Host factor 1 protein. Medical search. Frequent questions

As resistance against drugs targeting viral proteins emerges rapidly, we assessed the antiviral activity of already approved drugs that target cellular proteins involved in the viral life cycle and were orally bioavailable. (frontiersin.org)
A heterogeneous set of hypotheses have been proposed to explain the pathophysiology of long COVID involving viral factors, host factors, and tissue damage. (cdc.gov)
Although significantefforts have been focused on discovering inhibitors of a viral polymerase (NS5B) orprotease (NS3), strategies to cure HCV infection have been hampered by the limitedtherapeutic target proteins. (nature.com)
9 HCV encodesa single polypeptide protein that is subsequently cleaved into structural (core, E1, andE2) and nonstructural (NS2, NS3, NS4A/B and NS5A/B) subunits by both viral and hostproteases. (nature.com)
However, the risk varies widely depending on differences in factors such as co-occurrence with other sexually transmitted infections (STIs), level of viral load, stage of disease, and circumcision. (benthamscience.com)
This program supports basic and clinical research to determine the viral and host genetic factors involved in central nervous system (CNS) impairment caused by HIV-1 worldwide. (nih.gov)
Viral and host genetic factors contribute to pathophysiology of HIV-1 associated CNS dysfunction. (nih.gov)
The program encourages use of state-of-the-art approaches (e.g., transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequencing, single cell technologies, and systems biology) to identify and validate viral and host genetic factors that influence the pathophysiology of HIV-1 associated CNS dysfunction. (nih.gov)
Study the role of HIV-1 sequence diversity in understanding neurovirulence, neurotropism, discordant and compartmentalized viral evolution, CNS cell type-specific infection, regional genetic heterogeneity, and associated functional effects. (nih.gov)
Identify viral and host genetic signatures associated with HIV-1 associated CNS dysfunction. (nih.gov)
Study the role of viral epigenetic factors in the pathophysiology of HIV-1 associated CNS dysfunction. (nih.gov)
Understand the role of viral and host transcriptional regulation (including viral protein modifications, histone modifications, changes in chromatin structure, and non-coding RNA) in HIV-1 neuropathogenesis. (nih.gov)
Assess epigenetic host response to viral infection mediated through chromatin modification, non-coding RNAs, and DNA methylation. (nih.gov)
The pathogenesis of PEDV has been intensively studied, however, the viral proteins of PEDV and the host factors in target cells, as well as their interactions, which underly the molecular mechanisms of viral infection, remains to be illustrated and summarized. (authorea.com)
Vice versa, a number of host factors including receptors are required for the infection of PEDV per the interactions with the viral proteins, thereby affecting the reproduction and contributing to the life cycle of PEDV. (authorea.com)
In this review, we intend to provide an update understanding of the PEDV viral proteins and host factors and illustrate the interactions between them. (authorea.com)
A particle according to claim 1 or 2, wherein the heterologous polypeptide has specific binding affinity for a cognate receptor on die surface of an eukaryotic cell, binding to which does not allow infection of the cell by the viral particle. (sumobrain.com)
A particle according to any one of claims 1 to 9, wherein the protease cleavage site becomes accessible to die relevant protease only after the viral particle has become bound to an eukaryotic cell. (sumobrain.com)
We studied the course of infection by analysing the production of viral RNA, proteins and phage particles produced in the cell-free reactions. (fortunejournals.com)
The replication of the viral RNA was determined by RT-PCR, while the translation of the viral proteins was examined by radiolabelling, and the production of infectious phage particles was evaluated by double-layered plaque assays. (fortunejournals.com)
Specifically, the viral RNA was replicated, the viral proteins were translated, and infectious phage particles were produced in the cell-free infection systems. (fortunejournals.com)
The pattern of translation regulation of the viral proteins appeared similar to in vivo infection. (fortunejournals.com)
Virus particles have a nucleic acid genome and may also carry a few viral proteins, which are enclosed in a capsid of viral proteins or an envelope comprised of a small part of the host cell membrane. (fortunejournals.com)
Among these co-factors, hTIM-1 has been identified as an attachment factor to promote JEV infection through interacting with phosphatidylserine (PS) on the viral envelope . (bvsalud.org)

