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  • patients
  • This is a clinical trial of bone marrow transplantation for patients with the diagnosis of a genetic disease of blood cells that do not have an HLA-matched sibling donor. (clinicaltrials.gov)
  • Daily area under the curve (AUC) where AUC is based on average of 5 most severe symptoms (pain, fatigue, bone aches, numbness, disturbed sleep) being experienced by MM patients as measured by MDASI-MM, a multiple-symptom measure of cancer-related symptoms rate severity of physical, affective, and cognitive symptoms on 0-10 numeric scales, ranging from 0 'not present' to 10 'as bad as you can imagine. (clinicaltrials.gov)
  • In elderly patients, where the tolerance of aggressive induction therapy is often poor and curative options such as bone marrow transplantation HSCT are not available, the need for effective non-aggressive drug regimens for AML is even greater. (clinicaltrials.gov)
  • Determine transplantation-related mortality, leukemia-free survival, and overall survival of these patients. (bioportfolio.com)
  • 15 to 55 years of age without significant co-morbidity* undergoing HLA-matched sibling bone marrow transplantation (BMT) (BuCy conditioning): Patients receive busulfan IV once daily on days -7 to -4 and cyclophosphamide IV over 1-2 hours once daily on days -3 and -2. (bioportfolio.com)
  • and for patients of any age undergoing HLA-mismatched familial donor HSCT (BuFluATG conditioning): Patients receive busulfan IV once daily on days -7 and -6, fludarabine phosphate IV over 30 minutes once daily on days -7 to -2, anti-thymocyte globulin IV over 4 hours once daily on days -3 to -1, and methylprednisolone IV over 30 minutes once daily on days -4 to -1. (bioportfolio.com)
  • Patients receive IT methotrexate once every 2 weeks for 3 times after transplantation and platelet recovery. (bioportfolio.com)
  • Absent these causes, patients were diagnosed in the World Health Organization's classification as having either 1) Chronic eosinophilic leukemia, not otherwise specified, (CEL-NOS) if blood or bone marrow blast cells exceeded 2% or 5% of total nucleated cells, respectively, and other criteria were met or 2) idiopathic hypereosinophilic syndrome (HES) if there was evidence of eosinophil-induced tissue damage but no criteria indicating chronic eosinophilic leukemia. (wikipedia.org)
  • If the results show patients with low levels of lymphocytes, absence of granulocytes or absence of thymus then the patient may be suspected to have RD. RD can only be treated temporarily through Hematopoietic stem cell transplantation (HSCT) and Cytokine Therapy. (wikipedia.org)
  • This cure is commonly used in patients who are awaiting bone marrow transplantation. (wikipedia.org)
  • It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia. (wikipedia.org)
  • This has allowed HSCT to be conducted in the elderly and other patients who would otherwise be considered too weak to withstand a conventional treatment regimen. (wikipedia.org)
  • Heart transplantation is performed on patients with end-stage heart failure or severe coronary artery disease. (wikipedia.org)
  • resulted in promising data for the clinical use of ALG for preserving short-term and long-term kidney function in patients immediately after human kidney transplantation. (wikipedia.org)
  • Thymoglobulin is also an effective agent for preventing graft-vs.-host disease in patients receiving haematopoietic stem cell transplantation (HSCT). (wikipedia.org)
  • leukemia
  • However, for other cancers such as acute myeloid leukemia, the reduced mortality of the autogenous relative to allogeneic HSCT may be outweighed by an increased likelihood of cancer relapse and related mortality, and therefore the allogeneic treatment may be preferred for those conditions. (wikipedia.org)
  • Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (wikipedia.org)
  • autologous
  • He describes the evolution of his research, which has contributed significantly to advancing the field of gene transfer using retroviral vectors in the development of both autologous (AUTO) and allogeneic (ALLO) hematopoietic stem cell transplantation (HSCT) approaches to cancer immunotherapy, and the strategy of using chimeric antigen receptors (CARs) to modify T cells stimulating their activation, proliferation, and anti-tumor activity. (liebertpub.com)
  • These advantages have established autologous HSCT as one of the standard second-line treatments for such diseases as lymphoma. (wikipedia.org)
  • complications
  • As widespread implementation of prophylactic antimicrobial regimens has reduced the overall incidence of infectious complications after HSCT, the relative importance of non-infectious pulmonary complications as major causes of morbidity and mortality has increased. (endocrinologyadvisor.com)
  • efficacy
  • As multiple studies have demonstrated both its efficacy and safety in a clinical setting, it is also used in different minimization regimens to reduce the application of higher risk immunosuppressive agents such as corticosteroids and calcineurin inhibitors (CNIs) in solid organ transplantation. (wikipedia.org)
  • tissues
  • Clonal hypereosinophilia, also termed Primary hypereosinophelia or clonal eosinophilia, is a grouping of hematological disorder characterized by the development and growth of a pre-malignant or malignant population of eosinophils, a type of white blood cell, in the bone marrow, blood, and/or other tissues. (wikipedia.org)
  • The expanding population of eosinophils, initially formed in the bone marrow may spread to the blood and then enter into and injure various tissues and organs. (wikipedia.org)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • bloodstream
  • After entering the bloodstream, the stem cells travel to the bone marrow, where they begin to produce new white blood cells, red blood cells, and platelets in a process known as "engraftment. (stemcellcordblood.net)
  • Mobilization is the process by which progenitors are made to migrate from the bone marrow into the bloodstream, thus increasing their numbers in the blood. (wikipedia.org)
  • cancerous
  • In some individuals, the disease comes to light only after the cancerous cells overwhelm the bone marrow resulting in anemia producing tiredness or weakness. (wikipedia.org)
  • relapse
  • Opportunistic infections, such as Aspergillus, CMV and EBV, also constitute major causes of morbidity and non-relapse mortality following HSCT. (tregeneration.eu)
  • cancer
  • Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (wikipedia.org)
  • organ
  • As multiple studies have demonstrated both its efficacy and safety in a clinical setting, it is also used in different minimization regimens to reduce the application of higher risk immunosuppressive agents such as corticosteroids and calcineurin inhibitors (CNIs) in solid organ transplantation. (wikipedia.org)
  • complete
  • range, 0.2 to 17) who received unmanipulated allo-HSCT in second complete remission. (unipv.it)
  • intensity
  • The Score is independent from HSCT technology and is valid for standard and reduced intensity conditioning. (hematool.ch)
  • group
  • João Forjaz de Lacerda is an Attending Physician in the Hematology and Bone Marrow Transplantation Service of Hospital de Santa Maria, Associate Professor of Medicine and Head of Hematology at the University of Lisbon, and Group Leader of a translational research unit focusing on Hematology and Transplantation Immunology at iMM Lisboa. (tregeneration.eu)