CD98ProteinsProteinCharacterizationMonoclonalGlycoproteinsELISA KitAminoReactivityAntibodySerumNormalCellsAnti-humanCell linesResearchVirusBlood4F2hcSLC3A2Surface antigenSubunitGlycoproteinStimulatesFibroblastsAntibodiesExpressionCloneDiploidKeratinocytesRecombinantQuantitativeGeneticsELISASpeciesBindsSynthesisTestsTransportDescriptionHealth
CD989
- Antigens, CD98" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
- The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. (wakehealth.edu)
- It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. (wakehealth.edu)
- This graph shows the total number of publications written about "Antigens, CD98" by people in this website by year, and whether "Antigens, CD98" was a major or minor topic of these publications. (wakehealth.edu)
- Below are the most recent publications written about "Antigens, CD98" by people in Profiles. (wakehealth.edu)
- CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). (exbio.cz)
- Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD98 (MEM-108) PE. (exbio.cz)
- Dalton P, Christian HC, Redman CW, Sargent IL, Boyd CA: Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line. (exbio.cz)
- These glycoproteins include the CD98 heavy chain protein of Mus musculus (gbU25708) and the orthologous 4F2 cell surface antigen heavy chain of Homo sapiens (spP08195). (tcdb.org)
Proteins4
- They are the mammalian proteins inducing transport of dibasic and neutral amino acids across cell membranes and the mammalian 4F2 heavy-chain cell surface antigens, i.e ., proteins without any functional relatedness to amylolytic enzymes. (go.jp)
- The resulting technique maps the location of most of the proteins in a human cancer cell line and, in addition, determines how many copies of each protein there are. (elifesciences.org)
- One typical example is proteins modified with O-linked β- N -acetylglucosamine ( O -GlcNAc) and O-linked α- N -acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished. (mcw.edu)
- Then, the enzymatic reaction with galactose oxidase was utilized to specifically oxidize O-GalNAc, but not O -GlcNAc, generating the different tags between glycopeptides with O -GlcNAc and O-GalNAc that can be easily distinguishable by mass spectrometry (MS). Among O -GlcNAcylated proteins commonly identified in three types of human cells, those related to transcription and RNA binding are highly enriched. (mcw.edu)
Protein5
- 4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. (wikipedia.org)
- A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. (wakehealth.edu)
- In 1993, Lee et al cloned a human complementary DNA, rBAT (renal basic amino acid transporter) in chromosome 2, encoding a transport protein for cystine and dibasic amino acids. (medscape.com)
- Among glycoproteins exclusively in Jurkat cells, those involved in human T-lymphotropic virus type 1 (HTLV-1) infection are overrepresented, which is consistent with the cell line source and suggests that protein O -GlcNAcylation participated in the response to the virus infection. (mcw.edu)
- Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation. (mcw.edu)
Characterization1
- 1995) Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. (nih.gov)
Monoclonal2
- 4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin. (rupress.org)
- The 4F2 monoclonal antibody (mAb) has been shown to recognize a 120-kilodalton glycoprotein expressed on the cell surface of human peripheral blood monocytes, activated (but not resting) T or B cells, and T and B lymphoblastoid cell lines. (rupress.org)
Glycoproteins2
- Xu S, Zheng J, Xiao H, Wu R. Simultaneously Identifying and Distinguishing Glycoproteins with O -GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells. (mcw.edu)
- Glycoproteins with diverse glycans are essential to human cells, and subtle differences in glycan structures may result in entirely different functions. (mcw.edu)
ELISA Kit1
- Description: Quantitativesandwich ELISA kit for measuring Human Angiotensin 1-7 (Ang1-7) in samples from serum, plasma, cell culture supernates. (clinical-trial-logistics.com)
Amino1
- Various authors have studied amino acid transport in cell membranes obtained from the proximal renal tubule of humans, rats, and rabbits. (medscape.com)
Reactivity2
- Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Angiotensin 1-7 (Ang1-7) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (clinical-trial-logistics.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Beta 6 (ITGb6) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (antibody-tech.com)
Antibody2
- 1 2 Cell surface antigens CD38 and CD138 can be used to distinguish normal cells from clonal plasma cells, but more extensive use of immunophenotyping has been limited by a lack of universally accepted markers of MM. 3-5 Once diagnosed, the current standard-of-care for MM includes immunomodulatory drugs, proteasome inhibitors, steroids, and antibody therapies. (bmj.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Beta 6 (ITGb6) in tissue homogenates, cell lysates and other biological fluids. (antibody-tech.com)
Serum4
- Figure B. Alexa Fluor 647 conjugated Mouse anti Human CD3 ( MCA463A647 ) and StarBright Violet 440 conjugated Mouse anti Human CD69 ( MCA2806SBV440 ) All experiments performed on human blood stimulated with Cell Stimulation Reagent (without Brefeldin A) for 5 hours, gated on live single lymphocytes, in the presence of 10% human serum. (bio-rad-antibodies.com)
- Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Angiotensin 1-7 (Ang1-7) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (clinical-trial-logistics.com)
- Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Angiotensin 1-7 (Ang1-7) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (clinical-trial-logistics.com)
- Description: A competitive ELISA for quantitative measurement of Human Angiotensin 1-7 (ANG1-7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (clinical-trial-logistics.com)
Normal2
- In this report we show that 4F2 mAb specifically binds to the surface of adherent human embryonic fibroblasts but fails to bind to normal adult fibroblasts. (rupress.org)
- Finally, addition of 4F2 mAb inhibited the growth of cultured HT-1080 fibrosarcoma cell line, but had no inhibitory effect on various embryonic and adult normal or transformed fibroblasts. (rupress.org)
Cells7
- Moreover, 4F2 antigen was expressed on sarcoma-derived or SV40-transformed adult fibroblastic cells. (rupress.org)
- SV40 transformation of human diploid cells. (cellosaurus.org)
- The kinetics of thymine dimer excision in ultraviolet-irradiated human cells. (cellosaurus.org)
- Adenovirus: a probe for human cells deficient in DNA repair. (cellosaurus.org)
- Genetic analysis of indefinite division in human cells: identification of four complementation groups. (cellosaurus.org)
- The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. (cellosaurus.org)
- Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)
Anti-human5
- Figure A. Alexa Fluor488 conjugated mouse anti human CD3 ( MCA463A488 ) and Alexa Fluor647 conjugated mouse IgG1 isotype control ( MCA928A488 ). (bio-rad-antibodies.com)
- Figure B. Alexa Fluor488 conjugated mouse anti human CD3 ( MCA463A488 ) and Alexa Fluor647 conjugated mouse anti human CD69 ( MCA2806A647 ). (bio-rad-antibodies.com)
- Figure A. Alexa Fluor 488 conjugated Mouse anti Human CD3 ( MCA463A488 ). (bio-rad-antibodies.com)
- Figure B. Alexa Fluor 488 conjugated Mouse anti Human CD3 ( MCA463A488 ) and StarBright Violet 515 conjugated Mouse anti Human CD69 ( MCA2806SBV515 ). (bio-rad-antibodies.com)
- Figure A. Alexa Fluor 647 conjugated Mouse anti Human CD3 ( MCA463A647 ). (bio-rad-antibodies.com)
Cell lines1
- Human diploid lung fibroblast cell lines WI 26 and WI 38 exhibit isozyme shift of alkaline phosphatase after viral transformation. (cellosaurus.org)
Research1
- NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
Virus1
- Imai H , Shinya K , Takano R , Kiso M , Muramoto Y , Sakabe S , The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets. (cdc.gov)
Blood1
- All experiments performed on PBMCs extracted from human blood stimulated with PHA and LPS for 48 hours gated on lymphocytes in the presence of Human Seroblock ( BUF070A ). (bio-rad-antibodies.com)
4F2hc2
- [ 4 ] LAT1 requires another cell surface glycoprotein, the 4F2 heavy chain (4F2hc), for its functional expression and forming a heterodimeric complex. (medscape.com)
- Therefore, we investigated systematically the LAT1/4F2hc expression in 62 cases of human brain glioma by immunohistochemistry, and further analyzed the relation of LAT1/4F2hc expression with the glioma histopathological grade, malignant proliferation and angiogenesis in this study. (medscape.com)
SLC3A21
- 4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. (wikipedia.org)
