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Hypoxanthine PhosphoribosyltransferaseLesch-Nyhan SyndromeThioguanineX ChromosomeMutagensMutagenicity TestsEthylnitrosoureaDosage Compensation, GeneticMutation7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideMutagenesisPhosphoribosyl PyrophosphateCricetinaeCricetulusEthyl MethanesulfonatePhosphoglycerate KinaseHybrid CellsDNA AdductsBase SequenceNeonPolymerase Chain ReactionExonsGenesSex ChromosomesDNAMercaptoethylaminesCell LineAzaguanineRadon DaughtersReference StandardsButadienesDNA Mutational AnalysisMuridaeEthylene OxideMolecular Sequence DataChromosomes, ArtificialAlkylating AgentsEpoxy CompoundsPoint MutationLymphocytesRubberHypoxanthineSex Chromosome AberrationsAntimutagenic AgentsMethylnitronitrosoguanidineDNA DamageCHO CellsPentosyltransferasesLinear Energy TransferFibroblastsSequence DeletionGuanineCarcinogensDNA RepairT-LymphocytesReverse Transcriptase Polymerase Chain ReactionVDJ RecombinasesAdenineGene TargetingAzacitidineHeavy IonsHyperuricemiaPurinesAllelesClone CellsDNA PrimersGlucosephosphate DehydrogenaseRNA, MessengerGoutMicronucleus TestsGene DeletionBlastocystHypoxanthinesUltraviolet RaysGenetic LinkageDose-Response Relationship, RadiationChromosome MappingGenes, EssentialRecombination, GeneticGene ExpressionEmbryo, MammalianPyrenesSister Chromatid ExchangeGenetic VectorsCells, CulturedCell SurvivalGene Expression RegulationFrameshift MutationMicronuclei, Chromosome-DefectiveCloning, MolecularLac OperonThymidine KinaseGlyceraldehyde-3-Phosphate DehydrogenasesChemical IndustryMethylationTranslocation, GeneticMice, TransgenicBlotting, SouthernOccupational ExposureErythrocytes
Hypoxanthine-guanine PhosphoribosyltraGenePPIAMRNA
Hypoxanthine-guanine Phosphoribosyltra2
  • In this study, β-actin1 (ACTB1), elongation factor 1 alpha (EF1A1), hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1), ribosomal protein L7 (RPL7), tubulin beta 2C (Tubb2C), and ubiquitin-conjugating enzyme (UbcE) were evaluated as reference genes for normalization of real time RT-PCR data during Atlantic halibut development, in tissue of healthy and NNV-infected fish, and in in vivo and in vitro stimulated anterior kidney leucocytes. (uib.no)
  • This gene provides instructions for making an enzyme called hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1). (socialpsychology.info)
Gene5
  • LNS is caused by complete HPRT deficiency due to mutations in the HPRT1 gene (Xq26). (orpha.net)
  • CRISPR/Cas9-mediated generation of human embryonic stem cell sub-lines with HPRT1 gene knockout to model Lesch Nyhan disease. (istem.eu)
  • Lesch-Nyhan syndrome occurs when there is a mutation in the HPRT1 gene. (socialpsychology.info)
  • Mutations in the HPRT1 gene lead to reduced activity of the HPRT1 enzyme. (socialpsychology.info)
  • Confirmation of the diagnosis is most reliably made by identification of the HPRT1 gene. (medscape.com)
PPIA2
  • However, geNorm analysis (approach 2) of the ICGs indicated that the geometrical mean of PPIA, HPRT1, RNA18S and RPLPO can be considered a reliable approach for normalization of target genes in both control and DEX treated groups. (oregonstate.edu)
  • Our data indicated that the use of the geometrical mean of PPIA, HPRT1, RNA18S and RPLPO can provide a reliable normalization for the proposed study. (oregonstate.edu)
MRNA4
  • Genes best-ranked by GeNorm, NormFinder and BestKeeper.Figure three GPER mRNA assayed and normalized to IPO8, RPL4, GADPH, and HPRT1 mRNA. (icbinhibitor.com)
  • Normalization to IPO8 and RPL4 showed no important variation with the GPER mRNA content material amongst BE, BO and MA tumours (A, B). In contrast, GPER mRNA was greater in BE/BO in comparison with MA when normalized to GADPH (p = 0.002) or HPRT1 (p = 0.008) (C, D).Kolkova et al. (icbinhibitor.com)
  • Journal of Ovarian Research 2013, six:60 ovarianresearch.com/content/6/1/Page 9 ofFigure 4 UPAR mRNA assayed and normalized to IPO8, RPL4, GADPH, and HPRT1 mRNA. (icbinhibitor.com)
  • uPAR mRNA content material was higher in BO/MA than in BE when connected to IPO8 (p = 0.003) and RPL4 (p = 0.001) (A, B). No substantial differences have been identified in the volume of uPAR mRNA when it was normalized to GADPH or HPRT1 mRNA (C, D).normalization resulted in erroneous conclusions on expression of target genes. (icbinhibitor.com)