Our largest research area is the Type VI secretion system (T6SS) , which is widespread in Gram-negative bacteria and is a complex, dynamic nanomachine which 'fires' toxic effector proteins into target cells. (dundee.ac.uk)
A family of Type VI secretion system effector proteins that form ion-selective pores. (dundee.ac.uk)

The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). (nih.gov)

Recent studies have suggested that conservative missense mutations distal to the OGT catalytic domain lead to X-linked intellectual disability in boys, but it is not clear if this is through changes in the O-GlcNAc proteome, loss of protein-protein interactions, or misprocessing of HCF1. (rcsb.org)
Bacterial toxins also catalyze the non-covalent modification of host protein function or can modify host cell properties through direct protein-protein interactions. (springer.com)
Our laboratory is focused on understanding host-pathogen interactions, with emphasis on respiratory pathogens, and to use this knowledge to develop novel preventive and therapeutic strategies to protect against bacterial infection, especially in this era of increasing antibiotic resistance. (lu.se)
Our work focuses on the interactions between (A) factors used by pathogenic organisms to establish colonization and cause disease, (B) the role of the resident microbiota in modulating pathogen behavior, and (C) host factors and inflammatory responses associated with colonization and infection. (lu.se)
I am particularly interested in the virus-host interactions that take place when HIV establishes infection, and how HIV-2 can be used as a model to identify an HIV-1 vaccine or functional cure. (lu.se)
My research interests focus on understanding virus-host interactions, factors for virus entry, pathogenicity and immunogenicity, mechanisms of viruses to evade immune system, humoral immune response and possibilities of vaccine development. (lu.se)
By studying SARS-CoV-2 spike protein mutations, its ability to diversify and adapt, as well as antibody interactions we aim to create a pipeline to enable better understanding of these and future pathogens and ways to fight them in early stages through vaccines and new drug development. (lu.se)

Analysis of virulence related gene expression and computational simulations of pivotal proteins involved in pathogenesis demonstrate that myricetin downregulates the saeR global regulator and interacts with sortase A and α-hemolysin. (nature.com)
A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)
The exact pathogenesis is unclear, and factors that precipitate HSE are unknown. (medscape.com)

Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein, is a protein that in humans is encoded by the HCFC1 gene. (wikipedia.org)
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. (nih.gov)
To examine host cell responses to HCV infection, biologists have utilized conventionalhigh throughput (HTS) techniques, such as gene or proteomic expression profiling. (nature.com)
Background Gene expression profiling has successfully identified the prognostic significance of the host response in lymphomas. (haematologica.org)
Design and Methods We collected 33 cases of T-cell/histiocyte-rich large B-cell lymphoma and 56 cases of nodular lymphocyte-predominant Hodgkin's lymphoma and performed microarray gene expression profiling on ten cases of each lymphoma, to obtain a better understanding of the lymphoma host response. (haematologica.org)
Conclusions The gene expression profile of T-cell/histiocyte-rich large B-cell lymphoma, in comparison with that of nodular lymphocyte-predominant Hodgkin's lymphoma, shows features suggestive of a distinct tolerogenic host immune response that may play a key role in the aggressive behavior of this lymphoma, and that may serve as a potential target for future therapy. (haematologica.org)
For instance, cI refers to the gene, while cI is the resulting protein encoded by that gene. (wikidoc.org)
In the absence of cI proteins, the cro gene may be transcribed. (wikidoc.org)
In the presence of cI proteins, only the cI gene may be transcribed. (wikidoc.org)
The HCFC1 gene provides instructions for making a protein, called HCF-1, that helps regulate the activity of other genes. (medlineplus.gov)
One of several functions of the HCF-1 protein is to control the activity of a gene called MMACHC that is involved in the processing of vitamin B12 (also known as cobalamin). (medlineplus.gov)
It is thought that changes in these regions prevent HCF-1 from interacting with transcription factors, which disrupts normal gene activity. (medlineplus.gov)
The HCFC1 gene variants lead to production of an HCF-1 protein with reduced function. (medlineplus.gov)
They rely on their target cell for molecular building blocks, energy sources and host factors to replicate, since viruses are gene poor compared to their host [1]. (fortunejournals.com)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. (nih.gov)
In this review, we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson's disease, with a special emphasis on functional bacterial amyloid proteins, bacterial biosurfactants, endotoxins and short-chain fatty acids. (techscience.com)
Several viruses require lysosomal cathepsins to cleave structural proteins and thus depend on functional GlcNAc-1-phosphotransferase. (stanford.edu)
PEDV has multiple important structural and functional proteins which play various roles in the process of virus infection. (authorea.com)

