Homologue gene of drosophila. Medical search. Frequent questions

Homologues of PIAS proteins have been found in other eukaryotes, including Zimp/dPIAS in Drosophila melanogaster and zfPIAS4a in zebrafish. (wikipedia.org)
Homologues of PIAS proteins have been found in other eukaryotes, and several are listed below: Zimp/dPIAS in Drosophila melanogaster zfPIAS4a in zebrafish SIZ1 and SIZ2 in yeast PIAS proteins contribute to the control of gene expression, and may be considered transcriptional co-regulators. (wikipedia.org)
Show all known regulatory elements for a particular D. melanogaster gene. (flymine.org)
For a certain D. melanogaster gene, show the results from the BDGP in situ project. (flymine.org)
After acute injury in muscle of both mouse and the fruit fly Drosophila melanogaster (used as alternative in vivo model) this study found that RACK1 accumulated in regenerating fibers while it declined with the progression of repair process. (sdbonline.org)
Made using the fly model Drosophila melanogaster, this finding has been published in PloS Genetics this week. (sciencedaily.com)
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. (genscript.com)
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders. (genscript.com)
Sequence finishing and mapping of Drosophila melanogaster heterochromatin. (genscript.com)
The Release 5.1 annotation of Drosophila melanogaster heterochromatin. (genscript.com)
Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
Identification of transcription and processing signals of ribosomal genes of D. melanogaster. (cnr.it)
Genes + D. melanogaster homologues (filter on BLAST E-Value). (dbcls.jp)
Chromosomal location + Gene + D. melanogaster orthologue + Pathway. (dbcls.jp)
For a particular A. gambiae EST clone, show its chromosomal location, the corresponding A. gambiae gene, the D. melanogaster orthologue and the pathway. (dbcls.jp)
The intersex (ix) gene works in concert with doublesex (dsx) at the bottom of the sex-determination hierarchy to control somatic sexual differentiation in Drosophila melanogaster females. (unina.it)
The expression of Mvix cDNA in D.melanogaster transgenic flies indicates that the MvIX product, which shares a relatively high degree of homology with the D.melanogaster IX protein, is able to partially rescues the Drosophila mutant phenotype. (unina.it)

rbf1 , the Drosophila homolog of Rb , also displays a pro- apoptotic activity in proliferative cells. (sdbonline.org)
Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation and demonstrate its application to mammalian embryos. (homologyeffects.org)
Trans -homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. (homologyeffects.org)
Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans -homolog interactions in a Drosophila hybrid cell line and investigate complex types of pairing and functional roles. (homologyeffects.org)
The Mvix gene exhibits major complexity with respect to the Drosophila homolog. (unina.it)

Apart from PIAS1, each gene encodes two protein isoforms. (wikipedia.org)
Due to alternative splicing, some PIAS protein-encoding genes encode multiple protein products called isoforms. (wikipedia.org)
The CRB1 gene provides instructions for making a protein that plays an essential role in normal vision. (medlineplus.gov)
Most of the CRB1 gene variants responsible for Leber congenital amaurosis lead to an abnormally short, nonfunctional version of the CRB1 protein or significantly reduce the amount of this protein produced in cells. (medlineplus.gov)
This gene encodes a multi-domain scaffolding protein that is required for normal development. (thermofisher.com)
The human eight twenty-one (ETO, MTG8 or CBFA2T1) and related myeloid transforming gene products MTGR1 and MTG16 as well as the Nervy protein contain the NHR1-4 domains. (embl-heidelberg.de)
Molecular cloning of cDNA indicated that the AML1-MTG8-binding protein (MTGR1) is highly related to MTG8 and similar to Drosophila Nervy. (embl-heidelberg.de)
The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. (hindawi.com)
Mammalian tuberin protein, the product of a familial tuberous sclerosis gene which, when deleted, causes begnin tumours. (embl.de)
Drosophila Gigas protein, an homologue of tuberin involved in regulation of cell cycle. (embl.de)
The results suggest that the eIF4A gene is under the control of the DREF pathway and DREF is therefore involved in the regulation of protein synthesis. (genscript.com)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
Buffy often acts opposite to Debcl , the other Drosophila Bcl-2-family protein. (sdbonline.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
Genetic analysis has uncovered that genes necessary for epithelial polarity code for cytoskeletal proteins and their regulators, like the par-3 protein Bazooka ( Kuchinke, Grawe & Knust, 1998 ) or the EGF and laminin domains-containing protein Crumbs ( Tepass, Theres & Knust, 1990 ). (peerj.com)
In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
One example is the conserved Drosophila tumor-suppressor protein Lethal giant larvae (Lgl). (biologists.com)

