• A limited repertoire of genes homologous to known bacterial virulence factors were identified. (nih.gov)
  • Yeast one-hybrid assays showed that SsDREB protein specifically binds to the DRE sequence and could activate the expression of reporter genes in yeast, suggesting that the SsDREB protein was a CBF/DREB transcription factor. (hindawi.com)
  • Numerous abiotic stress-related genes and transcription factors (TFs) have been isolated from different plant species and overexpressed in homologous and heterologous systems to engineer stress tolerance [ 5 ]. (hindawi.com)
  • The Dehydration-responsive element-binding proteins (DREBs) are members of the APETALA2/ethylene-responsive element-binding factor (AP2/ERF) family of transcription factors in the promoters of stress-inducible genes [ 6 ]. (hindawi.com)
  • The A-1 subgroup, which includes the DREB1/CBF- (C-repeat binding factor-) like genes, are mainly induced by low temperature and activate the expression of many cold stress-responsive genes, whereas the A-2 subgroup, which is comprised of the DREB2 genes, mainly functions in osmotic stress [ 7 ]. (hindawi.com)
  • DREB2 homologous genes have been isolated from a variety of species [ 12 ]. (hindawi.com)
  • Estrogens regulate genes directly through binding to estrogen receptors alpha and beta (ERα and ERβ) that are ligand-activated transcription factors and indirectly by activating plasma membrane-associated ER which, in turns, activates intracellular signaling cascades leading to altered gene expression. (benthamscience.com)
  • Genes on the remaining homologous chromosome, however, are not recurrently mutated, and the identity of key 8p tumor-suppressor genes (TSG) is unknown. (jci.org)
  • Iss1 interacts with RNA surveillance factors Mmi1 and Rrp6, and importantly, Iss1 contributes to RNA elimination that forms heterochromatin at meiosis genes. (nih.gov)
  • Numerous putative virulence factors such as adhesins, autolysins, exoenzymes, capsule formation genes, immunomodulators, the phage-associated sasX gene, and SCC-associated spermidine N-acetyltransferase gene, pseudouridine and sorbitol utilization operons might explain clinical manifestations of S. petrasii isolates. (muni.cz)
  • POLQ is overexpressed in a range of cancer cells, including homologous recombination (HR) deficient cancer cells. (techscience.com)
  • PUF60 is an essential splicing factor functionally related and homologous to U2AF(65). (rcsb.org)
  • 2. Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA. (nih.gov)
  • The performance was measured as TFBS detection accuracy, defined as the proportion of nucleotides in functionally homologous TFBS which were correctly aligned. (nih.gov)
  • Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. (embl.de)
  • In mice this homologous region is found at distal chromosome 7. (wikipedia.org)
  • The human gene encoding factor X is primarily expressed in the liver and is located on the long arm of chromosome 13, just downstream from the gene for factor VII. (medscape.com)
  • Heterochromatin functions as a scaffold for factors responsible for gene silencing and chromosome segregation. (nih.gov)
  • Comparative genomics revealed the presence of new mobile genetic elements carrying antimicrobial resistance factors such as staphylococcal cassette chromosome (SCC) mec, transposones, phage-inducible genomic islands, and plasmids. (muni.cz)
  • The status of homologous recombination repair (HRR) gene mutations and their impact on the survival of patients with Chinese epithelial ovarian cancer (EOC) are still unclear. (frontiersin.org)
  • The protein is required for the non-homologous end joining (NHEJ) pathway of DNA repair. (wikipedia.org)
  • Non-homologous end joining (NHEJ) is one of two critical mechanisms utilized in humans to repair DNA double-strand breaks (DSBs). (rcsb.org)
  • Non-homologous end-joining factor 1 (NHEJ1), also known as Cernunnos or XRCC4-like factor (XLF), is a protein that in humans is encoded by the NHEJ1 gene. (wikipedia.org)
  • These data suggest that the SsDREB transcription factor is involved in the regulation of salt stress tolerance in tobacco by the activation of different downstream gene expression. (hindawi.com)
  • From NCBI Gene: This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). (nih.gov)
  • Using homologous recombination, I knocked out a CHD gene member. (nih.gov)
  • jettensis strains, and virulence factors homologous to other pathogenic staphylococci demonstrate the importance of the species in human disease. (muni.cz)
