Homologous protein caenorhabditis elegans proteins. Medical search. Frequent questions

For Caenorhabditis elegans (roundworm) or Drosophila (fruitfly) that live for 2-3 weeks or 2-3 months, respectively, aging occurs on a much smaller time scale of days to weeks. (biomedcentral.com)
First identified in Drosophila, the conserved Polycomb group (Pc-G) protein complexes were shown to be both writers (Polycomb Repressive Complex 2, PRC2) and readers (Polycomb Repressive Complex 1, PRC1) of H3K27me3 [ 19 , 20 , 21 ]. (biomedcentral.com)
Here we report the identification of a new receptor homologous to mGluRs found in Anopheles gambiae, Apis mellifera, and Drosophila melanogaster genomes and called AmXR, HBmXR, and DmXR, respectively (the mXRs group). (pasteur.fr)
They have only been studied in a few model organisms, such as Drosophila melanogaster , Caenorhabditis elegans , Schmidtea mediterranea and some vertebrates. (biomedcentral.com)
The repeat is found in a variety of proteins that include, vitellogenin receptor from Drosophila melanogaster, low-density lipoprotein (LDL) receptor [ ( PUBMED:6091915 ) ], preproepidermal growth factor, and nidogen (entactin). (embl.de)
We study a median of 16,101 genes across 2 mammalian genomes (human, mouse), 12 Drosophila genomes, 5 Caenorhabditis genomes, and an outgroup yeast genome, and demonstrate that accurate inference of evolutionary relationships and events across these species must account for frequent gene-tree topology errors due to both incomplete lineage sorting and insufficient phylogenetic signal. (biorxiv.org)
Double-stranded RNA (dsRNA) is a potent initiator of gene silencing in a diverse group of organisms that includes plants, Caenorhabditis elegans, Drosophila and mammals. (biomedcentral.com)

The powerful genetics, simple anatomy and short life span of the nematode Caenorhabditis elegans offer unique advantages in unraveling the molecular genetic network that regulates the integrity of neuronal structures and functions during aging. (biomedcentral.com)
The research group Genetics and Behavioral Disorders from the Maimonides Institute for Biomedical Research (IMIBIC) and the University of Cordoba has analyzed the effects of testosterone on the behavior of the nematode ("worm") Caenorhabditis elegans. (uco.es)
Here, we used a genomics/proteomics approach (including immunoblot experiments from pigs infected with T. suis ) to prioritize putative immunogenic excretory/secretory (E/S) proteins conserved across and specific to several gastrointestinal (GI) parasitic nematode species. (frontiersin.org)
A cocktail of five recombinant proteins optimized for conserved GI nematode targets was used immunize pigs and test for active antibody responses in both the serum and intestinal ileal fluid of immunized pigs. (frontiersin.org)
Here, we review recent advances, primarily in the nematode C. elegans, that have enhanced our understanding of the molecular mechanisms that enable post-mitotic neurons to maintain their functionality across different life stages. (bvsalud.org)
Egg-Laying and Locomotory Screens with C. elegans Yield a Nematode-Selective Small Molecule Stimulator of Neurotransmitter Release. (roylabutoronto.ca)