The seven proteins that belong to the mammalian PIAS family are encoded by four genes: PIAS1, PIAS2 (PIASx), PIAS3, and PIAS4 (PIASy). (wikipedia.org)
A novel cross-phylum family of proteins comprises a KRR1 (YCL059c) gene which is essential for viability of Saccharomyces cerevisiae cells. (nih.gov)
Leber congenital amaurosis: genes, proteins and disease mechanisms. (medlineplus.gov)
These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
Signaling genes necessary for orchestrating these processes (like the JNK pathway ( Rios-Barrera & Riesgo-Escovar, 2013 )) regulate cytoskeletal proteins, like the FERM-domain proteins Coracle ( Fehon, Dawson & Artavanis-Tsakonas, 1994 ) and Yurt ( Hoover & Bryant, 2002 ). (peerj.com)
However, since proteins with similar activities are present in mammals and since their mechanisms are likely to be conserved even if true sequence homologues are not identified, understanding how Rpr, Hid, and Grim act to bring about death is an important area of research. (caltech.edu)
these proteins are also important in regulating gene transcription. (biomedcentral.com)
Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. (embl-heidelberg.de)
The chromo and SET domains are conserved sequence motifs present in chromosomal proteins that function in epigenetic control of gene expression, presumably by modulating higher order chromatin. (embl-heidelberg.de)
In addition, Suv39h1/SUV39H1 proteins associate with M31, currently the only other characterized mammalian SU(VAR) homologue. (embl-heidelberg.de)

Mutations in trpÎ³, the homologue of TRPC6 autism candidate gene, causes autism-like behavioral deficits in Drosophila. (bvsalud.org)
In addition, they show that the behavioral defects caused by mutations in TRPC6 can be modeled in Drosophila , thereby establishing a paradigm to examine the impact of mutations in other candidate genes . (bvsalud.org)
Many variants (also called mutations) in the CRB1 gene have been found to cause Leber congenital amaurosis. (medlineplus.gov)
Leber congenital amaurosis and retinitis pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs homologue 1 (CRB1) gene. (medlineplus.gov)
Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12). (medlineplus.gov)
Mutations in the CRB1 gene cause Leber congenital amaurosis. (medlineplus.gov)
Mutations in some genes cause rare forms of T2DM, giving additional support for the genetic roles in the aetiology of the disease. (scialert.net)
Rothmund-Thomson syndrome, or poikiloderma congenitale, is a rare autosomal recessive disorder attributed to mutations of the RECQL4 helicase gene on 8q24. (medscape.com)
Rothmund-Thomson syndrome (poikiloderma congenitale) has been attributed to mutations of the RECQL4 gene on 8q24, which encodes a RecQ DNA helicase. (medscape.com)
Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. (medscape.com)
Rothmund-Thomson Syndrome: novel pathogenic mutations and frequencies of variants in the RECQL4 and USB1 (C16orf57) gene. (medscape.com)
Rare mutations have been described in genes involved in ovarian development and/or function such as FSHR (MIM 136435), LHCGR (MIM 152790), BMP15 (MIM 300247), POF1B (MIM 300603), NOBOX (MIM 610934), INHA (MIM 147380), GDF9 (MIM 601918), NR5A1 (MIM 184757), and FIGLA (MIM 608697) and in meiotic genes [ 9 - 23 ]. (hindawi.com)
Nevertheless, mutations in these genes account for a minority of cases of ovarian dysfunction, indicating that additional factors remain to be identified. (hindawi.com)
chem mutations genetically interact with mutations in cytoskeletal genes ( arm ) and with mutations in the epithelial polarity genes coracle, crumbs, and yurt . (peerj.com)
Mutations in genes with less extreme phenotypes may result in impaired cell movement and cell shape changes, hampering or preventing embryonic dorsal closure and head involution ( Rios-Barrera & Riesgo-Escovar, 2013 ). (peerj.com)
There are currently 20 retinal genes whose mutations cause the phenotype of LCA, accounting for about 70% of the cases, while the genes underlying the remaining 30% of patients await discovery. (aao.org)
Visual acuity (VA) in children with LCA varies significantly among patients with differing gene mutations and can be as low as no light perception (NLP). (aao.org)
What [MUTATIONS] in apolipoprotein genes are associated with disease? (dbcls.jp)

