• Here we report the production of full-length PfRH5 protein using a cGMP-compliant platform called ExpreS 2 , based on a Drosophila melanogaster Schneider 2 (S2) stable cell line system. (nature.com)
  • Drosophila melanogaster porcupine and its mouse homologue PORCN gene encode transmembrane bound endoplasmic reticulum proteins needed for the secretion of Wnt (Wingless and INT-1) proteins. (medscape.com)
  • In Drosophila melanogaster , the PORCN gene is involved in the processing of the wingless protein. (medscape.com)
  • Recently, these functions have been genetically dissected in the fruit fly Drosophila melanogaster , revealing a crucial role for cell-surface activation of the downstream effector kinase Akt in many of these processes. (silverchair.com)
  • Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
  • Several of the SNF and SWI genes of Saccharomyces cerevisiae encode proteins that are involved in the regulation of transcriptional activation. (bdbiosciences.com)
  • The retinoblastoma protein, Rb, stimulates the transcription of a number of genes. (bdbiosciences.com)
  • Muchardt C, Yaniv M. A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. (bdbiosciences.com)
  • Leber congenital amaurosis: genes, proteins and disease mechanisms. (medlineplus.gov)
  • Immunity genes are activated in the Drosophila fat body by Rel and GATA transcription factors. (sdbonline.org)
  • Surprisingly, 72% of known human neurological disease genes exist in Drosophila, including the Fragile X gene, so Drosophila has often been used to identify and understand genes that can cause human disease. (fraxa.org)
  • Following completion of the Drosophila genome sequence, we carried out comprehensive BLAST searches to annotate it with respect to apoptosis, and found sequence homologues of virtually all mammalian cell death genes with the exception of death receptors. (caltech.edu)
  • The only Drosophila cell death genes for which mammalian homologues have not been identified are the cell death activators Rpr, Hid, and Grim. (caltech.edu)
  • Using the Drosophila nephrocyte as a genetic screen platform, most genes involved in endocytosis and cell trafficking were screened, and the key components were identified of the cell trafficking pathway required for SD protein endocytosis and recycling. (sdbonline.org)
  • All genes in this SD protein endocytosis and recycling pathway, as well as SD proteins themselves, are highly conserved from flies to humans. (sdbonline.org)
  • Thus, these results suggest that the SD proteins in human kidney undergo the same endocytosis and recycling pathway to maintain the filtration structure, and mutations in any genes in this pathway could lead to abnormal SD and renal diseases. (sdbonline.org)
  • Se caracterizan por poseer un dominio de unión al ADN emparejado altamente conservado que se identificó por vez primera en genes de segmentación de DROSOPHILA. (bvsalud.org)
  • They are characterized by a highly conserved paired DNA-binding domain that was first identified in DROSOPHILA segmentation genes. (bvsalud.org)
  • The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. (nature.com)
  • This subfamily corresponds to the RRM in Xmas-2, the Drosophila homolog of yeast Sac3p protein, together with E(y)2, the Drosophila homologue of yeast Sus1p protein, forming an endogenous complex that is required in the regulation of mRNA transport and also involved in the efficient transcription regulation of the heat-shock protein 70 (hsp70) loci. (nih.gov)
  • This study implicates the Drosophila GAK homolog, auxilin (aux) , in a broad spectrum of parkinsonian-like symptoms. (sdbonline.org)
  • rbf1 , the Drosophila homolog of Rb , also displays a pro- apoptotic activity in proliferative cells. (sdbonline.org)
  • Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation and demonstrate its application to mammalian embryos. (homologyeffects.org)
  • Trans -homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. (homologyeffects.org)
  • Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans -homolog interactions in a Drosophila hybrid cell line and investigate complex types of pairing and functional roles. (homologyeffects.org)
  • Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. (biomedcentral.com)
  • Formins are multidomain proteins conserved from plants to fungi and vertebrates. (biomedcentral.com)