CRMP1-4 genes are roughly 60% homologous with the tetramer liver dihydropyrimidinase (DHPase), and also possess a similar structure to members of the metal-dependent amidohydrolases. (wikipedia.org)
In spite of these differences in life span, however, genes or signaling pathways that influence aging of C. elegans or the replicative span of Saccharomyces cerevisiae (baker's yeast) have been shown to be critical for longevity control in fly and in mice [ 1 , 2 ]. (biomedcentral.com)
Embryos homozygous for mutations in the unc-52, pat-2, pat-3, and unc- 112 genes of C. elegans exhibit a similar Pat phenotype. (illinois.edu)
The unc-52 (perlecan), pat-2 α-integrin), and pat-3 (β-integrin) genes encode ECM or transmembrane proteins found at the cell - matrix adhesion sites of both dense bodies and M-lines. (illinois.edu)
Furthermore, we show that integration of two separate phylogenomic pipelines yields increased accuracy, suggesting that their sources of error are independent, and finally, we leverage the resulting annotation of homologous genes to study the functional impact of gene duplication and loss in the context of rich gene expression and functional genomic datasets of the modENCODE, mouse ENCODE, and human ENCODE projects. (biorxiv.org)
The very premise of using model organisms to inform human biology relies on the fact that many biological processes, and the underlying genomic elements that encode them, are frequently conserved across large evolutionary distances, especially for protein-coding genes. (biorxiv.org)
A pair of genes from the same gene family is said to be homologous to each other, and the assumption is that homologous genes are likely to have similar biological functions. (biorxiv.org)
RAB11 was first found from cultured MDCK cell cDNA library screening for homologous genes of yeast YPT1/SEC4[3], and later identified as the 11th member of the Rab family[4]. (researchsquare.com)
Gene coexpression analysis refers to the en masse discovery of coexpressed genes from a large variety of transcriptomic experiments. (mdpi.com)
This entailed mining available transcriptomic and/or genomic sequence datasets for the presence of homologues of known TIMPs, predicting secondary structures of defined protein sequences, systematic phylogenetic analyses and assessment of differential expression of genes encoding putative TIMPs in the developmental stages of A. suum , N. americanus and Schistosoma haematobium which infect the mammalian hosts. (biomedcentral.com)

A team of scientists from the city of Cordoba has studied the effect of testosterone on behavior of the worm Caenorhabditis elegans, with the aim to analyze at the molecular level the interaction between the male hormone and the nervous system. (uco.es)
To Kill a Mocking Worm: Strategies to Improve Caenorhabditis elegans as a Model System for use in Anthelmintic Discovery. (roylabutoronto.ca)

Teneurins are transmembrane proteins that assist morphogenetic processes in many organisms. (biomedcentral.com)
Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. (biomedcentral.com)

A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination. (shibuyahiroki.com)

The new gene encodes a approximately 34-kilodalton protein that is highly homologous to human CPP32, Caenorhabditis elegans cell death protein CED-3, mammalian Ich-1 (Nedd2), and mammalian interleukin-1 beta converting enzyme. (deathbase.org)
Because of its high homology to the C. elegans Ced-3 gene, we named the new gene mammalian Ced-3 homologue Mch2. (deathbase.org)
There are several major differences that distinguish C. elegans neurons from their mammalian counterparts. (biomedcentral.com)
Mammalian Ric-8 proteins act as chaperones to regulate the cellular abundance of heterotrimeric G protein alpha subunits. (stanford.edu)
Characterization of the bip gene of Aspergillus awamori encoding a protein with an HDEL retention signal homologous to the mammalian BiP involved in polypeptide secretion. (wikigenes.org)

Adhesion G-protein-coupled receptors (aGPCRs) are characterized by the presence of auto-proteolysing extracellular regions that are involved in cell-cell and cell-extracellular matrix interactions1. (stanford.edu)
Tissue inhibitors of metalloproteases (TIMPs) are a multifunctional family of proteins that orchestrate extracellular matrix turnover, tissue remodelling and other cellular processes. (biomedcentral.com)
An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)

We previously isolated a C. elegans mutant where one pharyngeal neuron was frequently misplaced, and now show that it corresponds to a novel allele of ten-1 . (biomedcentral.com)
We compare the functions of these factors in specific neuron types of C. elegans with the actions of their orthologs in other invertebrate (D. melanogaster) and vertebrate (M. musculus) systems, highlighting remarkable functional conservation. (bvsalud.org)
In August of the same year, Oliver Hobert (PI) published a paper in Nature entitled "Unique homeobox codes delineate all the neuron classes of C. elegans" using up to 14 strains of "SunyBiotech C.elegans ", which also sets a record for the number of strains edited by SunyBiotech in a single paper. (sunybiotech.com)

The BCFAs biosynthesis in bacteria, Caenorhabditis elegans, mammals and their distribution in human tissues are summarized. (bvsalud.org)
Caenorhabditis elegans - plague bacteria biofilm blocks food intake. (microbiologyresearch.org)

