Hscs hematopoietic stem cells clone cells. Medical search. Frequent questions

Clonal hematopoiesis of indeterminate potential, or CHIP, is a common aging-related phenomenon in which hematopoietic stem cells (HSCs) or other early blood cell progenitors contribute to the formation of a genetically distinct subpopulation of blood cells. (wikipedia.org)
Haematopoietic stem cells or multipotent progenitors (HSC/MPPs) accumulated a mean of 17 mutations per year after birth and lost 30 base pairs per year of telomere length. (bvsalud.org)
Thus, HLA is necessarily involved in the immune-mediated damage of hematopoietic progenitors, either as an innocent bystander or as a culprit. (ashpublications.org)
PURPOSE OF REVIEW: Hematopoietic stem cells (HSCs) and progenitors are tasked with maintaining hematopoietic homeostasis in the face of numerous insults and challenges, including infection, inflammation, and exsanguination. (qmul.ac.uk)
It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. (angioproteomie.com)
We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)
Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors. (ox.ac.uk)
at 16 weeks after transplantation) competitive advantage of mutation affects the differentiation and function of different committed hematopoietic progenitors which may drive the disease phenotype. (academicediting.org)
For ITD-1 instance multiple myeloma a problem regarded as a malignancy of late-stage immunoglobulin-secreting plasma cells was lately present to contain subpopulations of pre-plasmablasts and Compact disc20+ B cell progenitors which propagate the disorder and mediate treatment level of resistance (23). (academicediting.org)
Msi2 expression is activated by cooperation between HoxA9 and Meis1 in Meis1 -immortalized hematopoietic progenitors [ 11 ]. (biomedcentral.com)

The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
Both aged and preleukemic HSCs are characterized by small subsets of clones that expand and self-renew massively with reduced differentiation capacity. (bist.eu)
Signal transduction down the Ras/MAPK pathway, including that critical to T cell activation, proliferation, and differentiation, has been generally considered to occur at the plasma membrane. (scielo.br)
Blood cell production is regulated by a variety of small proteins called cytokines that modulate the total number of cells by controlling the differentiation, proliferation, maturation, and/or the storage of cells in the marrow and circulation. (umontreal.ca)
Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation. (jdstemcellresearch.ca)
Here, we show that S1PR3, a receptor for the bioactive lipid sphingosine-1-phosphate, is a central regulator that drives myeloid differentiation and activates inflammatory programs in both HSCs and LSCs. (jdstemcellresearch.ca)
These signatures inversely correlated during early hematopoietic commitment and differentiation. (jdstemcellresearch.ca)
We used primary acute myeloid leukemia (AML) samples and human AML cell lines to investigate the regulatory mechanisms of autophagy and its role in AML differentiation. (hindawi.com)
Accordingly, scientists have developed protocols for the expansion, genetic modification and differentiation of stem cells to NK cells. (molcells.org)
I was investigating the role of epigenetic mechanisms during haematopoietic differentiation. (ox.ac.uk)
The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)
Stem cells are not specialized and the process of their specialization is called differentiation. (benthamscience.com)
Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
The production of terminally differentiated cells from such cells, therefore, requires successive changes of cell fates, meaning that genes relevant for the next stage of differentiation must be switched on and genes not relevant anymore must be switched off. (amegroups.org)
The development of the hematopoietic system has long served as model to understand how changes in gene regulatory networks drive the differentiation of the various blood cell types. (amegroups.org)
In vivo differentiation to cells from all three germlines was tested using a teratoma assay. (biomedcentral.com)
In vitro differentiation of GS-2 iPSCs into hematopoietic stem and progenitor cells was done using Op9 feeder layers and specified media. (biomedcentral.com)
Differentiation capacity into cells from all three germ layers was confirmed using the teratoma assay. (biomedcentral.com)

The establishment of a clonal population may occur when a stem or progenitor cell acquires one or more somatic mutations that give it a competitive advantage in hematopoiesis over the stem/progenitor cells without these mutations. (wikipedia.org)
We investigated the origin of SF3B1 mutations within the bone marrow hematopoietic stem and progenitor cell compartments in patients with MDS-RS. (nih.gov)
As few transcriptional changes underlie this transition, we used single-cell and bulk assay for transposase-accessible chromatin sequencing (ATAC-seq) on human HSCs and hematopoietic stem and progenitor cell (HSPC) subsets to uncover chromatin accessibility signatures, one including LT-HSCs (LT/HSPC signature) and another excluding LT-HSCs (activated HSPC [Act/HSPC] signature). (jdstemcellresearch.ca)
Understanding the molecular regulation of hematopoietic stem and progenitor cell (HSPC) engraftment is paramount to improving transplant outcomes. (qmul.ac.uk)