  • The protein encoded by ORF I215L was homologous to the family of ubiquitin-conjugating proteins. (nih.gov)
  • After PGC specification, murine germ cells go through several developmental stages that are tightly regulated both at the transcriptional level by transcription factors, but also at the translational level by RNA-binding proteins. (nature.com)
  • Salmonella Pathogenicity Island 1 (SPI-1) encodes a type three secretion system (T3SS), effector proteins, and associated transcription factors that together enable invasion of epithelial cells in animal intestines. (mdpi.com)
  • The candidates include a large number of essential proteins such as four canonical mRNA cleavage and polyadenylation factors. (nih.gov)
  • 2) Is a human epitope of interest found in orthologous/homologous proteins in model organisms or vice-versa? (hhs.gov)
  • CHD (Chromodomain-Helicase-DNA binding) proteins utilize energy from ATP hydrolysis to alter nucleosome position and access of DNA to transcription factors/polymerases. (nih.gov)
  • Following these repeats is a 350 residue domain that resembles part of the epidermal growth factor (EGF) precursor. (embl.de)
  • ORF I243L encoded a protein similar to the eukaryotic elongation factor SII. (nih.gov)
  • Insulin-like growth factor 2 ( IGF-2 ) is one of three protein hormones that share structural similarity to insulin . (wikipedia.org)
  • Factor X deficiency may arise because of reduced synthesis of the protein, which is known as type I deficiency state, or because of production of a dysfunctional molecule, which is known as type II deficiency state. (medscape.com)
  • Mammalian cells have 2 additional ER stress sensors: the membrane-bound transcription factor ATF6 and the receptor-type protein kinase PERK. (nature.com)
  • Expression patterns and different subcellular localization of the growth factors HDGF (hepatoma-derived growth factor) and HRP-3 (HDGF-related protein-3) suggest functions in addition to their mitogenic activity. (degruyter.com)
  • The ectopic expression of IFN regulatory factor 4-binding protein is correlated with the malignant behavior of human breast cancer cells. (atlasgeneticsoncology.org)
  • Overexpression of the Interferon regulatory factor 4-binding protein in human colorectal cancer and its clinical significance. (atlasgeneticsoncology.org)
  • However, there have been no systematic efforts to identify and validate the presence of tumor specific neoantigens in HNCs even though there is ample evidence to predict a high mutational load due to the known overlap of mutagenic risk factors of HNCs and lung cancers (i.e. tobacco). (nih.gov)
  • Poor nutrition, sedentary lifestyle, and obesity are among the primary risk factors. (nih.gov)
  • a heterologous COVID-19 mRNA vaccine is preferred over a homologous (matching) Janssen vaccine for booster vaccination. (cdc.gov)
  • The VISION Network § determined real-world VE of 1 Janssen vaccine dose and 2 alternative booster dose strategies: 1) a homologous booster (i.e., 2 Janssen doses) and 2) a heterologous mRNA booster (i.e., 1 Janssen dose/1 mRNA dose). (cdc.gov)
  • In addition, VE of these booster strategies was compared with VE of a homologous booster following mRNA primary series vaccination (i.e., 3 mRNA doses). (cdc.gov)
  • We conclude that IRE1A and IRE1B catalyse unconventional splicing of bZIP60 mRNA to produce the active transcription factor. (nature.com)
  • This recommendation was made in light of the risks for rare but serious adverse events following receipt of a Janssen vaccine, including thrombosis with thrombocytopenia syndrome and Guillain-Barré syndrome † ( 1 ), and clinical trial data indicating similar or higher neutralizing antibody response following heterologous boosting compared with homologous boosting ( 2 ). (cdc.gov)
  • Such factors included: repeated inhalation challenge with homologous antigen, time interval between challenges, and history of previous pulmonary reactions to heterologous antigens. (cdc.gov)
  • MyD88 harbors a domain homologous to the cytoplasmic portion of IL-1 receptors and TLR family members. (nih.gov)
  • 9. Discrete roles for Rad54 and Rdh54 during homologous recombination. (nih.gov)
  • 20. Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling. (nih.gov)
  • Factor X deficiency is a bleeding disorder that can be inherited or acquired. (medscape.com)
  • Inherited factor X deficiency is autosomal recessive, with heterozygotes most often remaining asymptomatic or having only a mild bleeding tendency. (medscape.com)
