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  • effector
  • Chimeric antigen receptors (CARs, also known as chimeric immunoreceptors, chimeric T cell receptors, artificial T cell receptors or CAR-T) are engineered receptors which graft an arbitrary specificity onto an immune effector cell (T cell). (wikipedia.org)
  • transplant
  • Identification of these antigens has led to greater success and longevity in organ transplant. (wikipedia.org)
  • This has become possible due to worldwide efforts of preclinical and clinical research focusing on issues of transplant immunology, reduction of transplant-associated morbidity, and mortality and efficient malignant disease eradication. (frontiersin.org)
  • The acute or fulminant form of the disease (aGvHD) is normally observed within the first 100 days post-transplant, and is a major challenge to transplants owing to associated morbidity and mortality. (wikipedia.org)
  • Even when a transplant donor and recipient are identical with respect to their major histocompatibility complex genes, the amino acid differences in minor proteins can cause the grafted tissue to be slowly rejected. (wikipedia.org)
  • proteins
  • 5 ⇓ - 7 The biological explanation is that naïve female-donor lymphocytes recognize several proteins encoded by the Y chromosome of a male recipient, which are called H-Y minor histocompatibility antigens. (bloodjournal.org)
  • Much is known about the proteins involved in antigen processing, but high fidelity ligand/epitope predictions are at present not possible. (mcponline.org)
  • Minor histocompatibility antigens are due to normal proteins that are in themselves polymorphic in a given population. (wikipedia.org)
  • DQ functions in recognizing and presenting foreign antigens (proteins derived from potential pathogens). (wikipedia.org)
  • When tolerance to self proteins is lost, DQ may become involved in autoimmune disease. (wikipedia.org)
  • peptide
  • This large number of identified ligands provides general insight into the presented peptide repertoire and antigen presentation. (mcponline.org)
  • The discovery of additional involved enzymes ( 3 , 4 ) and the exciting discovery of peptide splicing ( 5 ) have shown that antigen processing is even more complex than was previously thought. (mcponline.org)
  • minor
  • Based on this refined classification, we demonstrated that the quantitatively minor CD207 + CD103 + DDC subset is endowed with the unique capability of cross-presenting antigens expressed by keratinocytes irrespective of the presence of LCs. (rupress.org)
  • The presented B-lymphocyte ligandome is shown to be a rich source of information by the presence of minor histocompatibility antigens, virus-derived epitopes, and post-translationally modified HLA ligands, and it can be a good starting point for solving a wealth of specific immunological questions. (mcponline.org)
  • Employing expression-cloning methodology, we have identified a cDNA clone, MI-35, encoding the immunodominant H4b minor H antigen within the classical mouse H4 complex. (jove.com)
  • Patients
  • We studied 136 adult F→M HCT patients, with plasma prospectively collected through 3 years posttransplant, and measured immunoglobulin G against 6 H-Y antigens. (bloodjournal.org)
  • it is reserved for patients with life-threatening diseases. (wikipedia.org)
  • Thymoma-associated multiorgan autoimmunity (TAMA) is a severe often fatal disease that presents in some patients with thymoma. (wikipedia.org)
  • Patients often have a refractory disease course but some patients may respond to phototherapy. (wikipedia.org)
  • occurs
  • Collectively, these data revisit the transfer of antigen that occurs between keratinocytes and the five distinguishable skin DC subsets and stress the high degree of functional specialization that exists among them. (rupress.org)
  • In the setting of thymoma, abnormal thymic education occurs as a result of subtle differences in antigen processing. (wikipedia.org)
  • genetics
  • Exciting insights into the genetics of the human leukocyte antigen (HLA) system allowed improved donor selection, including HLA-identical related and unrelated donors. (frontiersin.org)
  • Primary
  • To be considered a primary immunodeficiency, the cause of the immune deficiency must not be secondary in nature (i.e., caused by other disease, drug treatment, or environmental exposure to toxins). (wikipedia.org)
  • lymphoma
  • These advantages have established autologous HSCT as one of the standard second-line treatments for such diseases as lymphoma. (wikipedia.org)
  • human
  • For medicine, study of human genetic variation may be important because some disease-causing alleles occur more often in people from specific geographic regions. (wikipedia.org)