Surface antigen3
- 18. Analysis of the expression of the 4F2 surface antigen in normal and neoplastic fibroblastic human cells of embryonic and adult origin. (nih.gov)
- A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. (nih.gov)
- 4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin. (cellosaurus.org)
Subunit1
- The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. (cellosaurus.org)
Glycoprotein2
Stimulates1
- 17. Leukemia inhibitory factor binds to human breast cancer cells and stimulates their proliferation. (nih.gov)
Fibroblasts1
- 12. Cell cycle regulated expression of nucleolar antigen P120 in normal and transformed human fibroblasts. (nih.gov)
Antibodies2
- Therefore, it is advantageous to know the interaction pattern between antibodies and their antigens. (bvsalud.org)
- Regions on the antigen which are recognized by the antibodies are called epitopes, and the respective molecular counterpart of the epitope on the mAbs is called paratope. (bvsalud.org)
Expression3
- 15. Expression of the ATDC (ataxia telangiectasia group D-complementing) gene in A431 human squamous carcinoma cells. (nih.gov)
- 19. Cell-surface glycoproteins of human sarcomas: differential expression in normal and malignant tissues and cultured cells. (nih.gov)
- [ 1 ] In terms of glucose supply, the over-expression of glucose transporter-1 (Glut-1) is related to increased glucose uptake in human tumors. (medscape.com)
Clone1
- 513-DCABH-10473 Host Species: Mouse Antibody Isotype: IgG2a Clone: 2C4 Species Reactivity: Human Immunogen: AKR1C1 (AAH20216, 1 a.a. ~ 110 a.a) partial recombinant. (gen9bio.com)
Diploid2
- SV40 transformation of human diploid cells. (cellosaurus.org)
- Human diploid lung fibroblast cell lines WI 26 and WI 38 exhibit isozyme shift of alkaline phosphatase after viral transformation. (cellosaurus.org)
Keratinocytes1
- 9. Transformation of human keratinocytes is characterized by quantitative and qualitative alterations of the T-16 antigen (Trop-2, MOv-16). (nih.gov)
Recombinant1
- Description: NAP1L4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 398 amino acids (1-375) and having a molecular mass of 45.2 kDa. (hiv-pharmacogenomics.org)
Quantitative1
- Description: A competitive ELISA for quantitative measurement of Human Mothers against decapentaplegic homolog 3(SMAD3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (antibody-tech.com)
Genetics1
- NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
ELISA2
- Description: A sandwich ELISA kit for detection of Potassium Inwardly Rectifying Channel Subfamily J, Member 10 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (clinical-trial-logistics.com)
- Description: A sandwich ELISA kit for detection of Mothers Against Decapentaplegic Homolog 2 from Human,Mouse,Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (hiv-pharmacogenomics.org)
Species2
- 544-MBS4381078 Species Reactivity: Human Specificity: Detects human MCAM in direct ELISAs and Western blots. (gen9bio.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Mothers Against Decapentaplegic Homolog 2 (Smad2) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (hiv-pharmacogenomics.org)
Binds1
- 544-MBS2056489 Secies Reactivity: Human Specificity: Detects human E‑Selectin/P‑Selectin (CD62E/P). Binds to COS cells transfected with human E-Selectin or human. (gen9bio.com)
Synthesis1
- Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. (nih.gov)
Tests1
- Thus, epitope hotspots may have greater potential to serve as antigens in diagnostic tests and vaccine development than peptides composed of only 15 amino acids. (bvsalud.org)
Transport1
- Various authors have studied amino acid transport in cell membranes obtained from the proximal renal tubule of humans, rats, and rabbits. (medscape.com)
Description1
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Mothers Against Decapentaplegic Homolog 2 (Smad2) in tissue homogenates, cell lysates and other biological fluids. (hiv-pharmacogenomics.org)
Health3
- The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Depart- ment of Health and Human Services, Atlanta, GA 30333. (cdc.gov)
- Use of trade names and commercial sources is for identification only and does not imply endorsement by the Public Health Service or the U.S. Department of Health and Human Services. (cdc.gov)
- The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. (nih.gov)