Homologous kinase. Medical search. Frequent questions

On the other hand, the expression of Rep Avibactam small molecule kinase inhibitor proteins, which produce a nick in the ITR, significantly increased non-homologous integration of the DNA fragment writing no homology towards the genome, but got no influence on gene concentrating on or arbitrary integration when the DNA fragment distributed homology using the genome. (scienceexhibitions.org)
Fibroblast growth factor homologous factors are intracellular signaling proteins. (nih.gov)
A quantitative biochemical interaction screen, a CIF peptide antagonist and genetic analyses together implicate SERK proteins as essential coreceptor kinases required for GSO1/SGN3 and GSO2 receptor activation. (unige.ch)
In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)
The intact receptor lacks tyrosine kinase activity, but binding of GH and dimerization results in association with JAK2, a member of the Janus kinase family, which results in self-phosphorylation of the JAK2 and a cascade of phosphorylation of cellular proteins. (medscape.com)

Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
A Candida albicans gene (CPH1) was cloned that encodes a protein homologous to Saccharomyces cerevisiae Ste12p, a transcription factor that is the target of the pheromone response mitogen-activated protein kinase cascade. (embl-heidelberg.de)

The purpose of this research was to assess if the usage of AAV sequences or appearance of Avibactam small molecule kinase inhibitor Rep protein is actually a feasible and beneficial tool for raising gene concentrating on or decreasing arbitrary integration. (scienceexhibitions.org)
however, to your understanding no comparative research continues to be performed to comprehend the function of ITRs Avibactam small molecule kinase inhibitor and Rep protein in gene concentrating on and arbitrary integration. (scienceexhibitions.org)
Thus, to review the result of ITRs on fungus gene concentrating on, we built a book vector pAAVLUL known Avibactam small molecule kinase inhibitor as, formulated with the gene interrupted by gene and flanked with the ITRs (Body?1B). (scienceexhibitions.org)
As shown in Physique?1B, the gene targeting fragment from your pAAVLUL was generated by two different restriction enzymes in order to keep Rabbit Polyclonal to RAB33A Avibactam small molecule kinase inhibitor the ITRs flanking both ends of the fragment, or not. (scienceexhibitions.org)
The TEC family kinase, BTK (Bruton's tyrosine kinase) is best known as the target of ibrutinib (IMBRUVICA®), the first-in-class covalent kinase active site inhibitor used to treat chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), Waldenström's macroglobulinemia (WM), and chronic graft-versus-host disease (cGVHD). (elifesciences.org)
Lenvatinib, a multi‑kinase inhibitor, serves a crucial role in the treatment of unresectable hepatocellular carcinoma (HCC). (spandidos-publications.com)
Lenvatinib is an oral multi-kinase inhibitor that inhibits mainly vascular endothelial growth factor receptor 1-3, fibroblast growth factor receptor (FGFR) 1-4, platelet-derived growth factor receptor (PDGFR) α, c-KIT, and RET ( 11 ). (spandidos-publications.com)
In terms of the disease control rate (complete response + partial response + stable disease ratio), response rate (complete response + partial response ratio), median progression-free survival, and median time to progression, lenvatinib shows significantly better results compared with sorafenib, another oral multi-kinase inhibitor (75.5 vs. 60.5%, 24.1 vs. 9.2%, 7.4 vs. 3.7 months, 8.9 vs. 3.7 months, respectively) ( 7 ). (spandidos-publications.com)
The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
JAK1/JAK2 kinase inhibitor indicated for treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. (medscape.com)
Multiple tyrosine kinase inhibitor. (medscape.com)

protein Rad52 strongly increases homologous recombination and gene targeting in HeLa cells [9,10]. (scienceexhibitions.org)
An alternative method of homologous recombination mediated gene targeting consists of exploiting the recombinogenic nature of the adeno-associated computer virus (AAV) vector genome [11]. (scienceexhibitions.org)
Notably, the presence of the ITRs flanking the gene targeting construct determines increased homologous recombination frequencies [19]. (scienceexhibitions.org)
Finally, codepletion of Rad51, an important homologous recombination repair protein, abrogates the DNA damage after SET8 depletion. (rupress.org)
AB - Homologous recombination (HR) is a faithful repair mechanism for double stranded DNA breaks. (imperial.ac.uk)

This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. (nih.gov)
Furthermore, inactivation of the prosurvival kinase Akt is a key step in its neurotoxic signaling pathway. (edu.au)

The bound zinc ion in the lid domain is clearly structurally homologous to Zinc-finger domains. (embl.de)
IGF binding involves 3 basic types of receptors: the structurally homologous insulin receptor and type 1 IGF receptor and the distinctive type 2 IGF-II/mannose-6-phosphate receptor. (medscape.com)

