Hospitalization chemotherapy induced febrile neutropenia. Medical search. Frequent questions

MONITOR-GCSF is a prospective, observational study of 1447 evaluable patients from 140 cancers centers in 12 European countries treated with myelosuppressive chemotherapy for up to 6 cycles receiving biosimilar GCSF prophylaxis. (unibas.ch)
BACKGROUND: Prophylactic growth-factor therapy with granulocyte colony-stimulating factor (G-CSF) reduces the risk of febrile neutropenia (FN) in patients with breast cancer initiating myelosuppressive chemotherapy. (bvsalud.org)
Neutropenia is a common dose-limiting toxicity of myelosuppressive chemotherapy and exposes patients to life-threatening infections and treatment delays. (jhoponline.com)

Patients were classified as under-, correctly-, or over-prophylacted with GCSF relative to guideline recommendations based on their chemotherapy risk, individual risk factors, and type of GCSF prophylaxis (primary versus secondary). (unibas.ch)
Given that chemotherapy-induced neutropenia is one of the most frequent adverse events (AEs) associated with cytotoxic chemotherapy and often leads to febrile neutropenia (FN), effective prophylaxis with granulocyte colony-stimulating factor therapies (G-CSFs) is key. (centerforbiosimilars.com)
PURPOSE: Clinical practice guidelines recommend the use of all approved granulocyte colony-stimulating factors (G-CSFs), including filgrastim and pegfilgrastim, as primary febrile neutropenia (FN) prophylaxis in patients receiving high- or intermediate-risk regimens (in those with additional patient risk factors). (bvsalud.org)
METHODS: To assess the relationship between G-CSF prophylaxis and incidence of FN/infection in week 1 versus beyond week 1 of the first chemotherapy cycle, a retrospective study was conducted using Medicare claims from 2005 through 2020 among patients with breast cancer initiating high-risk chemotherapy. (bvsalud.org)
Two cohorts were compared based on G-CSF prophylaxis within 3 days following chemotherapy initiation. (bvsalud.org)
Adults who had a diagnosis of cancer and received G-CSFs as prophylaxis for febrile neutropenia were included in this analysis. (jhoponline.com)
The results demonstrated that 47.22% and 8.2%, respectively, of G-CSF administrations did not have an indication supported by guideline recommendations for administering filgrastim and pegfilgrastim as prophylaxis for febrile neutropenia. (jhoponline.com)
Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: A systematic review. (trillium.de)
Antimicrobial prophylaxis and outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology clinical practice guideline. (trillium.de)
Prophylaxis of infectious complications with colony-stimulating factors in adult cancer patients undergoing chemotherapy - evidence-based guidelines from the Infectious Diseases Working Party AGIHO of the German Society for Haematology and Medical Oncology (DGHO). (trillium.de)
Granulocyte colony-stimulating factors for febrile neutropenia prophylaxis following chemotherapy: Systematic review and meta-analysis. (trillium.de)
Efficacy, effectiveness and safety of long-acting granulocyte colony-stimulating factors for prophylaxis of chemotherapy-induced neutropenia in patients with cancer: A systematic review. (trillium.de)
Pegfilgrastim prophylaxis is associated with a lower risk of hospitalization of cancer patients than filgrastim prophylaxis: A retrospective United States claims analysis of granulocyte colony-stimulating factors (G-CSF). (trillium.de)
The low incidence of adverse effects and chemotherapy dose changes, delays, and withdrawals supports the use of lenograstim as effective primary prophylaxis in South African patients being treated with a docetaxel-based regimen. (hindawi.com)
In response to restrictions brought on by the COVID-19 pandemic, our institution adopted triple intrathecal (IT) chemotherapy for CNS prophylaxis during HyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with high-dose methotrexate and cytarabine). (bvsalud.org)

