• HTLV-I is the causal agent of adult T cell leukemia (ATLL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (biomedcentral.com)
  • Tropical spastic paraparesis (TSP), also called HTLV-I-associated myelopathy (HAM) or HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a medical condition that causes weakness, muscle spasms, and sensory disturbance by human T-lymphotropic virus resulting in paraparesis, weakness of the legs. (wikipedia.org)
  • Phase II Study of Alemtuzumab (CAMPATH-1) in Patients with HTLV-1-Associated Adult T-cell Leukemia/lymphoma. (nih.gov)
  • To evaluate the efficacy, safety and pharmacokinetic profiles of KW-0761, the anti-CC chemokine receptor 4 (CCR4) antibody, when administered weekly for 8 weeks as an intravenous infusion at a dose of 1.0 mg/kg in relapsed subjects with CCR4-positive adult T-cell leukemia-lymphoma. (clinicaltrials.gov)
  • Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family that has been implicated in several kinds of diseases including very aggressive adult T-cell lymphoma (ATL), HTLV-I-associated myelopathy, uveitis, Strongyloides stercoralis hyper-infection and some other diseases. (wikipedia.org)
  • Two Chinese haemophiliacs treated with locally produced factor Ⅷ was sero-negative.The first AIDS patient from abroad died in Beijing in 1985 was also sero-positive.In conclusion ,the data indicated that the Chinese haemophilics were exposed to LAV/HTLV-Ⅲ via imported factor Ⅷ from USA. (cnki.com.cn)
  • Anti-GAG antibody titers detected by LIPS differentiated HTLV-infected subjects from uninfected controls with 100% sensitivity and 100% specificity, but did not differ between HTLV-I infected subgroups. (biomedcentral.com)
  • Blood transfusion products are screened for HTLV-1 antibodies, as a preventive measure. (wikipedia.org)
  • HTLV-1 can be transmitted via breastfeeding (mother to child), sexual contact, via blood contact (transfusion or needle sharing). (wikipedia.org)
  • Transmission of HTLV-I is believed to occur by sexual contact, from mother to child via breastfeeding, and through exposure to contaminated blood, either through blood transfusion or sharing of contaminated needles. (wikipedia.org)
  • The ability to clearly distinguish between clinical outcomes of HTLV-I infections in a robust and simple serological test would have obvious clinical utility. (biomedcentral.com)
  • Using data from two surveillance systems held at Public Health England, we described HTLV antibody testing patterns between 2008 and 2013 and the demographic and clinical characteristics of persons diagnosed with HTLV in England and Wales between 2004 and 2013. (eurosurveillance.org)
  • The subgroup HTLV-II also induces T-cell proliferation in vitro, but its role in disease is unclear. (sciencemag.org)
  • Antibody profiles were correlated with viral load and examined in longitudinal samples. (biomedcentral.com)
  • Once integrated, HTLV-1 continues to exist only as a provirus which can spread from cell to cell through a viral synapse. (wikipedia.org)
  • Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies. (lsbio.com)
  • For an evaluation that includes screening and confirmation, order HTLVI / Human T-Cell Lymphotropic Virus Types I and II (HTLV-I/-II) Antibody Screen with Confirmation, Serum. (testcatalog.org)
  • Licensure of screening tests for antibody to human T-lymphotropic virus type I". MMWR. (wikipedia.org)
  • The retrovirus is now generally called HTLV-I because later studies proved that ATLV is the same as the firstly identified human retrovirus called HTLV discovered by Bernard Poiesz and Francis Ruscetti and their co-workers in the laboratory of Robert C. Gallo at the National Cancer Institute. (wikipedia.org)
  • Simian HTLV-1 genotypes are interspersed in between the human genotypes indicating frequent animal-human and human-animal transmission. (wikipedia.org)
  • Additional tests can be requested by telephone or letter on samples received by the laboratory up to 2 years after the receipt of the sample (2 years in serology, 1 year in molecular), although it must be recognised that the archive sample available will have a limited volume and the antibody profile may be different to their current sample. (cmft.nhs.uk)
  • In Europe HTLV-1 is still uncommon, although it is present in some high-risk populations, including immigrants and intravenous drug users. (wikipedia.org)