AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
RNARNA, Small InterferingRNA, ViralRNA EditingRNA SplicingRNA, RibosomalRNA, BacterialDNA-Directed RNA PolymerasesRNA VirusesRNA InterferenceRNA, MessengerRNA, Double-StrandedRNA, CatalyticRNA FoldingRNA Polymerase IIRNA, FungalRNA StabilityRNA HelicasesRNA, AntisenseRNA Processing, Post-TranscriptionalRNA, TransferRNA, Small NuclearRNA PrecursorsRNA, UntranslatedNucleic Acid ConformationRNA CapsSequence Analysis, RNARNA, PlantRNA, ProtozoanBase SequenceRNA, NeoplasmRNA Ligase (ATP)DEAD-box RNA HelicasesRNA Polymerase IIIMolecular Sequence DataRNA Polymerase IRNA, NuclearRNA, GuideRNA, Ribosomal, 28SRNA, Ribosomal, 18SRNA-Binding ProteinsRNA, Ribosomal, 23SRNA TransportRNA, Spliced LeaderRNA, SatelliteRNA, Ribosomal, 16SAmino Acid SequenceRNA, ArchaealNucleic Acid HybridizationProtein BiosynthesisCell LineVirus ReplicationEscherichia coliRNA CleavageMutationOligoribonucleotidesRNA, Heterogeneous NuclearTranscription, GeneticRNA, Small CytoplasmicRNA 3' End ProcessingTemplates, GeneticRNA, Small UntranslatedHeLa CellsRibonucleoproteinsRibonucleasesPoly AGenome, ViralRNA, Ribosomal, 5.8SDNARNA, Long NoncodingRNA, Small NucleolarBinding SitesRNA Virus InfectionsProtein BindingRNA, ComplementaryUridinePromoter Regions, GeneticEndoribonucleasesCell NucleusRNA, ChloroplastModels, MolecularPlasmidsReverse Transcriptase Polymerase Chain ReactionKineticsSingle-Strand Specific DNA and RNA EndonucleasesBase PairingRNA, HelminthPlant VirusesDNA PrimersGene Expression RegulationSaccharomyces cerevisiaeTranscription FactorsRNA, Transfer, PheRNA, Transfer, LysRibosomesBlotting, NorthernDNA, ViralPolymerase Chain ReactionOligonucleotidesGene Silencing
SiRNAInterferenceSiRNAsMRNAMoleculesInhibitionPolymerase Chain ReMiRNAsTherapeuticsPathwayTransfectionAntisense oligonucleotideMicroRNAProteins2022AntiviralTherapeuticStablyMolecule2017GenesRISCMethodsReplicationTranscriptionTherapyMechanismGrowthFunctionalPiRNAExpressionArticleLongLikelihoodDevelopmentCellsType
SiRNA18
  • Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at first non-coding RNA molecules, typically 20-24 (normally 21) base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway. (wikipedia.org)
  • The mechanism by which natural siRNA causes gene silencing through repression of translation occurs as follows: Long dsRNA (which can come from hairpin, complementary RNAs, and RNA-dependent RNA polymerases) is cleaved by an endo-ribonuclease called Dicer. (wikipedia.org)
  • siRNA is also similar to miRNA, however, miRNAs are derived from shorter stemloop RNA products. (wikipedia.org)
  • The resulting transcript is a short hairpin RNA (shRNA), which can be processed into a functional siRNA by Dicer in its usual fashion. (wikipedia.org)
  • RNA interference (RNAi) is a sequence-specific RNA degradation mechanism mediated by small interfering RNA (siRNA), which represents a possible therapeutic application for the treatment of viral infections. (scienceopen.com)
  • Here we report the discovery and development of olpasiran, a first-in-class, synthetic, double-stranded, N -acetylgalactosamine-conjugated small interfering RNA (siRNA) designed to directly inhibit LPA messenger RNA translation in hepatocytes and potently reduce plasma Lp(a) concentration. (nature.com)
  • In this regard, small interfering RNA (siRNA), double-stranded RNA molecules able to specifically target the mRNA of pathological genes, have the potential to be of therapeutic value. (unive.it)
  • Small Interfering RNA (SiRNA) Market size is projected to be $964.17 Million by 2030 growing at a CAGR of 8.6% from 2023 to 2030, as per a recent study published by Cognitive Market Research. (cognitivemarketresearch.com)
  • Companies operating in Small Interfering RNA (SiRNA) market are focusing on strategic collaboration to meet customer need for a simplified, faster development process. (cognitivemarketresearch.com)
  • In terms of therapeutics, the Cancer segment dominates the Small Interfering RNA (SiRNA) market. (cognitivemarketresearch.com)