Patients who are under-prophylacted are at higher risk for disturbances to their chemotherapy regimens. (unibas.ch)
Data collected included the type of malignancy, chemotherapy regimens, and patient comorbidities. (jhoponline.com)
Recommendations from the NCCN and from the American Society of Clinical Oncology and the published literature regarding regimens associated with febrile neutropenia were used to determine appropriate therapy. (jhoponline.com)
Docetaxel-based chemotherapy regimens have substantially improved survival and recurrence rates for cancer patients. (hindawi.com)
Safety profile of docetaxel regimens includes toxicities, particularly a high risk of neutropenia and febrile neutropenia. (hindawi.com)
Systemic adjuvant chemotherapy with anthracycline- and taxane-containing regimens has become the standard first line treatment for early and metastatic breast cancer [ 5 ], with large phase III randomized trials showing extremely high long-term disease-free survival and overall survival rates (resp. (hindawi.com)
In fact, reducing the planned dose intensity of systemic adjuvant chemotherapy regimens by as little as 15% has been shown to significantly reduce time to progression and overall survival rates in women with metastatic breast cancer [ 5 ]. (hindawi.com)
G-CSFs have been shown to reduce overall mortality risk [ 8 , 11 ], reduce the incidence of other adverse events (grade 2 or greater anaemia, asthenia, anorexia, myalgia, nail disorders, and oral mucositis) associated with docetaxel-based chemotherapy regimens, and increase health related quality of life and consequently treatment compliance [ 8 , 12 ]. (hindawi.com)
In clinical trials, the addition of trilaciclib to extensive-stage small cell lung cancer chemotherapy treatment regimens reduced myelosuppression and improved clinical outcomes. (g1therapeutics.com)
Current standard chemotherapy regimens cure only a minority of patients with AML. (medscape.com)

A recent systematic review of the literature reported on randomized controlled trials and nonrandomized studies on the use of granulocyte colony-stimulating factor therapies (G-CSFs) to reduce the incidence of febrile neutropenia, and found that short- and long-acting therapies, when dosed according to guidelines, have little difference in their efficacy. (centerforbiosimilars.com)
Decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia. (drugs.com)

The current system of management of febrile neutropenia involves administration of prophylactic antimicrobials and hematopoietic growth factor supplements (granulocyte colony stimulating factor G-‐ CSF). (biomedgrid.com)
The objective of this protocol was to develop a reference tool for the evaluation and management of febrile neutropenia in a fourth-level cancer hospital in Ecuador and provide a guideline for a timely and adequate care of cancer patients. (ijpsonline.com)

Cytotoxic chemotherapy often induces febrile neutropenia and may lead to serious complications including mortality. (ijpsonline.com)
Do not administer between 14 days before and 24 hours after administration of cytotoxic chemotherapy. (drugs.com)
The most common risk factor for severe BSI is neutropenia due to cytotoxic chemotherapy [ 5 ]. (biomedcentral.com)

Despite recent therapeutic advances, febrile neutropenia is still a major cause of morbidity and mortality among cancer patients in Latin America and worldwide. (ijpsonline.com)

It is also crucial to assess the risk of serious complications in patients with febrile neutropenia, since this assessment will dictate the approach to therapy, including the need for inpatient admission, IV antibiotics, and prolonged hospitalization 2. (ukessays.com)
Predicting individual risk of neutropenic complications in patients receiving cancer chemotherapy. (trillium.de)
One of the most common complications in patients with febrile neutropenia, lymphoma, leukemia, and multiple myeloma is a bloodstream infection (BSI). (biomedcentral.com)

Febrile Neutropenia (FN) is a common complication of chemotherapy and a main cause of morbidity and mortality in cancer patients[ 1 ]. (ijpsonline.com)

Systematic review and meta-analysis of short- versus long-acting granulocyte colony-stimulating factors for reduction of chemotherapy-induced febrile neutropenia. (centerforbiosimilars.com)
Despite established guidelines for the use of granulocyte colony-stimulating factors (G-CSFs) in the prevention of febrile neutropenia, inappropriate prescribing practices have been reported. (jhoponline.com)
Granulocyte colony-stimulating factors (G-CSFs), which were first approved in 1991, are effective at reducing the risk for and duration of chemotherapy-induced febrile neutropenia, by stimulating the production and maturation of neutrophils. (jhoponline.com)
3 . Aapro MS et al: 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours. (trillium.de)
Acute myeloid leukemia or myelodysplastic syndrome in randomized controlled clinical trials of cancer chemotherapy with granulocyte colony-stimulating factor: A systematic review. (trillium.de)
The impact of the granulocyte colony-stimulating factor on chemotherapy dose intensity and cancer survival: A systematic review and meta-analysis of randomized controlled trials. (trillium.de)
Granulocyte colony-stimulating factor in the treatment of high-risk febrile neutropenia: A multicenter randomized trial. (trillium.de)
There is strong and consistent clinical evidence to show that granulocyte-colony stimulating factors (G-CSFs) reduce the risk of chemotherapy-induced neutropenia and therefore complicated neutropenia and can be used to maintain chemotherapy at the desired dose intensity or density and minimize delays in treatment [ 11 ]. (hindawi.com)

