have revealed that subcutaneous WAT can acquire BAT characteristics which include fatty acid and glucose utilization. (news-medical.net)
The following year, in 1964, two authors writing in the JOURNAL OF THE NATIONAL CANCER INSTITUTE reported changes in vaginal tissues in mice after exposure to estrogen shortly after birth. (ejnet.org)

The Department of Cell and Molecular Biology (CMB, https://ki.se/en/cmb/department-of-cell-and-molecular-biology) is one of five departments conducting advanced experimental research under one roof in the new building of Biomedicum, Karolinska Institutet (https://ki.se), one of Europe's largest laboratories with ultramodern facilities. (varbi.com)
The Spalding lab uses pioneering approaches such as single cell sequencing, radiocarbon dating, confocal microscopy and flow cytometry to investigate fundamental questions in human adipose tissue biology. (varbi.com)
The Spalding research group has developed a strong competency of working with human adipose tissue, developing novel technologies and methodologies such as single cell sequencing, flow cytometry, confocal microscopy and cell culture, to address pressing questions in human adipose tissue biology. (varbi.com)
Expertise in the fields of cell signalling, including protein-protein interations and adipose tissue biology is required. (varbi.com)
Knowledge of immunocytochemistry, confocal microscopy, primary tissue culture, flow cytometry, molecular biology (including gene editing) or next generation sequencing (such as RNA-seq) is an advantage. (varbi.com)
Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation. (ixcellsbiotech.com)
It is our goal to establish an ARC focused on understanding the relationship between metabolic disorders and Adipose Tissue Biology by studying adipose tissues from insulin sensitive and insulin resistant patients obtained during and after Bariatric Surgery. (bu.edu)
With collective efforts of faculty representing different expertise and disciplines, we are posed to begin the development at BUMC of a unique center of knowledge in the field of adipose tissue biology pre- and -post bariatric surgery. (bu.edu)

Obesity is defined as an expansion of white adipose (WAT) tissue that is associated with low grade inflammation which possibly contributes to the development of health complications such as diabetes, liver pathologies, dyslipidemia, cardiovascular diseases as well as some cancers [ 2 - 4 ]. (springer.com)
Notably, recent studies suggest that the accumulation of sphingolipids, namely ceramides and it's metabolites, play essential roles in the development of insulin resistance in tissues such as skeletal muscle, liver and, adipose tissue in obese rodents, and humans ( 6 - 20 ). (frontiersin.org)
Ectopic fat in tissues such as liver and muscle may be increased. (medscape.com)

We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obesity. (diabetesjournals.org)
In this detailed protocol we describe a protocol to isolate and characterize ASCs from human WAT. (edu.au)
2005) to describe in detail a complete technique to isolate and subsequently characterize human ASCs from human WAT biopsies. (edu.au)
To test this obesity we will characterize adipose tissue as a secretory organ using interstitial fluid sampling techniques and advanced peptide analysis in critically ill patients and healthy controls. (europa.eu)

Stromal vascular progenitors in adult human adipose tissue. (ixcellsbiotech.com)
This protocol is used to answer key questions related to the function of human adipose progenitors in the vascular microenvironment. (jove.com)
We show that a population of multipotent progenitors can be derived successfully from perivascular adipose tissue from patients with cardiovascular disease. (jove.com)

Methods Tissues were obtained from patients undergoing joint replacement surgery. (bmj.com)

This secretory profile, termed the senescence-associated secretory phenotype (SASP), is becoming well established as a negative regulator of tissue and whole-body health. (varbi.com)

Human lipodystrophies: genetic and acquired diseases of adipose tissue. (medscape.com)

Obesity is defined as an excess accumulation of white adipose tissue associated with a low grade inflammation which is one contributor to obesity complications such as diabetes. (springer.com)
Adipose tissue is a key nutrient-sensing depot that regulates excess energy storage and consumption. (frontiersin.org)
Excess adipose tissue, resulting in obesity, is currently one of the most serious threats to human health on a global level. (europa.eu)

After implantation, constructs from both conditions contained blood vessels stained for human CD31 and CD34, functionally connected to the host vasculature. (nih.gov)
Perivascular adipose tissue surrounds blood vessels and regulates cardiovascular physiology. (jove.com)

Although GCs cause global insulin resistance in vivo, we have previously shown that GCs are able to augment insulin action in human adipose tissue, contrasting with their action in skeletal muscle. (ox.ac.uk)

In this study, we aimed at generating osteogenic and vasculogenic constructs starting from the stromal vascular fraction (SVF) of human adipose tissue as a single cell source. (nih.gov)

Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)
In the second one, fibrosis could be a result of local adipose tissue inflammation induced by tissue expansion. (springer.com)

Hence, our aim was to investigate the association between circulating lipids and DNA methylation levels in human adipose tissue. (lu.se)
DNA methylation and gene expression were analysed genome-wide in subcutaneous adipose tissue from two different cohorts, including 85 men and 93 women, respectively. (lu.se)
Causal mediation analyses tested if adipose tissue DNA methylation mediates the effects of triglycerides on gene expression or insulin resistance. (lu.se)
We found 115 novel associations between triglycerides and adipose tissue DNA methylation, e.g. in the promoter of RFS1, ARID2 and HOXA5 in the male cohort (P ≤ 1.1 × 10-7), and 63 associations, e.g. within the gene body of PTPRN2 and COL6A3 in the female cohort. (lu.se)

In obese women, CD11c + ATM density was greater in subcutaneous than omental adipose tissue and correlated with markers of insulin resistance. (diabetesjournals.org)
These findings identify proinflammatory CD11c + ATMs as markers of insulin resistance in human obesity. (diabetesjournals.org)