  • 2] Pedigree analysis of patients with congenital factor X deficiency often reveals consanguinity. (medscape.com)
  • Acquired factor X deficiency can be caused by severe liver disease, vitamin K deficiency, or anticoagulant drugs such as warfarin. (medscape.com)
  • Factor X deficiency has also been reported in association with a variety of medical conditions, such systemic light-chain amyloidosis[3] -particularly in advanced cases[4] -and atypical chronic lymphoid leukemia. (medscape.com)
  • Treatment of factor X deficiency is individualized, but restoring circulating factor X levels to 10-40% of normal is usually adequate. (medscape.com)
  • Additionally, in patients with acquired factor X deficiency, treatment of the underlying cause may resolve the disorder. (medscape.com)
  • Vitamin K is ineffective in hereditary factor X deficiency but may be useful in certain acquired cases. (medscape.com)
  • In the 1950s, two independent groups first identified factor X deficiency. (medscape.com)
  • 12] Most often, missense mutations are the cause of congenital factor X deficiency. (medscape.com)
  • 15, 16, 17, 18, 19, 20, 21] Mutations in the Gla-domain of factor X, a 39 residue peptide that is part of its light chain, have been documented in at least 15 cases of factor X deficiency. (medscape.com)
  • 7. ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54. (nih.gov)
  • 13. Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1. (nih.gov)
  • Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium. (nih.gov)
  • A number of profibrotic mediators including platelet-derived growth factor (PDGF), fibroblast growth factor (FGF) and transforming growth factor-β are believed to play important roles in the pathogenesis of IPF. (ersjournals.com)
  • 4. Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors. (nih.gov)
  • This multi-functional DNA polymerase plays a key role in tumors with deficient homologous recombination (HR). This viewpoint aims to rationalize POLQ as a druggable target for HR-deficient tumors by providing recent research advancements related to POLQ. (techscience.com)
  • Fibroblast growth factor homologous factors (FHFs) are non-canonical members of the fibroblast growth factor family (FGF11-14) that were initially discovered to bind and regulate neuronal and cardiac voltage-gated Na+ channels. (duke.edu)
  • Fibroblast growth factor receptor 5 (FGF R5), also known as FGRL1, is a 65 kDa transmembrane member of the FGF receptor family (1). (rndsystems.com)
  • Nintedanib (international non-proprietary name), formerly known by its development code BIBF 1120, is a small molecule that was originally designed as an ATP-competitive inhibitor of fibroblast growth factor receptor (FGFR)-1 and vascular endothelial growth factor receptor (VEGFR)-2. (ersjournals.com)
  • The DNA damage response analysis suggest that DNA repair pathways, including the homologous recombination and REV1- and POLD3-mediated error-prone translesion synthesis pathways, are critical for the cells to tolerate to DNA damage caused by trace amount of Cr(VI). (nih.gov)
  • Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. (nih.gov)
  • Dehydration-responsive element-binding (DREB) transcription factor (TF) plays a key role for abiotic stress tolerance in plants. (hindawi.com)
  • In this study, a novel cDNA encoding DREB transcription factor, designated SsDREB , was isolated from succulent halophyte Suaeda salsa . (hindawi.com)
  • In this work, analysis of minimal commonly deleted 8p segments to identify candidate TSG implicated GATA4, a master transcription factor driver of hepatocyte epithelial lineage fate. (jci.org)
  • Its C-terminal domain belongs to the family of U2AF (U2 auxiliary factor) homology motifs (UHM), a subgroup of RNA recognition motifs that bind to tryptophan-containing linear peptide motifs (UHM ligand motifs, ULMs) in several nuclear proteins. (rcsb.org)
  • Nintedanib is a potent small molecule inhibitor of the receptor tyrosine kinases PDGF receptor, FGF receptor and vascular endothelial growth factor receptor. (ersjournals.com)
  • As nintedanib is also an inhibitor of platelet-derived growth factor receptor (PDGFR)-α and β, it was selected for development as a potential treatment for idiopathic pulmonary fibrosis (IPF). (ersjournals.com)
  • T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse. (atlasgeneticsoncology.org)
  • PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. (thermofisher.com)
