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  • infection
  • A complex and dynamic interaction exists between pathogens and host immune-defence mechanisms during the course of invasive infection. (nih.gov)
  • Most tick-borne pathogens (TBPs) are transmitted with tick saliva, with few notable exceptions such as Hepatozoon canis, where infection occurs through oral ingestion of ticks infected with oocysts. (frontiersin.org)
  • Together with tools such as tick cell lines and the widespread adaptation of RNA interference (RNAi) to study tick gene function, this has opened possibilities to study pathogen infection and transmission by ticks in greater detail. (frontiersin.org)
  • The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. (springer.com)
  • There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. (springer.com)
  • The inhibition of host immune responses on the one hand, and the protection of B. burgdorferi on the other hand, by this pleiotropic tick salivary protein are exemplary of the complexity of tick-host-pathogen interactions that collectively determine the outcome of an infection with B. burgdorferi. (uva.nl)
  • Thus, temperature has an impact on the property of the OMVs, and this might affect the outcome of infection by C. jejuni in different hosts. (diva-portal.org)
  • Our group aims at understanding and analyzing the interactions of pathogens with their host, leading to its infection and its possible destruction. (univ-mrs.fr)
  • More recently, similar strategies have begun to identify the host cell determinants required for infection. (asm.org)
  • In order to conduct a genome-wide loss-of-function CRISPR/Cas9-based screen of a pool of intestinal epithelial HT-29 cells, Pacheco and colleagues first needed to identify infection conditions that promote significant host cell death. (asm.org)
  • New proteins not present in controls were detected following infection, and additional changes both in number and amount of proteins were associated with incompatible or compatible interactions. (uwo.ca)
  • tritici (PST) and its host during infection. (jic.ac.uk)
  • The disease progress of EPEC can be studied in mice using the mouse-specific pathogen Citrobacter rodentium , which mimics the human course of infection. (asm.org)
  • Enteric foodborne pathogens, such as enterohemorrhagic Escherichia coli (EHEC) and Salmonella enterica serovar Typhimurium, or the surrogate murine infection model for EHEC, Citrobacter rodentium , are all examples of microorganisms that modulate the expression of their virulence repertoire in response to signals from the microbiota or the host, such as autoinducer-3 (AI-3), epinephrine (Epi), and norepinephrine (NE). (asm.org)
  • microbial
  • Bidirectional signals are detectable at the critical interface between the host and microbial invaders. (nih.gov)
  • This Review summarises current knowledge of microbial pathogenesis and host-pathogen interactions during sepsis and the ensuing development of potential therapeutics. (nih.gov)
  • My ultimate goal is to understand how the host-microbe interactions shape the evolution of microbial pathogenicity and plant immunity in both model and economically important plants. (tamu.edu)
  • Gabriel Gomila's Nanoscale Bioelectrical Characterization group and that of Antonio Juárez, Microbial Biotechnology and Host-pathogen Interaction, combined their expertise on microscopic electrical measurements and bacteria respectively to come up with a way to study the response to external electrical fields of just a single bacterial cell. (ibecbarcelona.eu)
  • Antonio Juárez's Microbial Technology and Host-Pathogen Interaction lab has formed a consortium with CZV Veterinaria, a leader in the manufacture of veterinary products based in Porriño, Galicia, and Valls Companys' pharmaceutical arm MEVET in Lleida. (ibecbarcelona.eu)
  • This microbial diversity not only puts the host into a complicated situation - distinguishing between microorganisms that can greatly decrease or increase its fitness - but also increases opportunity for horizontal gene transfer to occur in this environment. (cambridge.org)
  • Moreover, the microbial composition of the human GI tract varies with age, diet, host genetics, and external insults like antibiotic treatments ( 4 , 5 ). (asm.org)
  • The intestinal environment hosts a diverse microbial community that modifies and shapes the composition of the metabolites and chemical signals within the gut. (asm.org)
  • interplay
  • During this week's invited talk at Amrita School of Biotechnology (ASBT) , Dr. Kanury Rao shared his insights with the students and faculty about his groundbreaking work on the host-pathogen interplay between human macrophages infected with M. tuberculosis and the subsequent application of this research to drug discovery. (amrita.edu)
  • Infections and the severity of infections are controlled by a complex interplay of the pathogen?s genetics, the host?s genetics, and the environment. (omicsonline.org)
  • Ticks
  • Although our understanding of tick-host-pathogen interactions remain limited, advances in this field are facilitated by the increasing number of available genomic resources, including metabolomic, transcriptomic and proteomic datasets of various ticks and TBPs, and the recently published genome sequence assembly for Ixodes scapularis, an important vector of Borrelia burgdorferi and Anaplasma phagocytophilum in North America. (frontiersin.org)