Here we are reporting rare case series of capecitabine induced marrow aplasia in patients of colorectal cancer during adjuvant treatment. (jbclinpharm.org)
From the above three cases, it is evident that capecitabine causes hypocellular marrow, which we are using as adjuvant or palliative chemotherapy in colorectal cancer. (jbclinpharm.org)
In view of old age we started single agent capecitabine 1000 mg/m 2 twice daily for 14 days with 1 week off as adjuvant chemotherapy for total 6 months. (jbclinpharm.org)
Background: Despite a potentially curative treatment, the prognosis after upfront surgery and adjuvant chemotherapy for patients with resectable pancreatic ductal adenocarcinoma (PDAC) is poor. (unav.edu)

The real-world evidence provided by the MONITOR-GCSF study indicates that providing GCSF support may yield better CIN, FN, and CIN/FN-related hospitalization outcomes if patients are prophylacted at levels above guideline recommendations. (unibas.ch)
Three RCTs showed no significant difference in treatments in terms of hospitalization outcomes among treatments, while 2 reported a trend toward fewer hospitalizations with pegfilgrastim. (centerforbiosimilars.com)
Secondary outcomes were a stricter definition of FN and infection-related hospitalization. (bvsalud.org)
2,3 Kuderer and colleagues estimated a 9.5% (95% confidence interval, 9.5%-9.8%) direct mortality risk for patients with cancer who were hospitalized with febrile neutropenia.2 Suboptimal chemotherapy treatment may affect patient outcomes and the overall efficacy of cancer management. (jhoponline.com)
Conclusions: Pharmacokinetically-guided dose adjustment of standard chemotherapy treatments might improve survival outcomes in patients with pancreatic ductal adenocarcinoma. (unav.edu)

SC=standard chemotherapy. (pfizerpro.com)

Hospitalization is necessary in patients with acute myeloid leukemia for managing chemotherapy and for treating complications related to the disease and its treatment, usually infections or febrile neutropenic episodes. (medscape.com)
An overview of the concepts related to neutropenic fever, including definitions of fever and neutropenia and categories of risk are reviewed here. (ukessays.com)

With the increasing use of myelo-suppressive agents in the treatment of neoplastic and nonneoplastic diseases, the increased rate of infection in patients with neutropenia has been clearly established 3. (ukessays.com)
The definition of fever as an indicator of infection in patients with neutropenia has varied. (ukessays.com)

Neutrophils play a vital role in protecting against infection, so the duration and severity of neutropenia directly correlate with the total incidence of all infections, including those that are life threatening. (medscape.com)
The risk increases with the duration and severity of the neutropenia. (biomedgrid.com)
The duration and severity of neutropenia directly correlate with the total incidence of all infections and of those infections that are life threatening. (medscape.com)
Coadministration of palifermin within 24 hr of chemotherapy resulted in increased severity and duration of oral mucositis. (medscape.com)
Furthermore, lenograstim may increase the patient's exposure to chemotherapy allowing patients to receive optimal dosing and duration of treatment, benefitting survival. (hindawi.com)
The approval of COSELA is based on data from three randomized, placebo-controlled trials that showed patients receiving COSELA prior to the start of chemotherapy had clinically meaningful and statistically significant reduction in the duration and severity of neutropenia. (g1therapeutics.com)

Granotax was a prospective, open label, multicentre, national phase IV study that evaluated the incidence and severity of neutropenia in adult patients with solid tumors being treated with a docetaxel-based regimen while receiving the GCSF lenograstim. (hindawi.com)

[ 3 ] Major causes of acquired neutropenia are infection, drugs (through direct toxicity or immune effects), and autoimmunity. (medscape.com)
This approach can help reduce some chemotherapy-related toxicity, making chemotherapy safer and more tolerable, while also reducing the need for reactive rescue interventions. (g1therapeutics.com)