Based on this expression pattern, we conclude that Six3 is one of the most anterior homeobox gene reported to date. (nih.gov)
The high sequence similarity of Six3 with the Drosophila sine oculis, and its expression during eye development, suggests that this gene is the likely murine homologue. (nih.gov)
Finally, based on the chromosomal localization and the expression pattern of the mouse Six3 gene, the human Six3 cognate could be a good candidate to be at least one of the genes affected in patients with holoprosencephaly type 2 due to an interstitial deletion of 2p21-p22. (nih.gov)
Earlier studies using a candidate gene approach, family linkage studies and gene expression profiling uncovered a number of T2DM genes, but the genetic basis of common T2DM remained unknown. (scialert.net)
They can bind to the 3′ untranslated region (3′UTR) of target messenger RNAs (mRNAs) in order to regulate gene expression post-transcriptionally with no sequence specificity but by potential electrostatic interactions with the phosphate backbone of RNA 2 , 3 . (nature.com)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
Developmental dynamics of gene expression and alternative polyadenylation in the Caenorhabditis elegans germline. (nyu.edu)
beta-Actin-dependent global chromatin organization and gene expression programs control cellular identity. (nyu.edu)
For Aim 1, we analyzed both over-expression and loss of function for dfxr in sensory neurons in Drosophila. (fraxa.org)
Real-time PCR was used to study the expression pattern of formin genes. (biomedcentral.com)
Expression of forC, D, I and J increased during transition to multi-cellular stages, while the rest of genes displayed less marked developmental variations. (biomedcentral.com)
The type I target gene folded gastrulation is activated only in response to peak levels of the Dl gradient, so that expression is restricted to a subdomain of the presumptive mesoderm. (sdbonline.org)
The zerknullt target gene is repressed by high and low levels of the gradient, so that expression is restricted to the presumptive dorsal ectoderm. (sdbonline.org)
The directed expression of alpha-synuclein , a gene contributing to inherited forms of Parkinson disease (PD), in the dopaminergic neurons (DA) of flies provides a robust model of PD complete with the loss of neurons and accompanying motor defects. (sdbonline.org)
To alter the expression of Buffy in the dopaminergic neurons of Drosophila. (sdbonline.org)
The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
Subsequently, the expression of Buffy was altered in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Expression analysis of several Hox genes in human embryos. (cnr.it)
Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development. (cnr.it)
Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp). (cnr.it)
Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene. (cnr.it)
In 1995, Walter Gehring demonstrated the importance of Pax6 in an elegant experiment in which targeted ectopic expression of this gene in the fly generated eyes on legs, wings or antennae. (balzan.org)
Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. (homologyeffects.org)
ENU during the final week of gestat the rapidly changing patterns of gene In both the fetus and the pregnant ion is approximately 50 times that of expression in fetal target tissues, female rat, the target organ for single the mother. (who.int)
Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma. (medscape.com)