No BSA or other carrier proteins that could interfere with conjugation. (rndsystems.com)

ABSTRACT This study investigated the role of hyperhomocysteinaemia as a risk factor in Sudanese adults suffering from cardiovascular disease or malaria and children with protein-energy malnutrition. (who.int)

Endogenous synthesis of antigen results in efficient proteolytic peptide processing and presentation of peptide antigen on MHC class I proteins. (jci.org)
Genetic host risk factors include the D8/17 B-cell antigen and certain class II histocompatibility antigens. (msdmanuals.com)

Altogether, our data provide new insight into the central role of ACBD3 in recruiting PI4KB by enterovirus 3A and reveal the minimal domains of ACBD3 involved in recruiting PI4KB and supporting enterovirus replication.IMPORTANCE Similar to all other positive-strand RNA viruses, enteroviruses reorganize host cellular membranes for efficient genome replication. (uu.nl)
This Special Issue of Viruses is open to both empirical and mathematical/modelling papers addressing HIV/SIV dynamics in a broad sense (including within-host, cellular and population level dynamics). (mdpi.com)
Transmembrane Protein 41B (TMEM41B) and Vacuole Membrane Protein 1 (VMP1) are two ER-associated lipid scramblases that play a role in autophagosome formation and cellular lipid metabolism. (stanford.edu)
Additionally, the effects of cellular factors or events or signaling pathways on PEDV infection are also discussed. (authorea.com)
The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function. (k-state.edu)
HCF-1 helps regulate genes that are important in other cellular processes, such as progression of cells through the step-by-step process it takes to replicate themselves (called the cell cycle). (medlineplus.gov)

Moreover, hTIM-1-specific antibodies have been shown to downregulate JEV infectivity in cells . (bvsalud.org)
GAS M proteins share epitopes (antigenic-determinant sites that are recognized by antibodies) with proteins found in synovium, heart muscle, and heart valve, suggesting that molecular mimicry by GAS antigens from rheumatogenic strains contributes to the arthritis, carditis, and valvular damage. (msdmanuals.com)

Secretion systems, and the diverse proteins that they secrete, represent key virulence factors against eukaryotic host organisms. (dundee.ac.uk)
These target cells can be eukaryotic host cells, making the T6SS a classical virulence factor. (dundee.ac.uk)
More commonly, however, the target is rival bacterial cells, making the T6SS a key player in inter-bacterial competition and competitive fitness, and therefore an indirect virulence factor. (dundee.ac.uk)
We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. (nature.com)
The second focus topic is the evolution of HIV: its origins and historical evolution, its current evolution within the host and at the population level, co-evolution of virus and host, molecular evolution and the evolution of phenotypic traits (e.g. virulence, replication capacity or drug resistance). (mdpi.com)
Additionally, bacterial virulence proteins utilize many molecular mechanisms that are also conserved among viruses of importance to biosecurity. (k-state.edu)
The goal of this study is to characterize E. coli virulence proteins that disrupt the host immune response. (k-state.edu)
The goal of this study was to identify E. coli virulence proteins that inhibit innate immunity. (k-state.edu)
The goal of this study was to define the role of the NleF protein in enterohemorrhagic E. coli virulence. (k-state.edu)

