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  • aGvHD
  • Circulating microRNAs are expressed in body fluids and have recently been associated with the etiology of aGvHD, but global expression profiling in a HSCT setting is lacking. (frontiersin.org)
  • miR-146a ( p = 0.01), miR-20a ( p = 0.03), miR-18 ( p = 0.03), miR-19a ( p = 0.03), miR-19b ( p = 0.01), and miR-451 ( p = 0.01) were differentially expressed 14 days post-HSCT in patients who later developed aGvHD ( n = 47). (frontiersin.org)
  • Animal models and human correlative data suggest that lipopolysaccharides (LPS, or "endotoxin") derived from Gram-negative bacteria play a key role in HSCT-provoked aGVHD. (dana.org)
  • Variable-joining gene segment usage was not associated with aGvHD development, but a higher usage of V2-JP1 pairing and lower usage of V4-J2/V5-J2/V8-JP2 were observed in grafts given to nonrelapse patients. (jimmunol.org)
  • Undergo
  • However, patients who undergo HSCT acquire a state of immunodeficiency that causes significant mortality. (frontiersin.org)
  • reconstitution
  • In this review series, he will discuss current understanding of the polymorphic process of Treg reconstitution after HSCT and the appropriate intervention in the altered Treg homeostasis in each distinct reconstituting phase by low-dose IL-2 for better outcomes of patients after HSCT. (springer.com)
  • stem cell
  • Using a high-throughput sequencing platform, we sought to analyze the TCR γ-chain (TRG) repertoire of γδ T cells within donor stem cell grafts and address its potential impact on clinical response in the corresponding patients. (jimmunol.org)
  • infection
  • Our work identified five private overrepresented and one public CDR3 sequence (CATWDGPYYKKLF) associated with CMV infection, in addition to 12 highly frequent public sequences present exclusively in grafts given to nonrelapse patients. (jimmunol.org)
  • antibody
  • Initially, Campath-1 was not ideal for therapy because patients could, in theory, react against the foreign rat protein determinants of the antibody. (wikipedia.org)
  • To circumvent this problem, Greg Winter and his colleagues humanised Campath-1, by extracting the hypervariable loops that had specificity for CD52 and grafting them onto a human antibody framework. (wikipedia.org)
  • Typically, these receptors are used to graft the specificity of a monoclonal antibody onto a T cell, with transfer of their coding sequence facilitated by retroviral vectors. (wikipedia.org)
  • It consists of the humanized monoclonal antibody against CD22 (inotuzumab), linked to a cytotoxic agent from the class of calicheamicins called ozogamicin. (wikipedia.org)
  • The antibody, originally called G5/44, was created by grafting the complementarity-determining regions and some framework residues from the murine anti-CD22 mAb m5/44, onto human acceptor frameworks. (wikipedia.org)
  • Treg
  • Regulatory T cells (Treg) are a subset of CD4+ T-helper cells believed to maintain tolerance after HSCT. (hindawi.com)
  • leukemia
  • A CAR therapy for cancer, using a technique called adoptive cell transfer, has been approved by the US Food and Drug Administration for use against acute lymphoblastic leukemia. (wikipedia.org)
  • myelodysplastic
  • will present the evidence from studies regarding the use of hypomethylating agents (HMA), the FDA approved for the treatment of myelodysplastic syndromes after HSCT. (springer.com)
  • donors
  • This was more prominent in grafts from CMV + donors, which presented a more private repertoire, lower diversity, skewed distribution, and reduced usage of the V9-JP pairing. (jimmunol.org)
  • context
  • The use of PI3K/AKT/mTOR inhibitors has been scantily explored in the allo-HSCT context. (beds.ac.uk)
  • lymphocyte
  • In an in-vitro experiment, it has been shown that Alemtuzumab has antiviral properties against HIV-1 The origins of alemtuzumab date back to Campath-1 which was derived from the rat antibodies raised against human lymphocyte proteins by Herman Waldmann and colleagues in 1983. (wikipedia.org)