  • This can be attributed to siRNA being produced from the long dsRNAs and small hairpin RNAs with the help of enzyme dicer. (cognitivemarketresearch.com)
  • For instance, in 2021, Silence Therapeutics PLC entered the Chinese market through a partnering deal with Hansoh Pharmaceutical Group Co. Ltd. that involves developing short interfering RNA (siRNA) drugs against three undisclosed targets. (cognitivemarketresearch.com)
  • The aim of the current investigation was to delineate the role of kallikrein in the regulation of fibrosis, by 'knocking down' its expression using specific small interfering RNAs (siRNA). (le.ac.uk)
  • The endogenous trans-acting small interfering RNA (ta-siRNA) pathway plays a conserved role in adaxial-abaxial patterning of lateral organs in simple-leafed plant species. (elsevierpure.com)
  • Small interfering RNA (siRNA) is a powerful genetic tool that can bind to its target and reduces expression level of a specific gene. (sabanciuniv.edu)
  • Examples of these RNA therapies include antisense oligonucleotide (ASO), small interfering RNA (siRNA), and microRNA (miRNA) therapies. (medlineplus.gov)
  • The research team created a new application for a genetic technology called small interfering RNA (siRNA). (scienceblog.com)
  • Endosomal escape and subsequent cytosolic delivery of small interfering RNA (siRNA) therapeutics is believed to be highly inefficient. (lu.se)
Interference5
SiRNAs11
  • Naturally occurring siRNAs have a well-defined structure that is a short (usually 20 to 24-bp) double-stranded RNA (dsRNA) with phosphorylated 5' ends and hydroxylated 3' ends with two overhanging nucleotides. (wikipedia.org)
  • The Dicer enzyme catalyzes production of siRNAs from long dsRNAs and small hairpin RNAs. (wikipedia.org)
  • One class of such RNA agents is small interfering RNAs (siRNAs) that mediate viral message degradation with perfect base pairing to the target. (ca.gov)
  • Moreover, combinations with small RNAs capable of turning over multiple target substrates, such as siRNAs and ribozymes, showed greater inhibition to HIV replication in a one-month challenge assay. (ca.gov)
  • We demonstrate the versatility of the MCM7 platform in expressing and efficiently processing the siRNAs as miRNA mimics along with nucleolar small RNAs. (ca.gov)
  • This represents the first efficacious example of combining Drosha-processed siRNAs with small nucleolar ribonucleoprotein (snoRNP)-processed nucleolar RNA chimeras from a single intron platform for effective inhibition of viral replication. (ca.gov)
  • Here, we show that short interfering RNAs (siRNAs) specific for conserved regions of influenza virus genes can prevent and treat influenza virus infection in mice. (scienceopen.com)
  • Virus production in lungs of infected mice is reduced by siRNAs given either before or after initiating virus infection, by using slow i.v. administration of small volumes containing siRNAs in complexes with a polycation carrier. (scienceopen.com)
  • Background The usage of exogenous small interfering RNAs (siRNAs) for gene silencing has quickly become a widespread molecular tool providing a powerful means for gene functional study and fresh drug target identification. (biotech2012.org)
  • The usage of exogenous little interfering RNAs (siRNAs) for abolishing gene expression provides swiftly become a widespread molecular device providing a robust opportinity for gene useful study and brand-new drug focus on identification [8,9]. (biotech2012.org)
  • Two primary types of sequence-particular cleavage triggers have already been determined: siRNAs and micro RNAs (miRNAs), chemically synthesized respectively from longer dsRNA and miRNA precursor (pre-miRNA) by Dicer, a multidomain enzyme of the RNase III family members. (biotech2012.org)
MRNA6
  • It interferes with the expression of specific genes with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. (wikipedia.org)
  • After that this complicated triggers either mRNA degradation or translational repression of the mRNA with respect to the amount of complementarity between your RISC-linked RNA strand (the instruction strand) and the mark. (biotech2012.org)
