Homologous bacterial proteins. Medical search. Frequent questions

Mammalian and bacterial sugar transport proteins are homologous. (ox.ac.uk)
The Tel2 (also known as Telo2) and Tti1 proteins control the cellular abundance of mammalian PIKKs and are integral components of mTORC1 and mTORC2. (cipsm.de)

Furthermore, AtRAD54, which performs an important role in the homologous recombination repair pathway, was involved in the pairing of homologous loci with γ-irradiation. (nature.com)
We found that AtRAD54, which performs an important role in the homologous recombination (HR) repair pathway, was involved in the approach of two homologous loci under γ-irradiation. (nature.com)
Holliday junctions (HJs) are four-way DNA structures that occur in DNA repair by homologous recombination. (waw.pl)
The authors deliberately induced a single DSB in one of the homologous chromosomes in a diploid yeast strain and achieved homologous recombination-based "loss of heterozygosity" events within 20 kb of the target site. (life-science-alliance.org)
Thus, after the induction of a double-strand break an additionally supplied (modified) gene construct can be incorporated into the DNA by homologous recombination. (ersjournals.com)
What enzymes are involved with homologous recombination? (tedxhongkong.org)
What is homologous recombination? (tedxhongkong.org)
Main ways, recombination and headful packaging and transfers the bacterial genes from the donor cell. (tedxhongkong.org)
To track differentiating cell populations, reporter cell lines generated by homologous recombination (knock-in) or via BAC transgenes have been widely used in mouse cells (5-8 ). (lu.se)

While the initial MFS structures solved were of bacterial transporters, recently structures of the first eukaryotic structures have been published. (wikipedia.org)
To maintain homeostasis, the intracellular concentration of zinc(II) is strictly controlled by a family of metal-regulatory proteins in both prokaryotic and eukaryotic organisms. (bvsalud.org)
Here, a phylogenomic analysis was carried out to examine the validity of rival hypotheses suggesting alternative archaeal or bacterial origins to the eukaryotic N- glycosylation pathway. (biomedcentral.com)
The origin of the eukaryotic N- glycosylation pathway is not unique and less straightforward than previously thought: some basic components likely have proteoarchaeal origins, but the pathway was extensively developed before the eukaryotic diversification through multiple gene duplications, protein co-options, neofunctionalizations and even possible horizontal gene transfers from bacteria. (biomedcentral.com)
Also, comparative genomics have shown that many eukaryotic operational (metabolic) genes are closely related to bacterial homologues, while informational genes are more similar to archaeal ones [ 12 ]. (biomedcentral.com)
More than half of all eukaryotic proteins are glycoproteins, and 90 % of those are N- glycosylated [ 33 ]. (biomedcentral.com)
The evolution of flagella is of great interest to biologists because the three known varieties of flagella ( eukaryotic , bacterial , and archaebacterial) each represent an extremely sophisticated cellular structure that requires the interaction of many different and finely-tuned systems to function correctly. (fact-index.com)
The amino-terminal module of the poxvirus D6R/NIR proteins defines a novel conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses [ 1 ]. (expasy.org)
Author Summary In bacterial cells like in their eukaryotic counterparts precise spatiotemporal localization of proteins is critical for their cellular function. (researchdataservice.com)

One PCR product was sequenced and appeared to be in part homologous to the pla gene, but the adjacent sequence displayed high homology to genes coding for replicon ( rep) proteins in several bacterial genera in the family Enterobacteriaceae , e.g. (cdc.gov)
A Drug Target Protein (DTP) Database has been developed having mainly in silico predicted potential drug target proteins and non human homologous genes in bacterial human pathogens. (scialert.net)
For this, it identifies and clusters co-localized genes encoding proteins of secretion systems using sequence similarity search with Hidden Markov Model (HMM) protein profiles. (bvsalud.org)
The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
The accessory gene regulator ( agr ), a well-studied QS system, controls the expression of a series of virulence-associated protein genes in some Gram-positive bacteria 19, 20 . (ijpsr.com)
Bioinformatics strategies were used to find other homologous genes and proteins, which can also degrade HCH present in various bacteria for controlling of pollution and offer clue to prevent its entry in the food chain. (ispub.com)
Twenty genes form the basis of a bacterial CCM. (elifesciences.org)
Here only the bacterial genes that are close to the site of prophage are transferred. (tedxhongkong.org)
This excised phage DNA undergoes lytic cycle and infects another bacterium and transfers the bacterial genes from the donor bacterium. (tedxhongkong.org)
Of host cell DNA bacterium and transfers the bacterial genes that are close to the site of are! (tedxhongkong.org)
The present study has identified many potential immune-related genes in A. mylitta some of which are vertebrate homologues and others are hitherto unreported putative defence proteins. (biomedcentral.com)

