• protein
  • The introduction of the double bond in lathosterol at C-5 to form 7-dehydrocholesterol that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs 100 +/- 7 pmol/mg protein per min, P = NS). (jci.org)
  • Whereas l7Rn6 mRNA levels were indistinguishable from wild type, l7Rn6 4234SB homozygotes exhibited decreased expression of the truncated protein, suggesting protein instability. (genetics.org)
  • patient
  • Nous rapportons un cas d'un patient s n galais de 21 ans, dr panocytaire homozygote, qui pr sentait un ict re de type cholestatique chez qui l'exploration biologique concluait a une r activation d'une h patite B occulte. (panafrican-med-journal.com)