Loading...
  • peptides
  • Conceptual translation predicted 24,013 proteins, which were then subjected to detailed annotation which included pathway mapping of predicted proteins (including 112 excreted/secreted [ES] and 226 transmembrane peptides), domain analysis and GO annotation was carried out using InterProScan along with BLAST2GO. (biomedcentral.com)
  • pathways
  • Unigenes functionally associated to heat-shock proteins and glutathione were concurrently induced, suggesting the role of thylakoid-localized proteins and antioxidant-detoxification pathways as an effective strategy for responding to O 3 . (frontiersin.org)
  • For ES proteins, key pathways, including Fc epsilon RI, T cell receptor, and chemokine signalling as well as leukocyte transendothelial migration were inferred to be linked to immune responses, along with other pathways related to neurodegenerative diseases and infectious diseases, which warrant detailed future studies. (biomedcentral.com)
  • AKAPs also scaffold other signaling molecules into multi-protein complexes that function as crossroads between different signaling pathways. (frontiersin.org)
  • amino acid
  • The immediate response to Cr(VI) in LB-grown cells was up-regulation of proteins involved in inorganic ion transport, secondary metabolite biosynthesis and catabolism, and amino acid metabolism. (biomedcentral.com)
  • TonB-dependent siderophore receptors involved in ferric iron acquisition and amino acid adenylation domains characterized up-regulated systems under LB-Cr(VI) conditions, while DNA repair proteins and systems scavenging sulfur from alternative sources (e.g., aliphatic sulfonates) tended to predominate the up-regulated proteome profile obtained under M9L-Cr(VI) conditions. (biomedcentral.com)
  • Comparative analysis indicated that the core molecular response to chromate, irrespective of the nutritional conditions tested, comprised seven up-regulated proteins belonging to six different functional categories including transcription, inorganic ion transport/metabolism, and amino acid transport/metabolism. (biomedcentral.com)
  • interactions
  • Targeting AKAP coordinated protein complexes with high-affinity peptidomimetics or small molecules to tease apart distinct protein-protein interactions (PPIs) therefore offers important means to disrupt binding of specific components of the complex to better understand the molecular mechanisms involved in the function of individual signalosomes and their pathophysiological role. (frontiersin.org)
  • The existence of these specific complexes (illustrated in Figure 1 ) governed by protein-protein interactions (PPIs) creates an opportunity for new therapeutic strategies to control cAMP dependent signaling that is out of tune or involved in pathologies. (frontiersin.org)
  • bacterial
  • Some bacterial heat shock proteins are upregulated via a mechanism involving RNA thermometers such as the FourU thermometer , ROSE element and the Hsp90 cis-regulatory element . (wikipedia.org)
  • Adhesion domain superfamily (IPR008966) The bacterial adhesion domain is found in adhesin proteins, which form part of the adhesive pilus found on the cell surface. (ebi.ac.uk)
  • gene
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • HNF-4 participates in the hibernation-associated transcriptional regulation of the chipmunk hibernation-related protein gene. (abcam.com)
  • orthologous
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • Recent EST and full-length cDNA collections for two conifers, Sitka spruce ( Picea sitchensis ) and loblolly pine ( Pinus taeda ), together with full genome sequences for two angiosperms, Arabidopsis thaliana and poplar ( Populus trichocarpa ), offer an opportunity to infer the evolutionary processes underlying thousands of orthologous protein-coding genes in gymnosperms compared with an angiosperm orthologue set. (biomedcentral.com)
  • stresses
  • Increased synthesis of selected proteins in Drosophila cells following stresses such as heat shock was first reported in 1974. (wikipedia.org)
  • The present review summarizes current knowledge concerning the cardioprotective role of the heat shock proteins as occurs in heart damage, including relevant information about the stresses that regulate the expression of these proteins and their potential role as biomarkers of heart disease. (bjcvs.org)
  • Nucleus
  • Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. (abcam.com)
  • function
  • While intraspecies differences are believed to be influenced by selection on protein structure and function (reviewed in [ 10 - 14 ]), interspecies differences are influenced by (i) the efficacy of the DNA repair machinery, (ii) life history traits (e.g. generation time), (iii) metabolic rate, (iv) effective population size (random genetic drift), (v) purifying (background) selection and (vi) reproductive strategy. (biomedcentral.com)
  • binds
  • Phosphorylated form of HSP20 is proposed to interact with monomeric actin whereas dephosphorylated form binds polymeric actin filaments. (acris-antibodies.com)
  • section indicates at which position the protein binds a given metal ion. (uniprot.org)
  • Subunit
  • Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. (bioon.com.cn)
  • HSP70
  • and mitochondrial HSP70 (mtHSP70, GRP75 or mortalin) a 75 kDa protein that is found within the mitochondria. (acris-antibodies.com)
  • For example, Hsp60 , Hsp70 and Hsp90 (the most widely studied HSPs) refer to families of heat shock proteins on the order of 60, 70, and 90 kilodaltons in size, respectively. (wikipedia.org)
  • exchange protein
  • Employing a FRET-based biosensor constructed from the nucleotide binding domain of the type 1 exchange protein activated by cAMP, EPAC1, we demonstrated that moexipril markedly potentiated the ability of forskolin to increase intracellular cAMP levels. (nih.gov)
  • cell
  • By contrast, the chromate-responsive proteome derived under defined minimal growth conditions was characterized predominantly by up-regulated proteins related to cell envelope biogenesis, inorganic ion transport, and motility. (biomedcentral.com)
  • pathway
  • The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma. (abcam.com)
  • sequences
  • Detailed analysis of 6,058 raw EST sequences from dbEST revealed 315 putatively secreted proteins. (biomedcentral.com)
  • Key to the central dogma of molecular biology, protein-coding sequences (hereafter referred to as genes) have classically been regarded as a major unit of evolution. (biomedcentral.com)
  • cardiac
  • To date, at least seven different PDE4 proteins encoded in the four PDE4 genes have been detected in cardiac cells. (springer.com)
  • annotation
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • important
  • Six cysteine motif (SXC1) proteins, transthyretin proteins, C-type lectins, activation-associated secreted proteins (ASPs), which could represent potential candidates for developing novel anthelmintics or vaccines were few other important findings. (biomedcentral.com)
  • Adhesin proteins are important for receptor binding to. (ebi.ac.uk)
  • found
  • YebC-like (IPR029072) This domain is found in uncharacterised proteins, including E. coli protein YebC , a probable transcriptional regulator, and Aq1575 from Aquifex aeolicus. (ebi.ac.uk)
  • This domain can be found in TolB proteins (C-terminal), in soluble q. (ebi.ac.uk)
  • lens
  • Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. (bioon.com.cn)
  • Search
  • The literature survey was carried out based on the PubMed data using the descriptors "Heat shock protein" and "heart" as components of the search field title. (bjcvs.org)