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. (atsbio.com)
Objective: To investigate a safe and effective method for hematopoietic stem cell transplantation. (atsbio.com)
Upon transplantation into immune-deficient mice, SF3B1 mutated MDS-RS HSCs differentiated into characteristic ring sideroblasts, the hallmark of MDS-RS. (nih.gov)
Hematopoietic stem and progenitor cells (HSPCs) sustain life-long hematopoiesis and are first detected in the embryo by transplantation at embryonic day 10.5 (E10.5). (qmul.ac.uk)
Hematopoietic transplantation refers to the therapeutic procedure that involves the introduction of hematopoietic stem cells into a patient to reconstitute his or her immune system. (sagepub.com)
This sort of transplantation is most commonly performed in three clinical scenarios: (1) to treat malignancies such as cancer in which the immune system is weakened or impaired, (2) to replace an absent or poorly functioning hematopoietic or immune system, and (3) to treat genetic diseases caused by insufficient gene expression by performing a transplantation from donors with normal gene expression. (sagepub.com)
Bouhassira, Eric E. "Hematopoietic Transplantation: Cancer. (sagepub.com)
Edward Donnall Thomas, an American physician and scientist, gained recognition in the scientific community for conducting the first bone marrow transplant, a pioneering form of hematopoietic stem cell transplantation (HSCT). (asu.edu)
HSCs specifically are defined by their ability for self-renewal and to reconstitute the entire hematopoietic system following transplantation. (stemcell.com)
In experimental settings, the ability of human HSCs to reconstitute hematopoiesis is measured by transplantation into genetically immunocompromised mice (e.g. (stemcell.com)
It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)
Juvenile Myelomonocytic Leukemia (JMML) is an aggressive myeloproliferative neoplasm of childhood with a 5-year event free survival of 52% after hematopoietic stem cell transplantation (HSCT). (ashpublications.org)

CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. (thermofisher.com)
Observations of clonal heritability in hematopoietic stem cell (HSCs) lineage biases have suggested that this heterogeneity is determined by intrinsic and heritable properties. (bist.eu)
In sum, we show that connecting cellular states and cellular fates through high-resolution lineage tracing can be used to describe drivers for a variety of relevant stem cell properties. (bist.eu)
Next, an overview of several current models of hematopoietic lineage trees to identify developmental branching points between the lymphoid and myeloid cell compartments is discussed. (scielo.br)
Although inflammation dysregulates mature myeloid cells and influences stemness programs and lineage determination in HSCs by activating stress myelopoiesis, such roles in LSCs are poorly understood. (jdstemcellresearch.ca)
In fetal liver and adult bone marrow, Tie-2 is expressed by a subpopulation of hematopoietic progenitor cells characterized as Lineage markers^-, c-Kit^+, Sca1^+ cells. (thermofisher.com)
My research activity focuses on the role of haematopoietic lineage bias in the development of different types of acute leukaemias and how this contribution changes during ageing. (ox.ac.uk)
Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)
Phenotypic evaluation of mice with pan-hematopoietic versus B lineage-restricted appearance of transgene led to 100% embryonic lethality (fig. S3A). (academicediting.org)
Mice sacrificed at 12 months of age acquired no overt phenotype beyond the B lineage despite apparent activation of mitogen-activated proteins kinase (MAPK) signaling in B lineage cells (Fig. 3 A to fig and D. S3 G and F. = 0.006) upsurge in spleen weight aswell as the quantity and size of GC B cells in = 0.02) in Cd19-cre on HSC self-renewal. (academicediting.org)
Latest genomic analyses of leukemias of another lymphoid lineage T cell severe lymphoblastic leukemia (T-ALL) uncovered that a particular subset of T-ALL is normally highly similar on track and myeloid leukemic HSCs in gene appearance and mutational profile (25). (academicediting.org)
Acute myeloid leukemia (AML) results from the over-proliferation of progenitor cells of the myeloid lineage in the bone marrow. (ghrnet.org)
GS-2 iPSCs showed the capacity to differentiate into cells of the hematopoietic lineage. (biomedcentral.com)

Alternatively, clonal hematopoiesis may arise without a driving mutation, through mechanisms such as neutral drift in the stem cell population. (wikipedia.org)
My work also combines stochastic approaches to hematopoiesis, specifically with reference to the HSCs, to understand how clones are generated in a variety of normal and pathological conditions. (umontreal.ca)
Acute myeloid leukemia (AML) is a caricature of normal hematopoiesis driven from leukemia stem cells (LSC) that share some hematopoietic stem cell (HSC) programs including responsiveness to inflammatory signaling. (jdstemcellresearch.ca)
A member of the tyrosine kinase receptor family, Tie-2 is expressed on endothelial and a subset of hematopoietic cells and is believed to play a role in both angiogenesis and hematopoiesis during development of the mouse embryo. (thermofisher.com)
Cells carrying leukemic mutations can often be found in the blood of healthy individuals, a condition known as clonal hematopoiesis (CH). These mutant clones can be detected prior to the development of any hematologic malignancy, expand following exposure to chemotherapy, and can evolve into tMNs. (harvard.edu)
Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy. (harvard.edu)
Hairy cell leukemia (HCL) is certainly a chronic lymphoproliferative disorder seen as a somatic recently discovered somatic inhibition in hematopoiesis inside our murine choices aswell as in individuals with in HCL individuals we performed quantitative sequencing of the spot of ITD-1 p. (academicediting.org)
To address this knowledge gap, we developed an in vivo hematopoietic stem cell (HSC)-based large-scale CRISPR knockout screening platform to enable the genetic interrogation of hematopoiesis and broad aspects of immune cell function in vivo. (biorxiv.org)
To further elucidate the role of RUNX1 in hematopoiesis, we cloned the zebrafish ortholog ( runx1 ) and analyzed its function using this model system. (biologists.com)