This flexible computational tool uses the knowledge gathered from experimental studies to identify homologous systems in genome data. (bvsalud.org)
The delineation of protein domains within a polypeptide chain, namely at the genome scale, can be achieved in several ways but may remain problematic in many instances. (biomedcentral.com)
We have developed a new method for the identification of domains in unassigned regions through indirect connections and scaled up its application to the analysis of 434 unassigned regions in 726 protein sequences of Mycoplasma gallisepticum genome. (biomedcentral.com)
Genome editing is achieved by precisely targeting the nuclease activity of a modified bacterial protein (Cas9) via a user-defined guide RNA to a specific DNA sequence ( 1 ). (life-science-alliance.org)
Expert speakers will lead a discussion on not only scientific advances but also ethical considerations that need to be taken into account by focusing on two novel technologies: clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system-based genome editing and the use of (modified) stem cell therapies. (ersjournals.com)
It consists of an exonuclease introducing double-strand DNA breaks, which is the Cas9 protein, and a guide RNA that specifically directs the latter to the location of interest in the genome [ 2 ]. (ersjournals.com)
instead of T4 genome, a piece of host cell's bacterial DNA is packaged in the phage head. (tedxhongkong.org)
Bacteria and integrates its genome within the host cell 's bacterial DNA remains attached the. (tedxhongkong.org)
Cycle and infects another bacterium and transfers the bacterial DNA instead of T4 genome, a piece of cell. (tedxhongkong.org)

We have determined the sequences of the arabinose-H+ and xylose-H+ membrane transport proteins of Escherichia coli. (ox.ac.uk)
The major facilitator superfamily (MFS) is a superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmotic gradients. (wikipedia.org)

Amino-acid sequence homology of a polymorphic cellular protein from human lymphocytes and the chaperonins from Escherichia coli (groEL) and chloroplasts (Rubisco-binding protein). (wikidata.org)
The typical bacterial scenario seemed to be a two-component sHsps system of two homologous sHsps, such as the Escherichia coli sHsps IbpA and IbpB. (cipsm.de)

One bacteria-induced gene encodes a proteinthat, after expression in the baculovirus system, was shown to be apeptidoglycan recognition protein (PGRP). (embl-heidelberg.de)
In GRAM NEGATIVE BACTERIA, multiprotein complexes that function to translocate pathogen protein effector molecules across the bacterial cell envelope, often directly into the host. (bvsalud.org)
Several of the systems have homologous components functioning similarly in GRAM POSITIVE BACTERIA. (bvsalud.org)
Our results demonstrate that surface located Hsc70 on TG cells mediates the uptake of pathogenic bacteria and proteins containing the TPR domain inhibit the function of Hsc70 by binding to its EEVD motif. (biomedcentral.com)
We found that there was a higher degree of bacterial colonization in the placenta than in other organs, that there were many bacteria in trophoblast giant (TG) cells in the placenta and that an intracellular replication-defective mutant did not induce abortion. (biomedcentral.com)
Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila. (sdbonline.org)
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. (sdbonline.org)
These transport proteins appear to be unique to mitochondria, plant plastids, and obligate-intracellular bacteria. (usda.gov)
Tertiary structures of AgrA proteins of some pathogenic bacteria like Listeria monocytogenes, Chlamydia trachomatis, Enterococcus faecalis, Streptococcus pyogenes and Macrococcus canis showing antimicrobial resistance are not yet available in structural databases like PDB. (ijpsr.com)
The compositional and structural differences of the LytTR domain of AgrA proteins between the pathogenic and non-pathogenic bacteria were analyzed in our study. (ijpsr.com)
In bacteria, all nascent proteins bear the pretranslationally formed N-terminal formyl-methionine (fMet) residue. (microbialcell.com)
One possibility is that the similarity of the formyl and acetyl groups, their identical locations in N‑terminally formylated (Nt‑formylated) and Nt-acetylated proteins, and the recently discovered proteolytic function of Nt-acetylation in eukaryotes might also signify a proteolytic role of Nt‑formylation in bacteria. (microbialcell.com)
PCR using the new primer pair on a set of template DNAs of different bacterial genera showed that the method was selective for bacteria belonging to the family Sphingomonadaceae . (ispub.com)

