• Adenovirus genomes are linear, non-segmented double-stranded (ds) DNA molecules that are typically 26-46 Kbp long, containing 23-46 protein-coding genes. (wikipedia.org)
  • The example used for the following description is Human adenovirus E, a mastadenovirus with a 36 Kbp genome containing 38 protein-coding genes. (wikipedia.org)
  • While the precise number and identity of genes varies among adenoviruses, the basic principles of genome organization and the functions of most of the genes described in this article are shared among all adenoviruses. (wikipedia.org)
  • The 38 genes in the Human adenovirus E genome are organized in 17 transcription units, each containing 1-8 coding sequences. (wikipedia.org)
  • The proteins coded for by genes within these transcription units are mostly involved in regulation of viral transcription, in replication of viral DNA, and in suppression of the host response to infection. (wikipedia.org)
  • citation needed] The names, locations, and properties of the 38 protein-coding genes in the Human Adenovirus E genome are given in the following table. (wikipedia.org)
  • Control protein E1A activates transcription of a number of viral genes as well as genes of the host cell. (wikipedia.org)
  • Control protein E1B 55K binds to and inactivates the transcriptional regulator p53, thus blocking transcription of genes normally activated by p53 and contributing to the suppression of apoptosis. (wikipedia.org)
  • Bughio, F., M. Umashankar, J. Wilson, and F. Goodrum, 'Human Cytomegalovirus UL135 and UL136 Genes Are Required for Postentry Tropism in Endothelial Cells. (arizona.edu)
  • The mRNA and protein expression levels of PPARγ and downstream target genes were detected by RT-PCR and Western blot, respectively. (biomedcentral.com)
  • However, the binding rate of the transcription factor PPARγ to its target genes Acc, Adipoq, Lpin1 and Glut4 was enhanced, and thus increased the protein expression of P-FoxO1, PPARγ2, ACC, LPIN1, GLUT4 and ADIPOQ. (biomedcentral.com)
  • Top panel: a simplified map of the adenovirus serotype 5 genome showing the early genes (E1-E4) and the region from which the major late transcript is produced. (genemedi.com)
  • In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
  • In order to produce a replication-deficient vector, the two early genes E1A and E1B of adenovirus were replaced with transgene (the insertion antigen of the target pathogen) expression cassette, thereby preventing the virus from replicating in the host cell. (medicaltrend.org)
  • In addition, by genetically depleting the E3 and E4 genes of the adenovirus vector, the host cell-mediated elimination of adenovirus-infected cells and the instability of the transgene can be prevented. (medicaltrend.org)
  • The expression of the new gene or genes can then alter the DNA or RNA transcript used to synthesis proteins and therefore correct the disease. (familymednews.com)
  • c production of replication incompetent AAV vectors via transient plasmid transfection into 293 producer cells that express adenovirus type 5 E1 genes. (biomedcentral.com)
  • The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). (ecceterra.fr)
  • Besides the major ORF, additional early genes such as E4 and the viral oncogenes E6 and E7 are present in many PV, and E5 is encoded in, for example, genital Alpha-PV types. (creative-biolabs.com)
  • The strongest adenovirus vectors for make use of as vaccines derive from adenovirus serotype 5 (Advertisement5) (1C6). (synanet2020.com)
  • The index case and a further individual were diagnosed with an adenovirus serotype 4 co-infection. (biomedcentral.com)
  • The three proteins coded for by the E2A and E2B transcription units are all involved in replication of viral DNA. (wikipedia.org)
  • Adenovirus DNA replication begins at each end of the viral DNA, using the TP protein (rather than RNA) as a primer, so the viral DNA polymerase replicates every base of the genome. (wikipedia.org)
  • Adenovirus transcription is a two-phase event, early and late, occurring before and after viral DNA replication, respectively (Figure. (genemedi.com)
  • Life cycle of adenovirus is separated by DNA replication process into two distinct phases: the early and late, occurring before and after viral DNA replication, respectively. (genemedi.com)
  • To prevent infected cell lysis, recombinant replication deficiency virus has been developed as a gene delivery tool to replace wild-type adenovirus (recombinant AdV in "application" part). (genemedi.com)