Thus, telomerase activity and telomere maintenance are associated with the immortality of cancer cells, germ-line cells, and embryonic stem (ES) cells. (nature.com)
The embryonic site of definitive hematopoietic stem cell (dHSC) origination has been debated for decades. (qmul.ac.uk)
Embryonic stem cells are useful for experiments because they are self-renewing and able to develop into almost any cell type in the body. (asu.edu)
Yamanaka induced somatic cells to act like human embryonic stem cells (hESCs), allowing researchers to experiment with non-embryonic stem cells with a similar capacity as hESCs. (asu.edu)
His focus has ranged from the development of telomerase-based therapeutics to the application of human embryonic stem cells in regenerative medicine. (asu.edu)
As of 2009, West advocated using human somatic cell nuclear transfer techniques to derive human embryonic stem cells for therapeutic practice. (asu.edu)
James Alexander Thomson, affectionately known as Jamie Thomson, is an American developmental biologist whose pioneering work in isolating and culturing non-human primate and human embryonic stem cells has made him one of the most prominent scientists in stem cell research. (asu.edu)
According to the The Herald, he was the first, alongside his colleague Martin Evans, to isolate and culture embryonic stem cells. (asu.edu)
Embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) have pluripotency and can theoretically differentiate into all organs, tissues or cells. (ubigene.us)
Depending on the source, stem cells can be classified into two broad categories i.e. embryonic stem cells that are derived from embryos and non-embryonic stem cells that are derived from adult and fetal tissues. (benthamscience.com)
The non-embryonic stem cells like adult stem cells are in clinical use for many years and embryonic stem cells are now emerging as an alternative source for the same purpose with huge potentials in drug discovery and toxicological studies. (benthamscience.com)
Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
Mouse nuclear transfer embryonic stem cells (NT-ESCs) were first established in 2000, and then proved to be able to differentiate either in vivo or in vitro, and give rise to individual tissues through germ line transmission or tetraploid complementation. (benthamscience.com)

FLT3 ITD triggers the proliferation of the quiescent hematopoietic stem cell (HSC) pool but fails to directly transform HSCs. (biomedcentral.com)

The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
Analysis of supporting stromal cells within the tumor environment demonstrates vascular remodeling within the endothelial cells. (pklab.org)
For instance, properties of CSC in glioma in a mouse xenograft model were maintained by vascular endothelial cells ( Calabrese C, et al, Cancer Cell, Jan 2007;11(1):69-82 ). (pharmaceuticalintelligence.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)

This model has received support from studies showing subpopulations of blood cells harboring initiating but not late somatic mutations in patients with chronic lymphocytic leukemia (CLL), hairy cell leukemia (HCL), and AML. (wikipedia.org)
During ageing, molecular changes in HSCs often lead to a pre-malignant state for blood cancers termed "clonal haematopoiesis", which is characterised by the presence of HSC clones harbouring certain somatic mutations, primarily in genes involved in epigenetic regulation. (cha-mainz.de)
Screening for recurrently mutated genes in the mononuclear cell fraction revealed mutations in SF3B1 in 39 of 40 cases (97.5%), combined with TET2 and DNMT3A in 11 (28%) and 6 (15%) patients, respectively. (nih.gov)
All recurrent mutations identified in mononuclear cells could be tracked back to the phenotypically defined hematopoietic stem cell (HSC) compartment in all investigated patients and were also present in downstream myeloid and erythroid progenitor cells. (nih.gov)
While in agreement with previous studies, little or no evidence for clonal ( SF3B1 mutation) involvement could be found in mature B cells, consistent involvement at the pro-B-cell progenitor stage was established, providing definitive evidence for SF3B1 mutations targeting lymphomyeloid HSCs and compatible with mutated SF3B1 negatively affecting lymphoid development. (nih.gov)
Hematopoietic stem cells (HSCs) can acquire somatic mutations that promote clonal expansion, an age-related process detectable in the blood normal individuals. (harvard.edu)
The old model of tMN development in which mutations accumulate in hematopoietic stem and progenitor cells (HSPCs) induced directly by cytotoxic therapies has been challenged by newer data. (harvard.edu)
Whereas ALL is most commonly observed in paediatric patients, the incidence of AML increases with age, as does the number of recurrent mutations within the malignant clone. (ox.ac.uk)
HSCs are (with memory lymphocytes as the exception) the only long-lived cells in the haematopoietic system, a property that makes them a key target for the sequential accumulation of leukaemogenic mutations. (ox.ac.uk)
Moreover our use of granulocyte DNA as matched somatic cells may have obscured additional mutations acquired early in the hematopoietic compartment and present at related frequencies in granulocyte and HCL DNA. (academicediting.org)

All blood cells are derived from pluripotent hematopoietic stem cells, that self-renew and differentiate to maintain cell counts in the bone marrow and in circulation. (umontreal.ca)
The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the door to a new generation of regenerative medicine research. (molcells.org)
Among PSCs, the donors available for induced pluripotent stem cells (iPSCs) are greatest, providing a potentially universal cell source for all types of cell therapies including cancer immunotherapies using natural killer (NK cells). (molcells.org)
Among stem cells, induced pluripotent stem cells (iPSCs) have a number of features that make them ideal as the starting source. (molcells.org)
Shinya Yamanaka gained international prominence after publishing articles detailing the successful generation of induced pluripotent stem (iPS) cells, first in mice, then in humans. (asu.edu)
John D. Gearhart is a renowned American developmental geneticist best known for leading the Johns Hopkins University research team that first identified and isolated human pluripotent stem cells from human primordial germ cells, the precursors of fully differentiated germ cells. (asu.edu)
Kuldip S. Sidhu , " Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside ", Bentham Science Publishers (2012). (benthamscience.com)
Induced pluripotent stem cells, another types of pluripotent stem cells derived from any tissue by reprogramming and are the homologous source of stem cells. (benthamscience.com)
However, all developmental processes originate from pluripotent precursor cell types. (amegroups.org)
Induced pluripotent stem cells (iPSC) express genes associated with pluripotency, have the capacity for infinite expansion, and can differentiate into cells from all three germ layers. (biomedcentral.com)

