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Transcription FactorsTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceBinding SitesTranscriptional ActivationTrans-ActivatorsRNA, MessengerBasic Helix-Loop-Helix Transcription FactorsProtein BindingNuclear ProteinsTranscription Factor AP-1Cell LineRepressor ProteinsForkhead Transcription FactorsAmino Acid SequenceHomeodomain ProteinsSignal TransductionGene Expression Regulation, DevelopmentalDNABasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2MutationTransfectionCell NucleusCell DifferentiationKruppel-Like Transcription FactorsTranscription Factors, TFIIChromatin ImmunoprecipitationGenes, ReporterYY1 Transcription FactorHeLa CellsSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDCells, CulturedActivating Transcription Factor 3NFATC Transcription FactorsSp3 Transcription FactorTranscription Initiation SiteNF-kappa BReverse Transcriptase Polymerase Chain ReactionZinc FingersPaired Box Transcription FactorsElectrophoretic Mobility Shift AssayActivating Transcription Factor 2Transcription Factor TFIIBEnhancer Elements, GeneticRegulatory Sequences, Nucleic AcidE2F1 Transcription FactorRNA Polymerase IIGene Expression ProfilingPlasmidsCloning, MolecularBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMEF2 Transcription FactorsRecombinant Fusion ProteinsGene ExpressionGATA3 Transcription FactorGATA1 Transcription FactorGATA2 Transcription FactorGene Expression Regulation, FungalTCF Transcription FactorsGATA Transcription FactorsMicrophthalmia-Associated Transcription FactorSTAT1 Transcription FactorLuciferasesProtein Structure, TertiaryActivating Transcription FactorsTranscription Factor RelAE2F Transcription FactorsSaccharomyces cerevisiaeCell Line, TumorChromatinPhosphorylationOligonucleotide Array Sequence AnalysisHelix-Loop-Helix MotifsSaccharomyces cerevisiae ProteinsGene Expression Regulation, PlantGATA6 Transcription FactorActivating Transcription Factor 4Models, BiologicalTranscription Factor 7-Like 1 ProteinActivating Transcription Factor 1Cyclic AMP Response Element-Binding ProteinSequence Homology, Amino AcidTranscription Factor TFIIIAProto-Oncogene ProteinsBlotting, WesternMice, KnockoutTATA BoxNFI Transcription FactorsSequence AlignmentModels, GeneticTumor Cells, CulturedDown-Regulation
P107E2F1ProteinNegatively regulatedE2F2RegulatePromoterProliferating myoblastsProteinsInhibitorCell CycleGenesSmad3ProgressionCervicalComplexesExpressionTumorInductionActinCancerProcessesActivityActivationAssociationDevelopmentDirectly
P1072
  • Decreased ex pression of c Myc in keratinocytes is mediated by SMAD3 in association with transcription components E2F4 and E2F5, p107 co repressor and SMAD4. (mirnaarray.com)
  • We report that p107 and p130 formed transcriptional complexes with E2F4 on the FGFR1 promoter and repressed FGFR1 gene transcription in myogenic cells. (wikigenes.org)
E2F14
  • E2Fs, a set of genes that encode a family of transcription factors (TFs) in most higher eukaryotes, are generally divided into the following three subfamilies: transcriptional activator E2Fs (E2F1-E2F3), repressor E2Fs (E2F4-E2F5), and inhibitor E2Fs (E2F6-E2F8) [14,15]. (fortunepublish.com)
  • In cells arrested in G1 and G0, RB1-E2F1 and RBL2-E2F4 dimers recruit chromatin remodelers such as HDAC1, SWI/SNF and PRC2 to condense chromatin and turn off transcription. (aston.ac.uk)
  • In conclusion, we recognized the ncRNA pivot (including miR-193b-3p, CRNDE, etc.) and TF pivot (including E2F1, E2F4, etc.) that significantly regulate dysfunction modules. (cellmolbiol.org)
  • LIG_RB_pABgroove_1 (LxDLFD), LIG_RB_LxCxE_1 (LxCxE) and LIG_RBL1_LxSxE_2 (LxSxE).The LxDLFD motif binds to a deep groove formed between the A and B subdomains and is present in E2F family transcription factors (E2F1-5). (eu.org)
Protein8
  • Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the E2F family of transcription factors. (wikipedia.org)
  • These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids (Asp + Glu), and a tumor suppressor protein association domain which is embedded within the transactivation domain. (wikipedia.org)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • Another study that compared a pair of twins with discordant HIV infection status showed that several other genes are also differentially methylated, including insulin-like growth factor binding protein 6 ( IGFBP6 ) [ 19 ]. (biomedcentral.com)
  • Intervertebral disc degeneration Protein interaction network Enrichment Co-expression analysis Regulatory factors. (cellmolbiol.org)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • E2F transcription factor 2 (E2F2) protein is the transcription factor that plays an important role in tumorigenesis. (journalsmededu.pl)
Negatively regulated1
  • Our published findings demonstrate that the FGFR1 gene is positively regulated by the Sp1 transcriptional regulator and negatively regulated by the transcription factor E2F4. (rosalindfranklin.edu)
E2F21
  • E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry. (journalsmededu.pl)
Regulate5
  • In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
  • Growth modulating factors regulate CDK4/6-RBs-E2Fs axis. (aston.ac.uk)
  • The mechanisms that regulate myoblast cell proliferation versus differentiation involve extracellular signaling via growth factors, their cognate receptors, intracellular signal transduction cascades, and transcriptional regulation of genes associated with cell proliferation. (rosalindfranklin.edu)
  • Finally, non-coding RNAs (ncRNAs) and transcription factors that regulate the module are predicted based on hypergeometric testing. (cellmolbiol.org)
