Homology to escherichia structural homology protein. Medical search. Frequent questions

S. agalac-tiae neuA from tilapia maintains high structural homology and sequence identity with CMP-NeuNAc synthetases from other bacteria. (geneticsmr.com)
Sequence analysis reveals the presence of a protein of 497 amino acids in the Staphylococcus proline permease gene and the protein exhibits 49% homology with the PutP high-affinity proline permease of E. coli. (readabstracts.com)
Comparison of the predicted amino acid sequence of the CHA1 polypeptide with that of other serine/threonine dehydratases revealed several blocks of sequence homology. (unipr.it)
Thus, the amino acid sequence of rat liver serine dehydratase (SDH2) and the CHA1 polypeptide are 44% homologous allowing for conservative substitutions, while 36% similarity is found between the catabolic threonine dehydratase (tdcB) of Escherichia coli and the CHA1 protein. (unipr.it)
It shares significant sequence homology and similar mechanism with Fpg, a bacterial 8-oxoguanine glycosylase. (huji.ac.il)
is composed of two domains which, in spite of a negligible sequence homology, are characterized by very similar three dimensional folds. (expasy.org)
Similar restriction patterns between these gene sets suggested a high level of sequence homology. (elsevierpure.com)
In fact, sequence analysis showed that a 2.2-kb region, including the entire large and small subunit structural genes, was totally conserved in rbcL1-rbcS1 and rbcL2-rbcS2. (elsevierpure.com)
however it only has 25% sequence homology to IL-4 and is capable of IL-4 independent signaling. (biofargo.com)
Sequence conservation in this family has pointed to a conserved core, termed the NodB homology domain. (rcsb.org)
The PdaA structure provides a template for interpreting the wealth of sequence data on family 4 carbohydrate esterases in a structural context and represents a first step towards understanding the reaction mechanism of this family of enzymes. (rcsb.org)
The nucleotide sequence of a 961 base-pair segment of DNA containing the sdhB gene, which encodes the iron-sulphur protein subunit of the E. coli succinate dehydrogenase, has been determined. (worktribe.com)
The nucleotide sequence of a 3614 base-pair segment of DNA containing the sdhA gene, encoding the flavoprotein subunit of succinate dehydrogenase of Escherichia coli, and two genes sdhC and sdhD, encoding small hydrophobic subunits, has been determin. (worktribe.com)
The nucleotide sequence of the sucB gene, which encodes the dihydrolipoamide succinyltransferase component (E2o) of the 2?oxoglutarate dehydrogenase complex of Escherichia coli K12, has been determined by the dideoxy chain?termination method. (worktribe.com)
The nucleotide sequence of a 3180?base?pair segment of DNA, containing the sucA gene encoding the 2?oxoglutarate dehydrogenase component (E1o) of the 2?oxoglutarate dehydrogenase complex of Escherichia coli, has been determined by the dideoxy chain?t. (worktribe.com)
Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
The nucleotide series from the gene uncovered that the proteins is initially 143257-98-1 IC50 manufactured in a 13-kDa precursor type which includes an N-terminal sign sequence that is after that apparently removed ahead of release from the 10-kDa inhibitor through the cell. (bio2009.org)

In Escherichia coli, RbsR is responsible for regulation of genes involved in D-ribose metabolism. (wikipedia.org)
The codon usage frequency of neuA differed greatly in Escherichia coli and Homo sapiens genes, and neuA may be more efficiently expressed in eukaryotes (yeast). (geneticsmr.com)
The EvgS/EvgA two-component system of Escherichia coli is activated in response to low pH and alkali metals and regulates many genes, including those for the glutamate-dependent acid resistance system and a number of efflux pumps. (essex.ac.uk)
Genes adjacent to pvtramp were identified in silico to determine the degree of similarity between the protein sequences encoded by equivalent chromosomic fragments in P. falciparum and Plasmodium knowlesi . (biomedcentral.com)
The rbcL1 (rbcL2) and rbcS1 (rbcS2) genes were 1,422 and 333 bp in length and encoded 473- and 110-amino-acid proteins, respectively. (elsevierpure.com)
The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)

Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)
Functional expression in an Escherichia coli host helps clone the gene. (readabstracts.com)
PredictProtein--an open resource for online prediction of protein structural and functional features. (rostlab.org)
Moreover, to investigate the structural basis for the in vivo Structure Activity Relationship observed, we also conducted in silico virtual creening via homology modeling, molecular docking, and density functional theory (DFT) calculations. (emerginginvestigators.org)
Despite the structural differences between these secretion systems, they both show functional homology in the competition phenomenon and govern the social life of bacterial community. (am-online.org)
FN3 exhibits functional as well as structural modularity. (embl.de)