There are five distinct thresholds of gene activity in response to the Dorsal nuclear gradient in early embryos. (sdbonline.org)

The inhibition of porin under the control of neuronal Ddc-Gal4 result in short lifespan and in an age-dependent loss in locomotor function, phenotypes that are strongly associated with Drosophila models of Parkinson disease . (sdbonline.org)
Besides originally categorizing mutant phenotypes and gene classes, these studies lead to many mechanistic insights and principles of developmental processes. (peerj.com)

In this paper, we report the isolation of a sequence-related gene referred to as Six3. (nih.gov)
Based on its amino acid sequence, this gene can be included in the new Six/sine oculis subclass of homeobox genes. (nih.gov)
First, molecular events in T2DM pathogenesis have been examined directly by testing the role of sequence variants of specific candidate genes. (scialert.net)
The candidate gene approach focuses on the search for an association between T2DM and sequence variants in or near biologically defined candidate genes which have been chosen based on their known physiological function. (scialert.net)
Comparison of the three predicted human MTG8-related polypeptides to their Drosophila counterpart (nervy) highlights four separate regions of sequence conservation that may correspond to distinct domains. (embl-heidelberg.de)
Can you describe the sequence that led to the discovery of the sonic hedgehog gene? (learner.org)
The following eIF4A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
The ingenious scientist Walter Gehring then discovered (independently from Matthew Scott's group in the USA) that all homeotic genes have a 180 base pair sequence in common that he called the Homeobox. (balzan.org)
Following completion of the Drosophila genome sequence, we carried out comprehensive BLAST searches to annotate it with respect to apoptosis, and found sequence homologues of virtually all mammalian cell death genes with the exception of death receptors. (caltech.edu)
Based on sequence information from the SET domain, we have isolated human (SUV39H1) and mouse (Suv39h1) homologues of the dominant Drosophila modifier of position-effect-variegation (PEV) Su(var)3-9. (embl-heidelberg.de)

This finding supports the idea that mammals and insects share control genes such as eyeless/Pax6 (Halder, G., Callaerts, P. and Gehring, W. J. (1995) Science 267, 1788-1792), and also possibly other members of the regulatory cascade required for eye morphogenesis. (nih.gov)
The results strengthen the notion that was already being put forward in cancer research," explains Jordi Casanova, head of the Development and Morphogenesis in Drosophila lab and CSIC professor. (sciencedaily.com)

Simultaneous work in the field of developmental biology and work with Drosophila has established the INT1 gene is a homologue of the Drosophila segment polarity gene [2]. (chemdiv.com)
In addition, we show that these alleles genetically interact with epithelial polarity genes, and have epithelial polarity defects. (peerj.com)
In Drosophila and mammals, Lgl contributes to the maintenance of cell polarity and plays a role in asymmetric cell division. (biologists.com)

Show all alleles for a specific Drosophila gene. (flymine.org)

The TRPC6 ( transient receptor potential channel 6) represents an ASD candidate gene under an oligogenic/multifactorial model based on the initial description and cellular characterization of an individual with ASD bearing a de novo heterozygous mutation disrupting TRPC6 , together with the enrichment of disruptive TRPC6 variants in ASD cases as compared to controls. (bvsalud.org)
Isolation and characterization of alternative messenger RNAs coding class I HLA genes. (cnr.it)
Drosophila embryogenesis has proven to be an extremely powerful system for developmental gene discovery and characterization. (peerj.com)
Cloning and functional characterization of the intersex homologous gene in the pest lepidopteron Maruca vitrata. (unina.it)
Here we report the isolation and characterization of the Drosophila intersex (ix) homologue in the pest lepidopteron Maruca vitrata (Mvix). (unina.it)

This gene encodes a member of the trithorax group of transcriptional activators. (cancerindex.org)

Although Drosophila data strongly suggest a tight link between Dpp signaling and the Dachshund gene, a functional relationship between vertebrate Dach and BMP signaling remains undemonstrated. (biologists.com)
We showed that sarcolamban, encoding two smORFs of 28 and 29aa, is the true homologue of the vertebrate genes sarcolipin and phospholamban. (cabd.es)