Caenorhabditis elegans ANC-1, an ortholog of Nesprin-1/2, contains actin-binding and KASH domains at opposite ends of a long spectrin-like region. (ucdavis.edu)

The linker of the nucleoskeleton and cytoskeleton (LINC) complex is formed by the conserved interactions between Sad-1 and UNC-84 (SUN) and Klarsicht, ANC-1, SYNE homology (KASH) domain proteins, providing a physical coupling between the nucleoskeleton and cytoskeleton that mediates the transfer of physical forces across the nuclear envelope. (ucdavis.edu)
These two proteins share a region of homology with talin and members of the FERM super-family of proteins. (illinois.edu)
A total of 15 protein sequences with high homology to known eukaryotic TIMPs were predicted from the complement of sequence data available for parasitic helminths and subjected to in-depth bioinformatic analyses. (biomedcentral.com)

Post-translational modification of proteins at lysine residues by reversible acetylation is catalyzed by the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs), which act on both histone and non-histone substrates despite their names. (biomedcentral.com)
Finally, we reflect on recent findings implicating chromatin-modifying proteins, such as histone methyltransferases and Polycomb proteins, in the control of neuronal terminal identity. (bvsalud.org)
Along with PTMs, the partial or complete disassembly of nucleosomes allows the exchange and degradation of pre-existing histone proteins, with the incorporation of newly synthesised histones onto chromatin that can eventually result in the resetting of previous epigenetic marks. (aging-us.com)
These dedicated proteins are generally known as histone chaperones and effectively control histone supply and chromatin dynamics [ 8 ]. (aging-us.com)

1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction. (shibuyahiroki.com)
KASH proteins in the outer nuclear membrane comprise the cytoplasmic half of LINC complexes that connect nuclei to the cytoskeleton. (ucdavis.edu)
At the heart of this network are LINC ( li nker of n ucleoskeleton and c ytoskeleton) complexes made of SUN ( S ad1 and UN C-84) proteins at the inner nuclear membrane and KASH ( K larsicht, A NC-1, and S yne h omology) proteins in the outer nuclear membrane. (ucdavis.edu)
Cryogenic electron microscopy (cryo-EM) has widened the field of structure-based drug discovery by allowing for routine determination of membrane protein structures previously intractable. (stanford.edu)
Despite representing one of the largest classes of therapeutic targets, most inactive-state G protein-coupled receptors (GPCRs) have remained inaccessible for cryo-EM because their small size and membrane-embedded nature impedes projection alignment for high-resolution map reconstructions. (stanford.edu)
This study describes the identification of the unc-112 gene product, a novel, membrane-associated, intracellular protein that colocalizes with integrin at cell-matrix adhesion complexes. (illinois.edu)
Although Rab11a subcellular localization has been demonstrated by transgenic zebrafish [10], and molecular function of Rab11 proteins in primary cilia membrane assembly in Kupffer Vesicle has been studied [6], the developmental expression profile of Rab11 proteins in zebrafish remains elusive. (researchsquare.com)
They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. (pearltrees.com)

The SC is essential for intimate associations between homologous chromosomes and it also regulates genetic exchanges. (utah.edu)
The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline. (shibuyahiroki.com)

Jerome Goudeau team published a paper entitled "Addendum: A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage" using our strain PHX798 gld-1(syb798) . (sunybiotech.com)

The zebrafish Rab11a, Rab11ba and Rab11bb proteins are highly conserved during evolution, especially the GTPase domain, suggesting their important functions. (researchsquare.com)
Throughout evolution, eukaryotes adopted a network of highly conserved proteins that buffer the positive charges of histones, maintaining their solubility and, therefore, avoiding aberrant interactions with other cellular components. (aging-us.com)

Since May 2017, SunyBiotech has undertaken C. elegans gene editing services. (sunybiotech.com)

Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. (nih.gov)
Zebrafish rab11a was clustered in the Rab11a group, and rab11ba and rab11bb in the Rab11b group (Fig.1B) in the phylogenic tree constructed according to amino acid sequences of all the Rab11 proteins above. (researchsquare.com)
Thus, the PTGS degradation machinery in plants would lead to the elimination of the viral RNA, as long as the dsRNA trigger contains sequences homologous to the invading virus. (biomedcentral.com)