Key molecular determinants of this process are G protein-coupled receptor kinases (GRKs) and arrestins (Chuang, 1996a). (open.ac.uk)
Plants use leucine-rich repeat receptor kinases (LRR-RKs) to sense sequence diverse peptide hormones at the cell surface. (unige.ch)

Specifically designed to inhibit tyrosine kinase activity of the bcr-abl kinase in Ph+ leukemic CML cell lines. (medscape.com)

Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. (cdc.gov)
DNA-dependent protein kinase catalytic subunit (DNAPKcs) regulates non-homologous end joining (NHEJ) in DNA double strand break (DSB) repair. (cdc.gov)

Two highly homologous master kinases, the tumour suppressors ATM and ATR (Tel1 and Mec1 in yeast), coordinate cell cycle progression with repair during HR. Despite their importance, our molecular understanding of these apical coordinators has been limited, in part due to their large sizes. (imperial.ac.uk)

Our analysis indicated that ligand affinity differentially affected signaling pathways associated with specific kinases and biological processes. (nature.com)
Alterations in genes with potential clinical utility are observed in more than three quarters of the cases and included members of the PI3-kinase and homologous DNA repair pathways. (nih.gov)
The atypical protein kinase C (PKC) member PKC-zeta has been implicated in several signal transduction pathways regulating differentiation, proliferation or apoptosis of mammalian cells. (embl.de)
In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)

c-Src, an Src family kinase (SFK) member, is one of the aberrantly regulated enzymes involved in excitotoxic neuronal death. (edu.au)

Pyruvate kinase M2 (PKM2) is a key rate-limiting enzyme in glycolysis, and which plays a critical role in tumor progression in various malignancies. (researchsquare.com)
Hexokinase (HK), phosphofructokinase-1 (PFK-1) and pyruvate kinase (PK) are the three key enzymes in the glycolysis pathway. (researchsquare.com)
The combined results indicate that glycolysis is regulated by the compartmental expression of hexokinase 2, pyruvate kinase M1, and pyruvate kinase M2 in photoreceptors, whereas the inner retinal neurons exhibit a lower capacity for glycolysis and aerobic glycolysis. (molvis.org)

Creatine kinase (CK), lactate dehydrogenase (LDH), and amylase levels of preterm infants following long-term tocolysis in pregnant women are limited. (hindawi.com)
Asymptomatic increases in blood creatine kinase (CK) and amylase have been reported in pregnant women treated with tocolytic agents [ 2 - 5 ]. (hindawi.com)
Expression of nucleoside diphosphate kinase, mitochondria-associated adenylate kinase, and several mitochondria-associated creatine kinase isozymes was highest in the outer retina, whereas expression of cytosolic adenylate kinase and brain creatine kinase was higher in the cones, horizontal cells, and amacrine cells indicating the diversity of ATP-buffering strategies among retinal neurons. (molvis.org)

The alpha subunit is localized extracellularly and mediates ligand binding while the transmembrane beta subunit contains the cytoplasmic kinase domain and mediates intracellular signaling. (rndsystems.com)
Here, we show that stomatal closure to fungal chitin is conferred by the major PRRs for chitin recognition, LYK5 and CERK1, the receptor-like cytoplasmic kinase PBL27, and the SLAH3 anion channel. (elifesciences.org)

Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases. (ox.ac.uk)
Thus although the bioinformatics analysis and structure of YegS indicate that many of the ligand recognition determinants for lipid kinase activity are present, the absence of such activity may be due to specificity for a different lipid substrate or the requirement for activation by an, as yet, undetermined mechanism. (ox.ac.uk)
We focus on six 'core' effectors that operate in almost all these species - members of the Pak, WASP/WAVE, formin, lipid-kinase, IQGAP and NADPH oxidase families. (biomedcentral.com)

The master kinase LKB1 is a key regulator of several cellular processes, including cell proliferation, cell polarity and cellular metabolism. (sdbonline.org)

Although the function of YegS is not definitively known, it has been annotated as a potential diacylglycerol or sphingosine kinase based on sequence similarity with eukaryotic enzymes of known function. (ox.ac.uk)
However, biochemical assays showed that recombinant YegS is endogenously neither an active diacylglycerol nor sphingosine kinase. (ox.ac.uk)
These domains were first discovered as the loci of phorbol ester and diacylglycerol binding to conventional protein kinase C isozymes, which contain 2 C1 domains (C1A and C1B) in their N-terminal regulatory regions. (embl.de)

Selective compounds have been developed that target either the extracellular ligand-binding region of the EGFR (including a number of monoclonal antibodies [MAbs], immunotoxins, and ligand-binding cytotoxic agents) or the intracellular tyrosine kinase region (including various small-molecule inhibitors). (medscape.com)
The intracellular region contains the kinase domain sandwiched between the juxtamembrane domain used for docking insulin-receptor substrates (IRS), and the carboxy-terminal tail that contains two phosphotyrosine-binding sites. (rndsystems.com)