  • It can be found associated with other domains such as the BTB domain or the U-box in multidomain proteins. (embl.de)
  • HypE proteins contain a longer insert in their fido domain and are typically multidomain proteins. (expasy.org)
  • Cyclin-G-associated kinase (GAK) , a PD susceptibility gene identified through genome-wide association studies (GWAS), is a ubiquitous serine/threonine kinase involved in clathrin uncoating (see Drosophila Clathrin heavy chain ), though its PD-related function remains elusive. (sdbonline.org)
  • The highly conserved Asp-Gln-Arg triad within the GoLoco motif participates directly in GDP binding by extending the arginine side chain into the nucleotide binding pocket, highly reminiscent of the catalytic arginine finger employed in GTPase-activating protein. (embl-heidelberg.de)
  • Taken together, our findings suggest that the mechanism of signalling by Hedgehog family proteins has been highly conserved during evolution. (syr.edu)
  • In the early embryo, a myosin II-dependent contraction of the cortical meshwork asymmetrically distributes the highly conserved PDZ proteins PAR-3 and PAR-6, as well as an atypical protein kinase C (PKC-3), to the anterior. (biologists.com)
  • The p53 interacting partner protein NUMB (homology of numb protein) preserves this intrinsic cellular asymmetry by preventing ubiquitin-mediated proteolysis of p53 catalyzed by the MDM2 E3 ubiquitin ligase 11 . (nature.com)
  • A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
  • Signalling by members of the Hedgehog family of secreted proteins plays a central role in the development of vertebrate and invertebrate embryos. (syr.edu)
  • use an assay in which alkaline phosphatase-tagged cell surface proteins are used to stain live embryos overexpressing other cell surface proteins to identify Sticks and stones (Sns) as a possible ligand for the Lar receptor protein tyrosine phosphatase. (sciety.org)
  • Singh P, Coe J, Hong W. A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. (bdbiosciences.com)
  • The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
  • In accordance with its tumor suppressor role, the Retinoblastoma protein pRb can ensure pro-apoptotic functions. (sdbonline.org)
  • The high sequence similarity of Six3 with the Drosophila sine oculis, and its expression during eye development, suggests that this gene is the likely murine homologue. (nih.gov)
  • GSC, along with other transcription factors like Twist, FOXC2, and Snail, induce epithelial to mesenchymal transitions by regulating the cell adhesion proteins E-cadherin, α-catenin and γ-catenin expression in epithelial cells. (wikipedia.org)
  • However it has proved challenging to identify a heterologous expression platform that can produce a soluble protein-based vaccine in a manner compliant with current Good Manufacturing Practice (cGMP). (nature.com)
  • The chromo and SET domains are conserved sequence motifs present in chromosomal proteins that function in epigenetic control of gene expression, presumably by modulating higher order chromatin. (embl-heidelberg.de)
  • For Aim 1, we analyzed both over-expression and loss of function for dfxr in sensory neurons in Drosophila. (fraxa.org)
  • Using dominant negative and constitutively active forms of the protein kinase A subunits, we also show that expression of patched1 as well as of other sonic hedgehog targets, is regulated by protein kinase A activity. (syr.edu)
  • Furthermore, we show that the accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2, the fly homologue of the vertebrate lipid-storage protein perilipin. (silverchair.com)
  • To alter the expression of Buffy in the dopaminergic neurons of Drosophila. (sdbonline.org)
  • The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • Subsequently, the expression of Buffy was altered in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • Schymura D, Forstner M, Schultze A, Kröber T, Swevers L, Iatrou K, Krieger J. Antennal expression pattern of two olfactory receptors and an odorant binding protein implicated in host odor detection by the malaria vector Anopheles gambiae . (ijbs.com)
  • In this study, we have explored the expression of these olfactory proteins, as well as the ubiquitous odorant receptor heteromerization partner AgOR7, in the thirteen flagellomeres (segments) of female and male antenna. (ijbs.com)