More than 30 mammalian genes comprise the TGFβ superfamily of growth factors. (nature.com)
Moreover, the conservation of this genetic control of eye development throughout evolution was demonstrated by the fact that insect and mammalian genes are interchangeable. (balzan.org)

Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. (homologyeffects.org)

Mutants with a loss of the function of Pax6 (or its homologues Eyeless in Drosophila, Small eye in mouse, Aniridia in human) prevent eye development at early stages. (balzan.org)

PIAS1 is the only gene of this family that does not encode any isoforms. (wikipedia.org)
Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. (thermofisher.com)

3. Assembling genes involved in dendritic filopodia development into genetic signaling pathways and biochemical complexes. (fraxa.org)
Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)

The Drosophila sine oculis homeobox-containing gene is known to play an essential role in controlling the initial events of pattern formation in the eye disc and is also required for the development of other parts of the fly visual system including the optic lobes. (nih.gov)
Isolation and identification of the structural organization of the human homeobox gene family (HOX Complex). (cnr.it)
With Eddy De Robertis, he was the first to demonstrate the evolutionary conservation of Homeobox-containing genes present in all metazoan Bilateria, where they play a key role in patterning the body plan. (balzan.org)
This allows to conclude that Homeobox-containing genes are coding for transcription factors which regulate the activity of other genes. (balzan.org)
On this basis, Homeobox-containing genes are called developmental control genes. (balzan.org)
Walter Gehring made a second discovery of fundamental importance in developmental biology as he identified the Pax6 gene (which contains a Homeobox as well), a "master control gene" for eye development in all animals, including humans. (balzan.org)

p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization. (medscape.com)
The first gene we are identifying from this screen maps to a region containing Futsch, a MAP1B homologue, which regulates Fragile X in Drosophila. (fraxa.org)
Physical mapping studies indicate that all patients with the common deletion are haploinsufficient for subunit 3 of the COP9 signalosome ( COPS3 ), which is conserved from plants to humans, and in the plant Arabidopis thaliana regulates gene transcription in response to light. (bmj.com)

Dorsoventral (DV) patterning of the Drosophila embryo is initiated by a broad Dorsal (Dl) nuclear gradient, which is regulated by a conserved signaling pathway that includes the Toll receptor and Pelle kinase. (sdbonline.org)

In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila. (wikigenes.org)
The Huang (1997) paper also clearly summarizes what is known about the regulation of genes involved in dorsal/ventral patterning. (sdbonline.org)
Chromatin-dependent gene regulation is demonstrated by the potential of human SUV39H1 to increase repression of the pericentromeric white marker gene in transgenic flies. (embl-heidelberg.de)

For example, since most diseases are multigenic in origin, we are generating genome-wide genetic interaction maps for genes with essential roles in the early embryo that will help us understand how these interactions affect embryogenesis. (nyu.edu)
This overlap made us question whether the so-called epithelial-mesenchymal factors -- which activate genes associated with cell movement and migration, which are common in embryo development and are also present in metastasis -- play a role in tumour initiation," says Casanova. (sciencedaily.com)
The analysis of both authentic Dorsal target genes and defined synthetic promoters suggests that the ectopic gradient is sufficient to generate the full repertory of DV patterning responses along the AP axis of the embryo. (sdbonline.org)
For example, mesoderm determinants are activated in the anterior third of the embryo, whereas neurogenic genes are expressed in central regions. (sdbonline.org)
Shimmi, O., Umulis, D., Othmer, H. & O'Connor, M. B. Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo. (nature.com)