CDK-activating kinase (CAK) activates the cyclin-CDK complex by phosphorylating threonine residue 160 in the CDK activation loop. (wikipedia.org)
In vertebrates and Drosophila, CAK is a trimeric protein complex consisting of Cdk7 (a Cdk-related protein kinase), cyclin H, and Mat1. (wikipedia.org)
Cyclin dependent-kinase 2 (CDK2) plays important functions during the mitotic cell cycle and also facilitates several key events during germ cell development. (lu.se)

Mediates signal transduction from receptor kinase BRI1 by functioning as the substrate of BRI1. (utoronto.ca)

Membrane-induced dimerization activates BTK and we present here a crystal structure of an activation loop swapped BTK kinase domain dimer that likely represents the conformational state leading to trans-autophosphorylation. (elifesciences.org)
It phosphorylates and activates several downstream kinases, including AMP-dependent kinase, AMPK . (sdbonline.org)

Vectors based on AAV, which deliver single-stranded, linear DNA genomes, are able to efficiently introduce many types of mutations into homologous target loci at a frequency approaching 1% in mammalian cells, and are currently used as gene targeting vectors [13-16]. (scienceexhibitions.org)
Has been able to overcome imatinib resistance resulting from BCR/ABL kinase domain mutations. (medscape.com)
Under the conditions of the assays, was able to overcome imatinib resistance resulting from BCR/ABL kinase mutations in 32 of 33 mutations tested. (medscape.com)
KinMutBase ( http://bioinf.uta.fi/KinMutBase/ ) is a registry of mutations in human protein kinases related to disorders. (lu.se)
Kinases are essential cellular signaling molecules, in which mutations can lead to diseases, including immunodeficiencies, cancers and endocrine disorders. (lu.se)
KinMutBase version 3.0 contains 582 mutations in 20 tyrosine kinase domains and 13 serine/threonine kinase domains. (lu.se)
Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. (lu.se)
Ortutay C, Valiaho J, Stenberg K, Vihinen M. KinMutBase: A registry of disease-causing mutations in protein kinase domains. (lu.se)

Both receptors belong to the TAM (TYRO3, AXL and MER - MER proto-oncogene, tyrosine kinase) receptor tyrosine kinase family, which emerged as new potential targets in many oncological diseases, from leukaemia to solid tumours ( Graham et al, 2014 ). (nature.com)

The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
It has shown that miR-429 could inhibit the development of colorectal cancer via targeting in large tumor suppressor kinase (LATS2), and decreased miR-429 could promote the expression of SRY-box transcription factor 2 (SOX2) and B-cell lymphoma 2 (BCL2) to attenuate the neuronal injury induced by accumulation of amyloid β -protein [ 12 ]. (hindawi.com)
Glioblastoma (GBM), a very aggressive and incurable tumor, often results from constitutive activation of EGFR (epidermal growth factor receptor) and of phosphoinositide 3-kinase (PI3K). (sdbonline.org)

Conclusions Our outcomes indicate that ITRs could be a good device for lowering arbitrary integration, and consequently favor homologous gene targeting. (scienceexhibitions.org)
The LKB1 gene encodes a serine/threonine kinase that is mutated in the Peutz-Jeghers cancer syndrome. (nih.gov)
As part of a Kinase complex, TGFβ initiates a signal cascade that upregulates target gene expression. (quanterix.com)

os-4 (MAPK kinase kinase), os-5 (MAPK kinase), and os-2 (MAPK). (llu.edu)

LKB1 is homologous to the Par-4 polarity genes in C. elegans and D. melanogaster. (nih.gov)
LKB1 itself is a constitutively active kinase, which is regulated by posttranslational modifications and direct binding to phospholipids of the plasma membrane. (sdbonline.org)
This study reports that LKB1 binds to Phosphoinositide-dependent kinase (PDK1) by a conserved binding motif. (sdbonline.org)
Furthermore, a PDK1-consensus motif is located within the kinase domain of LKB1 and LKB1 gets phosphorylated by PDK1 in vitro. (sdbonline.org)

The N-terminal and C-terminal domains of YegS are however counter-rotated, relative to the polyphosphate/ATP NAD kinase archetype, such that the potential nucleotide binding site is blocked. (ox.ac.uk)

Inhibits BCR/ABL kinase. (medscape.com)

Chronic ER stress promotes apoptosis, at least in part through the UPR-induced transcription factor C/EBP homologous protein (CHOP). (jci.org)
These agents inhibit the activity of bcr-abl tyrosine kinase, resulting in decreased proliferation and increased apoptosis in Ph-positive cell lines. (medscape.com)

Cellular ATP is buffered by specialized equilibrium-driven high-energy phosphate (~P) transferring kinases. (molvis.org)

Taxonomy and function of C1 protein kinase C homology domains. (embl.de)

