VanillylmandelicDopamine metabolite homovanillic acidMetaboliteDOPACDihydroxyphenylacetic acidUrinaryAcetic acidSerumPhenolicMetabolitesAmino acidsCaffeic acidAscorbic AcidCerebralMetabolismMolecularFerulicBrainGamma-aminGABAVitroLowerCerebrospinal fluidUrineNeuroblastomaConcentrationsHydroxyindoleacetic acidNorepinephrinePlasmaMonoamine oxidaseCatecholamineTyrosineAromatic aminDeficientDerivativeAminoDopaminergicBiochemicalSolubleTaurineConcentrationParkinson's
Vanillylmandelic5
- Vanillylmandelic acid (VMA) is one of the metabolites of the catecholamines adrenaline (epinephrine) and noradrenaline (norepinephrine), hormones produced in the adrenal glands. (labtestsonline.org.uk)
- The vanillylmandelic acid (VMA) test is primarily used to detect and rule out neuroblastomas in children with an abdominal mass or other symptoms suggestive of the disease. (labtestsonline.org.uk)
- Homovanillic acid and vanillylmandelic acid were not detected in the urine. (contemporarypediatrics.com)
- Levels of urinary homovanillic acid and vanillylmandelic acid were within normal limits. (contemporarypediatrics.com)
- Additionally, urine catecholamine metabolite screening (Vanillylmandelic acid and homovanillic acid, VMA/HVA) is sometimes completed because excess production of these catecholamines and their metabolites is common in neuroblastoma. (chop.edu)
Dopamine metabolite homovanillic acid1
- In 1986, Stahl et al measured the dopamine metabolite homovanillic acid (HVA) in cerebrospinal fluid (CSF) before and after probenecid administration in healthy controls and in patients with HD. (medscape.com)
Metabolite2
- Homovanillic acid (HVA) is a major catecholamine metabolite that is produced by a consecutive action of monoamine oxidase and catechol-O-methyltransferase on dopamine. (wikipedia.org)
- We mapped the effect of a conditioned stressor on the concentration of the DA metabolite homovanillic acid (HVA) in distinct amygdaloid nuclei and other brain nuclei and areas and the effect of DZ (1 or 3 mg/kg) on the conditioned response in drug-experienced subjects. (duke.edu)
DOPAC6
- In vivo microdialysis with HPLC-ED was used to measure dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the nucleus accumbens of the rat, prior, during, and after 15-min periods of electrical brain stimulation at sites in the ventral tegmental area (VTA) that supported intracranial self-stimulation (ICSS). (nih.gov)
- Endogenous homovanillic acid (HVA) and DOPAC were isolated from the corpus striatum and estimated fluorometrically. (erowid.org)
- DESIGN/METHODS: Putamen and caudate DA, homovanillic acid (HVA), dihydroxyphenylacetic acid (DOPAC), and 3-methoxytyramine (3MT) levels were analyzed by high pressure liquid chromatography with electrochemical detection in 182 HAAS brains. (cdc.gov)
- Following intraperitoneal administration of the non-competitive N-methyl-D-aspartate (NMDA) antagonist dizocilpine (MK-801), levels of the dopamine (DA) metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) increased in mouse striatum and limbic forebrain. (eurekamag.com)
- Acute clozapine challenge (5-40 mg/kg i.p) produced dose-dependent increased extracellular levels of DA and its metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the medial prefrontal cortex of awake, free-moving rats as measured by in vivo brain microdialysis. (elsevierpure.com)
- We used high-performance liquid chromatography (HPLC) to measure the levels of DA and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the dialysis perfusates. (lu.se)
Dihydroxyphenylacetic acid1
- In contrast, neither MDMA nor MDA caused any widespread or long-term changes in the content of the catecholaminergic markers (i.e., norepinephrine, dopamine, 3,4 dihydroxyphenylacetic acid and homovanillic acid) or in the number of [3H]mazindol-labeled norepinephrine or dopamine uptake sites in the brain regions examined. (erowid.org)
Urinary1
Acetic acid1
- A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid. (nih.gov)
Serum2
- and platelet count, 9210 3 /?L. Levels of serum electrolytes, liver enzymes, lactate dehydrogenase, and uric acid were all within normal limits. (contemporarypediatrics.com)
- A. Increased serum levels of homovanillic acid may be seen, especially when psychosis is present. (antidepressantsfacts.com)
Phenolic3
- Previously, the neuroprotection of phenolic acids and flavonoids in the brain has been indicated. (aaem.pl)
- This study measured anticholinesterase activities of 9 phenolic acids and 6 flavonoids, singly or in combination. (aaem.pl)
- Szwajgier D, Borowiec K. Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors. (aaem.pl)
Metabolites1