Three Dimensional Structural Modelling of Lipase Encoding Gene from Soil Bacterium Alcaligenes sp. (ugm.ac.id)
An existing strategy helps identify the structural gene encoding the high-affinity proline permease of Staphylococcus aureus. (readabstracts.com)
This strongly suggests that CHA1 is the structural gene for the yeast catabolic serine (threonine) dehydratase. (unipr.it)
The pvtramp gene was amplified from cDNA of P. vivax schizont stages, cloned and expressed in Escherichia coli . (biomedcentral.com)
For each of these factors we will construct isogenic non-polar mutations in the structural gene and test the mutants for decreased adherence in differential intestinal epithelial cell lines, freshly harvested human intestinal epithelial cells, and in a gnotobiotic piglet model of disease. (usda.gov)
Catalytic activity of the recombinant protein was detected only when amino acid residues encoded by the integrase gene were added to the N-terminus of the reverse transcriptase-RNase H domain. (cnrs.fr)
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. (biofargo.com)
The sdhB structural gene comprises 711 base pairs (237 cod. (worktribe.com)
A degenerate oligonucleotide produced from a incomplete amino acid series of this proteins was utilized to isolate its structural gene from 143257-98-1 IC50 a genomic cosmid collection. (bio2009.org)
The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. (nih.gov)

By using in silico tools, LipJG3 was related to the transporter protein sequences. (ugm.ac.id)
The N-terminal amino acid sequences of the subunit proteins, synthesized in Escherichia coli, were determined by Edman degradation and found to agree with the deduced amino acid sequences, except for the N-terminal methionine residue. (elsevierpure.com)
DNA structural and physical properties reveal peculiarities in promoter sequences of the bacterium Escherichia coli K-12. (openwetware.org)

The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. (nih.gov)

Given the tight relation between protein structure and function, we present a set of methods to analyze protein topology, implemented in the VLDP program, relying on Laguerre space partitions built from series of molecular dynamics snapshots. (nature.com)
The first task performed by VLDP is to build the Laguerre, or weighted Voronoi, diagram of the data, typically a set of positions describing the molecular structure as provided by bio-structural techniques, e.g. crystallography, NMR spectroscopy or simulation (molecular dynamics, Monte-Carlo, etc. (nature.com)
Current research goals in the lab relate to the spatio-temporal coordination of FGF2 secretion in living cells, the analysis of the molecular mechanism by which FGF2 physically traverses the plasma membrane and the relevance of this process for other unconventional secretory proteins such as HIV Tat. (db-engine.de)
Conversely, bioinformatics tools offer an alternative that allows prediction of 3D protein structures by molecular dynamics and homology modeling making it faster, cheaper, and highly reliable. (scientificarchives.com)
Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)

The Ribose repressor (RbsR) is a bacterial DNA-binding transcription repressor protein and a member of the LacI/GalR protein family. (wikipedia.org)
Some bacterial proteins closely related to rhodanese are also thought to express a sulfotransferase activity. (expasy.org)
To date, only one bacterial factor has been shown to mediate intestinal adherence by O157:H7, the outer membrane protein intimin which was originally discovered in the Principal Investigator's laboratory. (usda.gov)
We discovered that the group III inhibitor includes a extremely steady cationic 10-kDa proteins that is released in to the lifestyle supernatant and that is bacteriolytic for just delicate S. ipomoeae strains rather than other streptomycete types or various other bacterial genera analyzed. (bio2009.org)
Homology-based reconstruction of regulatory networks for bacterial and archaeal genomes. (openwetware.org)

abstract = "Escherichia coli endonuclease VIII (Nei) excises oxidized pyrimidines from DNA. (huji.ac.il)