The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
This process is tightly regulated by the multipotent properties of haematopoietic stem cells (HSCs) residing in the bone marrow (BM). (cha-mainz.de)
Woods K and Guezguez B (2021) Dynamic changes of the bone marrow niche: mesenchymal stromal cells and their progeny during aging and leukemia . (cha-mainz.de)
Guezguez B, Campbell CJV, Boyd AL, Karanu F, Casado FL, Di Cresce C, Collins TJ, Shapovalova Z, Xenocostas A and Bhatia M (2013) Regional localization within the bone marrow influences the functional capacity of human HSCs . (cha-mainz.de)
MDS/MPN are usually characterized by a hypercellular bone marrow (BM) with increased proliferation in one or more of the myeloid lineages which is also accompanied by dysplastic features (as a result of increased programmed cell death). (encyclopedia.pub)
Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
Applications Tested: The TEK4 antibody has been tested by blocking of staining with fluorochrome conjugated TEK4 on mouse bone marrow cells. (thermofisher.com)
HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche. (thermofisher.com)
Bone marrow transplants are considered to be the first successful example of tissue engineering, a field within regenerative medicine that uses hematopoietic stem cells (HSCs) as a vehicle for treatment. (asu.edu)
NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
We examined the CD45 dim CD34 + CD38 - CD133 + cells on bone marrow samples of hematologic malignancies and healthy controls using four-color flow cytometry experiments. (researchsquare.com)
Interestingly, the CD45 dim CD34 + CD38 - CD133 + cells were highly expressed in bone marrow of patients with AML compared to that of healthy controls (HC). (researchsquare.com)
In this study, we focused on measuring LSCs easily in the bone marrow cells from AML patients by developing a four-color flow cytometric analysis. (researchsquare.com)
Interaction between stromal cells and acute myeloid leukemia (AML) cells in bone marrow (BM) is known to contribute importantly to chemoresistance and disease recurrence. (biomed.news)
Here, we demonstrate that in a niche-like co-culture system, AML cells took up functional mitochondria from bone marrow stromal cells (BMSCs) and inhibition of such mitochondrial transfer by metformin, the most commonly prescribed drug for type 2 diabetes mellitus, significantly enhanced the chemosensitivity of AML cells co-cultured with BMSCs. (biomed.news)
The remainder of the substance - the so-called formed elements - are created from hematopoietic stem cells (HSCs) in the bone marrow. (berkshire.com)
According to the National Institutes of Health (NIH), these blood stem cells can 'differentiate to a variety of specialized cells, can mobilize out of the bone marrow into circulating blood, and can undergo programmed cell death, called apoptosis-a process by which cells that are detrimental or unneeded self-destruct. (berkshire.com)

HSCs had been differentiated to myeloid cells by treatment with G-CSF regarding to Shin et al. (azd1152.com)
Background & aims: Myeloid cells are key regulators of cirrhosis, a major cause of mortality worldwide. (pklab.org)
Because stromal cells can modulate the functionality of myeloid cells in vitro, targeting stromal-myeloid interactions has become an attractive potential therapeutic strategy. (pklab.org)
One reason for this is that unlike adult myeloid cells subsets of normal adult B cells are characterized by the capacity to self-renew and differentiate as part of their normal function. (academicediting.org)

Aberrant expression of a third marker such as Thy-1/CD90 negativity, expression of CLL-1 and IL-3R (CD123), intermediate levels of aldehyde dehydrogenase and co-expression of common chromosomal translocation may be used to distinguish from normal hematopoietic stem cells. (ghrnet.org)

In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)
In a very interesting chapter, Z. PANCER and M. D. COOPER first consider the emergence of lymphocytes as a novel circulatory cell type in vertebrates and then discuss phylogenetic aspects of the superfamily of LRR - containing proteins and their role in immunity. (scielo.br)

Stem cells are emerging as an important source of material for diseases in regenerative medicine. (benthamscience.com)
The study of biology of stem cells is the hallmark of the recent emerging field of regenerative medicine and medical biotechnology. (benthamscience.com)

Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
Second although our analyses of the VAF of the mutation in HSPC subsets from HCL individuals these analyses used cDNA where the level of wild-type and mutant manifestation may differ from your VAF at the level of genomic DNA in these cell subsets. (academicediting.org)
In this study, we observed that the expression of pseudouridine (Ψ) synthase 10 is increased in aged hematopoietic stem and progenitor cells (HSPC) and enforced protein of Ψ synthase 10 (PUS10) recapitulates the phenotype of aged HSC, which is not achieved by its Ψ synthase activity. (haematologica.org)

Although NK precursors and immature NK cells have been identified in mice and humans, the precise sites where NK cell maturation take place are not yet fully defined. (scielo.br)
Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo. (qmul.ac.uk)
Depletion of Runx1 with antisense morpholino oligonucleotides abrogated the development of both blood and vessels, as demonstrated by loss of circulation, incomplete development of vasculature and the accumulation of immature hematopoietic precursors. (biologists.com)

CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)

There already exist several protocols to genetically modify and differentiate iPSCs into NK cells, and each has its own advantages with regards to immunotherapies. (molcells.org)
The necessary intrinsic pathways that are utilized by this cancer stem cell population to maintain both self-renewal and the ability to differentiate are believed to be a result of the environment where cancer stem cells reside. (pharmaceuticalintelligence.com)
DHX15 was down-regulated when AML patients achieved disease remission or when leukemia cell lines were induced to differentiate. (oncotarget.com)