  • In cancer research, it will provide high-throughput and valuable insights into differences in an individual's tumor as compared with constitutional DNA, mRNA expression, and protein expression and activity. (cnrs.fr)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • We have examined in this study whether or not increased expression of clusterin is able to protect neuronal cells against intracellular protein aggregation and cytotoxicity, characteristics that are strongly implicated in a range of neurodegenerative diseases. (biomedcentral.com)
  • We further showed that the expression of TDP-43 in transgenic Drosophila neurons induced ER stress and that co-expression of clusterin resulted in a dramatic clearance of mislocalized TDP-43 from motor neuron axons, partially rescued locomotor activity and significantly extended lifespan. (biomedcentral.com)
  • We also showed that in Drosophila photoreceptor cells, clusterin co-expression gave ER stress-dependent protection against proteotoxicity arising from both Huntingtin-Q128 and mutant (R406W) human tau. (biomedcentral.com)
  • The first gene we are identifying from this screen maps to a region containing Futsch, a MAP1B homologue, which regulates Fragile X in Drosophila. (fraxa.org)
  • In vitro analysis reveals that LDN193189 inhibits a number of intracellular kinases such as, mitogen activated protein kinase 14 and 8 ( p38and c-Jun N -terminal kinase respectively), as well as those associated with AKT (serine/threonine kinase) and mTOR (mammalian target of rapamycin) signaling mechanisms. (sigmaaldrich.com)
  • In Drosophila, transduction of the Hedgehog signal is intimately associated with the activity of protein kinase A and the product of the segment polarity gene patched. (syr.edu)
  • The PAR proteins include the PDZ domain-containing PAR-3 and PAR-6, the atypical protein kinase PKC-3, the serine/threonine kinase PAR-1 and, in nematodes, the putative ubiquitin E3 ligase PAR-2. (biologists.com)
  • Two classes of intracellular proteins act as inhibitors of G protein activation: GTPase activating proteins (GAPs), which enhance GTP hydrolysis and guanine dissociation inhibitors (GDIs), which inhibit GDP dissociation. (embl-heidelberg.de)
  • Disrupting any component in this pathway led to disrupted SD on the cell surface and intracellular accumulation of mislocalized SD proteins. (sdbonline.org)
  • This work identifies Drosophila S2 cells as a clinically-relevant platform suited for the production of 'difficult-to-make' proteins from Plasmodium parasites, and identifies a PfRH5 sequence variant that can be used for clinical production of a non-glycosylated, soluble full-length protein vaccine immunogen. (nature.com)
  • Based on sequence information from the SET domain, we have isolated human (SUV39H1) and mouse (Suv39h1) homologues of the dominant Drosophila modifier of position-effect-variegation (PEV) Su(var)3-9. (embl-heidelberg.de)
  • However, since proteins with similar activities are present in mammals and since their mechanisms are likely to be conserved even if true sequence homologues are not identified, understanding how Rpr, Hid, and Grim act to bring about death is an important area of research. (caltech.edu)
  • For full protein sequence information download the Certificate of Analysis pdf. (ubiquigent.com)
  • 1995). UBE2D2 shares 95% and 79% sequence identity with the Drosophila and S. cerevisiae homologues respectively. (ubiquigent.com)
  • The proximal half of the Drosophila E-cadherin extracellular region is dispensable for many cadherin-dependent events but required for ventral furrow formation. (brh.co.jp)
  • In vitro, the FH2 domain competes with barbed-end capping proteins and is necessary and sufficient to nucleate actin polymerization, but the FH1 domain, which interacts with profilin-actin, funnels actin to the nucleation vicinity and confers full activity to the molecule [ 1 ]. (biomedcentral.com)
  • Galphao and Pcp2 binding was confirmed in vitro using glutathione S-transferase-Pcp2 fusion proteins and in vitro translated [35S]methionine-labeled Galphao. (embl-heidelberg.de)
  • Direct binding between the two proteins was confirmed in vitro, although it requires extensive multimerization of Lar, and is conserved between PTPRF/D and Nephrin homologues. (sciety.org)
