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  • membrane
  • why is my cell nucleus stain green as in the FITC should not it only stain the cell membrane? (biology-online.org)
  • At the cellular level, sortilin functions in protein transport between the Golgi apparatus, endosome, lysosome, and plasma membrane, leading to its involvement in multiple biological processes such as glucose and lipid metabolism as well as neural development and cell death. (wikipedia.org)
  • In addition, two hydrophobic loops have been detected in this domain and act to anchor the protein in the cell membrane. (wikipedia.org)
  • As a sorting receptor on the cell surface and on the endoplasmic reticulum-Golgi apparatus within the cell, sortilin is involved in the transport of a wide variety of intracellular proteins between the trans-Golgi network, endosome, lysosome, and secretory granules, as well as the plasma membrane. (wikipedia.org)
  • This molecular function enables sortilin to participate in various biological processes, including the transport of GLUT4 to the plasma membrane of fat and skeletal muscle cells in response to insulin. (wikipedia.org)
  • Most defensins function by binding to the microbial cell membrane, and, once embedded, forming pore-like membrane defects that allow efflux of essential ions and nutrients. (wikipedia.org)
  • tumor cell
  • The fine regulation of the brain-derived neurotrophic factor (BDNF) by sortilin is required for both neuronal and tumor cell survival. (wikipedia.org)
  • Furthermore, it appears that sortilin participates in the progression of breast cancer and contributes to tumor cell adhesion and invasion. (wikipedia.org)
  • pathways
  • Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. (semanticscholar.org)
  • Emerging evidence suggests that reactive oxygen (ROS) and nitrogen (RNS) species can contribute to diverse signalling pathways of inflammatory and tumour cells. (hindawi.com)
  • Overview of cell death signaling pathways. (koreascience.or.kr)
  • Therefore, FHL2 translocation could be important in regulating the different molecular signaling pathways which modify carcinogenesis, for example, nuclear translocation of FHL2 is related to aggressiveness and recurrence of prostate cancer Similar evidence also has been identified in experiment using A7FIL+ cells and NIH 3T3 cell line as the disease model. (wikipedia.org)
  • cytochrome
  • META-treated HT29 cells also showed the release of cytochrome c from the mitochondria into the cytosol, activation of caspase-3, caspase-8, and caspase-9, and proteolytic cleavage of poly ADP-ribose polymerase (PARP). (koreascience.or.kr)
  • exert
  • However, whether this peptide can be functionally expressed in LAB and exert activity on cancer cells, thus providing a potential alternative administration manner in the future, has not been demonstrated. (biomedcentral.com)
  • tissues
  • This gene is a marker of columnar epithelium and is expressed in a variety of tissues including goblet cells of the intestines and colon. (wikipedia.org)
  • Since, however, many studies on the identification, quantification, and actions of 13(S)-HODE in cells and tissues have employed methods that did not distinguish between these isomers, 13-HODE is used here when the actual isomer studied is unclear. (wikipedia.org)
  • Moreover
  • Moreover, prolonged drug incubation (up to 168h) resulted in massive detachment of cells from culture plates, which together with Annexin V/PI results, indicated that necrosis was the main response of HT29 cells to C-1748 treatment. (biomedsearch.com)
  • Cancer
  • Our results suggest that L. lactis is an ideal cell factory for secretory expression of tumor metastasis-inhibiting peptide KiSS1, and the KiSS1-producing L. lactis strain may serve as a new tool for cancer therapy in the future. (biomedcentral.com)
  • In this study, we evaluated the anti-oxidative and anti-cancer activities of the methanol extract of T. africana Decne (META) and the molecular mechanisms of its anti-cancer effects in human colon carcinoma HT29 cells. (koreascience.or.kr)
  • Cell cycle control and cancer. (koreascience.or.kr)
  • Interestingly, a significant role for sortilin has recently also been reported in the field of oncology, as it has been detected in several cancer cell lines. (wikipedia.org)
  • The success of this strain's construction helped to inhibit migration and expansion of cancer cells, showing that the secretion properties of L.lactis of this particular peptide illustrates a hopeful future in Cancer therapy. (wikipedia.org)
  • protein
  • In type I cells, active caspase-8 directly cleaves downstream procaspase-3 (9) , whereas a small amount of caspase-8 activated in type II cells truncates the BH3 domain-containing proapoptotic Bcl-2 family protein (BID). (aacrjournals.org)
  • This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. (wikipedia.org)
  • cytokines
  • Tumour Cell Lines HT-29 and FaDu Produce Proinflammatory Cytokines and Activate Neutrophils In Vitro: Possible Applications for Neutrophil-Based Antitumour Treatment," Mediators of Inflammation , vol. 2009, Article ID 817498, 13 pages, 2009. (hindawi.com)
  • membranes
  • Mid2p acts later in cytokinesis to organize septins during septation, or the invagination of inner membranes, outer membranes, and the cell wall that occurs in order to separate daughter cells completely. (wikipedia.org)
  • Defensins are antimicrobial peptides that act mainly by disrupting the structure of bacterial cell membranes and are found in many compartments of the body. (wikipedia.org)