No prior knowledge of gene or gene effects is necessary, but the genetic locus must have sufficient impact on the disease susceptibility to be detectable. (scialert.net)
In this regard, this gene causes overgrowth of the wing, modifies tissue structure, and activates a series of genetic changes in order to facilitate initial tumour growth. (sciencedaily.com)
1. Testing the genetic requirements of dfxr (Drosophila Fragile X related gene) in dendritic filopodia development. (fraxa.org)
We are developing a genetic model for analyzing dendrite and dendritic spine development utilizing Drosophila, or fruit flies. (fraxa.org)
Title: A genetic screen for maternal-effect suppressors of decapentaplegic identifies the eukaryotic translation initiation factor 4A in Drosophila. (genscript.com)
Role of Otx1 and Otx2 in brain evolution: functional equivalence between the invertebrate Orthodenticle and the murine OTX1 and OTX2 gene products supports a conserved genetic program of brain development between insects and mammals. (cnr.it)
Other genes whose mutation produces homeotic transformations were discovered and analysed by Edward Lewis in the United States using classical genetic techniques. (balzan.org)

The two successive nanos gene duplications may result from the second and third whole genome duplication events at the basis of Vertebrates and Teleosts respectively. (nature.com)
In Vertebrates, three Nanos paralogous genes were described. (nature.com)
Taken together, these data identify Nanos as primordial genes with highly conserved functions for both, the migration of the germinal cells and their maintenance in adults. (nature.com)
In Vertebrates, Nanos paralogous genes were associated to partial redundancies and specific functional evolutions. (nature.com)
Nanos was first identified in Drosophila , where it represses the translation of target mRNAs through binding to their 3′ UTR and has a conserved function in germ cell development across species. (hindawi.com)
Members of the evolutionarily conserved Nanos gene family are preferentially expressed in the ovaries and are known to play an important role in germ cell development, maintenance, and survival [ 24 - 30 ]. (hindawi.com)
In Drosophila, the single Nanos gene (Nos) is required for development of the abdomen as well as for germ line maintenance [ 31 , 32 ]. (hindawi.com)
Three Nanos homologues exist in mouse, with Nanos2 and Nanos3 functioning primarily in male germ cell development and maintaining PGCs viability, respectively [ 33 , 34 ]. (hindawi.com)

The transcription factor of the Pax6 gene is critical for the development of the eye in all organisms endowed with a visual system. (balzan.org)

To overcome the shortcomings of the candidate gene studies, investigators have applied a genome-wide linkage scan strategy in which regularly spaced markers are traced in families and sibling pairs for segregation with T2DM. (scialert.net)

Drosophila has long been an attractive, genetically tractable model system in which to study fundamental processes such as apoptosis which are common to higher eukaryotes. (caltech.edu)

In particular, GATA genes are overexpressed in liver metastasis in colon cancer patients, as well as in several human tumours, such as those of the breast, ovary, pancreas and colon. (sciencedaily.com)
eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary. (genscript.com)

Approximately 20 genes consistently associated with T2DM mainly implicate pancreatic β-cell function in the pathogenesis of T2DM. (scialert.net)
A major challenge in systems biology is how to extract meaningful biological insights from large heterogeneous data sets that probe different aspects of gene function. (nyu.edu)
This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)
Absence of the Fragile X gene function in both humans and Drosophila results in abnormal behavior and neuroanatomical defects. (fraxa.org)
We hope to identify other genes that function together with the Fragile X gene to properly form dendrites. (fraxa.org)
Histone lysine methylation is part of the histone code that regulated chromatin function and epigenetic control of gene function. (embl-heidelberg.de)
Our aim is not only to understand and predict the function of individual smORFs, but of smORFs as a whole, as a new class of genes in the genome. (cabd.es)
Extrapolation of this result suggests that some 50% of transcribed smORFs could be translated, that is near 12,000 Drosophila smORFs of which currently only 152 have suspected homologues and hence suspected peptide function. (cabd.es)
Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development. (medscape.com)

By integrating diverse functional genomics data, we seek to gain a better understanding of how different groups of genes work together to coordinate cellular and developmental processes. (nyu.edu)

He showed that the Homeodomain binds to specific DNA sequences of the promoter region of certain genes. (balzan.org)