Evidence suggest that a patient's genetic predisposition together with environmental factors, such as exposure to pathogens that exhibit molecular mimicry, disturb immune tolerance ( 4 ). (frontiersin.org)
Protein secretion systems are molecular machines used by bacterial cells to translocate specific sets of proteins out of the bacterial cell, either to the extracellular milieu or directly into target cells (eukaryotic or prokaryotic. (dundee.ac.uk)
Examine molecular and genetic mechanisms of potential subtype/clade differences in HIV-1 neuropathogenesis. (nih.gov)
Taken together, our data indicate that diverse mammalian poxviruses use a conserved molecular claw in a C7-like protein to target SAMD9 and overcome host restriction. (uthscsa.edu)
In many cases, vaccines are not available or are ineffective, and the basic molecular microbiology of the host-pathogen interaction is relatively poorly understood. (k-state.edu)

According to this data, the described receptors and EmSmadA are likely to play an important role in the parasitic development and could be involved in mechanisms of the host- parasite interaction during alveolar echinococcosis. (uni-wuerzburg.de)
Interaction between hTIM-1 and Envelope Protein Is Important for JEV Infection. (bvsalud.org)
The interaction between hTIM-1 and JEV relies on specific binding sites , respectively, ND114115 in the hTIM-1 IgV domain and K38 of the E protein . (bvsalud.org)
Taken together, these findings suggested that hTIM-1 protein directly interacts with JEV E protein and mediates JEV infection , in addition to the PS-TIM-1 interaction. (bvsalud.org)

In the following paragraphs, we will write genes in italics and their associated proteins in Roman. (wikidoc.org)
HCF-1 interacts with proteins called transcription factors, which attach (bind) to specific regions of DNA and help control the activity of particular genes. (medlineplus.gov)
Neurological and developmental problems are especially severe in individuals with cblX type, in part due to disruption of the activity of other genes normally regulated by the HCF-1 protein. (medlineplus.gov)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

Host proviral and antiviral factors for SARS-CoV-2. (nih.gov)

Structural analyses revealed that all three Echinococcus factors displayed domain structures which are characteristic of the respective protein families. (uni-wuerzburg.de)

Protein, nucleic acid, enzyme. (go.jp)
A particle according to claim 1, further comprising the nucleic acid sequence encoding die protease cleavage signal. (sumobrain.com)

2) The presence of LYSET is critical for cancer cell proliferation in nutrient-deprived environments in which extracellular proteins must be catabolized. (stanford.edu)

Altogether, these findings uncover a novel coordination between ER and lysosomes, in which local release of amino acids and other factors from ER-associated lysosomes patterns and regulates translation of mRNAs encoding secretory and membrane proteins. (janelia.org)
Surface membrane proteins of Schistosoma mansoni / by Lyn L. Dean. (who.int)

It is increasingly becoming recognised that protein secretion systems can also be important mediators of competition between bacterial cells, with such systems delivering anti-bacterial toxins. (dundee.ac.uk)

Additionally, we found that the hTIM-1 soluble ectodomain protein effectively inhibits JEV infection in vitro . (bvsalud.org)

Furthermore, on the amino acid sequence level, all three factors shared considerable homologies with corresponding host factors. (uni-wuerzburg.de)
Despite their different functions and only 23% sequence identity, the two proteins have very similar overall structures, displaying a previously unidentified fold comprised of a compact 12-stranded antiparallel β-sandwich wrapped in two short α helices. (uthscsa.edu)
5. describe the sequence of events that lead to septic shock (know the microbial triggers and the host mediators that led to septic shock). (atsu.edu)