- "Improvements in FMD at 6 h after consumption were correlated with the appearance of metabolites derived from anthocyanin and chlorogenic acid, notably hippuric, hydroxyhippuric acid, and homovanillic acid," they added. (nutraingredients.com)
Amino acids1
Caffeic acid1
- At 1-2 hours after consumption of the blueberry polyphenols, the researchers found that ferulic acid, isoferulic acid, vanillic acid, 2-hydroxybenzoic acid, benzoic acid, and caffeic acid were significantly increased. (nutraingredients.com)
Ascorbic Acid1
- In the first experiment, 62% (15/24) of 6-OHDA pre-treated rats and 45% (11/24) of those receiving ascorbic acid as control solution progressed to motor limbic seizures evolving to SE, after the administration of pilocarpine. (scielo.br)
Cerebral1
- Cerebral protective and cognition-improving effects of sinapic acid in rodents. (aaem.pl)
Metabolism1
- The gold standard treatment of severe disorders of BH4 metabolism is based on replacement therapy with BH4, 5-hydroxytryptophan, L-dopa, and carbidopa, with the addition, in certain cases, of folinic acid supplements and pramipexole. (thieme-connect.de)
Molecular2
- Cellular, molecular and biochemical studies in human subjects report changes affecting the gamma-amino butyric acid (GABA) system, specifically somatostatin-expressing (SST+) GABAergic interneurons, across brain disorders and during aging. (nature.com)
- Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. (nih.gov)
Ferulic1
- Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo. (aaem.pl)
Brain1
- Homovanillic acid is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain. (wikipedia.org)
Gamma-amin2
- Fee C, Banasr M, Sibille E. Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: cortical microcircuit and therapeutic perspectives. (nature.com)
- Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders. (nature.com)
GABA1
- Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate, and, thus, are reasonable candidate susceptibility genes for these conditions. (nature.com)
Vitro1
- Furthermore, retinoic acid increased the expression of LAMA5 and MTG2 in vitro. (bvsalud.org)
Lower1
- Perches, regardless of whether they were cooled or not, caused greater muscle deposition and wing bone mineralization as well as lower homovanillic acid/dopamine turnover. (purdue.edu)
Cerebrospinal fluid5
- In 1986, Stahl et al measured the dopamine metabolite homovanillic acid (HVA) in cerebrospinal fluid (CSF) before and after probenecid administration in healthy controls and in patients with HD. (medscape.com)
- This article presents new evidence that cerebrospinal fluid levels of the dopamine metabolite homovanillic acid are related to the severity of psychosis in schizophrenia. (elsevierpure.com)
- These results support the concept that homovanillic acid levels in cerebrospinal fluid vary as a function of psychosis rather than being related to the diagnosis of schizophrenia per se. (elsevierpure.com)
- RTTRD scores were correlated with age, ability to walk and speak, mutation type, and, in a small subgroup (n=9), cerebrospinal fluid (CSF) homovanillic acid (HVA) and 5-hydroxyindole-acetic acid levels. (omeka.net)
- D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians. (cdc.gov)
Urine5
- Nishi M, Miyake H, Takeda T, Takasugi N, Hanai J, Kawai T. Urinary vanillylmandelic acid and homovanillic acid levels in randomlysampled urine for the mass screening of neuroblastoma. (healthmatters.io)
- Kaluzna-Czaplinska J, Socha E, Rynkowski J. Determination of homovanillic acid and vanillylmandelic acid in urine of autistic children by gas chromatography/mass spectrometry. (healthmatters.io)
- Furthermore, dopamine turnover did not appear to be affected by the supplementation, as [homovanillic acid] HVA levels in urine were not affected. (fabresearch.org)
- Increased urine homovanillic acid. (librepathology.org)
- Laboratory testing reveals anemia, and elevated levels of homovanillic acid and vanillylmandelic acid are detected in the urine. (osmosis.org)
Neuroblastoma5
- Quercetin, an over-thecounter supplement, causes neuroblastoma-like elevation of plasma homovanillic acid. (healthmatters.io)
- Urinary homovanillic and vanillylmandelic acid in the diagnosis of neuroblastoma: report from the Italian Cooperative Group for Neuroblastoma. (healthmatters.io)
- 13. The relationship between homovanillic/vanillylmandelic acid ratios and prognosis in neuroblastoma. (nih.gov)
- A higher than normal amount of the substances homovanillic acid (HMA) and vanillyl mandelic acid (VMA) may be a sign of neuroblastoma . (cookchildrens.org)
- Williams CM, Greer M. Homovanillic acid and vanilmandelic acid in diagnosis of neuroblastoma. (edu.pk)