2. Identification of genes required for normal dendritic filopodia development. (fraxa.org)
Title: Identification of the Drosophila eIF4A gene as a target of the DREF transcription factor. (genscript.com)
Identification of an Otx gene-dosage dependent mechanism required for patterning of developing brain and proper positioning of midbrain-hindbrain isthmic organizer. (cnr.it)

In collaboration with Juan Botas (Baylor College of Medicine), we found that high levels of wild-type Ataxin-1 produce effects similar to mutant Ataxin-1 in Drosophila and mice. (bcm.edu)

Researchers have demonstrated that genes activated during metastasis are also able to initiate primary tumor development, and they explain the molecular mechanism involved. (sciencedaily.com)
Researchers headed by Jordi Casanova at the Institute for Research in Biomedicine (IRB Barcelona) now demonstrate that genes activated during metastasis are also able to initiate primary tumour development, and they explain the molecular mechanism involved. (sciencedaily.com)
Proviral infection at the "site of the highest degree" was thought to be the mechanism of carcinogenesis, giving the first name to the gene found along this pathway as INT1. (chemdiv.com)

the fly gene most similar to TRPC6 ), cause a number of behavioral defects that mirror features seen in ASD patients , including deficits in social interactions (based on courtship behavior ), impaired sleep homeostasis (without affecting the circadian control of sleep ), hyperactivity in both young and old flies , and defects in learning and memory . (bvsalud.org)

Variants in the CRB1 gene account for 9 to 13 percent of all cases of this condition. (medlineplus.gov)
The role of HMT gene variants in prostate cancer remains unknown. (cancerindex.org)

This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)

The research was conducted on the fruit fly Drosophila, an established model for studying epithelial tumours. (sciencedaily.com)

We show here that the resultant AML1-MTG8 gene product specifically and strongly interacts with an 85-kDa phosphoprotein. (embl-heidelberg.de)

With a $35,000 grant from FRAXA Research Foundation in 2003, Dr. Jay Brenman and his team at the University of North Carolina utilized the fruit fly (Drosophila) to model disease and examined the fly model of Fragile X in an effort to understand the basic mechanisms of disease. (fraxa.org)

CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. (embl-heidelberg.de)
We characterize two human MTG8-related genes, MTGR1 and MTGR2 (HGMW-approved symbols CBFA2T2 and CBFA2T3). (embl-heidelberg.de)
The study is based on the observation that benign human tumours or tumours at stages well before metastasis express some genes associated with this process. (sciencedaily.com)
Surprisingly, 72% of known human neurological disease genes exist in Drosophila, including the Fragile X gene, so Drosophila has often been used to identify and understand genes that can cause human disease. (fraxa.org)
For a specified human disease, show all associated human genes and their Drosophila homologues as identified with BLAST. (dbcls.jp)

As he was working on his doctorate, he isolated a new mutation in Drosophila causing the transformation of the antennae into legs, a mutation which is called Antennapedia. (balzan.org)

He goes on to say "And that is that the same genes can activate tumour growth and metastasis, and therefore some tumours are conferred metastatic capacity from their very outset. (sciencedaily.com)

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Diseases1

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Analytical, Diagnostic and Therapeutic Techniques and Equipment25

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Information Science4

Health Care3

Melanogaster17

Homolog5

Protein20

Proteins10

Mutations18

Expression27

Embryos1

Phenotypes2

Sequence10

Morphogenesis2

Polarity3

Alleles1

Characterization5

Encodes1

Vertebrate2

Mammalian genes2

Somatic1

Eyeless1

Isoforms2

Pathways2

Homeobox6

Regulates3

Dorsoventral1

Regulation3

Embryo5

Genetic7

Nanos8

Pax61

Genome-wide1

Eukaryotes1

Ovary2

Function9

Functional genomics1

Sequences1

Identification3

Mutant1

Mechanism3

Interactions1

Variants2

Apoptosis1

Epithelial1

Strongly1

Fruit fly1

Human5

Mutation1

Tumours1