  • A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection. (leibniz-liv.de)
  • Adipocyte commitment of 3T3-L1 cells is required to support human adenovirus 36 productive replication concurrent with altered lipid and glucose metabolism. (leibniz-liv.de)
  • Evidence that the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments. (leibniz-liv.de)
  • Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers. (leibniz-liv.de)
  • and with each passage, the virus replicates in chicken cells more efficiently and loses replication in human cells. (medicaltrend.org)
  • Although the replication ability of live attenuated pathogens is mostly limited by human cells, there is still a rare level of replication risk, which can make pathogens more virulent through genetic mutations. (medicaltrend.org)
  • Adenovirus is often used as a viral vector to produce vaccines with replication ability and vaccines with replication defects. (medicaltrend.org)
  • The human papillomavirus (HPV) E2 protein is a multifunctional protein essential for the control of virus gene expression, genome replication and persistence. (microbiologyresearch.org)
  • Upon co-expression in keratinocytes, L1 reduces nucleolar association of E2 protein, and when co-expressed with E1 and E2, L1 is partially recruited to viral replication factories. (microbiologyresearch.org)
  • Birch pollen extract enhances human cytomegalovirus replication in monocyte-derived dendritic cells. (resist-cluster.de)
  • Early proteins are involved in viral replication, life cycle, and regulation of viral gene expression, while the late proteins assemble the viral capsid. (creative-biolabs.com)
  • Generally, pathogen products used in subunit vaccines include purified or recombinant protein-inactivated bacterial toxins, or polysaccharides present on surface capsules. (medicaltrend.org)
  • Recombinant Human IFN-beta Protein Binding Activity Recombinant Human IFN‑ beta (Catalog # 8499-IF) exhibits anti-viral activity in HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. (bio-techne.com)
  • CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (bio-techne.com)
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (bio-techne.com)
  • Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. (ecceterra.fr)
  • Adenovirus (Ad) vectors are among the most commonly used viral vectors in gene therapy clinical trials because they have the following advantages. (hindawi.com)
  • On the other hand, Ad vectors also have a number of disadvantages, including their low transduction efficiency in cells lacking coxsackievirus-adenovirus receptor (CAR) and their induction of innate immune responses. (hindawi.com)
  • Schematic of the adenovirus genome and adenovirus-based vectors. (genemedi.com)
  • Intro Adenovirus vectors are believed a respected viral vector system for vaccines for their powerful immunogenicity and making feasibility. (synanet2020.com)
  • Adenovirus-based vectors can handle generating powerful and protecting T cell and antibody reactions in animal versions (7C17), and medical data conclusively display that Advertisement5 vectors can induce powerful Compact disc8+ and Compact disc4+ T cell and antibody reactions in vaccinated volunteers (18C25). (synanet2020.com)
  • The Advertisement5-centered hexon-modified vectors which contain subgroup D hypervariable areas (Advertisement43 or Advertisement48) induced powerful transgene-specific immune reactions which were unaffected by Advertisement5-particular NAb in murine and SLC2A3 non-human primate vaccine versions. (synanet2020.com)
  • They support the development of E1/E4-removed vectors predicated on Advertisement5 aswell as choice adenovirus serotypes (43C46). (synanet2020.com)
  • Commonly used vectors include adenoviruses, adeno-associated viruses, retroviruses and the herpes simplex virus. (familymednews.com)
  • As long-lived viral DNA within specific cellular reservoirs is responsible for persistent hepatitis B virus, Herpes simplex virus, and human immunodeficiency virus infections, the discovery of AAV vectors with strong tropism for hepatocytes, sensory neurons and T cells, respectively, is of particular interest. (biomedcentral.com)
  • Identification of natural isolates from various tissues in humans and non-human primates has generated an extensive catalog of AAV vectors with diverse tropisms and transduction efficiencies, which has been further expanded through molecular genetic approaches. (biomedcentral.com)