The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)
As a test-case, the membrane protein FepA is investigated in its full environment, yielding a more precise description of the protein surface. (nature.com)
Membrane proteins, such as those operating transport through the membrane in a controlled way, are prone to show interesting topological properties related to their function. (nature.com)
Our study uses classical algorithms such as space partitions and Dijkstra paths search 9 , applied in an original and novel way by taking into account the full representation of a membrane protein including the solvent and the lipid bilayer (Fig. 1 ). (nature.com)
The FepA membrane protein is surrounded by a lipid bilayer separating the extracellular medium and the periplasm. (nature.com)
The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins. (rostlab.org)
However, recent data have revealed that structures similar to those found in PFTs are found in membrane active proteins across disparate phyla. (nih.gov)
Of note, domains found in membrane-attack complex proteins of complement and perforin (MACPF) resemble cholesterol-dependent cytolysins from Gram-positive bacteria, and the Bcl family of apoptosis regulators share similar architectures with Escherichia coli pore-forming colicins. (nih.gov)
These and other correlations provide considerable help in understanding the structural requirements for membrane binding and pore formation. (nih.gov)
The structure of TVISS is more complicated and comprises a series of proteins with structural homology to bacteriophage tail proteins and membrane proteins, which build the core of the system (Tss proteins). (am-online.org)
NCK is a major adaptor protein involved in membrane receptor signalling and modulation of actin cytoskeleton dynamics. (eu.org)

This antimicrobial proteins which may be classified being a bacteriocin because of its proteinaceous ribosomally produced nature displays no significant homology to various other known protein and represents simply the next example (another getting from Streptomyces virginiae [24]) of the bacteriocin made by a streptomycete. (bio2009.org)
The primary barriers for invading respiratory pathogens are the respiratory tract epithelial cells and antimicrobial proteins generated by these cells. (cdc.gov)

Presence of an intracellular small immunity protein (CdiI) protects E.coli cells from autoinhibition. (am-online.org)
Type III modules are present in both extracellular and intracellular proteins. (embl.de)

Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during translation of the upstream TnaC leader peptide, a process for which interactions between the TnaC nascent chain and the ribosomal exit tunnel are critical. (cipsm.de)
Expression of the cytoplasmic part of the protein alone also gives constitutive activation, which is lost if the constitutive PAS mutations are present. (essex.ac.uk)
Here we present a structure for this domain of MOKV P, obtained by expression of full-length P in Escherichia coli, which was subsequently truncated during crystallization. (pasteur.fr)

Herein, we report a group of variants structurally derived from Escherichia coli O157:H7 MAL ( Ec MAL). (springeropen.com)

In Bacillus subtilis, RbsR was shown to interact with Histidine-containing protein (HPr), an allosteric effector of the related LacI/GalR protein Catabolite Control Protein A (CcpA). (wikipedia.org)
NMR structure of lipoprotein YxeF from Bacillus subtilis reveals a calycin fold and distant homology with the lipocalin Blc from Escherichia coli. (rostlab.org)
We concluded that all six penicillin-type antibiotics inhibit Staphylococcus epidermidis , Escherichia coli , and Neisseria sicca with varying degrees of efficacy but exhibited no inhibition against Bacillus cereus . (emerginginvestigators.org)

however, analysis of structural dynamics of Fpg/Nei family proteins has been hindered by the lack of structures of uncomplexed and DNA-bound enzymes from the same source. (huji.ac.il)
While the vast majority of these enzymes display broad activity towards canonical dNTPs, exemplified by Sterile Alpha Motif (SAM) and Histidine-aspartate (HD) domain-containing protein 1 (SAMHD1), which blocks reverse transcription of retroviruses in macrophages by maintaining dNTP pools at low levels, Escherichia coli (Ec)- dGTPase is the only known enzyme that specifically hydrolyzes dGTP. (biorxiv.org)
2019 ). Structure-guided protein engineering has replaced the natural mutation of enzymes as one of the main tools of evolution (Cheng et al. (springeropen.com)
In the assembly of the Clostridium cellulolyticum cellulosome, the multiple cohesin modules of the scaffolding protein CipC serve as receptors for cellulolytic enzymes which bear a dockerin module. (rcsb.org)
Currently, there are no structural studies of any of its enzymes, hence the determination of the three-dimensional (3D) structure of Pi GlcK-1 becomes a significant contribution to the deduction of its functions, its interaction with ligands, and possible regulatory mechanisms. (scientificarchives.com)
A structural comparison of the predicted model with other structures of crystallized glucokinases enzymes allowed us to identify both the regions of interaction with their classical substrates (glucose and ATP) and those involved in the binding of other substrates such as fructose and ADP. (scientificarchives.com)

Two of these factors have homology to previously described adhesins in other enteric pathogens and the third factor has no obvious homology to previously described adhesins. (usda.gov)
At least two mammalian pathogens, enteropathogenic Escherichia coli (EPEC) and vaccinia virus, exploit NCK as part of their infection strategy. (eu.org)

Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)
Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral properties of the green fluorescent protein (GFP). (cipsm.de)
All three structures are virtually identical, demonstrating that the mutations did not affect the overall conformation of the protein in its free state. (huji.ac.il)

