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  • transplantation
  • Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. (biomedcentral.com)
  • Hematopoietic stem cells (HSCs) have been used for more than 35 years for transplantation therapy to treat acute and chronic leukemia, lymphoma, marrow failure and congenital immune deficiency. (biomedcentral.com)
  • For HSC transplantation all three types of HSCs are used, but for most other applications mobilized peripheral blood HSCs are most commonly used. (biomedcentral.com)
  • The administration of G-CSF daily for 4 to 6 days results in a 10- to 30-fold increase in the number of circulating HSCs [ 8 , 9 ] and G-CSF-mobilized HSCs collected by apheresis have been used for transplantation, immune therapy and the treatment of cardiac ischemia. (biomedcentral.com)
  • 1, 2 Various assay formats have been developed that differ in the choice of donor and host mouse strains, the method to ablate or suppress host hematopoiesis prior to donor cell transplantation, the detection methods used to identify the progeny of donor-derived stem cells, and the endpoints and criteria for "successful" engraftment. (stemcell.com)
  • Using this NSG transplantation model, we then provided evidence of a reduced contribution of low dose irradiated HSCs towards longterm haematopoiesis. (bl.uk)
  • HSCs with reduced DNMT1 fail to self-renew efficiently post-transplantation. (wikipedia.org)
  • intrinsic
  • The mechanisms by which AMD3100 and G-CSF alter HSC trafficking and mobilization are different suggesting that HSCs with different intrinsic properties maybe be mobilized by these agents. (biomedcentral.com)
  • progeny
  • The most common method for identifying the progeny of transplanted HSCs is to use genetic differences between donor and recipient mouse strains. (stemcell.com)
  • proliferate
  • HSCs are self-renewing cells: when they proliferate, at least some of their daughter cells remain as HSCs, so the pool of stem cells is not depleted.This phenomenon is called asymmetric division. (wikipedia.org)
  • mutations
  • The combination of these two ideas, that clonal hematopoiesis might be common in the elderly population and that AML evolves from pre-leukemic populations, led to the hypothesis that malignancy-associated mutations could also contribute to asymptomatic clonal hematopoiesis in healthy individuals. (wikipedia.org)
  • This view gained mechanistic support in 2012 when it was found a number of the women who showed evidence for clonal hematopoiesis through X-inactivation skew also had mutations in the hematologic-malignancy-associated gene TET2. (wikipedia.org)
  • The advent of next-generation DNA sequencing has allowed for the targeted identification of somatic mutations involved in clonal hematopoiesis at the population level. (wikipedia.org)
  • The other main common finding is that there are many different mutations involved in clonal hematopoiesis. (wikipedia.org)
  • absent
  • One common finding has been that observable clonal hematopoiesis is virtually absent from the under-40 population, with a sharp uptick in frequency past 60 years of age. (wikipedia.org)
  • This expression profile links to the importance of HOXA9 in the HSC, as it mirrors the fact that HSCs are absent in the developing embryo, undergoing initial production in the fetal stage, and are vital in the adult. (wikipedia.org)
  • blood
  • Having clonal hematopoiesis has been linked to a more than 10-fold increased risk of developing a blood cancer, though the overall likelihood is still low. (wikipedia.org)