  • One amino acid change in the receptor-binding domain of fiber and 6 amino acid pattern is the result of a mutation of the Bam HI restriction variations in E4 ORF 6/7 were identified between 2 site at 0.93 map units of the genome. (cdc.gov)
  • provide evidence that the rapid divergence of Ad7d to a Particularly interesting were the distinctive patterns of cir- novel genome type Ad7l could have been due to viral culating genome types during the Ad7 epidemic in Korea strategies involving multiple sequence changes in E4. (cdc.gov)
  • Genetic variations between the Ad7d and Ad7l genome types have been studied by analyzing the sequences of hexon, E3, fiber, and E4 ORF 6/7 peptides. (cdc.gov)
  • It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
  • Without integration into host genome, adenovirus genome remains in an episomal state, which guarantees the low risk of mutation (Fig. 8). (genemedi.com)
  • Furthermore, co-distribution of E2 and L1 was detected in the nuclei of upper suprabasal cells in stratified epithelia of HPV16 genome-containing primary human keratinocytes. (microbiologyresearch.org)
  • The strain QH-1665/2018 genome is comprised of 36,014 nucleotides and encoded 36 putative proteins. (biomedcentral.com)
  • Gene therapy using an adenovirus vector: A new gene is injected into an adenovirus vector, which is used to introduce the modified DNA into a human cell. (familymednews.com)
  • For most serotypes, adenovirus infection is mediated by the high-affinity binding of the fiber-knob region to a receptor of target cell, named as the coxsackie-Ad receptor (CAR), which mainly determines the viral tropism [44]. (genemedi.com)
  • In humans, 57 adenovirus serotypes have been identified and further divided into 7 subgroups (A-G). Most adenovirus-based vaccines are prepared using adenovirus type 5 (Ad5). (medicaltrend.org)
  • Currently, human adenoviruses (HAdVs) are classified into seven groups (HAdV-A to HAdV-G), including 52 serotypes and 90 genotypes [ 4 ]. (biomedcentral.com)
  • To investigate this issue, we examined properties of p53 in normal human cells infected by E1B mutant viruses that display defective entry into the late phase or viral late mRNA export. (princeton.edu)
  • Then the endosome acidifies, resulting in disassociation of capsid proteins and transportation of viral DNA into nucleus. (genemedi.com)
  • Encapsidation proteins IVa2, 52K, and L1, and hexon assembly protein 100K are involved in assembly of viral capsids. (wikipedia.org)
  • Compared to their presence in strains of Ad7d, 2 restriction isolated in Korea during nationwide outbreaks from 1995 to fragments (8,400 and 2,650 bp) are lost in strains of Ad7l, 2000, the genetic variabilities of Ad7d and Ad7l were stud- which contain a new fragment equal in length to the sum ied by sequence analysis of hexon, fiber, E3, and E4 open of those 2 fragments. (cdc.gov)
  • Phylogenetic trees based on hexon, fiber, and E4 sug- early region 4 (E4) (unpub. (cdc.gov)
  • Fiber and E4 ORF 6/7 peptides were chosen for study because of close proximity to a mutation site at 0.93 map units, and hexon and E3 peptides were chosen because of their reported genetic heterogeneities. (cdc.gov)
  • Hexon and penton structures form the capsid of AdV, and fiber protein mediates the binding of the virion to the cell surface and is a major determinant of viral tropism. (genemedi.com)
  • Hexon may be the many abundant adenoviral structural proteins, and studies also show that it's the major focus on for NAb (23, MCI-225 31, 32). (synanet2020.com)
  • These NAbs focus on the nine hypervariable areas that type the exposed surface area from the hexon proteins (31, 33). (synanet2020.com)
  • This study aims to investigate the molecular mechanism of Adenovirus type 36 (Ad36) in adipocyte differentiation and glucolipid metabolism. (biomedcentral.com)
  • Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes. (leibniz-liv.de)
  • Human Adenovirus Type 5 Infection Leads to Nuclear Envelope Destabilization and Membrane Permeability Independently of Adenovirus Death Protein. (leibniz-liv.de)
  • It is well established that the human subgroup C adenovirus type 5 (Ad5) E1B 55 kDa protein can regulate the activity and concentration of the cellular tumor suppressor, p53. (princeton.edu)
  • a threonine-to-methionine amino acidity substitution at the positioning equal to residue 342 from the wild-type proteins. (synanet2020.com)