All together, these areas contribute towards a better understanding of how Gram-negative bacterial pathogens interact with each other and with the host organism to proliferate and cause disease. (dundee.ac.uk)
Factors that correlate with an increase in this risk have been identified for both the host and the organism. (medscape.com)
Humans are the only hosts of the organism and is present in the upper respiratory tract. (who.int)

These soluble hydrolases are tagged with mannose-6-phosphate (M6P) moieties in sequential reactions by the Golgi-resident GlcNAc-1-phosphotransferase complex and NAGPA/UCE/uncovering enzyme (N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase), which allows their delivery to endosomal/lysosomal compartments through trafficking mediated by cation-dependent and -independent mannose-6-phosphate receptors (MPRs). (stanford.edu)
We renamed TMEM251 to LYSET (lysosomal enzyme trafficking factor) to establish nomenclature reflective to this gene's function. (stanford.edu)
Here, we used genome-scale CRISPR screens to identify Lysosomal Enzyme Trafficking factor (LYSET) as essential for infection by cathepsin-dependent viruses including SARS-CoV-2. (stanford.edu)
This enzyme helps break down certain protein building blocks (amino acids), fat building blocks (fatty acids), and cholesterol. (medlineplus.gov)
Finally, we have studied the effect of a host factor, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), on HIV-1 RT. (umsystem.edu)

LYSET is a Golgi-localized transmembrane protein important for the retention of the GlcNAc-1-phosphotransferase complex in the Golgi-apparatus. (stanford.edu)

This pore-forming toxin has been reported as an important protein that mediates tissue damage promoted by S. aureus . (nature.com)

From these animals the virus can spread to domestic poultry or directly to humans and other mammalian hosts ( 5 ). (frontiersin.org)
Receptor kinases play an important role in the communication of cells with their environment and could be involved in hormonal communication- mechanisms between parasitic helminths and their mammalian hosts. (uni-wuerzburg.de)

Once implanted at the apex, Mtb must engage the host immune response to drive matrix destruction, resulting in cavities within which it proliferates exponentially. (ersjournals.com)
Within the lung, Mtb is initially contained by granuloma formation, the characteristic host immune response to the pathogen [ 7 ]. (ersjournals.com)
Higher attack rates occur with certain streptococcal M protein serotypes and a stronger host immune response (likely resulting from as-yet-uncharacterized genetic tendencies). (msdmanuals.com)

It catalyses the O-GlcNAc posttranslational modification of nucleocytoplasmic proteins and proteolytic maturation of the transcriptional coregulator Host cell factor 1 (HCF1). (rcsb.org)

A special feature of these bacteria, despite its relatively small genome, is the ability to adapt in different host environments. (aaem.pl)
In gastric carcinoma cells, EBV is not integrated into the host genome but maintained as a type of plasmid called an episome. (spandidos-publications.com)

Histamine and its receptors represent a complex system of immunoregulation with distinct effects mediated by four GPCRs (G protein-coupled receptors HRs 1-4) and their differential expression, which changes according to the stage of cell differentiation and microenvironmental influences. (hindawi.com)
The pleiotropic effects of histamine are mediated by 4 histamine receptors (HRs), H1R, H2R, H3R, and H4R, which are G protein-coupled receptors. (hindawi.com)
However, the reasons why JEV prefers to use hTIM-1 over other PS binding receptors are unknown. (bvsalud.org)

It regulates the transcription of the cI protein and the Cro protein. (wikidoc.org)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)

The current understanding of LYSET's importance regarding human biology is 3-fold: 1) highly pathogenic viruses that depend on lysosomal hydrolase activity require LYSET for infection. (stanford.edu)
To understand the mechanism behind this observation, we applied in vitro biochemical assays, which were performed with four patient-derived reverse transcriptase (RT) proteins isolated from HIV-1B, HIV-1C, CRF01_AE, and CRF02_AG viruses. (umsystem.edu)
See Herpes Simplex Viruses: Test Your Knowledge , a Critical Images slideshow, for more information on clinical, histologic, and radiographic imaging findings in HSV-1 and HSV-2. (medscape.com)