  • During PDA progression, pancreatic acinar cells lose activity of the ClassI/II bHLH factors that regulate quiescence. (oncotarget.com)
Promoter2
  • LncRNA HAND2-AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74. (nih.gov)
  • For the other hand, down regulation of Id proteins in epithelial cells is because of activated SMAD3 that induces activating transcription factor expression then together with ATF directly represses the Id promoter. (mirnaarray.com)
Proliferating myoblasts1
  • Among these genes is the fibroblast growth factor receptor 1 (FGFR1) gene which is expressed in proliferating myoblasts and down-regulated during differentiation. (rosalindfranklin.edu)
Proteins1
  • Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
Inhibitor1
  • Furthermore, PARP1 is indispensible for transcription of the pro-survival kinases MAP2K6, ERK1/2 and AKT1, and for maintaining MAPK activity by suppressing transcription of the MAPK inhibitor, MPK1. (aston.ac.uk)
Cell Cycle8
  • Cancer genetics, DNA damage response, apoptosis, cell cycle My current research is focused on two transcription factors that respond to DNA damage and play important roles in regulating tumor development. (mdanderson.org)
  • Here we demonstrate that the dynamics of Nuclear Factor kappa B (NF-κB) signalling and the cell cycle are prioritised differently depending on the timing of an inflammatory signal. (edgehill.ac.uk)
  • Using iterative experimental and computational analyses, we show physical and functional interactions between NF-κB and the E2 Factor 1 (E2F-1) and E2 Factor 4 (E2F-4) cell cycle regulators. (edgehill.ac.uk)
  • The E2F transcription factor family regulates the expression of various cellular promoters, particularly those involved in the cell cycle. (avivasysbio.com)
  • Our latest findings demonstrate that cell cycle progression, which dictates oxidant level in stress-free conditions, determines PARP1 transcription. (aston.ac.uk)
  • In summary, cell cycle controlled PARP1 transcription helps cells to adapt to a pro-oxidant redox shift. (aston.ac.uk)
  • Their growth arrest is reversible and under certain conditions, such as induction by growth factors, cytokines, nutrients, or chemical agents, the cells can re-enter the cell cycle to proliferate again. (biomedcentral.com)
  • E2F Transcription Factors in Cancer, More than the Cell Cycle. (journalsmededu.pl)
Genes4
Smad31
Progression1
  • TFDP1 may be the first example of a family of related transcription factors and may have a role in progression of some hepatocellular carcinomas by promoting growth of the tumor cells. (avivasysbio.com)
Cervical1
  • Using computational predictions, we revealed that HPV-positive cervical cancers are regulated by transcription factors including, SOX2, E2F, NANOG, OCT4, and MYC, which control various processes such as the renewal of cancer stem cells, and the proliferation and differentiation of tumour cells. (fortuneonline.org)
Complexes1
  • Release of retinoblastoma-based repressive complexes from E2F-dependent gene promoters in response to cell transition to S phase enables transcription of PARP1. (aston.ac.uk)
Expression3
  • Although emerging evidence indicates that E2Fs are implicated in various cancer types, the diverse expression patterns and prognostic values of E2F transcription factors in SKCM have yet to be elucidated. (fortunepublish.com)
  • This enzyme contributes to repair of oxidative DNA damage by supporting several strand break repair pathways and nucleotide or base excision repair pathways, as well as acting as a co-activator of transcription factors such as NRF2 and HIF1a, which control expression of antioxidant enzymes involved in removal of electrophiles and secondary metabolites. (aston.ac.uk)
  • This signaling culminates in regulation of transcription factors governing expression of the slow myosin heavy chain 2 gene - indicative of the slow muscle fiber phenotype. (rosalindfranklin.edu)
Tumor1
  • Huang Y, Jiang T, Chen J, Yin GY, Fan J. Effects of kartogenin on the attenuated nucleus pulposus cell degeneration of intervertebral discs induced by interleukin-1beta and tumor necrosis factor-alpha. (cellmolbiol.org)
Induction1
  • Transcription factor induction of vascular blood stem cell niches in vivo. (stembook.org)
Actin1
  • However, mechanistic details are lacking, and recent studies have implicated ALMS1 in several processes including endosomal trafficking, actin organisation, maintenance of centrosome cohesion and transcription. (springer.com)
Cancer1
  • 2009. E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. . (oregonstate.edu)
Processes1
  • Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (lookformedical.com)
Activity2
  • Conversely, the phosphorylation of Put3p is not dependent on GATA factor activity. (openrepository.com)
  • We previously found that promoting transcriptional activity of the Class I bHLH factor E47 in highly aggressive PDA cells induced stable growth arrest in vitro and in vivo . (oncotarget.com)
Activation2
  • The whole adipogenic process was driven by a coordinated activation of transcription factors and epigenetic modulators. (biomedcentral.com)
  • Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics. (stembook.org)
Association1
Development1
  • Despite of the relevance of this issue, very little is known about the factors regulating the development of adipose tissue in fish, and the possible health alterations associated to an increased fat deposition. (biomedcentral.com)
Directly1
  • DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. (lookformedical.com)