Furthermore, we identified the core RNAi protein machinery in Symbiodinium . (biomedcentral.com)
Dicer and Argonaute proteins), the products they produce are not, and hence RNAi might be an example of molecular exaptation [ 19 ]. (biomedcentral.com)
In Caenorhabditis elegans , RNAi can be achieved by feeding worms Escherichia coli expressing dsRNA corresponding to a specific gene [ 21 ]. (biomedcentral.com)

Founded in 2016, SunyBiotech Co., Ltd is committed to providing high-quality and efficient C. elegans gene editing services to p restigious university laboratories worldwide. (sunybiotech.com)

Here we report that beta-amyloid precursor protein (APP) and death receptor 6 (DR6, also known as TNFRSF21) activate a widespread caspase-dependent self-destruction program. (deathbase.org)
Firstly, the research team has identified a C. elegans gene (named NHR -69), which acts as a testosterone receptor. (uco.es)
Sterile alpha and toll/interleukin receptor (TIR) motif containing protein 1 (SARM1) is an NAD+ hydrolase and cyclase involved in axonal degeneration. (umassmed.edu)
Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. (embl.de)

Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins. (mcmaster.ca)
Duan H, Li Y, Lim HY, Wang W. Identification of 5-nitrofuran-2-amide derivatives that induce apoptosis in triple negative breast cancer cells by activating C/EBP-homologous protein expression. (omrf.org)
The authors propose that the asymmetric segregation of the NuRD complex in C. elegans is regulated in a V-ATPase-dependent manner, that this plays a crucial role in determining the differential expression of the apoptosis activator egl-1 and that it is therefore critical for the life/death fate decision in this species. (elifesciences.org)
BCL2 proteins are described as 'crucial regulators of apoptosis' (PMID:15868100)and the intrinsic apoptosis pathway is initiated by the release of mitochondrial cytochrome c into the cytoplasm, which results in the activation of caspases (15102863) - help in generating a defintion for intrinsic apoptosis? (geneontology.org)
does all activation of caspases require other proteins also involved in apoptosis - therefore shouldn't this term be a part of apoptosis? (geneontology.org)
how to decide whether a protein is involved in '+ve reg of apoptosis or induction ([GO:0006917])?emily. (geneontology.org)

An antibody-protein array of putative immunogenic proteins was developed from a combined bioinformatic, experimental, and literature-based prioritization of homologous parasite proteins. (frontiersin.org)
Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). (nih.gov)

Analysis of DEGs also revealed that minicircle-encoded photosynthesis proteins seem to be common targets of transcriptional regulation. (biomedcentral.com)

In this review, we first summarize recent breakthroughs in the morphological and functional characterization of C. elegans neuronal aging. (biomedcentral.com)
As a robust genetic model for aging, insights from C. elegans neuronal aging studies will contribute to our mechanistic understanding of human brain aging. (biomedcentral.com)

lyrata (Lyre-leaved rock-cress) hypothetical protein (at5g25770) , arath-C7A10.830 Arabidopsis thaliana DNA chromosome 4,gene C7A10.830 No. 2 AT4G36530 , arath-F1N18.12 Arabidopsis thaliana (Mouse-ear cress) f1n18.12 AT1G29840 protein , arath-F1P2.110 Arabidopsis thaliana (Mouse-ear cress). (inrae.fr)
The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins. (utah.edu)
Chromosome pairing and synapsis during Caenorhabditis elegans meiosis. (utah.edu)
Dynein-Dependent Processive Chromosome Motions Promote Homologous Pairing in C. elegans Meiosis. (utah.edu)
Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. (shibuyahiroki.com)

The focus is on recent studies elucidating the best-understood network of LINC complexes, those used throughout C. elegans development. (ucdavis.edu)
Lionel Pintard (PI) published a paper entitled "Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans" in the well-known academic journal Developmental Cell , in which the strain PHX207 npp-1(syb207) IV was used. (sunybiotech.com)