However, clear evidence for functional NK cell subsets exists in humans and the presence of NK cells in the thymus and immature NK cells in the liver suggests specific functions for NK cells in the tissues. (scielo.br)
Here we identified distinct subsets of human long-term (LT)-HSCs that responded differently to regeneration-mediated stress: an immune checkpoint ligand CD112 lo subset that exhibited a transient engraftment restraint (termed latency) before contributing to hematopoietic reconstitution and a primed CD112 hi subset that responded rapidly. (jdstemcellresearch.ca)

Assessment of stem cell function in vitro as well as in vivo established that only HSCs and not investigated progenitor populations could propagate the SF3B1 mutated clone. (nih.gov)
This could be highly impactful in other in vivo stem cell systems where clonal bottlenecks make conventional functional genomics approaches more difficult. (bist.eu)
This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
In addition, metformin potentiated the antitumor efficacy of cytarabine (Ara-C) in vivo in an NCG immunodeficient mouse xenograft model by inhibiting the mitochondrial transfer and OXPHOS activity in the engrafted human AML cells. (biomed.news)

Autophagy is an intracellular degradation system that ensures a dynamic recycling of a variety of building blocks required for self-renewal, homeostasis, and cell survival under stress. (hindawi.com)
Basal macroautophagy (thereafter referred to as autophagy), a catabolic recycling system in cells, is key to maintaining cellular homeostasis and survival. (hindawi.com)
While the importance of autophagy for cell homeostasis and survival has long been appreciated, its role in tumorigenesis and cancer progression is still developing [ 10 , 11 ]. (hindawi.com)
DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease. (ox.ac.uk)
Regenerative tissues follow a hierarchical organization with adult stem cells at the top maintaining tissues and normal adult cells during homeostasis and regeneration during cell loss from injury. (pharmaceuticalintelligence.com)
No significant alteration of hematopoietic homeostasis and HSC function is observed in young Pus10-/- mice, while aged Pus10-/- mice exhibit mild alteration of hematopoietic homeostasis and HSC function. (haematologica.org)

it is thought that this subpopulation is "clonally" derived from a single founding cell and is therefore made of genetic "clones" of the founder. (wikipedia.org)

Somatic base substitution mutation rates in intestinal epithelial cells were elevated 2 to 4-fold in all individuals, except for one showing a 31-fold increase, and were also increased in other tissues. (bvsalud.org)
In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)
Gene expression data shown in Fig.?S1B confirms that PMA-differentiated THP-1 macrophages and principal macrophages have very similar appearance profiles for essential macrophage markers, while differing from two epithelial cell types greatly. (azd1152.com)

Of major interest is the signalling crosstalk between HSCs, immune cells and the BM microenvironment. (cha-mainz.de)
Our findings provide biological insights into the interplay between tumor cells and the ccRCC microenvironment. (pklab.org)
Analysis of 22 tumor samples, including multiple myeloma, gastric, breast and thyroid cancers, shows that Numbat can reconstruct the tumor copy number profile and precisely identify malignant cells in the tumor microenvironment. (pklab.org)
Therefore, disruption of a crosstalk between AML cells and BM microenvironment may offer a promising therapeutic strategy for AML treatment. (biomed.news)

The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. (thermofisher.com)
Pagliuca et al 1 show that patients with AA have a reduced structural divergence of homologous HLA alleles, possibly contributing to reduced T-cell receptor repertoire diversity, cross-reactivity, and emergence of auto-reactive T-cell clones. (ashpublications.org)
This is associated with a smaller size than predicted of the immunopeptidomic spectrum, thus accounting for decreased T-cell receptor (TCR) diversity. (ashpublications.org)
Research of binding and of a SIRP-expressing cancers LPA receptor 1 antibody line additionally verify in keeping with molecularly comprehensive simulations of the connections between Compact disc47 and SIRP on a single cell surface. (azd1152.com)
Jawed vertebrates (gnathostomes) generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish (agnathans) assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding molecules. (scielo.br)
Moreover, the CD34 + CD38 - progenitor cells expressed variable amounts of the target receptor CD33, CD133 and c-kit (CD117) [ 20 ]. (researchsquare.com)
Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)

PBMC, peripheral bloodstream monocytic cells, a THP-1 monocyte series and RBCs), plus mesenchymal stem cells Cinnamaldehyde (MSCs), and A549 lung adenocarcinoma cells. (azd1152.com)

Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. (thermofisher.com)
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. (jdstemcellresearch.ca)
Depletion of GSPT1 by CC-90009 rapidly induces acute myeloid leukemia (AML) apoptosis, reducing leukemia engraftment and leukemia stem cells (LSCs) in large-scale primary patient xenografting of 35 independent AML samples, including those with adverse risk features. (jdstemcellresearch.ca)
Even though stem cell source for myeloid malignancies such as myeloproliferative neoplasms myelodysplastic syndromes and acute myeloid leukemia (AML) is definitely well established a link between aberrations in HSPCs and development of mature lymphoid malignancies has been less thoroughly investigated. (academicediting.org)
A similar observation was made by Oravecz-Wilson et al (2009) stating that despite remarkable responses to the tyrosine kinase inhibitor imatinib, CML patients show imatinib refractoriness because leukemia stem cells in CML are resistant tyrosine kinase ( Oravecz-Wilson KI, et al, Cancer Cell, 4 Aug 2009;16(2):137-48 ). (pharmaceuticalintelligence.com)
Leukemia stem cells (LSCs) in acute myeloid leukemia (AML) played important roles in development of leukemia, chemotherapeutic drug resistance, and disease relapse and progression. (researchsquare.com)
Therefore, our results suggest that CD45 dim CD34 + CD38 - CD133 + cells in AML might have the potential of leukemia stem cells. (researchsquare.com)
Acute myeloid leukemia (AML) is generally regarded as a stem cell disease, and it originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity [ 1 , 2 ]. (researchsquare.com)
DHX15 was highly expressed in hematopoietic stem cells and leukemia cells but was lowly expressed in mature blood cells. (oncotarget.com)
DHX15 silencing greatly inhibited leukemia cell proliferation and induced cell apoptosis and G1-phase arrest. (oncotarget.com)
Knockdown of DHX15 inhibited the nuclear translocation and activation of the NF-kB subunit P65 in leukemia cells. (oncotarget.com)