  • We used the amyotrophic lateral sclerosis-associated protein TDP-43 as a primary model to investigate the effects of clusterin on protein aggregation and neurotoxicity in complementary in vitro, neuronal cell and Drosophila systems. (biomedcentral.com)
  • These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
  • Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus. (nih.gov)
  • The FH1 domain is also a binding site for diverse SH3-domain containing proteins like Src-like non-receptor tyrosine kinases, WISH (WASP-interacting SH3 protein) and IRSp53 (insulin receptor substrate) in mammals, and Hof1p in yeast [ 6 ]. (biomedcentral.com)
  • To search for novel proteins that interact with Galphao, a mouse brain library was screened using the yeast two-hybrid interaction system. (embl-heidelberg.de)
  • Yeast RNA polymerase II transcription factor B 73kDa subunit (TFB1), the homologue of BTF2. (embl.de)
  • Yeast DOS2 protein. (embl.de)
  • Transfected Brm, expressed in cells lacking endogenous protein, can cooperate with the glucocorticoid receptor (GR) in transcriptional activation. (bdbiosciences.com)
  • Immunodetection of endogenous Suv39h1/SUV39H1 proteins in a variety of mammalian cell lines reveals enriched distribution at heterochromatic foci during interphase and centromere-specific localization during metaphase. (embl-heidelberg.de)
  • It has also been used to inhibit SMAD (homologues of the Drosophila protein, mothers against decapentaplegic), in order to prevent non neuronal differentiation. (sigmaaldrich.com)
  • The data collected from the whole-exome sequencing, as well as the phenotypical presentation of SAMS, indicates that in mammals, the goosecoid protein is involved with the regulation and migration of neural crest cell fates and other mesodermal patterning, notably joints like the shoulders and hips. (wikipedia.org)
  • In Drosophila and mammals, Lgl contributes to the maintenance of cell polarity and plays a role in asymmetric cell division. (biologists.com)
  • Receptor-like protein-tyrosine phosphatases (RPTPs) have cytoplasmic phosphatase domains and cell adhesion molecule (CAM)-like extracellular domains that interact with cell-surface ligands and/or co-receptors. (sciety.org)
  • BepA, an anti-apoptotic bacterial effector protein, which is a type IV secretion system substrate. (expasy.org)
  • It has been previously shown that rbf1 pro-apoptotic activity depends on its ability to decrease the level of anti-apoptotic proteins such as the Bcl-2 family protein Buffy. (sdbonline.org)
  • We find a striking correlation between the accumulation of patched1 transcripts and cells responding to sonic hedgehog activity both in the neurectoderm and mesoderm, suggesting that like its Drosophila counterpart, patched1 is regulated by sonic hedgehog activity. (syr.edu)
  • Ction mutation in Drosophila blue cheese gene (bchs) outcomes in an age-dependent accumulation of ubiquitinated protein aggregates and amyloid precursor-like proteins and reduces life span. (adenosine-kinase.com)
  • The ability of neurons to manage the burden of misfolded proteins and to resist their accumulation into insoluble protein deposits depends critically on the functioning of molecular chaperones. (biomedcentral.com)
  • GAP proteins specific for Rap contain a conserved region of around 200 amino-acid residues, the RapGAP domain. (embl.de)
  • Alfy is a substantial, 3527 amino acid lengthy protein, which contains many different functional domains, which includes a FYVE domain suggesting an affinity for PI(three)-P wealthy endosomes. (adenosine-kinase.com)
  • In heterotrimeric G-protein signalling, cell surface receptors (GPCRs) are coupled to membrane-associated heterotrimers comprising a GTP-hydrolysing subunit G-alpha and a G-beta/G-gamma dimer. (embl-heidelberg.de)
  • Odor-detection in the malaria mosquito Anopheles gambiae involves large families of diverse proteins, including multiple odorant binding proteins (AgOBPs) and olfactory receptors (AgORs). (ijbs.com)
  • The receptors AgOR1 and AgOR2, as well as the binding protein AgOBP1, have been implicated in the recognition of human host odors. (ijbs.com)
  • MyD88 is an adapter protein in the signal transduction pathway mediated by interleukin-1 (IL-1) and Toll-like receptors. (cnrs.fr)
  • The SD protein endocytosis and recycling pathway was found to contain clathrin , dynamin , AP-2 complex, like-AP180 (Lap) , auxilin and Hsc70-4 (the endocytosis part) followed by Rab11 and the exocyst complex (the recycling part). (sdbonline.org)