Villalobos-Piña L, Rojas A, Acosta H. First In silico Structural Model of Glucokinase-1 from Phytophthora infestans Reveals a Possible Pyrophosphate Binding Site. (scientificarchives.com)
In this work we present the first structural model obtained by in silico tools for Pi GlcK-1. (scientificarchives.com)

The Ty1 enzyme was expressed as a hexahistidine-tagged fusion protein in Escherichia coli to facilitate purification of the recombinant protein by metal-chelate chromatography. (cnrs.fr)

Here, we built a homology model of the periplasmic region of EvgS, based on the structure of the equivalent region of the BvgS homologue, to guide mutagenesis of potential key residues in this region. (essex.ac.uk)
This study describes the identification of the P. falciparum thrombospondin-related apical merozoite protein homologue in P. vivax (PvTRAMP) and examines its potential to be further evaluated as vaccine candidate. (biomedcentral.com)
The PfTRAMP homologue in P. vivax , here denoted as PvTRAMP, is a 340-amino-acid long antigen encoded by a single exon that could have a potential role in cytoadherence, as indicated by the presence of a thrombospondin structural homology repeat (TSR) domain. (biomedcentral.com)

3, 137-155 (1996) REFERENCE 9 AUTHORS Fujita,N., Mori,H., Yura,T. and Ishihama,A. TITLE Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region JOURNAL Nucleic Acids Res. (nig.ac.jp)

A contactdependent growth inhibition (CDI), primarily found in Escherichia coli strains, utilizes CdiB/CdiA protein of type Vb secretion system, described also as two-partner secretion (TPS) system, to inhibit growth of non-kin strains, where cell contact is required. (am-online.org)
The pathogenic S. ipomoeae strains 78-61 (group I) 88 (group II) 91 and 88-03 (both group III) have already 143257-98-1 IC50 been defined (8) and had been conserved on silica gel crystals (22) and revived on S. ipomoeae development agar (SIGA) (8 143257-98-1 IC50 10 Escherichia coli hosts for cloning had been DH10B (Lifestyle Technology Inc.) and XL1-Blue MR (Stratagene). (bio2009.org)

Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. (embl.de)
The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. (nih.gov)

Escherichia coli O157 is recognized worldwide as an Shiga toxin production was determined by using a important cause of diarrheal disease, which in some commercially available enzyme-linked immunosorbent patients is followed by hemolytic uremic syndrome and assay (ELISA) kit (Premiere EHEC, Meridian death (1). (cdc.gov)

The reliability of these tools is based on the use of databases of solved protein structures that can serve as homology templates in the simulation and structural prediction of proteins [ 5 ]. (scientificarchives.com)

The enzyme assumes a fold related to a (beta/alpha)8 barrel, with a long groove on the surface of the protein that harbours all conserved residues. (rcsb.org)

The smaller proteins are generally of prokaryotic origin while the larger ones are of eukaryotic origin. (tcdb.org)
The larger eukaryotic and archaeal proteins possess N- and C-terminal hydrophilic extensions. (tcdb.org)

The recombinant protein produced in E. coli should be useful for further biochemical and structural analyses and for a better understanding of the role of integrase in the activation of reverse transcriptase. (cnrs.fr)

Several local but functionally relevant structural changes are also evident in other parts of the enzyme. (huji.ac.il)
Rhodanese domains, either catalytic or inactive (i.e. where the active-site Cys is replaced by another residue), are also found associated with other protein domains such as MAPK-phosphatases or thiL, an Escherichia coli enzyme involved in thiamin and thiouridine biosynthesis. (expasy.org)
While dNTPases display activity towards dNTPs, such as SAMHD1 -which blocks reverse transcription of HIV-1 in macrophages- Escherichia coli (Ec)-dGTPase is the only known enzyme that specifically hydrolyzes dGTP. (biorxiv.org)

Characterization of promoters in archaeal genomes based on DNA structural parameters. (openwetware.org)

These glycoproteins include the CD98 heavy chain protein of Mus musculus (gbU25708) and the orthologous 4F2 cell surface antigen heavy chain of Homo sapiens (spP08195). (tcdb.org)

The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)

RhdA is a periplasmic protein probably involved in the transport of sulfur compounds. (expasy.org)

Structural genomics reveals EVE as a new ASCH/PUA-related domain. (rostlab.org)

These findings raise the need for further structural analyses on Pi GlcK-1. (scientificarchives.com)