Zinc(II) ions play critical roles in all known life as structurally important stabilizing ions in proteins, catalytically active metals in enzymes, and signaling agents impacting physiological changes. (bvsalud.org)
These low and high-resolution data sets originates from T3SSes from different species and can also be collected from other structurally homologous systems, such as the flagella. (lu.se)

This model represents one of several families of proteins related to bacterial flagellar biosynthesis proteins and involved in bacterial type III protein secretion systems. (nih.gov)

The mGluRs possess the seven putative transmembrane domains which are characteristic of GPCR proteins. (bdbiosciences.com)
Putative proteins with homology to the KilA-N domain have also been identified in Maverick transposable elements of the parabasalid protozoa Trichomonas vaginalis [ 2 ]. (expasy.org)
Of the four putative novel defence proteins (DFPs) annotated by PSI-BLAST three showed similarity to extracellular matrix proteins from vertebrates implicated in innate immunity, while the fourth was similar to, yet distinct from, the anti-microbial protein cecropin. (biomedcentral.com)

These observations popularized the opinion according to which the eukaryotes are a chimeric lineage that resulted from the endosymbiosis of the bacterial ancestor of mitochondria within a bona fide archaeon [ 13 , 14 ] or a previous bacterium/archaeon consortium [ 15 - 17 ]. (biomedcentral.com)
The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)

The two halves of the protein pack against each other in a clam-shell fashion, sealing via interactions at the ends of the transmembrane helices and extracellular loops. (wikipedia.org)
The sizable extracellular N-terminal domain is homologous to bacterial periplasmic binding proteins and serves as the glutamate binding site. (bdbiosciences.com)
A similar His3Asp site found in calprotectin (S100A8/S100A9, calgranulin A/B), a closely related human S100 protein, can sequester divalent metal ions from the solute-binding proteins (SBPs) pneumococcal PsaA (pneumococcal surface protein A) and staphylococcal MntC (manganese transport protein C). Both SBPs are components of Mn(II) transporters and capture extracellular Mn(II) ions for subsequent delivery into the bacterial cytosol. (bvsalud.org)
Furthermore, plasma membrane proteins and intracellular proteins can be released into the extracellular space by regulated or non-regulated processes. (cipsm.de)

Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein. (yeastgenome.org)
Secondly, the two statistical applications mainly (A) Amino Acid Dynamics and (B) amino acid composition were added in the database for analysis of sequence of drug target proteins. (scialert.net)
From our results and the sequence homology, weconclude that PGRP is a ubiquitous protein involved in innate immunity,conserved from insects to humans. (embl-heidelberg.de)
These changes involve rare high-energy states with protein-ssisted base flipping that are readily accessible for the cognate DNA sequence but not for non-cognate sequences. (waw.pl)
Experimental and/or computational methods can be used to identify domains in the given protein sequence. (biomedcentral.com)
Due to high evolutionary divergence, it is not always possible to identify distantly related protein domains by sequence search techniques. (biomedcentral.com)
Recently, long-standing suspicions that tubulin was homologous to FtsZ (based on very weak sequence similarity and some behavioral similarities), were impressively confirmed in 1998 by the independent resolution of the 3-dimensional structures of the two proteins. (fact-index.com)
Using the amino acid sequence from the Las encoded translocase, a homologous protein was identified in Ca. Liberibacter solanacearum (Lso), the bacterium associated with zebra chip disease. (usda.gov)
We are also interested in understanding how oligomerization specificity is encoded in protein sequence and structure, in particular in coiled-coils. (lu.se)

