Sequence1
- GTx1-15 displays sequence homology with other ion channel toxins from several spider species. (wikipedia.org)
Peptide1
- This peptide has a molecular weight of approximately 4 kDa and is amidated at its carboxy terminus. (wikipedia.org)
Calcium4
- GTx1-15 is a toxin from the Chilean tarantula venom that acts as both a voltage-gated calcium channel blocker and a voltage-gated sodium channel blocker. (wikipedia.org)
- It specifically inhibits: T-type calcium channel Cav3.1 Sodium channels Nav1. (wikipedia.org)
- They are members of the large 4x6 ion channel family, which also include the voltage gated calcium channels, and NALCN channels. (uwaterloo.ca)
- Despite the structural homology with Nav1, the selectivity filter DEEA makes the Nav2 channel calcium selective. (uwaterloo.ca)
Human2
- The effectiveness of GTx1-15 as a blocker of human cloned Nav and Cav channels is summarized below: Ono S, Kimura T, Kubo T (September 2011). (wikipedia.org)
- Unlike the highly conserved α- subunits, the multifunctional auxiliary subunits of human sodium channel, β1-4, have no structural analogs among invertebrates, although insectal Tip-E and TEH have a similar function. (uwaterloo.ca)