A particle according to claim 1 or 2, wherein the heterologous polypeptide has no specific binding affinity for a eukaryotic cell surface component. (sumobrain.com)

HCF1 is a member of the highly conserved host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. (wikipedia.org)
Here, we report a method that combines transcriptome expression analysiswith unbiased proteome reactivity profiling to identify novel host cell responsefactors in HCV infection. (nature.com)
Programmed death-1 receptor (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1) pathway blockade is a promising therapy for treating cancer. (nih.gov)
It also functions as an L-Selectin ligand and may be involved in the inhibition of stem cell differentiation and leukocyte-endothelial adhesion (1, 2). (rndsystems.com)
Delineate the genetic basis of host restriction factors in CNS cell types. (nih.gov)
Gupta DD, Saha S, Chakrabarti MK (2005) Involvement of protein kinase C in the mechanism of action of Escherichia coli heat-stable enterotoxin (STa) in a human colonic carcinoma cell line, COLO-205. (springer.com)
Among them, the S and N proteins play vital roles in biological processes related to PEDV survival via interacting with the host cell proteins. (authorea.com)
1 Initial studies demonstrated that a particular subgroup of T-cell-rich B-cell lymphomas mirror nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and are characterized by a T-cell and histiocyte-rich stroma. (haematologica.org)
EBV was the first virus to be associated with human malignancy, which was discovered from a Burkitt's lymphoma cell line in 1964 ( 1 ). (spandidos-publications.com)
Subsequent studies revealed that EBV caused a number of different human malignancies, such as nasopharyngeal carcinoma (NPC), Hodgkin's lymphoma, extranodal NK/T-cell lymphoma, nasal type and lymphoproliferative disorders of immunocompromised hosts ( 2 ). (spandidos-publications.com)
Once the phage has injected its DNA into its host , the phage DNA may integrate itself into the host cell chromosome. (wikidoc.org)
Thus the prophage is duplicated with every cell division of the host. (wikidoc.org)
The DNA of the prophage that is expressed in that state codes for proteins that look out for signs of stress in the host cell. (wikidoc.org)
At that point, the prophage reactivates, excises itself from the DNA of the host cell and enters its lytic cycle . (wikidoc.org)
When all resources of the host are depleted from building new phages, the host cell is lysed (the cell membrane is broken down), and the new phages are released. (wikidoc.org)
The injection of chronically infected mice with a lentiviral vector encoding LCMV MHC class I and II T cell epitopes and a soluble programmed cell death 1 microbody rapidly cleared the virus. (jci.org)
Vaccination by direct injection of lentiviral vector was more effective in sterile alpha motif and HD-domain containing protein 1-knockout (SAMHD1-knockout) mice, suggesting that lentiviral vectors containing Vpx, a lentiviral protein that increases the efficiency of dendritic cell transduction by inducing the degradation of SAMHD1, would be an effective strategy for the treatment of chronic disease in humans. (jci.org)
Here, we investigate the spatial distribution and regulation of mRNAs encoding these membrane and secretory proteins (termed "secretome" mRNAs) through live cell, single molecule tracking to directly monitor the position and translation states of secretome mRNAs on ER and their relationship to other organelles. (janelia.org)
The cell-free infection systems were based on cell-free protein expression systems: two commercial systems and one custom-made system. (fortunejournals.com)
The cell- ations in these signals (see Table 1 for a glossary of terms). (lu.se)

Then, by colonizing tissues, they initiate production of Erp and CRASP proteins, which bind regulators and components of complement and repress the cytolytic effect of the host's serum. (aaem.pl)
Indeed, we found that all in the latter group of proteins bind SAMD9. (uthscsa.edu)
Both Int and IHF bind to attP and form an intasome , a DNA-protein-complex designed for site-specific recombination of the phage and host DNA. (wikidoc.org)