Coupling with G proteins provides the metabotropic glutamate receptors (mGluRs) with the capacity for intracellular signal transduction. (bdbiosciences.com)
The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins. (bdbiosciences.com)
Although the bacterial translocase has been characterized in other intercellular pathogens such as Chlamydia trachomatis and Rickettsia prowazeki, this is the first characterization of an ATP/ADP translocases in an obligate-intracellular plant pathogen and, given the conservation of the ATP uptake mechanism, may represent an evolutionary link between plant and animal pathogens. (usda.gov)

There is little apparent homology with the lactose-H+ (LacY) or melibiose-Na+ (MelB) transport proteins of E. coli. (ox.ac.uk)
In order to derive structures of these AgrA proteins, homology modeling approach was employed. (ijpsr.com)

Our results suggest that the transient reduction in inter-allelic distance and increase in pairing frequency of homologous loci after DSB result in partial chromatin reorganisation of interphase nuclei and that AtRAD54 contributes to the subcellular movement of homologous loci in the HR repair pathway. (nature.com)
Human S100A12 (calgranulin C, EN-RAGE) is a Zn(II)-sequestering host-defense protein that contributes to the metal-withholding innate immune response against microbial pathogens. (bvsalud.org)
Here we show that heat shock cognate protein 70 (Hsc70) contributes to bacterial uptake by TG cells and the EEVD motif of Hsc70 plays an important role in this. (biomedcentral.com)
Starting with a degron: N-terminal formyl-methionine of nascent bacterial proteins contributes to their proteolytic control. (microbialcell.com)

claiming that two homologous chromosomes paired between complementary sequences lead to the formation of a cross-stranded structure that physically links the two component helices. (iucr.org)

This domain is found in a family of animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme [ ( PUBMED:9707603 ) ], and some bacterial homologues. (embl-heidelberg.de)

Studies have demonstrated that food allergens are transported in large quantities across the epithelium by binding to cell surface IgE/CD23, which opens a gate for intact dietary allergens to transcytose across the epithelial cells that protect the antigenic protein from lysosomal degradation in enterocytes. (medscape.com)
After exhibiting a diffuse localization in the cytoplasm ComGA accumulates preferentially at polar clusters where it co-localizes with other competence proteins to form the transformation machinery [4 13 Upon dilution into fresh medium ComGA stays at the poles for 120 minutes before delocalizing presumably through degradation or inactivation ultimately reversing elongation inhibition [12]. (researchdataservice.com)
We addressed this hypothesis about fMet‑based degradation signals, termed fMet/N-degrons, using specific E. coli mutants, pulse-chase degradation assays, and protein reporters whose deformylation was altered, through site-directed mutagenesis, to be either rapid or relatively slow. (microbialcell.com)
The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)

An attractive pathway to resolve this problem of resistance may be achieved by targeting the bacterial quorum sensing (QS) process. (ijpsr.com)
An attractive pathway to resolve the problem of bacterial resistance to current antibacterial agents is targeting bacterial QS 10-14 . (ijpsr.com)

The modeled proteins were validated by several methods, and the physico-chemical properties of these refined protein structures were predicted using in-silico methods. (ijpsr.com)

Nowadays, the production of full Wolbachia genomes does not require the physical isolation of the bacterial strains from their respective hosts, and the bacterium is often sequenced as a by-catch of host genomic projects. (bvsalud.org)
The BLASTP search results showed that the homologous proteins of glycosidases related to raffinose utilization are widely distributed in 196 of the 528 gut bacterial strains. (rsc.org)