  • The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes. (microbiologyresearch.org)
  • A novel interaction between the human papillomavirus type 16 E2 and E1^E4 proteins leads to stabilization of E2. (microbiologyresearch.org)
  • 1278\1278\BAD35103.1\Human adenovirus type 4\Human adenovirus type 4 gene for fiber protein, complete cds,isolate:1998-4439. (or.jp)
  • 1278\1278\BAD35104.1\Human adenovirus type 4\Human adenovirus type 4 gene for fiber protein, complete cds,isolate:TC-18040. (or.jp)
  • 1278\1278\BAD35105.1\Human adenovirus type 4\Human adenovirus type 4 gene for fiber protein, complete cds,isolate:TC-18465. (or.jp)
  • 884\684\AAN64737.1\Human adenovirus type 4\Human adenovirus type 4 early region 3, complete sequence. (or.jp)
  • 1205\321\AAN64738.1\Human adenovirus type 4\Human adenovirus type 4 early region 3, complete sequence. (or.jp)
  • 1791\633\AAN64739.1\Human adenovirus type 4\Human adenovirus type 4 early region 3, complete sequence. (or.jp)
  • 2297\525\AAN64740.1\Human adenovirus type 4\Human adenovirus type 4 early region 3, complete sequence. (or.jp)
  • Nevertheless, the high prevalence of Advertisement5-particular neutralizing antibodies (NAb) in human being populations, in sub-Saharan Africa especially, gets the potential to limit the potency of Advertisement5-centered vaccines (23, 27C30). (synanet2020.com)
  • In addition, non-replicating mRNAs can be used to produce RNA-related vaccines that involve mRNA sequences encoding pathogen-specific proteins (antigens) in host cells. (medicaltrend.org)
  • In live attenuated vaccines, pathogens that infect humans are continuously passaged in vivo (animal embryos) or in vitro (cell culture). (medicaltrend.org)
  • Conjugate vaccines are made by combining polysaccharide residues in the bacterial surface capsule with carrier proteins (such as diphtheria toxoid protein). (medicaltrend.org)
  • In RNA vaccines, mRNA is used as a template for the endogenous synthesis of the target pathogenic protein (antigen). (medicaltrend.org)
  • Such vaccines do not include other protein sequences that induce self-amplification of the inserted mRNA sequence. (medicaltrend.org)
  • Adenovirus-based vaccines can induce antibody-mediated and T-cell- mediated immune responses. (medicaltrend.org)
  • Structural basis of mitochondrial protein import by the TIM23 complex. (ucsf.edu)
  • Structural model for factor X inhibition of IgM and complement-mediated neutralization of adenovirus. (ucsf.edu)
  • Structural basis of BAM-mediated outer membrane β-barrel protein assembly. (ucsf.edu)
  • Engineering mouse apolipoprotein A-I into a monomeric, active protein useful for structural determination. (uchicago.edu)
  • Genomic and phylogenetic analysis of two guinea pig adenovirus strains recovered from archival lung tissue. (leibniz-liv.de)
  • Human respiratory syncytial virus (HRSV) is a major cause of lower respiratory tract disease in children and the elderly for which there is still no effective vaccine. (unina.it)
  • We have previously shown that PanAd3-RSV, which is a chimpanzee adenovirus-vectored vaccine candidate that expresses a secreted form of the HRSV F protein together with the N and M2-1 proteins of HRSV, is immunogenic in rodents and nonhuman primates, and protects mice and cotton rats from HRSV challenge. (unina.it)
  • Because the extent to which protection demonstrated in rodent models will translate to humans is unclear, we have exploited the calf model of bovine RSV (BRSV) infection, which mimics HRSV disease in children more closely than do experimental models of unnatural laboratory hosts, to evaluate the safety and efficacy of the PanAd3-RSV vaccine. (unina.it)
  • KIR3DS1 directs NK cell-mediated protection against human adenovirus infections. (leibniz-liv.de)
  • Human adenoviruses (HAdVs) are prevalent in patients with respiratory infections, in which recombination has important implications for viral detection and pathogenicity. (biomedcentral.com)
  • Most other viral gastroenteritis infections are caused by astrovirus or enteric adenovirus. (merckmanuals.com)
  • Tissue reservoirs of antiviral T cell immunity in persistent human CMV infection. (arizona.edu)
  • Infection process of adenovirus. (genemedi.com)
  • Protein-Protein Interactions Facilitate E4orf6-Dependent Regulation of E1B-55K SUMOylation in HAdV-C5 Infection. (leibniz-liv.de)