  • Intrathecal applications of BC-1215 (a Fbxo3 activity inhibitor), Fbxl2 mRNA-targeting small-interfering RNA, and ω-conotoxin GVIA (a Ca V 2.2 blocker) attenuated RIM1α upregulation, enhanced RIM1α expression, and exhibited no effect on RIM1α expression, respectively. (jneurosci.org)
  • A first RNA molecule comprises a double-stranded sequence, which includes a guide strand sequence that is complementary to a portion of an mRNA transcript encoded by the target gene. (genomeweb.com)
  • CircRNAs are newly discovered noncoding RNAs formed through the alternative splicing of premessenger RNA (mRNA). (hindawi.com)
  • In many of these techniques, the pieces of RNA interact with a molecule called messenger RNA (or mRNA for short). (medlineplus.gov)
Molecules3
  • this is what enables the molecules to form the RNA-Induced Silencing Complex (RISC). (wikipedia.org)
  • Such methods generally comprise providing a cell with one or more precursor nucleic acid sequences that encode two or more RNA molecules. (genomeweb.com)
  • Several other antisense RNAs as well as the more malleable small interfering RNA molecules ('-sirans') are currently in early-phase clinical trials. (medscape.com)
Inhibition3
  • Abstract Combinational therapy with small RNA inhibitory agents against multiple viral targets allows efficient inhibition of viral production by controlling gene expression at critical time points. (ca.gov)
  • Moreover, we demonstrated enrichment/selection for cells expressing levels of the antiviral RNAs that provide optimal inhibition under the selective pressure of HIV. (ca.gov)
  • The inhibition occurred at two points in the viral life cycle, after fusion and before reverse transcription and during transcription of viral RNA from integrated provirus. (scienceopen.com)
Polymerase Chain Re1
MiRNAs1
  • Here we explore combinations of different classes of therapeutic anti-HIV-1 RNAs expressed from within the context of an intronic MCM7 (minichromosome maintenance complex component-7) platform that naturally harbors 3 microRNAs (miRNAs). (ca.gov)
Therapeutics2
  • Recently, therapeutics have shown a vast diversification from small-molecule drugs. (cognitivemarketresearch.com)
  • New York, United States, 2022-Jun-06 - /EPR Network/ - RNA-Based Therapeutics and Vaccines Market is all set to witness a CAGR of 86.6% in the next decade. (express-press-release.net)
Pathway2
  • The Drosophila piRNA pathway provides an RNA-based immune system that defends the germline genome against selfish genetic elements. (nih.gov)
  • A Heterochromatin-Specific RNA Export Pathway Facilitates piRNA Production. (oeaw.ac.at)
Transfection1
Antisense oligonucleotide1
  • Bepirovirsen is a potential first-in-class antisense oligonucleotide that targets all HBV messenger RNA and acts to decrease levels of viral proteins. (medscape.com)
MicroRNA5
  • Endogenous MCM7 MicroRNA Cluster as a Novel Platform to Multiplex Small Interfering and Nucleolar RNAs for Combinational HIV-1 Gene Therapy. (ca.gov)
  • In this current study, we utilized an endogenous microRNA (miRNA) cluster as a platform to express multiple anti-HIV small RNAs. (ca.gov)
  • dblp: P-SAMS: a web site for plant artificial microRNA and synthetic trans -acting small interfering RNA design. (uni-trier.de)
  • A total 3 short hairpin RNA (sh)‑lncRNA XIST sequences, overexpression vector (oe)‑lncRNA XIST, microRNA (miR)‑320a mimic, miR‑320a inhibitor, PIK3CA inhibitor, and their corresponding controls were transfected in hepatic carcinoma cells. (spandidos-publications.com)
  • Interestingly, ZNFX1 antisense RNA 1 (ZFAS1) could abolish its tumor suppressor effect by binding microRNA (miR)-150, while miR-150 could inhibit the invasion of hepatic carcinoma cells by inhibiting zinc finger E-box binding homeobox 1 (ZEB1) and matrix metalloproteinases (MMP)14 and MMP16 ( 10 ). (spandidos-publications.com)
Proteins3
  • Finally, anti-HIV RNA decoys that aim to titrate out early essential viral replication proteins Tat and Rev are constructed. (ca.gov)
  • An RNA therapy called RNA aptamer therapy introduces small pieces of RNA that attach directly to proteins to alter their function. (medlineplus.gov)