Publications eligible for inclusion in the review involved adults with nonmyeloid malignancies receiving chemotherapy. (centerforbiosimilars.com)

All RTCs showed similar levels of dose reduction of chemotherapy or delays in anticancer treatment for short- and long-acting agents. (centerforbiosimilars.com)
Repeated infections results in prolonged periods of hospitalisation, delay in treatment and chemotherapy dose reductions. (biomedgrid.com)
Myelotoxicity and dose intensity of chemotherapy: Reporting practices from randomized clinical trials. (trillium.de)
Two (0.5%) patients and 32 (8.1%) patients had dose delayed due to febrile neutropenia and neutropenia, respectively. (hindawi.com)
Four (1.0%) patients and 32 (8.1%) patients had a dose changed due to febrile neutropenia and neutropenia, respectively. (hindawi.com)
Furthermore, they can lead to delays and dose reductions in chemotherapy treatment, thereby potentially compromising the efficacy of chemotherapy and, consequently, patient outcome [ 10 ]. (hindawi.com)
See "Major side effects of low-dose methotrexate" and "Hepatotoxicity associated with chronic low-dose methotrexate for nonmalignant disease" and "Methotrexate-induced lung injury" and "Initial treatment of rheumatoid arthritis in adults" and "Treatment of rheumatoid arthritis in adults resistant to initial conventional synthetic (nonbiologic) DMARD therapy" . (medilib.ir)
These complications impact patients' quality of life and may also result in chemotherapy dose reductions and delays. (g1therapeutics.com)
VENCLEXTA is indicated in combination with azacitidine, or decitabine, or low-dose cytarabine for the treatment of newly diagnosed acute myeloid leukemia (AML) in adults 75 years or older, or who have comorbidities that preclude use of intensive induction chemotherapy. (venclextahcp.com)

Numerous changes in antibiotics may be necessary until infections and neutropenia resolve. (medscape.com)
Other considerations related to complications of febrile neutropenia include decreased quality of life and the use of broad-spectrum antibiotics. (jhoponline.com)
Prophylactic antibiotics are often used in pediatric patients for the treatment of acute myeloid leukemia (AML) and relapsed acute lymphoblastic leukemia (ALL), and for those undergoing hematopoietic stem cell transplant (HSCT) who are receiving intensive chemotherapy. (jhoponline.com)

List medications that can cause neutropenia and thrombocytopenia, and state drugs that are useful for neutropenia. (ashp.org)
Concurrent anemia, thrombocytopenia, and/or an abnormal result on a peripheral blood smear from a patient with neutropenia suggest an underlying hematologic disorder. (medscape.com)
First, the production of normal blood cells markedly decreases, which results in varying degrees of anemia , thrombocytopenia , and neutropenia . (medscape.com)

The lymphoma was eliminated with chemotherapy in February 2010. (cureyourowncancer.org)
Additionally, the positive data from the ECHELON-2 trial demonstrated that in patients with previously untreated CD30-positive peripheral T-cell lymphoma, ADCETRIS in combination with chemotherapy was superior to the control arm for progression-free survival and overall survival, representing an important milestone for ADCETRIS as a potential therapy in this setting where standard of care has not changed in several decades. (covaipost.com)

However, neutropenia is detected in these patients only after the onset of infection limiting the efficacy of these therapeutic interventions. (biomedgrid.com)

The critical element in reducing neutropenia related mortality is early diagnosis before the onset of infection and fever resulting in reduced need for hospitalisation and a faster neutrophil recovery. (biomedgrid.com)
After transplantation, most febrile episodes require in-patient treatment and observation until profound neutropenia and clinically significant infection resolves. (medscape.com)
The primary outcome was FN or infection, defined as hospitalization with neutropenia, fever, or infection diagnosis. (bvsalud.org)
Results were similar for strictly defined FN (overall aOR, 1.29 for week 1 and 0.12 for beyond week 1) and infection-related hospitalization (overall aOR, 1.33 for week 1 and 0.27 for beyond week 1). (bvsalud.org)
CONCLUSIONS: Overall, the rates of chemotherapy-related FN and infection in week 1 of the first chemotherapy cycle are similar for patients receiving and not receiving G-CSF, suggesting continued risk in week 1 despite prophylactic G-CSF. (bvsalud.org)
Tuberculosis (see the image below) is one type of infection that may cause neutropenia. (medscape.com)
Since our data suggest that required to induce early events of viral infection RAE 1, we have a situation where. (microrna1.com)
Gesamtverm Gens MCMV infection PI3K/Akt our data, based on data with HCMV and that this activation to induce signaling through PI3K p110a RAE RAE first required significant induction in cells infected with MCMV There are three classes obtained enzymes in the superfamily of PI3K class I, II and III. (microrna1.com)
Chemotherapy-induced myelosuppression may lead to increased risks of infection, severe anemia, and/or bleeding. (g1therapeutics.com)