Various stress response proteins (heat shock, phage shock, cold shock) from all phyla. (expasy.org)

The Cdc25 family of protein dual specificity phosphatases (EC 3.1.3.48 ). (expasy.org)

Our lab investigates unconventional mechanisms of protein secretion from mammalian cells. (db-engine.de)

These proteins contain two related domains known as the chromo- and the chromoshadow-domain. (cipsm.de)
Mutations that constitutively activate the protein at pH 7 map to the PAS domain. (essex.ac.uk)
Rhodanese-like proteins are either composed of a single catlytic rhodanese domain, as found in glpE, or composed of two rhodanese domains, with the C-terminal domain displaying the putative catalytic Cys as observed in Rhobov and rhdA. (expasy.org)
We also developed a profile which covers the entire rhodanese homology domain. (expasy.org)
We also constructed, by homology modeling, a theoretical structure of the pUL105 N-terminal domain which indicates that the mutated conserved amino acids in this domain could be involved in ATP hydrolysis. (frontiersin.org)
A complex with the substrate analogue N-acetyl-glucosamine was refined to 2.25 A resolution, revealing interactions of an aspartic acid and three histidines, all conserved in the NodB homology domain, with the ligand. (rcsb.org)
Taxonomic distribution of proteins containing FN3 domain. (embl.de)
The complete taxonomic breakdown of all proteins with FN3 domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing FN3 domain in the selected taxonomic class. (embl.de)
The Src Homology 2 (SH2) domain is a major protein interaction module that is central to tyrosine kinase signaling. (eu.org)
Mutations identified in many SH2 domain-containing proteins as well as the SH2 domain itself are associated with human diseases ranging from cancers, diabetes, to immunodeficiencies. (eu.org)
The C-terminal half of the SH2 domain exhibits greater structural variability and provides a platform for accommodating different kinds of SH2-binding motifs. (eu.org)

The Tir protein of EPEC binds NCK1/NCK2 SH2 domains through a high affinity pYDEV motif ( Frese,2006 ). (eu.org)

New drugs targeting essential viral proteins other than pUL54 are therefore urgently needed. (frontiersin.org)

Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)
Important proteins for TVISS are also haemolysin coregulated protein (Hcp), which has a hexameric, tubular structure, and VgrG protein (valine-glycine repeat G). VgrG plays a dual role in the process: is a chaperone protein in the secretion of effector toxin or/and is secreted as a toxin itself. (am-online.org)

We have produced a topology model of a C. cellulolyticum dockerin and of a Cc-cohesin/dockerin complex using homology modeling and available biochemical data. (rcsb.org)

Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)

Rhodanese homology domains are structural modules of about 120 amino acids, which occur in the three major evolutionary phyla [ 9 ]. (expasy.org)

However, experimental determination of protein structures remains a costly and time-consuming challenge. (scientificarchives.com)

We find that the electrophysiological and structural properties of these proteins indicate that they are new members of the ligand-gated ion channel superfamily. (nih.gov)

ACCESSION AP009048-129 PROTEIN_ID BAB96710.2 SOURCE Escherichia coli str. (nig.ac.jp)

These methods dramatically increase the likelihood of producing proteins that cannot fold or assemble appropriately. (cipsm.de)

Some animal proteins, for example, those in the LAT family (TC# 2.A.3.8) including ASUR4 (gbY12716) and SPRM1 (gbL25068) associate with a type 1 transmembrane glycoprotein that is essential for insertion or activity of the permease and forms a disulfide bridge with it. (tcdb.org)
They are members of the rBAT family of mammalian proteins (TC #8.A.9). (tcdb.org)

Anatomy7

Organisms17

Diseases1

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes72

Disciplines and Occupations1

Information Science4

Health Care2

Sequence17

Genes7

Functional6

Gene10

Sequences3

Subunit1

Molecular5

Bacterial5

Abstract1

Membrane11

Antimicrobial proteins2

Intracellular2

Expression3

O157:H71

Bacillus3

Enzymes6

Pathogens2

Conformation3

Silico2

Purification1

Homologue3

Nucleic Aci1

Strains2

Extracellular2

Shiga1

Prediction1

Residues1

Eukaryotic2

Recombinant protein1

Enzyme3

Characterization1

Homo1

Transcription1

Periplasmic1

Reveals1

Analyses1

Cold-shock1

Phosphatases1

Mammalian cells1

Domain12

Binds1

Viral1

Secretion2

Biochemical1

Regulation1

Amino acids1

Structures1

Superfamily1

ACCESSION1

Fold1

Family2