My research team has discovered several mechanisms by which bacterial proteins subvert the host innate immune system to promote bacterial colonization and transmission. (k-state.edu)

Examine the role of host genetic factors, including epigenetic mechanisms in regulating susceptibility to HIV-1 associated CNS dysfunction. (nih.gov)

One-third of the mammalian proteome is comprised of transmembrane and secretory proteins that are synthesized on endoplasmic reticulum (ER). (janelia.org)

The lambda phage will remain in the lysogenic state if cI proteins predominate, but will be transformed into the lytic cycle if cro proteins predominate. (wikidoc.org)
Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. (cdc.gov)

Replication of 15 loci involved in human plasma protein N-glycosylation in 4802 samples from four cohorts. (nih.gov)
A subsequent quantitative chemical proteomic mapping studyled to the identification of a target protein, T-plastin (PLST) and its regulationof HCV replication. (nature.com)
1 Thecurrently available treatments use a combination of an HCV protease inhibitor withribavirin and PEGylated alpha interferon to disrupt virus replication, but the therapyis effective in only half of the people infected with HCV genotype 1 and even in thosepatients the efficacy is limited. (nature.com)
Here, we revealed a role of a Golgi-residing protein, ACBD3, as a mediator of PI4KB recruitment upon enterovirus replication. (uu.nl)

Several features of lentiviral vectors have made them advantageous for the expression of therapeutic proteins in vivo. (jci.org)

In June 2023, the Centers for Disease Control and Prevention hosted the webinar Evaluating and Supporting Patients with Long COVID in Returning to Work . (cdc.gov)

Changes in the synthesis of outer proteins are the first strategy of borreliae in avoiding the destructive effect of the host's immune system. (aaem.pl)
Influence of host factors on phosphatidylcholine synthesis in Schistosoma mansoni / by Bruce W. Young. (who.int)

The body uses methionine to make proteins and other important compounds. (medlineplus.gov)

All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
Nevirapine (NVP) belongs to the first generation of NNRTIs, however HIV-1 develops resistance mutations frequently during NVP treatment. (umsystem.edu)

Lysosomal release of amino acids at ER three-way junctions regulates transmembrane and secretory protein mRNA translation. (janelia.org)

However, the mechanistic contribution of host and tumor PD-L1 and PD-1 signaling to the therapeutic efficacy of PD-L1 and PD-1 blockade remains elusive. (nih.gov)
Here, we evaluated 3 tumor-bearing mouse models that differ in their sensitivity to PD-L1 blockade and demonstrated a loss of therapeutic efficacy of PD-L1 blockade in immunodeficient mice and in PD-L1- and PD-1-deficient mice. (nih.gov)
2) The direct bactericidal activity of HAMLET, a human milk protein-lipid complex, against various bacterial species as well as its adjuvant activity in sensitizing bacteria to a broad range of common antibiotics to provide novel therapeutic strategies against respiratory and other infections with antibiotic-resistant bacteria. (lu.se)

In fact, when new combinations between different HIV-1 subtypes occurs, it results in different Unique Recombinant Forms (URFs), some developed into Circulating Recombinant Forms (CRFs) as propagated in three or more epidemiologically unlinked individuals. (benthamscience.com)
In this study, we determined the biochemical characteristics of HIV-1 RTs from various subtypes and determined kinetic constants of inhibition by EFdA, NVP, and RPV. (umsystem.edu)
The results show that all of the tested HIV-1 RTs incorporate EFdA with better efficiency than their natural cognate substrate, dATP, which suggests that EFdA would be effective against all of the tested HIV-1 subtypes. (umsystem.edu)

Additionally, expression of PD-L1 on dendritic cells and macrophages in ovarian cancer and melanoma patients correlated with the efficacy of treatment with either anti-PD-1 alone or in combination with anti-CTLA-4. (nih.gov)