Recently, adipose tissue has been shown to synthesise and release highly bioactive substances: classical adipokines (eg, leptin, adiponectin) and various proinflammatory factors such as cytokines, chemokines, growth factors and complement components. (bmj.com)
The cumulative loss of fat leads to a decrease in adipose-derived adiponectin and leptin. (medscape.com)

Aging-associated decline in the functions of tissues and organs represents a major risk factor in the development of chronic disease ( 1 ). (frontiersin.org)
Simulation of radiation dose distribution in human organs and tissues is possible by tissue equivalent materials. (hindawi.com)
ICRU report 44 [ 1 ] describes various types of tissue substitutes for human organs and tissues. (hindawi.com)
A large part of the body's internal communication and control is carried out via the bloodstream, where hormones and other chemical messengers move about, carrying signals that not only govern sex and reproduction but also coordinate organs and tissues that work together to keep the body functioning properly. (ejnet.org)

We further connected these findings to altered mRNA expression levels in adipose tissue (e.g. (lu.se)

CONCLUSIONS: In this human subcutaneous adipocyte cell line, prolonged GC exposure, even in the presence of high insulin concentrations, is able to cause insulin sensitization. (ox.ac.uk)

Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subject" by Michael Spencer, Brian S. Finlin et al. (uky.edu)
The adipose (but not muscle) of FO-treated subjects demonstrated a decrease in macrophages, a decrease in MCP-1, and an increase in capillaries, and subjects with the most macrophages demonstrated the greatest response to treatment. (uky.edu)

BACKGROUND: Angiogenesis plays an important role in tissue repair. (minervamedica.it)

Objectives (1) To compare spontaneous and stimuli-induced adipocytokine secretion by articular adipose tissue (AAT) and synovial membrane (SM) explants obtained from patients with rheumatoid arthritis (RA). (bmj.com)
Recent studies have indicated that adipose tissue plays a major role in the secretion of inflammatory factors, which have been called adipo-cytokines or adipokines. (europa.eu)

Obesity elicits immune cell infiltration of adipose tissue provoking chronic low-grade inflammation. (diabetesjournals.org)
1 In RA, numerous cytokines play a fundamental role in inflammation and joint destruction and are thought to originate primarily from synoviocytes and leucocytes that massively infiltrate synovial tissue. (bmj.com)
More recent studies suggest that inflammation in adipose tissue could be a key factor leading to these illnesses. (bu.edu)
For the present proposal we will test the hypothesis, that adipose tissue is one of the links between systemic inflammation causing insulin resistance in critically ill patients and low-grade inflammation causing insulin resistance in obesity. (europa.eu)

They are characterized by their bioaccumulation properties in the fatty parts of biological beings, such as blood, breast milk and fatty tissues via the food chain ( Smith and Gangolli, 2002 ). (scialert.net)
Bioaccumulation is the ability of a substance to accumulate in fatty tissue of aquatic organisms. (janusinfo.se)
Hazard expresses the inherent, environmentally harmful characteristics of a pharmaceutical substance, such as resistance to degradation (persistence), ability to accumulate in adipose tissue (bioaccumulation), and its toxicity to aquatic organisms (toxicity). (janusinfo.se)

Tissue explants were treated with proinflammatory cytokines relevant to RA pathogenesis (interleukin 1β (IL-1β), tumour necrosis factor (TNF), interferon γ, IL-15, IL-17, IL-23). (bmj.com)
Conclusion Rheumatoid AAT is highly reactive tissue which upon stimulation secretes considerable amounts of proinflammatory (IL-6, IL-8, TNF) and anti-inflammatory (IL-1Ra) cytokines and classical adipokines. (bmj.com)

Secondary aims were to explore how adipose tissue distribution is associated with cardio-metabolic status (cardiac dysfunction and metabolic syndrome) in patients. (nih.gov)
Risk factors for metabolic syndrome were measured and associations with adipose tissue distribution explored. (nih.gov)

Causal mediation analyses tested if adipose. (lu.se)
We examined the cis-regulatory landscape of fat during human origins by performing comparative analyses of chromatin accessibility in human and chimpanzee adipose tissue using rhesus macaque as an outgroup. (anthropogeny.org)

Extracellular matrix is a fibrillar network composed of structural (collagens) and adhesion (fibronectin) proteins crucial for tissue architecture and biological pathway Histol Histopathol 27:1515-1528, 2012 . (springer.com)
The extracellular matrix is essential for the architecture of the tissue and a myriad of associated biological functions. (springer.com)

However many more pro and anti-inflammatory mediators produced by the adipose tissue have been described since then. (springer.com)

It is also present and metabolically active in adult humans, but its prevalence decreases as humans age. (wikipedia.org)

Anatomy29

Organisms9

Diseases20

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology2

Phenomena and Processes44

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science2

Health Care2

Geographicals1

Mesenchymal stem10

Brown Adipos8

Circulating triglycerides1

MSCs13

Bone12

Metabolism7

Stem7

Depots4

Adipocytes8

Lipid1

Vitro3

Lean and obese2

Visceral3

Hypoxia2

Subcutaneous white2

Cells20

Genes3

Obese subjects1

Serum9

Mice3

Biology8

Liver3

Characterize4

Progenitors3

Methods1

Phenotype1

Lipodystrophies1

Excess3

Blood vessels2

Skeletal1

Vascular1

Fibrosis2

Methylation4

Markers2

Adiponectin2

Organs4

Expression1

Adipocyte1

Macrophages2

Angiogenesis1

Secretion2

Inflammation4

Bioaccumulation3

Cytokines2

Metabolic syndrome2

Analyses2

Extracellular2

Inflammatory1

Decreases1