For decades, biologists have noted that stem-cells in adult tissues show extensive functional heterogeneity. (bist.eu)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)
Telomeric DNA consists of short guanine-rich repeat sequences in all eukaryotes with linear chromosomes, and its length in human somatic cells is remarkably heterogeneous among individuals ranging from 5 to 20 kb, according to age, organ, and the proliferative history of each cell ( Wright and Shay, 2005 ). (nature.com)

We aimed to investigate how human liver stromal cells impact myeloid cell properties and to understand the utility of a stromal-myeloid coculture system to study these interactions in the context of cirrhosis. (pklab.org)
Altogether, this study identifies a potential application of metformin in sensitizing AML cells to chemotherapy and unveils a novel mechanism by which metformin executes such effect via blocking the mitochondrial transfer from stromal cells to AML cells. (biomed.news)

Single-cell RNA sequencing (scRNA-seq) has the potential to investigate both genetic and nongenetic sources of tumor heterogeneity in a single assay. (pklab.org)
We found substantial heterogeneity of HyPer7 dynamics between individual cells. (biomed.news)

Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
The 2% threshold was chosen in part because of technical limitations (i.e., analytic sensitivity of clinically available sequencing assays) but also because very small clones are of unclear clinical significance. (wikipedia.org)
That acquired idiopathic AA is a T cell-mediated disorder is clearly proven by the clinical efficacy of antithymocyte globulin 4 and by a number of experimental observations. (ashpublications.org)

2000). Compact disc47 exists over the macrophage also, which raises the chance of binding of SIRP to Compact disc47 inside the same membrane, as continues to be postulated for various other receptors on various other immune system cells (Doucey et al. (azd1152.com)

In addition, the number and the migratory activity of these cells are inversely correlated with risk factors such as hypertension, hypercholesterolemia, diabetes, and metabolic syndrome. (intechopen.com)

A dose of 1.5 mg/kg of CD117-ADC (~12 µg Streptavidin-ZAP) optimally resulted in depletion of >99% of immunophenotypic and functional HSCs. (atsbio.com)
Functional screen identifies regulators of murine hematopoietic stem cell repopulation. (qmul.ac.uk)
Moreover, the chemotherapy given to these patients mainly caused neutropenia, while having little effect on the proportion and functional phenotype of T and B cells, and T cell clonal expansion. (aging-us.com)
Although there has been lot of debate on the cell of origin of CSC, according to the classical concept CSC are defined by their functional properties. (pharmaceuticalintelligence.com)

This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)
The stimulus for the change of cell fate originates from extrinsic signals which set a cascade of intracellular processes in motion that eventually terminate at the genome leading to changes in gene expression and the development of alternate gene regulatory networks. (amegroups.org)
In the developing embryo, TFs regulating the assembly/disassembly of transcriptional complexes and ultimately gene expression, are directed by complex extrinsic signalling processes which connect all cells within a multi-cellular organism to their environment. (amegroups.org)

Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
The heterogeneous populations which constitute a niche include both stem cells and surrounding differentiated cells. (pharmaceuticalintelligence.com)
Also, these cell populations directly correlated with poor survival [ 2 , 5 ]. (researchsquare.com)

These ATG genes are highly conserved in mammalian cells, allowing to study their functions also in higher eukaryotes [ 1 - 4 ]. (hindawi.com)
Ubigene has modified over 5000 genes from more than 200 cell lines with our exclusive innovation CRISPR-U™ technology. (ubigene.us)
Ubigene exclusive KO Cell Line Bank, over 5000 KO cell lines, covering thousands of genes from 8 popular signaling pathways and nearly 100 diseases. (ubigene.us)

In my project I would like to investigate the role of haematopoietic stem cells (HSCs) bias in the development of MLL-induced acute leukaemias during ageing. (ox.ac.uk)

Applications Tested: This HIB19 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains. (thermofisher.com)
Here we performed single-cell RNA sequencing in peripheral blood samples of 3 healthy donors (HDs), 4 COVID-19 patients (Covs) and 4 COVID-19 patients with active gynecological tumor (TCs) pre- and post- anti-tumor treatment. (aging-us.com)
The RAB27A protein is responsible for the peripheral distribution of melanosomes in melanocytes and exocytosis of cytotoxic granules in the cytosol of cytotoxic T cells (CTL) and natural killer (NK) cells. (biomedcentral.com)

Nfix Promotes Survival of Immature Hematopoietic Cells via Regulation of c-Mpl. (qmul.ac.uk)
Furthermore, activation of autophagy allows to extend cell survival when exposed to different types of stressors such as starvation or cytotoxic drugs. (hindawi.com)
Single-cell transcriptomic analysis of tumor cells from the primary tumors reveals a distinct transcriptional signature that is predictive of metastatic potential and patient survival. (pklab.org)
Here, we perform single-cell RNA sequencing (scRNA-seq) on 19 human NB samples coupled with multiplex immunohistochemistry, survival analysis, and comparison with normal fetal adrenal gland data. (pklab.org)
Several different cell types demonstrate a survival benefit. (pklab.org)
Evaluation of embryos generated from crossing transgenic mice to didn't result in decreased survival or within an overt hematopoietic phenotype. (academicediting.org)
Additionally, the high levels of the CD45 dim CD34 + CD38 - CD133 + cells in AML patients were an independently significant poor risk factor for overall survival and event free survivals. (researchsquare.com)
TRM relates to patient characteristics and general health while drug resistance or overall survival is characteristic of the AML clone. (ghrnet.org)