Further taxon sampling is critical to understand the evolution and diversification of this protein and its functional roles in animals. (biomedcentral.com)

Our results show that PAD inhibition leads to an increase in DGCR8 mRNA and protein. (umassmed.edu)
Integration of smRNA and mRNA expression profiling identified a variety of processes that could be under microRNA control, e.g. protein modification, signaling, gene expression, and response to DNA damage. (biomedcentral.com)

Our first major publication on nematicides was our 2015 Nature Comm paper, which described the screening of over 67,000 small molecules for their ability to disrupt C. elegans development and viability. (roylabutoronto.ca)
These findings suggest that homologous dsRNA could serve as protective molecules against virus infections, provided that inexpensive and effective means of production and delivery of adequate interference products onto plants surfaces were previously developed. (biomedcentral.com)

Collapsin response mediator protein family or CRMP family consists of five intracellular phosphoproteins (CRMP-1, CRMP-2, CRMP-3, CRMP-4, CRMP-5) of similar molecular size (60-66 kDa) and high (50-70%) amino acid sequence identity. (wikipedia.org)
Background: Rab proteins are GTPases responsible for intracellular vesicular trafficking regulation. (researchsquare.com)
Rab/Ypt proteins are small GTP-binding proteins of the Ras superfamily and are key players in intracellular vesicular trafficking regulation [1, 2]. (researchsquare.com)

In the same year, several other studies cloned CRMPs-1-4 in rat and dihydropyrimidinase (DHPase) homologous sequence of CRMPs-1, -2, and -4 in human fetal brain. (wikipedia.org)
CRMP1-5 are between 564 and 572 amino acids and these proteins are found to be approximately 95% conserved between mouse and human. (wikipedia.org)
In addition, over 80 % of its proteins are homologous to human', says Professor Ruiz. (uco.es)
The 720-amino acid UNC-112 protein is homologous to Mig-2, a human protein of unknown function. (illinois.edu)
Superoxide production in Galleria mellonella hemocytes: identification of proteins homologous to the NADPH oxidase complex of human neutrophils. (microbiologyresearch.org)
In the present study, we conducted a large-scale investigation of TIMP proteins of a range of neglected human parasites including the hookworm Necator americanus , the roundworm Ascaris suum , the liver flukes Clonorchis sinensis and Opisthorchis viverrini , as well as the schistosome blood flukes. (biomedcentral.com)

Caenorhabditis elegans represents a valuable model for investigating ACD, given its invariant cell lineage and conserved mechanisms of ACD. (elifesciences.org)

Proteins supported by a single continuous cDNA sequence lead to underlining the name/ending of the variant. (nih.gov)

The IMIBIC research group has pioneered the use of Caenorhabditis elegans as an experimental system to analyze basic neurobiological mechanisms involved in autism in vivo. (uco.es)
Structures of Ric-8B in complex with Galpha protein folding clients reveal isoform specificity mechanisms. (stanford.edu)

The protein sequence of CRMP1-4 is approximately 75% homologous with each other, while CRMP5 is only 50-51% homologous with each of the other CRMPs. (wikipedia.org)
The deduced 4660-aa sequence, expected to constitute a mature protein of M(r) 516,715, consists of a probable N-terminal signal peptide sequence (25 aa), an extracellular region (4400 aa), a single transmembrane domain (22 aa), and a C-terminal cytoplasmic tail (213 aa). (embl.de)
3] They are composed of a family of related proteins sharing common structural and sequence features. (pearltrees.com)

The turquoise diamond represents the 12 conserved amino acids at the N-terminal end of the Sall proteins that interact with the HDC NuRD [ 14 ]. (biomedcentral.com)
Here, we demonstrate that the nucleosome remodeling and deacetylase (NuRD) complex is asymmetrically segregated into the surviving daughter cell rather than the apoptotic one during ACDs in Caenorhabditis elegans . (elifesciences.org)
Asymmetric segregation of NuRD during ACDs of C. elegans Q neuroblast. (elifesciences.org)