The emergence of antimicrobial resistance severely threatens our ability to treat bacterial infections. (frontiersin.org)
ß-Lactam antibiotics comprise one of the most widely used therapeutic classes to combat bacterial infections. (bvsalud.org)
On the other hand, intestinal infections may increase paracellular permeability, allowing the absorption of food proteins without epithelial processing. (medscape.com)
Fighting bacterial infections by interfering with their command language and disrupting virulence expression could serve as a viable alternative. (ijpsr.com)
Fighting bacterial infections by interfering with their command language or QS and disrupting virulence expression could serve as an alternative way to inhibit growth 15-18 . (ijpsr.com)
[ 1 , 2 ] The clinical picture is characterized by marked leukocytosis and localized bacterial infections that are difficult to detect until they have progressed to an extensive level secondary to lack of leukocyte recruitment at the site of infection. (medscape.com)
Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
ICAP at Columbia University is being funded to develop a network of four hospitals in Kenya to improve their ability to detect bacterial infections, determine antibiotic resistance in the infections, assess antibiotic use and the prevalence of healthcare-acquired infections, and develop an antibiotic stewardship collaborative to improve the use of antimicrobials at the hospitals. (cdc.gov)

These effectors are involved in producing surface structures for adhesion, bacterial motility, manipulation of host functions, modulation of host defense responses, and other functions involved in facilitating survival of the pathogen. (bvsalud.org)
Borrelia burgdorferi , an emerging bacterial pathogen, is maintained in nature by transmission from one vertebrate host to another by ticks. (cdc.gov)
By means of DNA sequencing of a large sample collection of the pathogen from across the United States, we studied the gene for the bacterium's highly diverse OspC protein, protective immunity against which develops in animals. (cdc.gov)

Here, we describe how to identify protein secretion systems in bacterial genomes using the MacSyFinder program. (bvsalud.org)

Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. (embl-heidelberg.de)

This family is homologous to, but distinguished from, flagellar biosynthetic protein FlhB (TIGRFAMs model TIGR00328). (nih.gov)
An obvious approach to the evolutiuon of the bacterial flagellum is suggested by the fact that a subset of flagellar components can serve a function as a Type III transport system. (fact-index.com)
This schematic diagram highlights the assembly process of the bacterial flagellar filament and the cap-filament complex. (biblestudymanuals.net)

Protein secretion systems are complex molecular machineries that translocate proteins through the outer membrane and sometimes through multiple other barriers. (bvsalud.org)
The ribosomal operons mainly 16S rDNA has proven to be a stable and specific molecular marker for bacterial identification. (ispub.com)
Small heat shock proteins (sHsps) are molecular chaperones that prevent the aggregation of nonnative proteins. (cipsm.de)

The uptake of a sugar across the boundary membrane is a primary event in the nutrition of most cells, but the hydrophobic nature of the transport proteins involved makes them difficult to characterize. (ox.ac.uk)

List of external identifiers for the protein from various database sources. (yeastgenome.org)

CRISPR/Cas9 is a bacterial protein-RNA complex. (ersjournals.com)

Domain assignment to the protein sequences has paramount importance in the post genomic era. (biomedcentral.com)
Although the number of AgrA protein sequences has increased exponentially, the number of experimentally determined protein structures lags far behind. (ijpsr.com)
Total 38 nucleotides and 36 proteins sequences of linA and linB were used for constructing the phylogeny. (ispub.com)

We have recently shown that it is possible to enhance prediction of domains in the unassigned regions by 25% through indirect connections in the class III adenylyl cyclase domain containing proteins [ 10 ]. (biomedcentral.com)
Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently. (uchicago.edu)
A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. (uchicago.edu)

Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD). (yeastgenome.org)
It has been discovered that a large number of bacterial species produce many virulence factors and form biofilms, which are regulated by the cell to cell communication process called quorum sensing (QS) 7-9 . (ijpsr.com)

What are the two major enzymatic properties of E. Coli RecA protein? (tedxhongkong.org)
E. Coli RecA protein the donor bacterium bacterial cell in transfomation is probaly dead bacterium to another by virus. (tedxhongkong.org)

Soybean protein ranks second as an antigen in the first months of life, particularly in infants with primary cow's milk intolerance who are placed on a soy formula. (medscape.com)
Brucella abortus and Listeria monocytogenes were used as the bacterial antigen in this study. (biomedcentral.com)