  • Rather, the localization of p53 to E1B containing nuclear sites observed during infection by Ad5 was prevented by mutations that impair interaction of the E1B protein with p53 and/or with the E4 Orf6 protein. (princeton.edu)
  • This information would enhance the understanding of recombination of HAdV-C, and might assist with effective prevention and control of respiratory adenovirus infection in Qinghai Province. (biomedcentral.com)
  • The relevance of the adenovirus co-infection remains unclear and merits further investigation. (biomedcentral.com)
  • However, the contribution(s) of these functions of the E1B protein to viral reproduction remains unclear. (princeton.edu)
  • In vivo studies of HDL assembly and metabolism using adenovirus-mediated transfer of ApoA-I mutants in ApoA-I-deficient mice. (uchicago.edu)
  • Influence of dietary lipids on hepatic mRNA levels of proteins regulating plasma lipoproteins in baboons with high and low levels of large high density lipoproteins. (uchicago.edu)
  • CAR receptor-fiber-knob adenovirus interaction and internalization process [46]. (genemedi.com)
  • Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy. (docksci.com)
  • The Human Papillomavirus (HPV) E2 protein, which inhibits the E6 and E7 viral oncogenes, is believed to have antioncogenic properties. (docksci.com)
  • Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes. (microbiologyresearch.org)
  • The papillomavirus major capsid protein L1. (microbiologyresearch.org)
  • Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus. (microbiologyresearch.org)
  • The L1-L5 transcription units are transcribed later in the viral reproductive cycle, and code mostly for proteins that make up components of the viral capsid or are involved in assembly of the capsid. (wikipedia.org)
  • The control proteins of the E4 transcription unit are involved in regulating transcription of viral DNA. (wikipedia.org)
  • Hale, A. E., D. Collins-McMillen, E. M. Lenarcic, S. Igarashi, J. P. Kamil, F. Goodrum, and N. J. Moorman, 'FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation. (arizona.edu)
  • Lee, S. Hee, K. Caviness, E. R. Albright, J-H. Lee, C. B. Gelbmann, M. Rak, F. Goodrum, and R. F. Kalejta, 'Long and Short Isoforms of the Human Cytomegalovirus UL138 Protein Silence IE Transcription and Promote Latency. (arizona.edu)
  • The Qinghai adenovirus strain(QH-1665/2018) was isolated from an outpatient, whom was one month old and diagnosed with an influenza-like illness at Women's and Children's Hospital of Qinghai Province on November 26, 2018. (biomedcentral.com)
  • QH-1665/2018 caused adenovirus-like CPE of HEp-2 cells, and the cultures underwent three passages to obtain high-titer stocks. (biomedcentral.com)
  • 2018) Valoración de un nuevo ensayo quimioluminiscente en comparación con ELISA en la detección de IgG contra el virus de la hepatitis E. Revista de la Sociedad Andaluza de Microbiología y Parasitología Clínica. (vircell.com)
  • Kim, J. Heon, D. Collins-McMillen, J. C. Buehler, F. D. Goodrum, and A. D. Yurochko, 'Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34+ Human Progenitor Cells. (arizona.edu)
  • The steady-state concentrations of p53 were significantly higher in cells infected by the E1B 55 kDa null mutant Hr6 or three mutants carrying small insertions in the E1B 55 kDa protein coding sequence than in Ad5-infected cells. (princeton.edu)
  • These results indicate that the E1B protein fulfills an early function that correlates efficient entry into the late phase with the localization of E1B and p53 in the nucleus of Ad5-infected normal human cells. (princeton.edu)
  • To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. (mdpi.com)
  • 293-ORF6 cells exhibit both Advertisement5 early area 1 (E1) and E4 gene items (43). (synanet2020.com)
  • Eventually, the virus attains an attenuated state, in which it can still trigger the required human immune response, but cannot replicate in human cells. (medicaltrend.org)
  • One of the first hurdles of gene therapy is successful introduction of the corrected gene into the human cells. (familymednews.com)
  • The HAdV positive samples were inoculated onto human laryngeal epidermoid cancer cells (HEp-2) cultured with DMEM containing 2% FBS for virus isolation. (biomedcentral.com)
  • Methods: Gene transfer to human endothelial cells, porcine vascular smooth muscle cells and cultured rat thoracic aortas was examined. (unipv.it)