Haematopoiesis is required for the daily regeneration of blood and immune cells throughout life. (cha-mainz.de)
Continuous supply of immune cells throughout life relies on the delicate balance in the hematopoietic stem cell (HSC) pool between long-term maintenance and meeting the demands of both normal blood production and unexpected stress conditions. (jdstemcellresearch.ca)

Because Down syndrome leukemogenesis initiates during fetal development, we characterized the cellular and developmental context of preleukemic initiation and leukemic progression using gene editing in human disomic and trisomic fetal hematopoietic cells and xenotransplantation. (jdstemcellresearch.ca)

Although HCL is definitely a relatively rare malignancy the present data further demonstrate that mature B cell malignancies can initiate in the HSC compartment. (academicediting.org)

An in silico cell-to-cell interaction analysis highlights the CXCL9/CXCL10-CXCR3 axis and the CD70-CD27 axis as potential therapeutic targets. (pklab.org)
In addition, this cell population might be a novel therapeutic target for AML. (researchsquare.com)
Under such circumstances, the idea of "therapeutic cloning" was proposed, indicating the generation of ESCs from SCNT embryos for therapeutic purpose. (benthamscience.com)

Our long-term objectives are to understand the genetic pathways that control human hematopoietic stem cells (HSCs) and to determine how changes in these programs lead to generating leukemic stem cells (LSC). (jdstemcellresearch.ca)

SAGA complex member expression is significantly reduced in aged HSCs and upregulated with heterochronic parabiosis, suggesting a novel mechanism of age-associated hematopoietic decline and rejuvenation. (biorxiv.org)

Zebrafish runx1 is expressed in hematopoietic and neuronal cells during early embryogenesis. (biologists.com)

As the HUMARA assay is based on the epigenetic state of cells, the underlying genetic determinants of the clonal expansion remained to be uncovered. (wikipedia.org)
We further established a multi-disciplinary collaboration with pathologists curating a large biobank of human BM biopsies from an aged population to study the immunological and transcriptional changes in clonal haematopoiesis and related leukaemia by combining spatial multiplex confocal imaging, single-cell sequencing analysis and BM organoid co-culture assays. (cha-mainz.de)
We have previously shown that expressed barcodes can enable simultaneous read-out of transcriptome and clonal information from the same single cell. (bist.eu)
Numbat exploits the evolutionary relationships between subclones to iteratively infer single-cell copy number profiles and tumor clonal phylogeny. (pklab.org)
Likewise Kikushige lately demonstrated which the propensity to create clonal B cells in sufferers with the older B cell malignancy CLL is normally obtained in the HSC area (24). (academicediting.org)
Notably, anti-PD-L1 treatment massively increased cytotoxic scores of NK cells, and T cells, and facilitated clonal expansion of T cells in these patients. (aging-us.com)

Hematopoietic stem and progenitor cells (HSPCs) are necessary for life-long blood production and replenishment of the hematopoietic system during stress. (qmul.ac.uk)
Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
CD34 is a transmembrane phosphoglycoprotein that was first identified on HSPCs, but its expression is also present on other cell types, such as vascular tissue. (stemcell.com)
Rising evidence shows that HSPCs might enjoy essential roles in various other neoplasms of mature B cells. (academicediting.org)
However a more considerable mutational analysis of HCL cells and combined HSPCs will become needed to more definitively address this query. (academicediting.org)

Benoit YD*, Guezguez B*, Boyd AL and Bhatia M (2014) Epigenetic modulation of Wnt/Glycogen synthase kinase-3 signaling to target human cancer stem cells . (cha-mainz.de)

In evolutionary biology, this condition is supposed to confer a disadvantage because of a less efficient T-cell response against tumors and infectious agents. (ashpublications.org)
2 Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom. (nih.gov)
In an excellent issue, J.P. Di SANTO focuses on murine NK cells, although parallels to human NK cell biology are also made. (scielo.br)
9 Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. (jci.org)

Just as the observation of the same DNA mutation in a subset of cells suggests a single founding source, this X-inactivation skew suggests that a greater than expected number of cells are being generated from the same precursor. (wikipedia.org)
A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness. (jdstemcellresearch.ca)