Neutropenia is a decrease in circulating (ie, nonmarginal) neutrophils in the blood. (medscape.com)
Chemotherapy treatments for cancer are well-‐ known to be associated with a depletion of white blood cells, in particular neutrophils, causing a condition known as chemotherapy-‐ induced neutropenia (CIN), as described in Figure 1. (biomedgrid.com)
Neutropenia is a decrease in circulating neutrophils in the nonmarginal pool, which constitutes 4-5% of total body neutrophil stores. (medscape.com)

Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. (trillium.de)
Impact of pegfilgrastim on early all-cause mortality in patients receiving cancer chemotherapy. (trillium.de)

These improvements in outcome are very welcome, yet they do have associated substantial toxicities, especially a moderate-to-high risk of neutropenia or febrile neutropenia (FN) [ 8 ]. (hindawi.com)
thus, any impairment of glomerular filtration rate (GFR) will result in sustained serum levels of the drug that may induce bone marrow or other toxicities. (medilib.ir)

Treatment for patients with acute myeloid leukemia involves intensive chemotherapy to destroy the leukemic cell population as rapidly as possible and to prevent the emergence of a resistant clone. (medscape.com)
3 Patients receiving intensive chemotherapy for AML or ALL and those undergoing HSCT have an increased risk for serious bacterial infections. (jhoponline.com)

Where neutropenia is significant, it is associated with an increased risk of systemic infections that lead to sepsis and death (1,2,3,7,9). (biomedgrid.com)
Decreased blood concentrations of red blood cells (RBCs), white blood cells (WBC), especially granulocytes, and platelets result from diverse systemic cancer therapies, especially conventional chemotherapy drugs, and radiation therapy. (msdmanuals.com)

Some congenital disorders that predispose patients to AML include Bloom syndrome , Down syndrome , congenital neutropenia, Fanconi anemia , and neurofibromatosis . (medscape.com)