  • Immunoblot analysis was used to determine relative protein quantities within cells. (biomedcentral.com)
  • Measured in anti-viral assays using HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. (bio-techne.com)
  • Apoptosis-inducing factor (AIF), named for its involvement in cell death pathways, is a mitochondrial protein that regulates metabolic homeostasis. (biomedcentral.com)
  • Hancock, M. H., J. Mitchell, F. D. Goodrum, and J. A. Nelson, 'Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways. (arizona.edu)
  • AlgP is a DNA-binding protein with a 154 amino acid C-terminal domain enriched in "KPAA" repeats and variants of this repeat, with an overall sequence composition similar to the C-terminal tail of eukaryotic histone H1. (bvsalud.org)
  • Mature human IFN-beta shares 47% and 46% amino acid sequence identity with the mouse and rat proteins, respectively. (bio-techne.com)
  • Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. (embl.de)
  • Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. (embl.de)
  • result suggests fiber and E4 ORF 6/7 peptides participate in the evolution of Ad7. (cdc.gov)
  • This phenotype is associated with interaction of E2 with the Mitotic Checkpoint Complex (MCC) proteins Cdc20, MAD2 and BUBR1. (docksci.com)
  • However, the combination of the bacterial part and the carrier protein induces a powerful and comprehensive immune response. (medicaltrend.org)
  • Control protein E3 14.7K protects the virus from host antiviral responses. (wikipedia.org)
  • Rak, M. A., J. Buehler, S. Zeltzer, J. Reitsma, B. Molina, S. Terhune, and F. Goodrum, 'Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency. (arizona.edu)
  • Ligand and G-protein selectivity in the κ-opioid receptor. (ucsf.edu)
  • Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein. (uchicago.edu)
  • Here, we show for the first time to our knowledge that HPV16 E2 directly associates with the major capsid protein L1, independently of other viral or cellular proteins. (microbiologyresearch.org)
  • Membrane protein E3 RID-alpha and membrane protein E3 RID-beta performs a variety of molecular functions that contribute to inhibiting apoptosis. (wikipedia.org)
  • Conserved E1B-55K SUMOylation in different human adenovirus species is a potent regulator of intracellular localization. (leibniz-liv.de)
  • Control protein E1B 19K suppresses apoptosis by mimicking the action of cellular protein Bcl-2. (wikipedia.org)
  • The entry of AdV into human body stimulates a wide spectrum of innate cellular responses, which might last a few minutes to hours and result in blood pressure changes, thrombocytopenia, inflammation, and fever [47]. (genemedi.com)
  • E2 is expressed throughout the differentiation-dependent virus life cycle and is functionally regulated by association with multiple viral and cellular proteins. (microbiologyresearch.org)
  • Characterization of cholesteryl ester transfer protein inhibitor from plasma of baboons (Papio sp. (uchicago.edu)
  • We have developed mouse models that mimic this human SNP and have demonstrated that the humanized p53 variants are functional and display the expected difference in apoptotic capacity in mouse tissues. (mdanderson.org)
  • The AAV capsid protein, which forms the virions' outer shell, is the primary determinant of tissue tropism, transduction efficiency, and immunogenicity. (biomedcentral.com)
  • The AAV virion contains 60 VP proteins in a 1:1:10 ratio (VP1:VP2:VP3). (biomedcentral.com)
  • Naturally occurring variant of mouse apolipoprotein A-I alters the lipid and HDL association properties of the protein. (uchicago.edu)
  • Molecular basis of translation termination at noncanonical stop codons in human mitochondria. (ucsf.edu)
  • This study was designed to examine the effect of temperature on the efficiency of adenovirus-mediated gene transfer. (unipv.it)
  • 0.001 vs. 10 degrees C). Conclusions: The present study demonstrates that the efficiency of adenovirus-mediated gene transfer is significantly reduced at lower temperatures. (unipv.it)
  • Organizations willing to rely on a healthy workforce should implement human resource management strategies focused on leadership training capable of boosting employees' hardiness. (123dok.org)
  • From this perspective, the specific approach applied to human resources management acting within organizations could considerably affect employees' well-being and their attainment of crucial organizational outcomes. (123dok.org)