  • Importantly, better understanding of the host immune response to Borrelia and ticks will bring us closer to the development of clear-cut diagnostic tests and therapeutic compounds that can specifically and favorably target the immune response against the bacterium. (uva.nl)
  • gene
  • Approaches may include, but are not limited to, isolation of cDNAs specific for candidate alleles, characterization of new Mla-mutant specificities, functional analyses of candidate alleles via barley and wheat transformation, or use of expressed resistance gene sequences as traps in the yeast two-hybrid system to identify interacting gene products in the host and/or pathogen. (bio.net)
  • The host-pathogen interaction between wheat and yellow rust induces temporally coordinated waves of gene expression. (jic.ac.uk)
  • Search
  • In a search for factors involved in specificity, advantage was taken of the fact that the resistant interaction between soybean cv Altona and Phytophthora megasperma f. sp. (uwo.ca)
  • genetic
  • In the same genetic background (cv Altona and race 4), three proteins accumulated in the incompatible interactions and one protein was restricted in occurrence to the temperature-induced compatible interaction. (uwo.ca)
  • Human
  • to reconstruct the temporal signaling network of the human host by integrating protein-protein interaction (PPI) and the phosphoproteomic data. (frontiersin.org)
  • We compared in vitro interaction of S. suis with human and porcine intestinal epithelial cells (IEC). (sigmaaldrich.com)
  • S. suis interaction with human and pig IEC correlates with S. suis serotype and genotype, which can explain the zoonotic potential of SS2. (sigmaaldrich.com)
  • In 2003, severe acute respiratory syndrome (SARS) was first recognized.This emerging clinical entity is caused by a novel coronavirus that may have jumped from an animal niche to become a significant human pathogen. (gkhub.info)
  • Staphylococcus
  • Liese, J., Rooijakkers, S. H. M., van Strijp, J. A. G., Novick, R. P. and Dustin, M. L. (2013), Intravital two-photon microscopy of host-pathogen interactions in a mouse model of Staphylococcus aureus skin abscess formation. (wiley.com)
  • methods
  • The complementary use of both methods leads to a network which conserves the information about temporality, direction of interactions, while revealing the hidden entities in the signaling. (frontiersin.org)
  • The successful applicant will work with Associate Professor Garry Myers (UTS) and Dr Alicia Oshlack (MCRI) to apply or develop statistical and computational bioinformatic methods for analyzing and integrating transcriptomic, proteomic and epigenetic data generated by a variety of cutting-edge methodologies, including host/pathogen RNA-Seq, single-infected-cell RNA-Seq, BS-Seq, mass spectrometry and ChIP-Seq. (bioconductor.org)
  • ratio
  • He analyzes the structure of epidemics based on three fundamental variables: the initial inoculum, the progeny/parent ratio of the pathogen, and the latent period. (bookdepository.com)
  • parasite
  • sequenced patient and parasite transcriptomes in 46 P. falciparum -infected Gambian children to better understand malarial host-pathogen interactions. (sciencemag.org)
  • Integrating these transcriptomic data with estimates of parasite load and detailed clinical information allowed consideration of potentially confounding effects due to differing leukocyte proportions in blood, parasite developmental stage, and whole-body pathogen load. (sciencemag.org)
  • infections
  • Such pathogens present real clinical problems in managing infections that were easily treatable just a few years ago. (gkhub.info)
  • Some infections, most notably that caused by HIV, immunocompromise the host in and of themselves. (gkhub.info)
  • processes
  • It is now widely thought that the host response to sepsis involves many, concomitant, integrated, and often antagonistic processes that involve both exaggerated inflammation and immune suppression. (nih.gov)
  • Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. (springer.com)
  • resistant
  • This observation, along with the "foamy phenotype" caused by excess production of triacylglycerols associated with infected macrophages, coupled with a unique perspective of looking at the problem on hand, helped Dr. Rao to elucidate an elegant mechanism by means of which Mtb becomes resistant to host immunity. (amrita.edu)
  • The strong selective pressure for cells resistant to toxin uptake enables the screening of pools of host cells, as opposed to arrayed libraries, saving in both cost and labor. (asm.org)
  • virulent
  • Although the initial encounter between a susceptible host and a virulent organism frequently results in disease, some organisms can be harbored in the host for years before disease becomes clinically evident. (gkhub.info)
  • recognition
  • This recognition, in turn, led to the introduction of terms to explain states in which microbes exist within hosts without causing overt disease and why some microbes only cause disease in certain hosts. (omicsonline.org)
  • type
  • glycinea race 4 becomes susceptible at 32(DEGREES)C thus providing in a single race-cultivar combination differences in interaction type without the uncertainties introduced when comparisons are made between cultivars or races with different genotypes. (uwo.ca)