  • The Rad51 filament then executes homology search and DNA strand invasion into a homologous duplex donor DNA ( Kowalczykowski, 2015 ). (elifesciences.org)
  • Here we tested the ability of human male somatic cells to directly convert into a meiotic germ cell-like phenotype by inducing them with a combination of selected key germ cell developmental factors. (nature.com)
  • For this reason double-strand breaks are preferentially repaired by homologous recombination and it is typically carried out after DNA synthesis when the two daughter DNA molecules are in proximity, and one can serve as a template for repair of the other. (jove.com)
  • If the basepairs mismatch, the invading DNA dissociates and looks for other homologous regions. (jove.com)
  • The invading strand searches for undamaged, homologous sequences in the genomic DNA by trying to form base pairs in a block of three nucleotides. (jove.com)
  • Our studies showed the Tf1 insertions result from single strand annealing (SSA), a non-canonical form of homologous recombination mediated by Rad52. (nih.gov)
  • The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. (jove.com)
  • Using glutathione S-transferase pulldown experiments, isothermal titration calorimetry, and NMR titrations, we find that Puf60-UHM binds to ULM sequences in the splicing factors SF1, U2AF65, and SF3b155. (rcsb.org)
  • For each divergence distance, we generated 1,000 replicate homologous sets, each having four promoter sequences with the same divergence distance from their ancestral sequence. (nih.gov)
  • Each sequence contained exactly one functional binding site for each of the six transcription factors: Pax6, TP53, IRF2, PPARG, ROAZ, and YY1E2F. (nih.gov)
  • Treatment options include factor X concentrate, fresh frozen plasma, and prothrombin complex concentrates (PCCs). (medscape.com)
  • Activation by the extrinsic pathway occurs via the complex of tissue factor and factor VIIa. (medscape.com)
  • Factor Xa is ultimately inactivated by forming a complex with antithrombin, which then undergoes hepatic clearance. (medscape.com)
  • Based on our knowledge of the murine germ line development, here we present a model for direct germ cell-like conversion from human somatic cells in vitro by genetic induction of selected key germ cell factors. (nature.com)
  • The scope of research supported by this FOA could include animal models and cell culture models investigating potential mechanisms involved in the pathogenesis of lung cancer, as well as studies incorporating the analysis of human tissue to define the critical factors leading to lung carcinogenesis. (nih.gov)
  • A census of human transcription factors: function, expression and evolution. (nih.gov)
  • Commercially, only the homologous fibrin sealants obtained from human blood are available, which are highly efficient but very expensive. (scielo.br)
  • Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system. (atlasgeneticsoncology.org)
  • H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (nih.gov)
  • Factor Xa can suppress the coagulation cascade by inactivating both factor VIII and tissue factor. (medscape.com)
  • In this context, the demand for higher productivity under prevailing conditions requires improving photosynthetic efficiency and biomass production, as well as increased crop tolerance to abiotic factors, to facilitate the usage of marginal lands and partially salinized waters. (frontiersin.org)
  • This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), invites research project grant applications for studies elucidating the role of the microenvironment and inflammation in lung carcinogenesis, as well as studies on the influence of these factors on the cell of origin and putative lung tumor cells. (nih.gov)
  • Clotting factor X, or Stuart-Prower factor, is a vitamin K-dependent serine protease that serves as the first enzyme in the common pathway of thrombus formation. (medscape.com)
  • As the first step in the common pathway to thrombus formation, factor X can be activated by products of both the intrinsic and extrinsic clotting cascades. (medscape.com)
  • Once formed, factor Xa is then responsible for the conversion of prothrombin to its active form, thrombin, which is responsible for activating fibrinogen and allowing clot formation. (medscape.com)
  • The objectives of this study were to (a) evaluate allotransplantation feasibility for restoration of ovarian function and (b) assess efficacy of synthetic preimplantation factor (PIF) monotherapy as sole immune-acceptance regimen. (nih.gov)