One of the major side effects of cancer chemotherapy is myelosuppression leading to an obligate period of neutropenia. (biomedgrid.com)
Neutropenia is a serious adverse effect frequently associated with cancer chemotherapy (1,7). (biomedgrid.com)
Transfer to a pediatric cancer center is usually necessary for initial diagnostic studies and is mandatory for management of chemotherapy and treatment-related complications. (medscape.com)
For many years, most children in the United States were treated with chemotherapy protocols developed by the Children's Cancer Group and the Pediatric Oncology Group. (medscape.com)
Guideline recommendations for the prevention and/or treatment of patients with febrile neutropenia have been published by the National Comprehensive Cancer Network (NCCN), the American Society of Clinical Oncology (ASCO), the European Society for Medical Oncology (ESMO), and the Infectious Diseases Society of America (IDSA). (jhoponline.com)
Febrile neutropenia is a common and serious complication of cancer chemotherapy. (ijpsonline.com)
This document compiles updated information available on the definition, risk factors, evaluation methods, treatment and special situations in cancer patients with febrile neutropenia. (ijpsonline.com)
Colony-stimulating factors for febrile neutropenia during cancer therapy. (trillium.de)
Filling in the gaps: Reporting of concurrent supportive care therapies in breast cancer chemotherapy trials. (trillium.de)
Participation in virtual mind-body fitness classes may be effective at reducing hospitalizations, urgent care visits, and the length of hospital stays among patients with cancer by about 50%, according to new findings presented by Mao et al at the 2023 ASCO Quality Care Symposium (Abstract 473). (ascopost.com)
Researchers have found that patients who have breast cancer who undergo treatment with taxanes show a pattern of clinically meaningful, persistent sensory and motor symptoms associated with chemotherapy-induced peripheral neuropathy, according to new findings presented by Trivedi et al at the 2023. (ascopost.com)
First patient is 51 year old male with locally advanced rectal cancer, developed persistent pancytopenia after 5th cycle of chemotherapy. (jbclinpharm.org)
Decreases in RBCs result from a direct effect of the cancer (especially in blood and bone marrow cancers such as leukemias, lymphomas, and multiple myeloma) and from effects of cancer therapy, especially conventional cancer (chemotherapy) drugs. (msdmanuals.com)
Decreases in platelets result from a direct effect of the cancer (especially blood and bone marrow cancers such as leukemias, lymphomas, and multiple myeloma) and from effects of cancer therapy, especially conventional chemotherapy drugs. (msdmanuals.com)
In contrast to medical science that seeks a cure for cancer, nursing science attempts to reduce adverse effects from chemotherapy and stress to improve the quality of life during and after treatment. (luriechildrens.org)
Patterns of chemotherapy usage in hospitalized breast cancer patients. (kku.ac.th)
It is given after chemotherapy and surgery to help the body destroy the cancer cells. (survivornet.com)
PROSTVAC is a therapeutic cancer vaccine which is designed to induce an anti-tumor immune response. (survivornet.com)
Determine if prostate-specific antigen (PSA)-TRICOM combined with enzalutamide will increase time to progression (as defined by Prostate Cancer Clinical Trials Working Group 2 criteria, incorporated in section 5.2) in chemotherapy-naive metastatic castration resistant prostate cancer patients compared to enzalutamide alone. (survivornet.com)
Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML): Monitor patients with breast and lung cancer using UDENYCA in conjunction with chemotherapy and/or radiotherapy for signs and symptoms of MDS/AML. (drugs.com)
GTHX ), a commercial-stage oncology company, today announced that the U.S. Food and Drug Administration (FDA) has approved COSELA™ (trilaciclib) for injection to decrease the incidence of chemotherapy-induced myelosuppression in adult patients when administered prior to a platinum/etoposide-containing regimen or topotecan-containing regimen for extensive-stage small cell lung cancer (ES-SCLC). (g1therapeutics.com)
The approval of trilaciclib (COSELA) is an important advance in the treatment of patients with extensive-stage small cell lung cancer receiving chemotherapy," said Dr. (g1therapeutics.com)
Chemotherapy is an effective and important weapon against cancer. (g1therapeutics.com)
However, chemotherapy does not differentiate between healthy cells and cancer cells. (g1therapeutics.com)

The most serious and life-threatening side effect of chemotherapy is myelosuppression, or damage to the bone marrow, resulting in reduced white blood cells, red blood cells and platelets. (g1therapeutics.com)
By contrast, trilaciclib provides the first proactive approach to myelosuppression through a unique mechanism of action that helps protect the bone marrow from damage by chemotherapy. (g1therapeutics.com)
G1 is proud to deliver COSELA to patients and their families as the first and only therapy to help protect against chemotherapy-induced myelosuppression. (g1therapeutics.com)
COSELA is administered intravenously as a 30-minute infusion within four hours prior to the start of chemotherapy and is the first FDA-approved therapy that helps provide proactive, multilineage protection from chemotherapy-induced myelosuppression. (g1therapeutics.com)

Unadjusted and regression-adjusted proportions of patients experiencing each outcome during week 1 versus beyond week 1 of the first chemotherapy cycle were compared. (bvsalud.org)
Blot S, Vandewoude K, De Bacquer D, Colardyn F: Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: Clinical outcome and length of hospitalization. (karger.com)
The primary outcome of the study was to assess the incidence of bacteremia during periods of neutropenia. (jhoponline.com)

Infections lead to fever known as febrile neutropenia (FN). (biomedgrid.com)

Based upon the level of ANC, neutropenia is categorized as mild, moderate or severe. (ukessays.com)
Capecitabine induced transient neutropenia is seen but persistent pancytopenia due to severe hypo cellular marrow is not yet been reported. (jbclinpharm.org)