[1] The US Department of Health and Human Services emphasizes that "long COVID is not one condition. (cdc.gov)
This abtibody does not react with human Factor XIII B-chain or human Factor XII. (fishersci.com)
Here, we validated that both TMEM41B and VMP1 are essential host dependency factors for all four serotypes of dengue virus (DENV) and human coronavirus OC43 (HCoV-OC43), but not chikungunya virus (CHIKV). (stanford.edu)
Human sterile alpha motif domain-containing 9 (SAMD9) protein is a host restriction factor for poxviruses, but it can be overcome by some poxvirus host-range proteins that share homology with vaccinia virus C7 protein. (uthscsa.edu)
Recombinant full length protein corresponding to Human Hsp90 alpha. (abcam.com)
Human immunodeficiency virus (HIV) is divided into type 1 (HIV-1) and type 2 (HIV-2). (umsystem.edu)
zooepidemicus strains that the M-like protein SzM is crucial for the binding of fibrinogen to the bacterial surface and for survival in equine and human blood. (lu.se)
Plasma protein absorption assays and flow cytometry analysis revealed that pronounced binding of human fibrinogen is a common phenotype of human S. equi subsp. (lu.se)

The TodS and TodT proteins form a previously unrecognized and highly specific two-component regulatory system in which the TodS sensor protein contains two input domains, each of which are coupled to a histidine kinase domain. (nih.gov)
A host lipid kinase, PI4KB, plays an important role in this membrane rearrangement. (uu.nl)

Thus, PD-L1-expressing dendritic cells and macrophages may mechanistically shape and therapeutically predict clinical efficacy of PD-L1/PD-1 blockade. (nih.gov)

Annual epidemics represent an important disease burden and cause an estimated 250,000-500,000 deaths worldwide, and occasional pandemics are associated with increased morbidity and mortality ( 1 , 2 ). (frontiersin.org)

Our results showed that A3G does inhibit the activity of HIV-1 RT by affecting the catalytic rate of dNTP incorporation (kcat), supporting the direct inhibition mechanism. (umsystem.edu)

The final form of this protein consists of noncovalently bound N- and C-terminal chains which interact through electrostatic forces. (wikipedia.org)
These variants occur in regions of the protein that help it to interact with other proteins. (medlineplus.gov)
Here, we demonstrated that hTIM-1 can directly interact with JEV E protein . (bvsalud.org)

Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160 kDa. (fishersci.com)

Transport to lysosomes relies on GlcNAc-1-phosphotransferase-mediated tagging of soluble enzymes with mannose 6-phosphate (M6P). (stanford.edu)

A potential pathogen must be able to compete against host microflora, other pathogens and other residents of environmental reservoirs in order to mount a successful infection. (dundee.ac.uk)
The pathogen is then transmitted to new hosts by cough aerosol generation. (ersjournals.com)

Anatomy20

Organisms47

Diseases11

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes83

Information Science4

Named Groups1

Health Care1

Viral24

Effector proteins2

Lipoprotein receptor-related protein1

Interactions7

Pathogenesis3

Gene16

Functional4

CARRIER PROTEINS1

Abstract1

Antigen2

Cellular6

Antibodies2

Virulence9

Molecular5

Interaction4

Genes4

Antiviral factors1

Structural1

Nucleic acid2

Extracellular1

Membrane proteins2

Secretion1

Inhibits1

Sequence3

Organism3

Enzyme5

Transmembrane protein1

Mediates1

Mammalian hosts2

Immune response3

Transcriptional1

Genome2

Receptors3

Transcription2

Viruses3

Polypeptide1

Cell20

Bind3

Innate1

Mechanisms1

Proteome1

Predominate2

Replication4

Vivo1

20231

Synthesis2

Methionine1

Mutations2

Secretory1

Therapeutic3

Subtypes3

Additionally1

Human8

Kinase2

Macrophages1

Morbidity and morta1

Inhibit1

Interact3

Subunit1

Soluble1

Pathogen2