  • This study provides the first in vivo evidence of trapped SD proteins in clathrin-coated pits at the plasma membrane when this pathway is disrupted. (sdbonline.org)
  • We found that AR was ubiquitinated by an E3 ubiquitin ligase, myosin regulatory light chain interacting protein (MYLIP) and then degraded through the ubiquitin-proteasome pathway. (oncotarget.com)
  • The enzymes of the ubiquitylation pathway play a pivotal role in a number of cellular processes including regulated and targeted proteosomal degradation of substrate proteins. (ubiquigent.com)
  • In Drosophila, the Toll pathway was originally characterized for its role in the dorsoventral patterning of the embryo. (cnrs.fr)
  • This paper claims to identify a long-sought ligand for the receptor protein tyrosine phosphatase Lar that mediates its functions in neuromuscular junction development, mushroom body development, and photoreceptor axon targeting. (sciety.org)
  • Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
  • The 32-aa MYND domain (for myeloid, Nervy, and Deaf-1) contains non-DNA-binding zinc fingers that are thought to mediate protein-protein interactions (Gross, 1996). (sdbonline.org)
  • Drosophila has long been an attractive, genetically tractable model system in which to study fundamental processes such as apoptosis which are common to higher eukaryotes. (caltech.edu)
  • We identified the strongest of these suppressors as dBruce, a large protein with an N-terminal baculovirus IAP repeat (BIR), characteristic of inhibitors of apoptosis (IAPs), and a C-terminal ubiquitin conjugation domain (E2). (caltech.edu)
  • Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)
  • LDN193189 hydrochloride has been used as an ALK2/3 (type I receptor serine-threonine kinases) inhibitor, to study the effect of TGFβ1/2/3 (tumor growth factor β) and BMP (bone morphogenetic protein) signaling on spinal cord development in zebrafish. (sigmaaldrich.com)
  • STP, serine/threonine protein phosphatase. (rupress.org)
  • The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
  • Together, these results suggested that CNPY2 promoted cell growth of PC cells by inhibition of AR protein degradation through MYLIP-mediated AR ubiquitination. (oncotarget.com)
  • Leber congenital amaurosis and retinitis pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs homologue 1 (CRB1) gene. (medlineplus.gov)
  • Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12). (medlineplus.gov)
  • It is possible some of the other novel mutations we identify will also affect proteins that may have a connection to Fragile X, or we may be able to connect to dfxr in the future. (fraxa.org)
  • Rap small G proteins have been implicated in various cellular processes such as exocytosis, cAMP signalling, cell adhesion and cell proliferation. (embl.de)
  • Since Wnt signaling proteins cannot be released without the PORCN protein, and Wnt signaling is important for normal embryonic development, the defects found in this disorder are related to lack of Wnt signaling. (medscape.com)
  • We have cloned a homologue of patched from the zebrafish Danio rerio and analysed the spatiotemporal regulation of its transcription during embryonic development in both wild-type and mutant animals. (syr.edu)
  • In an experiment that injected cells with GSC and observed the effects of uninjected cells, GSC recruited neighboring uninjected cells in the dorsal blastopore lip of the Xenopus gastrula to form a twinned dorsal axis, suggesting that the goosecoid protein plays a role in the regulation and migration of cells during gastrulation. (wikipedia.org)
  • Drosophila Gigas protein, an homologue of tuberin involved in regulation of cell cycle. (embl.de)
  • The insulin/insulin-like growth factor signalling (IIS) cascade performs a broad range of evolutionarily conserved functions, including the regulation of growth, developmental timing and lifespan, and the control of sugar, protein and lipid metabolism. (silverchair.com)
  • AR protein levels are controlled by both transcriptional regulation [ 4 , 5 ] and post-transcriptional regulation [ 6 ]. (oncotarget.com)
  • 1. Testing the genetic requirements of dfxr (Drosophila Fragile X related gene) in dendritic filopodia development. (fraxa.org)