Here we sequenced 3,579 genomes from single cell-derived colonies of haematopoietic cells across 10 human subjects from 0 to 81 years of age. (bvsalud.org)
Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. (nature.com)
The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. (nature.com)
Here we review the role of telomeres and telomerase in the function and capacity of the human stem cells. (nature.com)
The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization. (jdstemcellresearch.ca)
Furthermore, T cells and NK cells complement each other in that certain immune suppression mechanisms taken by tumor cells that are effective against T cells, such as the downregulation of human leukocyte antigens (HLA), have proven to be stimulatory for NK cells. (molcells.org)
The HeLa cell line was the first immortal human cell line that George Otto Gey, Margaret Gey, and Mary Kucibek first isolated from Henrietta Lacks and developed at The Johns Hopkins Hospital in Baltimore, Maryland, in 1951. (asu.edu)
An immortal human cell line is a cluster of cells that continuously multiply on their own outside of the human from which they originated. (asu.edu)
Scientists use immortal human cell lines in their research to investigate how cells function in humans. (asu.edu)
Understanding the complete immune cell composition of human neuroblastoma (NB) is crucial for the development of immunotherapeutics. (pklab.org)
Mouse anti-human CD45-FITC (Clone 2D1, Cat No. 347463), Mouse Anti-human CD34-PE [Clone 8G12 (also known as HPCA2), Cat No. 348057], Mouse anti-human CD38-PE-Cy™5 (Clone HIT2, Cat No. 555461) and appropriated isotype control antibodies were purchased from BD Biosciences (San Diego, CA, USA). (researchsquare.com)
The human body is made up of about 220 different kinds of specialized cells such as nerve cells, muscle cells, fat cells and skin cells. (benthamscience.com)
However, the derivation of human NT-ESCs goes with the destruction of clone embryos, leading to fierce ethical disputes. (benthamscience.com)

Specifically, it refers to transfecting the homologous targeting vector carrying modified gene into mouse ESCs, injecting the positive clones into blastocysts, and then transplanting them into surrogate mice to obtain chimeric mice. (ubigene.us)
We assessed the self-renewal of HSCs from CD45.2 V600E control mice in competitive repopulation assays. (academicediting.org)

We have found clone-intrinsic programs that characterize aged HSCs, as well as preleukemic mutant HSCs. (bist.eu)

5 Even if the identification of the target antigen(s) remains elusive, it is plausible that these auto-reactive T cells recognize specific epitopes presented on hematopoietic progenitor/stem cells (HSCs) through HLA molecules. (ashpublications.org)

However, there is an incomplete understanding of its stimulus, when it occurs in the progression from normal to cancer cell and the APOBEC enzymes responsible. (bvsalud.org)
During chemotherapy, patients frequently experience neutropenia due to the non-selective cytotoxicity of anti-cancer agents, so exogenous G-CSF is administered to boost cell counts on the system. (umontreal.ca)
Dr. John Dick on his famous discovery of cancer stem cells, and the puzzle of research (UHN Behind the Breakthrough Podcast, 2020) In this episode, Dr. John Dick takes us behind the scenes on his career, building on the pioneering work of Drs. James Till and Ernest McCulloch-the first to define the properties of stem cells. (jdstemcellresearch.ca)
Adoptive cell transfer (ACT) is the latest arsenal in the battle against cancer. (molcells.org)
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults. (pklab.org)
What are cancer stem cells? (pharmaceuticalintelligence.com)
Cancer stem cells can also generate non-CSC progeny that is comprised of differentiated cells and forms tumor bulk. (pharmaceuticalintelligence.com)
For instance, Li et al (2008) reported that CSC accumulated in the breast of women with locally advanced tumors after cytotoxic chemotherapy had eliminated the bulk of the tumor cells ( Li X,et al, J Natl Cancer Inst, 7 May 2008;100(9):672-9 ). (pharmaceuticalintelligence.com)
Formerly OXPHOS was thought to be reduced in tumours and that glycolysis was the critical pathway for generation of ATP but it is now clear that OXPHOS, at least in many tumour types, plays a critical role in delivering the bioenergetic and macromolecular anabolic requirements of cancer cells. (biomed.news)

Understanding how hematopoietic cells evolve under the selective pressures of therapy is a major focus of the Sperling lab. (harvard.edu)

2004). Whenever a macrophage engages a personal cell, a phagocytic synapse forms where binding of SIRP to Compact disc47 network marketing leads to local deposition of SIRP and phosphatase-mediated signaling that opposes engulfment (consuming) of personal cells including tumor cells (Fig.?1Awe, higher) (Oldenborg et al. (azd1152.com)
Unlike primary NK cells, those prepared from iPSCs can be prepared with a homogeneous quality and are easily modified to exert a desired response to tumor cells. (molcells.org)

Therefore the paradigm of linking B cell malignancies to counterparts in normal B cell development has been a predominant model to describe the cell of source for these disorders and could have got obscured the id of a far more primitive cell of origins. (academicediting.org)

Based on these data, we tested the hypothesis that rare SETBP1 mutant clones exist at diagnosis in many patients who relapse, and that these rare cells undergo positive selection during treatment. (ashpublications.org)

Anatomy50

Organisms16

Diseases26

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Psychiatry and Psychology1

Phenomena and Processes47

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Named Groups3

Health Care5

Progenitors10

Differentiation20

Progenitor cell4

Transplantation13

Lineage13

Hematopoiesis9

Embryonic13

Quiescent hematopoietic1

Endothelial cells4

Mutations10

Pluripotent10

Bone18

Myeloid cells4

Normal hematopoietic1

Lymphocytes2

Regenerative medicine2

HSPC3

Precursors3

Multipotent1

Differentiate3

Subsets2

Vivo4

Homeostasis6

Subpopulation1

Epithelial3

Microenvironment4

Receptor7

Mesenchymal1

Leukemia11

Tissues3

Somatic cells3

Stromal2

Heterogeneity2

Clinical3

20001

Inversely correlated1

Functional4

Gene expression3

Populations3

Genes3

Acute1

Peripheral4

Survival8

Immune cells2

Fetal1

Compartment1

Therapeutic3

Leukemic stem cells1

Reduced in aged1

Neuronal1

Clonal6

HSPCs5

Epigenetic1

Biology4

Subset2

Human13

Mice2

Preleukemic1

Molecules1

Cancer9

Selective1

Tumor cells2

Malignancies1

Mutant clones1