  • expression
  • Next, we demonstrated that HCT8 cells surviving after exposure to C-1748 were in the state of senescence, based on altered cell morphology and expression of a pH 6-dependent beta-galactosidase. (biomedsearch.com)
  • inflammatory
  • It has been determined that a large group of proteases cleave and activate PARs receptors, including proteases from: a) the coagulation cascade, b) inflammatory cells, and c) the digestive tract. (wikipedia.org)
  • actin
  • Binding of F-actin by anillin only occurs during cell division. (wikipedia.org)
  • It is hypothesized that by regulating actin bundling, anillin increases the efficiency of actomyosin contractility during cell division. (wikipedia.org)
  • lactis
  • L. lactis cells are cocci that group in pairs and short chains, and, depending on growth conditions, appear ovoid with a typical length of 0.5 - 1.5 µm. (wikipedia.org)
  • proteins
  • Using iTRAQ based proteomics method, we identified 1985 specific proteins, out of which 212 were found to be significantly changed in two cell lines. (currentproteomics.com)
  • mammalian cells
  • The antileishmanial activity of the naphthoquinone derivatives was evaluated against promastigotes and intracellular amastigotes of Leishmania (Leishmania) infantum and their cytotoxicity was verified in mammalian cells. (jove.com)
  • 3-Methyladenine which stops macroautophagy at the sequestration step in mammalian cells also inhibits the phosphoinositide 3-kinase (PI3K) activity raising the possibility that PI3K signaling controls the macroautophagic pathway (Blommaart, E. F. C., Krause, U., Schellens, J. P. M., Vreeling-Sindelárová, H., and Meijer, A. J. (1997) Eur. (semanticscholar.org)
  • inhibit
  • As such, the main purpose of dephosphorylation by alkaline phosphatase is to increase the rate of diffusion of the molecules into the cells and inhibit them from diffusing out. (wikipedia.org)
  • The success of this strain's construction helped to inhibit migration and expansion of cancer cells, showing that the secretion properties of L.lactis of this particular peptide illustrates a hopeful future in Cancer therapy. (wikipedia.org)
  • Therapeutic miR-26a delivery using adeno-associated virus (AAV) is able to inhibit cancer cell formation while also inducing tumour-specific apoptosis and providing dramatic protection from disease progression without toxicity. (wikipedia.org)
  • myeloid
  • Essential thrombocythemia (ET) and primary myelofibrosis (PMF) are chronic diseases characterized by clonal hematopoiesis and hyperproliferation of terminally differentiated myeloid cells. (bloodjournal.org)
  • regulation
  • PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control. (wikipedia.org)
  • tumorigenesis
  • In LSCC, its upregulation correlates with metastasis and poor prognosis, while its downregulation reduces tumor cell motility and tumorigenesis. (wikipedia.org)
  • miR-26a again suppresses tumorigenesis in nasopharyngeal cells in vivo, with suppressed expression of c-myc, cyclins D3 and E2, and cyclin-dependent kinases CDK4 and CDK6. (wikipedia.org)
  • enzymes
  • consequently, COX-2 appears to be the principle COX making 13(S)-HODE in cells expressing both enzymes. (wikipedia.org)
  • novel
  • Additionally, in a novel strategy with biological approach for synthesis of silver nanoparticles (AgNPs), a toxic substance, using sodium para-hydroxybenzoate tetrahydrate (SPHT) isolated from Vitex negundo leaves, treatment of sodium para-hydroxybenzoate tetrahydrate (SPHT) improved the hydroxyl and carboxylic functional groups mediators in edhibited a stronger ability towards synthesis of AgNPs which indicated the apoptotic effect on human colon cancer cell lines. (blogspot.com)
  • vivo
  • After validation of their effectiveness on survival of colorectal cancer cell lines harboring B-RAF or K-RAS mutations, their efficacy was assessed in vitro and in vivo , alone or concomitantly with chemotherapy, on CSC self-renewal capacity, tumor recurrence, and Wnt signaling. (aacrjournals.org)
  • lines
  • Use only Express Delivery (overnight) for cell lines. (addexbio.com)
  • Collectively, casticin also promoted Cell Death in cell division with the same mechanisms in other cancer cell lines, including HCT-116, SW480 and Caco-2 cells. (blogspot.com)
  • L leaves and its apoptotic effect on human colon cancer cell lines by Durai P1, Chinnasamy A2, Gajendran B1, Ramar M1, Pappu S3, Kasivelu G4, Thirunavukkarasu A5. (blogspot.com)
  • Nasopharyngeal carcinoma miR-26a is commonly downregulated in nasopharyngeal carcinoma samples and cell lines. (wikipedia.org)
  • hypoxia
  • Cancer cells often face conditions of nutrient deprivation, hypoxia, alterations in glycosylation status and calcium flux [ 1 , 2 ], leading to the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) lumen. (biomedcentral.com)
  • resistant
  • Recently, we demonstrated that cancer cells with constitutive or acquired resistance to chemotherapy are also resistant to ER stress-triggered cell death. (biomedcentral.com)
  • Since the periplasmic gap is more prone to environmental variation than the inner cell, alkaline phosphatase is suitably resistant to inactivation, denaturation, or degradation. (wikipedia.org)
  • activation
  • Overall, in uFB cultured HCC cells, a high degree of genetic instability appears to facilitate the inactivation of regular and tumor suppressor proteins at the same time as the activation of HCC relevant proteins like CYP1A and CYP3A. (mek-inhibitors.com)