  • We are developing a genetic model for analyzing dendrite and dendritic spine development utilizing Drosophila, or fruit flies. (fraxa.org)
  • Genetic analysis in Drosophila showed that Pink1 acts upstream of Parkin [258]. (adenosine-kinase.com)
  • The inactive GDP bound form is promoted by GTPase-activating proteins (GAPs). (embl.de)
  • The inhibition of porin under the control of neuronal Ddc-Gal4 result in short lifespan and in an age-dependent loss in locomotor function, phenotypes that are strongly associated with Drosophila models of Parkinson disease . (sdbonline.org)
  • Group A Streptococcus (GAS), a β-haemolytic human pathogen, expresses a NEAT protein, Shr, which binds several haemoproteins and extracellular matrix (ECM) components. (tcdb.org)
  • The human Brm protein has been reported to be a 180 kDa nuclear factor that acts as a transcriptional activator when fused to a heterologus DNA binding domain. (bdbiosciences.com)
  • Hyperactivation of IIS has been implicated in the generation of many different human tumours, which are frequently defective for the tumour-suppressor protein PTEN, a PtdIns(3,4,5)- P 3 phosphatase that directly antagonizes the effects of PI3-kinases( Goberdhan and Wilson,2003b ). (silverchair.com)
  • Alfy, the human homologue of Drosophila blue cheese, is involved in the selective disposal of ubiquitinated protein aggregates. (adenosine-kinase.com)
  • Alfy-mediated aggrephagy makes use of p62/SQSTM1, the human homologue of Drosophila Ref(2)P. Alfy, with each other withBioMed Research International target a variety of OMM substrates for example Mfn: ubiquitinating them and targeting them for proteasomal degradation [257]. (adenosine-kinase.com)
  • Cell-fate-determinant molecule NUMB-interacting protein (TBC1D15) is overexpressed and contributes to p53 degradation in TICs. (nature.com)
  • Protein degradation by the ubiquitin/proteasome system requires 3 types of enzymes and proceeds through 3 steps. (oncotarget.com)
  • Co-immunoprecipitation has shown that the Shigella flexneri effector protein (OspG) interacts with UBE2D2 (Kim et al. (ubiquigent.com)
  • Homeobox protein goosecoid (GSC) is a homeobox protein that is encoded in humans by the GSC gene. (wikipedia.org)
  • Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
  • Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
  • Errors in the formation of goosecoid protein in mice and humans have a range of consequences on the developing embryo typically in regions of neural crest cell derivatives, the hip and shoulder joints, and craniofacial development. (wikipedia.org)
  • Absence of the Fragile X gene function in both humans and Drosophila results in abnormal behavior and neuroanatomical defects. (fraxa.org)
  • In humans, HypE is thought to interact with Huntingtin, one of the major proteins in the Huntington's disease protein interaction network. (expasy.org)
  • Mammalian Purkinje-cell protein-2 (Pcp2). (embl-heidelberg.de)
  • It may function as a cell-type specific modulator for G protein-mediated cell signalling. (embl-heidelberg.de)
  • Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. (embl-heidelberg.de)
  • Pcp2 (Purkinje cell protein-2) was identified as a partner for Galphao in this system. (embl-heidelberg.de)
  • Here, we summarize the major nanoscopic techniques and illustrate how these approaches were used in Drosophila model systems to revisit a series of well-known cell biological phenomena. (bvsalud.org)
  • Gosens I, den Hollander AI, Cremers FP, Roepman R. Composition and function of the Crumbs protein complex in the mammalian retina. (medlineplus.gov)
  • Most of our understanding of Pink1 and Parkin function comes from Drosophila. (adenosine-kinase.com)
  • Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development. (medscape.com)
  • This signaling mechanism is predicted to be functionally similar to other posttranslation modifications such as phosphorylation, SUMOylation or acetylation, because the added moiety changes the activity of the modified protein. (expasy.org)
  • With the examples of synaptic active zones, centrosomes and sarcomeres, we will explain the instrumental role of super-resolution imaging pioneered in Drosophila in understanding fundamental subcellular constituents. (bvsalud.org)
  • Various Arabidopsis thaliana (Mouse-ear cress) hypothetical proteins. (embl.de)
  • also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). (cancerindex.org)