One live-cell imaging technique, a chromatin-tagging system that is based on the bacterial operator/repressor system, has been a powerful technique for analysing chromatin dynamics and arrangement in real time 11 , 12 . (nature.com)
We revealed that the homologous loci kept a constant three-dimensional distance in the nucleus using live-cell imaging with a bacterial operator/repressor system. (nature.com)
however, bacterial resistance to ß-lactams is now widespread, and new strategies are urgently needed to target PBPs and other proteins involved in bacterial cell wall formation. (bvsalud.org)
A key requirement in the identification of strategies to overcome resistance is a deeper understanding of the roles of the PBPs and their associated proteins during cell growth and division, such as can be obtained with the use of selective chemical probes. (bvsalud.org)
BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. (nih.gov)
It shares mechanistic similarities based on the use of polyisoprenol lipid carriers with other glycosylation pathways involved in the synthesis of bacterial cell wall components (e.g. peptidoglycan and teichoic acids). (biomedcentral.com)
Non-IgE mediated food allergies involve T-cell mediated immunity to certain food proteins. (medscape.com)
Bacterial ATP/ADP translocases transport ATP from the host cell cytosol, across the lipid bilayer, and into the bacterial cell. (usda.gov)
During bacterial exponential growth the morphogenetic actin-like MreB proteins form membrane-associated assemblies that move processively following trajectories perpendicular to the long axis of the cell. (researchdataservice.com)
Our findings suggest a model in which MreB sequestration by the late competence protein ComGA prevents cell elongation during the escape from competence. (researchdataservice.com)
Among the different classes of proteins regulating bacterial cell elongation the bacterial actin-like MreB proteins have been the most studied over the past fifteen years. (researchdataservice.com)
MreB proteins (Mre for Murein cluster e) are essential for cell. (researchdataservice.com)
The formylation of N-terminal Met in bacterial proteins is not strictly essential for either translation or cell viability. (microbialcell.com)
The flagellum is an ion-powered rotary motor, anchored in the membranes surrounding the bacterial cell. (biblestudymanuals.net)
A. Specialised Transduction: In this process, the bacteriophage gets attached to a bacterial cell wall at the receptor site and the nucleic acid of bacteriophage is transferred into the cyto-plasm of â ¦ Mutations. (tedxhongkong.org)
This T4 head gets a tail and becomes a viral particle and is capable of infecting another bacterial cell. (tedxhongkong.org)
Questions Name the three types of bacterial exchange of DNA The donor bacterial cell in transfomation is probaly dead. (tedxhongkong.org)
At times, a piece of host cell 's bacterial DNA is in. (tedxhongkong.org)
This macromolecular assembly comprises more than 20 conserved proteins that form a series of ring-like structures and a needle-shaped protrusion, which allows the transport of proteins into a host cell. (lu.se)

Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. (bdbiosciences.com)
Biochemical fractionation showed that IglA is a soluble cytoplasmic protein and immunoprecipitation experiments demonstrate that it interacts with the downstream-encoded IglB. (biomedcentral.com)

They are homologous with each other and, unexpectedly, with the glucose transporters of human hepatoma and rat brain cells. (ox.ac.uk)

The major facilitator superfamily (MFS) are membrane proteins which are expressed ubiquitously in all kingdoms of life for the import or export of target substrates. (wikipedia.org)

Recent studies indicate that CRISPR-induced DNA cuts may also result in the exchange of genetic information between homologous chromosome arms. (life-science-alliance.org)
[ 3 ] Genetic variations in receptors for bacterial products are likely to be related to allergic sensitizations. (medscape.com)

Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)

Bacterial DNA could be separated from host DNA based on genomic size. (bvsalud.org)
In this chapter, we describe a complete pipeline of analysis, starting from (i) the integration of information from a reference set of experimentally studied systems, (ii) the identification of conserved proteins and the construction of their HMM protein profiles, (iii) the definition and optimization of "macsy-models," and (iv) their use and online distribution as tools to search genomic data for secretion systems of interest. (bvsalud.org)
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl-heidelberg.de)