However, the term granulocytopenia is often used synonymously with neutropenia and, in that sense, is again confined to the neutrophil lineage alone. (medscape.com)
An absolute neutrophil count between 1000 and 1500/microL corresponds to mild neutropenia. (ukessays.com)
Neutropenia Neutropenia is a reduction in the blood neutrophil count. (msdmanuals.com)

Comparison of pegfilgrastim with filgrastim on febrile neutropenia, grade IV neutropenia and bone pain: A meta-analysis of randomized controlled trials. (trillium.de)
It is the first and only therapy designed to help protect bone marrow (myeloprotection) when administered prior to treatment with chemotherapy. (g1therapeutics.com)
Myeloprotection is a novel approach of protecting HSPCs in the bone marrow from chemotherapy-induced damage. (g1therapeutics.com)

Leukocyte depletion of transfused blood products may prevent alloimmunization to platelets and should be used in patients expected to need platelet transfusions during multiple courses of chemotherapy or for candidates for hematopoietic cell transplants. (msdmanuals.com)

In the MONITOR-GCSF study of chemotherapy-induced (febrile) neutropenia with biosimilar filgrastim, 56.6% of patients were prophylacted according to amended EORTC guidelines, but 17.4% were prophylacted below and 26.0% above guideline recommendations. (unibas.ch)
In all, 4.66% of pegfilgrastim treatment was administered on the same day as chemotherapy administration, despite guideline recommendations for a 24- to 72-hour wait period between the administrations of chemotherapy and G-CSF. (jhoponline.com)

The treatment caused significant nausea, vomiting, febrile neutropenia (fever resulting from abnormally low white blood cell count), and pneumonia requiring hospitalization. (cureyourowncancer.org)

Although, historically, chemotherapy was used for palliation of symptoms, during the last few years the median overall survival of patients with advanced CRC has been substantially increased from 12 months to about 21-22 months when all of the available chemotherapeutic agents are administered [ 3 ]. (biomedcentral.com)
PI3K confinement Lich Is particularly important for the growth and survival of the cell with embroidery and is an important means of cellular Transformation FF Ren, another condition Cilomilast SB-207499 known to induce the expression of NKG2D ligands for rdern. (microrna1.com)

Because of the patient's need for intense chemotherapy and supportive care, guaranteed venous access is critical. (medscape.com)

Prognostic factors in resectable cholangiocarcinoma patients: Carcinoembryonic antigen, lymph node, surgical margin and chemotherapy. (kku.ac.th)

Patients with hematologic malignancies are at highest risk for suffering profound and prolonged neutropenia. (rebelem.com)

Our findings support the guideline recommendation that CIN/FN risk be assessed at the beginning of each chemotherapy cycle. (unibas.ch)
The risk assessment and the diagnostic approach to patients presenting with febrile neutropenia are also discussed. (ukessays.com)
Employ more intensive measures (IV hydration, frequent monitoring, hospitalization) as overall risk increases. (venclextahcp.com)
Particularly high risk are those undergoing induction chemotherapy or stem cell transplant. (rebelem.com)
[ 4 ] Particularly increased risk exists for AML that occurs after chemotherapy for another disease or for de novo AML with an abnormality of chromosomes 5, 7, or both. (medscape.com)

Anatomy4

Diseases73

Chemicals and Drugs74

Analytical, Diagnostic and Therapeutic Techniques and Equipment73

Phenomena and Processes12

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena3

Humanities1

Information Science6

Named Groups3

Health Care58

Geographicals2

Myelosuppressive chemotherapy3

Prophylaxis15

Regimens10

Incidence of febrile neutropenia2

Management of febrile neutropenia2

Cytotoxic chemotherapy3

Major cause of morbidity1

Complications in patients3

Complication of chemotherapy1

Granulocyte8

Adjuvant4

Outcomes5

Standard chemotherapy1

Neutropenic2

Patients with neutropenia2

Duration6

Severity1

Toxicity2

Malignancies receiving ch1

Dose9

Antibiotics3

Thrombocytopenia3

Lymphoma2

Efficacy1

Infection9

Neutrophils3

Mortality2

Toxicities2

Intensive chemotherapy2

Systemic2

Anemia1

Cancer24

Myelosuppression4

Outcome3

Infections1

Severe2

Neutrophil3

Bone3

Hematopoietic1

Guideline recommendations2

Treatment1

Survival2

Patient's1

Resectable1

Profound1

Risk5