• In view of the role for the Src homology domain 2-bearing protein tyrosine phosphatase- 1 (SHP-1) in modulating TCR signaling, we investigated the influence of SHP- 1 on TCR-mediated apoptosis by assaying the sensitivity of peripheral T cells from SHP-1-deficient viable motheaten (me(v)) mice to cell death following TCR restimulation. (elsevier.com)
  • Involvement of interleukin-1beta in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120-induced apoptosis in the neocortex of rat. (semanticscholar.org)
  • Src homology phosphotyrosyl phosphatase 2 mediates cisplatin-related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells. (nih.gov)
  • Furthermore, IL-6 is required for experimentally induced autoimmune diseases or autoimmunity, including type II collagen- and antigen-induced arthritis ( 18 - 20 ), myelin oligodendrocyte protein-induced experimental autoimmune encephalomyelitis ( 21 , 22 ), and pristane-induced autoantibody production ( 23 ). (rupress.org)
  • The inhibitory effect of IL-6 on Fas ligand expression during activation-induced cell death (AICD) was augmented in gp130 F759/F759 T cells in a manner dependent on the tyrosine residues of gp130 required for signal transducer and activator of transcription 3 activation. (rupress.org)
  • The transcription factor signal transducer and activator of transcription (STAT)-3 is recruited to the phosphorylated tyrosine residues in the YXXQ motif of gp130, where it is activated and dimerized, and subsequently enters the nucleus and regulates gene expression ( 24 , 25 ). (rupress.org)
  • In summary, we have discovered a specific cross-talk between the adenylate cyclase cascade and the IL-6-induced MAPK (mitogen-activated protein kinase) cascade and have investigated its impact on IL-6-dependent gene expression. (biochemj.org)
  • WMJ-S-001 induced p38 mitogen-activated protein kinase (p38MAPK) activation. (frontiersin.org)
  • Gene transcripts and protein expression of cytokines and chemokines produced by microglia will be investigated after stimulation of Siglec-11. (dana.org)
  • The present study used full sequences of the cagA gene and CagA protein of 22 H. pylori strains in gastric cancer and peptic ulcer patients from Southern Vietnam to make a comparison of genetic homology among Vietnamese strains and between them and other strains in East Asia. (pubmedcentralcanada.ca)
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. (nih.gov)
  • In addition, the unique insert sequence of PTPX1 shares identity with PSSA, a protein involved in phosphatidylserine biosynthesis. (cshl.edu)
  • However, this model has not been validated in normal T cells, and it has been challenged by evidence that a T cell line lacking detectable SHP-2 is still inhibited by CTLA-4 ligation and by the failure to demonstrate direct interaction between CTLA-4 and SHP-2 proteins in vitro ( 14 ). (jimmunol.org)
  • 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drospohila DSTPK61 kinase. (springer.com)
  • Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. (springer.com)
  • Schmidt N, Thieu V, Mann B, Ahyi A, Kaplan M. Bruton's tyrosine kinase is required for TLR-induced IL-10 production. (labome.org)
  • Mitogenic hyperresponsiveness of synovial cells to the LIF/IL-6 family of cyto-kines was caused by sustained gp130-mediated SHP-2/ras/Erk activation due to impaired STAT-mediated induction of suppressor of cytokine signaling (SOCS) proteins which normally limits gp130 signaling. (rupress.org)
  • Beside many other activities, IL-6 is the major inducer of acute phase proteins in the liver, acts as a differentiation factor for blood cells, as migration factor for T-cells and is a potent inducer of the chemokine MCP-1 (monocyte chemoattractant protein-1). (biochemj.org)
  • Type I fibrillar collagen may be the most abundant proteins in our body crucial for the development and power of bones epidermis and tendon. (achemmic.com)
  • CagA is encoded by cagA , located in the cagPAI (pathogenicity island) region of the H. pylori genome, and the presence of this protein is a marker of cagPAI . (pubmedcentralcanada.ca)