We show homotypic fusion and necessary protein sorting (HOPS) binds Vam7 by means of it's subunits Vps16 as well as Vps18. (notes.io)
cGAMP binds the protein STING, which activates innate immune responses that stimulate T cells. (bvsalud.org)
Lipid2
Membrane mix inside endomembrane technique comes after a detailed purchase associated with events: membrane tethering, mediated by Rabs and also tethers, assemblage regarding disolveable N-ethylmaleimide-sensitive factor (NSF) attachment health proteins receptor (SNARE) buildings, and also lipid bilayer combining. (notes.io)
The most common use of this technology is to encode antigenic proteins on mRNAs that are delivered to cells via lipid nanoparticle (LNP) formulations. (bvsalud.org)
SNARE7
We study the membrane traffic machinery of the late endocytic pathway, including the role of the ESCRT (endosomal sorting complex required for transport), HOPS ((homotypic fusion and vacuole protein sorting) and SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes, as well as ion channels and the multifunctional protein VARP (Vps9 and ankyrin repeat containing protein), which regulates the function of the SNARE protein, VAMP7. (cam.ac.uk)
Heterotypic late endosome-lysosome membrane fusion is mediated by a trans -SNARE (soluble N -ethylmaleimide-sensitive factor-attachment protein receptor) complex comprising Syntaxin7, Vti1b, Syntaxin8 and VAMP7 (vesicle-associated membrane protein 7). (silverchair.com)
This differs from the trans -SNARE complex required for homotypic late endosome fusion in which VAMP8 replaces VAMP7. (silverchair.com)
This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. (nih.gov)
Membrane mix inside endomembrane technique comes after a detailed purchase associated with events: membrane tethering, mediated by Rabs and also tethers, assemblage regarding disolveable N-ethylmaleimide-sensitive factor (NSF) attachment health proteins receptor (SNARE) buildings, and also lipid bilayer combining. (notes.io)
Furthermore, many of us noticed which Vps16, Vps18, as well as the Sec1/Munc18 proteins Vps33, which part of the HOPS complex, hole towards the Q-SNARE complicated. (notes.io)
Cleavage of any one of the three neuronal SNARE proteins blocks fusion of synaptic vesicles to plasma membranes, thus preventing neurotransmitter release from neurons. (nature.com)
Vesicles5
PTPN9 colocalized with ATG16L1 and was essential for homotypic fusion of ATG16L1 + vesicles during starvation-induced autophagy. (nih.gov)
Cells are compartmentalized by specialized organelles (little organs within each cell), and cargo including proteins is moved between these compartments by trafficking of vesicles. (cam.ac.uk)
Late endosomes are MVBs (multivesicular bodies) with ubiquitinated membrane proteins destined for lysosomal degradation being sorted into their luminal vesicles by the ESCRT (endosomal sorting complex required for transport) machinery. (silverchair.com)
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. (nih.gov)
The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. (nih.gov)
Endosome1
Late endosome-lysosome fusion is preceded by tethering that probably requires mammalian orthologues of the yeast HOPS (homotypic fusion and vacuole protein sorting) complex. (silverchair.com)
Syntaxin1
and BoNT/C also cleaves the plasma membrane protein syntaxin 1. (nature.com)
VAMP7 is also required for lysosome fusion with the plasma membrane and its retrieval from the plasma membrane to lysosomes is mediated by its folded N-terminal longin domain. (silverchair.com)
Required for lysosome fusion1
Recruitment of VPS33A to HOPS by VPS16 is required for lysosome fusion with endosomes and autophagosomes. (cam.ac.uk)
Lysosomal1
Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. (nih.gov)
Exocytosis1
In Ca2+-stimulated exocytosis , many additional proteins are important in the Ca2+ regulation of the basic membrane trafficking apparatus. (pharmaceuticalintelligence.com)
VAMP1
Similar to BoNT/B/D/F/G, BoNT/X cleaves vesicle-associated membrane proteins (VAMP) 1, 2 and 3, but at a novel site (Arg66-Ala67 in VAMP2). (nature.com)
Degradation2
We aim to understand how the membrane traffic machinery moves specific proteins around the cell for their normal function and for their degradation, the latter taking place in the lysosome organelle. (cam.ac.uk)
Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
Lysosome1
We aim to understand the coordination of fusion and fission events in the lysosome regeneration cycle linking endolysosomes and terminal storage lysosomes as well as the disruption of this cycle that occurs in some diseases. (cam.ac.uk)
Endosomes1
Cargo is delivered from late endosomes to lysosomes by kissing and direct fusion. (silverchair.com)
Regulation1
Here, we discovered a novel role of the protein tyrosine phosphatase PTPN9 in the regulation of homotypic ATG16L1 vesicle fusion and early autophagosome formation. (nih.gov)
The ATG16L1 precursor fusion contributes to development of phagophore structures and is critical for the biogenesis of autophagosomes. (nih.gov)
Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Transport2
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)
Function1
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
Requires1
Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. (nih.gov)