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  • GvHR
  • We have investigated the relevance of mucosal mast cells (MMC) to the mechanisms of this enteropathy by using graft-versus-host reaction (GvHR) in the rat as a model of mucosal delayed type hypersensitivity. (bmj.com)
  • Inhibition of graft-versus-host-reaction (gvhr) by in vitro incubation" by N Kiger, I Florentin et al. (jax.org)
  • Combination of ATL and ATH,which were congenic recombinant strains differing only in H-2I and S region from each other, was chosen to induce class II-GvHR.Selective activation against partner's alloantigen of graft CD4^+ T cells was the primary event of the GvHR and then led to concomitant activation of both graft and host cells. (nii.ac.jp)
  • GVHD
  • There are now compelling data on the role of host tissue destruction as the initial insult, extensive interactions of cellular donor and host components, a complex network of cytokines, adhesion molecules, and other components in the development of GVHD. (springer.com)
  • Application of the principles of cytokine signaling to the clinical setting may necessitate new trial design structures that take into consideration donor and host characteristics as well as the kinetics of GVHD development. (springer.com)
  • GvHD is commonly associated with stem cell transplant (bone marrow transplant), but the term also applies to other forms of tissue graft. (wikipedia.org)
  • Lichen
  • The term lichenoid reaction (or lichenoid lesion) refers to a lesion of similar or identical histopathologic and clinical appearance to lichen planus (i.e. an area which resembles lichen planus, both to the naked eye and under a microscope). (wikipedia.org)
  • bone
  • Marked enhancement of donor type chimerism was also found when F1 thymocytes were added to nude bone marrow cells, indicating that the enhancement of bone marrow engraftment by T cells is not only mediated by alloreactivity against residual host cells but may rather be generated by growth factors, the release of which may require specific interactions between T cells and stem cells or between T cells and bone marrow stroma cells. (osti.gov)
  • severe
  • In the more severe reactions, the foci of endothelial destruction may be so numerous as to overlap, resulting in complete immunologic destruction of the entire endothelium. (arvojournals.org)
  • cells of the host
  • Microchimerism is the presence of a small number of cells that originate from another individual and are therefore genetically distinct from the cells of the host individual. (wikipedia.org)
  • severe reactions
  • In the more severe reactions, the foci of endothelial destruction may be so numerous as to overlap, resulting in complete immunologic destruction of the entire endothelium. (arvojournals.org)
  • Monitor patients and discontinue DUCORD infusion for severe reactions. (nih.gov)