Through de novo transcriptome assembly with the RNA-seq reads from whole organ samples of C. virgata at the germination stage (2 days after germination, DAG), early young development stage (8 DAG), young development stage (17 DAG), and adult development stage (28 DAG), we identified 21,589 unified transcripts (contigs) and found that 19,346 and 18,156 protein-coding transcripts were homologous to those in rice and Arabidopsis , respectively. (frontiersin.org)

On the way to activation, disassembly of the SH3-SH2- kinase core opens a new autoinhibitory site on the kinase domain for PHTH domain binding that is ultimately released upon interaction of PHTH with PIP3. (elifesciences.org)
Together, these data provide the first structural elucidation of full-length BTK and allow a deeper understanding of allosteric control over the BTK kinase domain during distinct stages of activation. (elifesciences.org)
5 ]. The three domains (SH3, SH2, kinase), the SH2-kinase linker, the activation loop and the active site are labeled. (elifesciences.org)

In 2015 the BTK SH3-SH2-Kinase fragment was crystallized [ 5 ]. (elifesciences.org)

Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. (embl.de)

Janus-associated kinases (JAKs) JAK1 and JAK2 mediate the signaling of a number of cytokines and growth factors that are important for hematopoiesis and immune function. (medscape.com)

Structures of the autoinhibited SRC family kinases were solved in 1997 revealing, for the first time, the compact arrangement of the SH3 and SH2 domains assembled onto the distal side of the catalytic kinase domain [ 4 ]. (elifesciences.org)

The active site of Cdk2 lies in a cleft between the two lobes of the kinase. (wikipedia.org)

CryoEM reconstructions support conformational heterogeneity in the PHTH-PRR region wherein the globular PHTH domain adopts a range of states arrayed around the autoinhibited SH3-SH2-kinase core. (elifesciences.org)
The TEC and SRC kinases share the SH3-SH2-kinase domain arrangement (the 'Src module') ( Fig. 1a ). (elifesciences.org)
One-half of the domain swapped BTK structure represents the current model for autoinhibited BTK and closely resembles the compact structure of autoinhibited SRC kinases ( Fig. 1b ). (elifesciences.org)
The compact structure of the SH3-SH2-kinase region of BTK is exacted from the domain swapped dimer structure (PDB: 4XI2) solved by Wang et al. (elifesciences.org)
The domain arrangement of Aer2 is unusual, with a PAS sensing domain sandwiched between five HAMP domains, followed by a C-terminal kinase-control output domain. (llu.edu)
The large INS R extracellular domain is organized into two successive homologous globular domains, which are separated by a Cysteine-rich domain, followed by three fibronectin type III domains. (rndsystems.com)
Here, we report that in cultured cortical neurons and in vivo in a rat model of focal ischemic stroke, the tyrosine kinase Src is cleaved by calpains at a site in the N-terminal unique domain. (edu.au)

In this review, we summarize recent advances in the structural and molecular understanding of these key components in HR, compare the common and distinct features of these kinases and suggest aspects of structural components that are likely to be involved in regulating its activity. (imperial.ac.uk)

BTK, a TEC-family tyrosine kinase activated by the B-cell antigen receptor, contains a variety of regulatory domains and it is subject to complex regulation by membrane phospholipids, protein ligands, phosphorylation, and dimerization. (elifesciences.org)
Here, CDK2 is involved in the regulation of meiotic transcription, the pairing of homologous chromosomes, and the maturation of meiotic crossover sites. (lu.se)

We have produced crystals of full-length BTK for the first time but despite efforts to stabilize the autoinhibited state, the diffraction data still reveals only the SH3-SH2-kinase core with no electron density visible for the PHTH-PRR segment. (elifesciences.org)

Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). (embl.de)

Although low-affinity ligands induced phosphorylation of the Cd3 chains of the T cell receptor and the interaction of Cd3 with the Zap70 kinase as strongly as high-affinity ligands, they failed to activate Zap70 to the same extent. (nature.com)

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes10

Information Science2

Proteins6

Mitogen-activa4

Inhibitor11

Recombination5

Signaling pathway2

Structurally homologous2

Receptor kinases2

Tyrosine kinase activity1

Protein kinase catalytic2

Highly homologous1

Pathways4

Family kinase1

Pyruvate kinase3

Creatine kinase3

Cytoplasmic kinase2

Lipid3

Metabolism1

Diacylglycerol3

Intracellular2

Cyclin3

Signal Transduction1

Activates2

Mutations8

Receptors1

Tumor3

Gene3

MAPK1

LKB14

YegS1

Inhibits1

Apoptosis2

Cellular1

Homology1

Arabidopsis1

Activation3

Fragment1

Divergence1

JAK21

19971

Cleft1

Domain7

Structural1

Regulation2

Reveals1

Motif1

Strongly1