Distinct TERB1 domains regulate different protein interactions for meiotic telomere movement. (shibuyahiroki.com)
High-resolution structures of GPR56 and LPHN3 in their active, G-protein-coupled states, reveal that after dissociation of the extracellular region, the decrypted TA peptides engage the seven-transmembrane domain core with a notable conservation of interactions that also involve extracellular loop 2. (stanford.edu)

Moreover, F-C3G significantly extended the survival rate by 20.67% of Caenorhabditis elegans under heat stress by antioxidation in vivo. (bvsalud.org)
In this study, we combined in vivo C. elegans genetics and in silico molecular dynamics simulations to understand the relation between the length and amino acid composition of the luminal KASH domain, and the function of the SUN-KASH complex. (ucdavis.edu)
In agreement with our models, our in vivo results show that swapping the KASH domains of ANC-1 and UNC-83, or shortening the KASH domain of ANC-1, both result in a nuclear anchorage defect in C. elegans . (ucdavis.edu)

This research study, published in the journal Frontiers in Cellular Neuroscience as "Epigenetic effect of testosterone in the behavior of C. elegans. (uco.es)
Protein citrullination is a post-translational modification of arginine that controls a diverse array of cellular processes, including gene regulation, protein stability, and neutrophil extracellular trap (NET) formation. (umassmed.edu)
The LINC complex can perform distinct cellular functions by pairing various KASH domain proteins with the same SUN domain protein. (ucdavis.edu)

The complete taxonomic breakdown of all proteins with LDLa domain is also avaliable . (embl.de)

Rab11 proteins, members of the Rab GTPase family, are known to regulate vesicular recycling during embryonic development. (researchsquare.com)
Among various Rab proteins, Rab11 is known to localize to recycling endosome and regulate vesicular recycling and primary ciliogenesis, playing a key role in Kupffer vesicle development in zebrafish [5-7]. (researchsquare.com)

In C. elegans , the ten-1 gene can be transcribed from two distinct promoters to produce the transcripts ten-1a and ten-1b , which respectively encode two isoforms of the protein: TEN-1L, which contains all the teneurin domains described above (see Fig. 1F ), and TEN-1S, which lacks the ICD but contains the rest of the protein including the transmembrane domain. (biomedcentral.com)
In addition to distinct cytoplasmic domains, the luminal KASH domain also varies among KASH domain proteins of distinct functions. (ucdavis.edu)

Group of researchers led by Goshima found out that CRMP-2 played a role in the transduction of the extracellular Semaphorin 3A (Sema3A), an inhibitory protein for axonal guidance in chick dorsal root ganglion (DRG). (wikipedia.org)
Despite the overall architectural similarity with our earlier structures of Ric-8A complexed to Galphaq and Galphai1, Ric-8B distinctly accommodates an extended loop found only in Galphas/olf proteins. (stanford.edu)

Nuclear positioning is mediated by a conserved network of nuclear envelope proteins that interacts with force generators in the cytoskeleton. (ucdavis.edu)

Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI). (pasteur.fr)

Our lab is studying a conserved protein complex that assembles between meiotic chromosomes in almost all eukaryotes � the synaptonemal complex (SC). (utah.edu)
The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor. (shibuyahiroki.com)

Anatomy9

Organisms6

Diseases1

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Psychiatry and Psychology1

Phenomena and Processes37

Information Science4

Health Care1

Drosophila7

Nematode6

Genes10

Worm2

Organisms2

Recombination1

Mammalian5

Extracellular matrix3

Neuron3

Bacteria2

Ortholog1

Homology3

Histone4

Membrane8

Regulates2

Germ1

Highly conserved2

20171

Sequences3

RNAi3

20161

Receptor4

Apoptosis6

Putative2

Transcriptional1

Neuronal2

Chromosome5

Complexes2

Functional1

MRNA2

Molecules2

Intracellular3

Human6

Lineage1

CDNA1

Mechanisms2

Sequence3

NuRD3

Interactions2

Vivo3

Cellular3

Breakdown1

Regulate2

Distinct2

Found2

Cytoskeleton1

Actin1

Meiotic2