Concentrations2
- The concentrations of serum homovanillic acid (HVA), luteinizing liormone (LH), follicle-stimulating hormone (FSH) and testosterone (T) were examined in 20 male schizophrenic patients not taking neuroleptic drugs, 44 treated with neuroleptic drugs, and 15 male healthy control subjects. (uhi.ac.uk)
- We included therapy-refractory OCD patients treated with DBS (41 year) and performed a baseline assessment of symptoms, as well as plasma concentrations of thyroid-stimulating hormone (TSH), prolactin, growth hormone, copeptin and homovanillic acid. (mssm.edu)
Hydroxyindoleacetic acid2
- Summary Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and tryptophan (TRP) were measured in the CSF obtained from the basal cistern of 20 patients, who had undergone surgical obliteration of bleeding aneurysms within 3 days after subarachnoid haemorrhage (SAH). (zib.de)
- In Alzheimer subjects, a significant relationship (inverse) was found between 5-hydroxyindoleacetic acid concentration and the number of neurofibrillary tangles. (ox.ac.uk)
Norepinephrine3
- Dopamine then becomes norepinephrine using the enzyme dopamine beta-hydroxylase, which requires copper and ascorbic acid for optimal activity. (healthmatters.io)
- Elevations of homovanillic acid can be seen with lack of vitamin cofactors for enzymes within the metabolism of dopamine or the production of norepinephrine. (healthmatters.io)
- Tyrosine hydroxylase converts tyrosine to 3,4-dihydroxyphenylalanine (DOPA), which is converted to dopamine under the effect of aromatic l-amino acid decarboxylase, then dopamine β-hydroxylase converts dopamine to norepinephrine and phenylethanolamine N -methyltransferase converts norepinephrine to epinephrine. (medscape.com)
Plasma3
- Plasma homovanillic acid (HVA) levels were measured hourly for a 24-hour period in 10 patients with schizophrenia during treatment with placebo and fluphenazine. (jamanetwork.com)
- Doran AR , Labarca R , Wolkowitz OM , Roy A , Douillet P , Pickar D. Circadian Variation of Plasma Homovanillic Acid Levels Is Attentuated by Fluphenazine in Patients With Schizophrenia. (jamanetwork.com)
- RESULTS: alpha-Methylparatyrosine produced similar significant decreases in plasma 3-methoxy-4-hydroxyphenylethyleneglycol and homovanillic acid levels in the treatment groups. (biopsychiatry.com)
Monoamine oxidase1
- Dopamine can be metabolized to homovanillic acid using both monoamine oxidase (MAO) and catechol-Omethyltransferase (COMT). (healthmatters.io)
Catecholamine1
- Dietary flavonols contribute to false-positive elevation of homovanillic acid, a marker of catecholamine-secreting tumors. (healthmatters.io)
Tyrosine1
- Effects of oral L-tyrosine administration on CSF tyrosine and homovanillic acid levels in patients with Parkinson's disease. (wehaveparkinsons.com)
Aromatic amin1
- Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. (nih.gov)
Deficient1
- Low levels of urinary HVA imply deficient production of dopamine due to decreased amino acid precursors or lack of vitamin cofactors throughout the production cycle. (healthmatters.io)
Derivative1
- Capsaicin, A water-insoluble derivative of Homovanillic acid, is the active component present and responsible for its benefits. (naturmedscientific.com)
Amino1
- It is designated chemically as (-)-L-α-amino-β-(3,4-dihydroxybenzene) propanoic acid. (nih.gov)
Dopaminergic1
- Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease. (wehaveparkinsons.com)
Biochemical1
- Correlations among CSF homovanillic acid (HVA) values and other biochemical, clinical, neuroradiological, and electrophysiological parameters were analysed. (nih.gov)
Soluble1
- Soluble salts of weak acids (e.g., carbonates, acetates, sulfides, and cyanides) do not exist in aqueous solution or in water, since they undergo complete hydrolysis, resulting in the precipitation of aluminum hydroxide [Al(OH)3]. (nih.gov)
Taurine1
- We evaluated on a common and validated in vitro system the selectivity of 4-pyridoxic acid (PDA), homovanillic acid (HVA), glycochenodeoxycholate-3-sulphate (GCDCA-S) and taurine towards different renal transporters, including multidrug resistance-associated protein, and assessed the in vivo biomarker sensitivity towards the strong organic anion transporter (OAT) inhibitor probenecid at 500 mg every 6 h to reach close to complete OAT inhibition. (manchester.ac.uk)
Concentration1
Parkinson's1
- There are of course three more ingredients in Restore Gold™, each added due to their positive support in Parkinson's research, Grape Seed Extract, Acetyl L-Carnitine, and Alpha Lipoic Acid (ALA) are also included at specific dosages. (wehaveparkinsons.com)