  • Because of their surface charge, asbestos fibers can adsorb to cellular macromolecules (proteins, DNA, RNA) and cell surface proteins. (cdc.gov)
20221
  • New York, United States, 2022-May-16 - /EPR Network/ - The global Small RNA Detection Market is expected to grow at a stupendous rate In Upcoming Years. (express-press-release.net)
Antiviral1
  • Gene therapy approaches are attractive alternatives where the most vulnerable immune cells are modified with antiviral small RNAs with the goal to engineer an HIV-resistant immune system. (ca.gov)
Therapeutic1
  • A growing understanding of RNA functions and their vital role in various diseases has promoted its potential therapeutic usage. (cognitivemarketresearch.com)
Stably1
  • We demonstrated persistent expression of each anti-HIV RNAs in CEM T cell lines that stably integrate the transgene. (ca.gov)
Molecule1
  • however, small-molecule RAS blockers are contraindicated because of fetal toxicity. (jci.org)
20171
  • 2017. Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. . (oregonstate.edu)
Genes1
  • Whithout mutations we would know very little about inheritance and the existence of genes. (intechopen.com)
RISC1
  • Duplex is normally unwounded and one strand is normally selectively incorporated in to the RNA-induced silencing complicated (RISC). (biotech2012.org)
Methods1
  • Methods for accurately and precisely sampling and quantifying viral RNA in wastewater that are representative of viral shedding within a community are available and continue to be improved. (cdc.gov)
Replication1
  • Interestingly, cells with optimal level of small RNA expression to effectively inhibit viral replication were enriched under the selective pressure of HIV, demonstrating the importance of balancing expression and functionality for successful gene therapy applications. (ca.gov)
Transcription2
Therapy5
  • The combinations of si/snoRNAs represent a new paradigm for combinatorial RNA-based gene therapy applications. (ca.gov)
  • What are CAR T cell therapy, RNA therapy, and other genetic therapies? (medlineplus.gov)
  • RNA Therapy: Current Status and Future Potential. (medlineplus.gov)
  • Other questions include when NA therapy can be safely stopped, what other factors predict response, and whether RNA therapy-induced loss of HBsAg materially improves long-term outcomes, Hoofnagle writes. (medscape.com)
  • Bepirovirsen is just one RNA-based HBV therapy now being pursued. (medscape.com)
Mechanism1
  • The aim of the present study was to reveal the new molecular mechanism of long non‑coding (lnc)RNA XIST in the development of hepatic carcinoma. (spandidos-publications.com)
Growth1
  • Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization. (medscape.com)
Functional1
  • A universal method for the rapid isolation of all known classes of functional silencing small RNAs. (oeaw.ac.at)
PiRNA1
  • The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation. (oeaw.ac.at)
Expression1
  • Similarly, specific silencing of the expression of the eIF4E gene, caused by a small interfering RNA, resulted in significant cytotoxicity and cell death. (cdc.gov)
Article1
  • Is the Subject Area "Small interfering RNA" applicable to this article? (plos.org)
Long1
  • Long non-coding (lnc)RNAs play important roles in the development, differentiation, proliferation and apoptosis of cells ( 6 , 7 ). (spandidos-publications.com)
Likelihood1
  • The accomplishment further increases the likelihood that tiny mechanical devices working at the quantum level can someday supplement electronic devices for new products. (scienceblog.com)
Development1
  • Studies report that circular RNAs (circRNAs) derived from exosomes may play a key role in GDM development. (hindawi.com)
Cells1
  • Exosomes secreted by the umbilical cord mesenchymal stromal cells (UMSCs) and circular RNAs (circRNAs) derived from exosomes have been shown to be associated with the progression of GDM-related complications. (hindawi.com)
Type1
  • Several techniques, called RNA therapies, use pieces of RNA, which is a type of genetic material similar to DNA, to help treat a disorder. (medlineplus.gov)