The basic fold of the MFS transporter is built around 12, or in some cases, 14 transmembrane helices (TMH), with two 6- (or 7- ) helix bundles formed by the N and C terminal homologous domains of the transporter which are connected by an extended cytoplasmic loop. (wikipedia.org)
The protein product of the translocase gene demonstrated characteristics typical for members in this family of proteins, including 12 transmembrane helices and an isoelectric point of 9.4. (usda.gov)
Bioinformatic analysis of the protein revealed 12 transmembrane helices and an isoelectric point of 9.4, both of which are characteristic of this family of proteins. (usda.gov)

Eight metabotropic glutamate receptors (mGluR1-8) and several Ca[2+] sensing receptors belong to a novel G-protein coupled receptor (GPCR) family. (bdbiosciences.com)

Here we report data collected from differential scanning calorimetry (DSC) experiments aimed to measure the structural stability of AdcR, the fully complimented Zn2AdcR complex, and the protein/DNA complex Zn2AdcR/dsDNA. (bvsalud.org)
These conformational changes and the relief of protein-induced structural tension of the DNA facilitate coordination between the two cuts. (waw.pl)
Protein domains are the structural, functional and evolutionary units of proteins. (biomedcentral.com)
expressing rubisco and its associated chaperones (green), carboxysome structural proteins (purple), and an inorganic carbon transporter (orange). (elifesciences.org)
Our goal is to use high-resolution structural modeling techniques guided by constraints taken from lower resolution experimental data to generate structural models of important biological protein assemblies for which high resolution structural determination is unfeasible. (lu.se)

The first structures were of the glycerol 3-phosphate/phosphate exchanger GlpT and the lactose-proton symporter LacY, which served to elucidate the overall structure of the protein family and provided initial models for understanding the MFS transport mechanism. (wikipedia.org)
3D structures of these proteins are essential to determine most of their functions, and for the development of agents that can be explored as therapeutic agents. (ijpsr.com)
Many biological processes are controlled by large multi-component protein assemblies, the size and complexity of which typically precludes the determination of their high-resolution structures. (lu.se)
Currently we are working with development of methods to determine structures of fibrillar proteins by a combination of structure modeling and X-ray fiber diffraction interference. (lu.se)
Previous work in this area has been on modeling the assembly structure of the type III secretion system and prediction of the high-resolution structures of homo-oligomeric proteins using limited experimental data from Nuclear Magnetic Resonance (NMR) in order to speed up the process of structure determination. (lu.se)

Both proteins mediate protein-protein and protein-RNA interactions for cooperative RNA-binding during spliceosome assembly. (cipsm.de)

The results of this study demonstrate that IglA and IglB are interacting cytoplasmic proteins that are required for intramacrophage growth. (biomedcentral.com)
see also Asai and Koonce, 2001) shows that the more complex protein family of cilial dynein has an obvious ancestor in a simpler cytoplasmic dynein (which itself appears to be a result of a four-fold duplication of a smaller motif). (fact-index.com)

Moreover, protein synthesis by the cytosolic ribosomes of eukaryotes does not involve the formylation of N-terminal Met. (microbialcell.com)

A peptidoglycan recognition protein in innate immunity conserved frominsects to humans. (embl-heidelberg.de)

We also found that DNA double-strand breaks (DSBs) induce the approach of the homologous loci with γ-irradiation. (nature.com)
Moreover, the distance between two homologous loci in the interphase nucleus was shortened by γ-irradiation, which induces DNA double-strand breaks (DSBs). (nature.com)

Transduction is the process by which bacterial DNA is moved from one bacterium to another by a virus. (tedxhongkong.org)
Generalized transduction is the process by which any bacterial gene may be transferred to another bacterium via a bacteriophage, and typically carries only bacterial DNA and no viral DNA. (tedxhongkong.org)

In essence, this is the packaging of bacterial DNA into a viral envelope. (tedxhongkong.org)
New host cells infected by these viral particles received bacterial DNA instead of viral DNA. (tedxhongkong.org)
Viral particles received bacterial DNA remains attached to the site of prophage are. (tedxhongkong.org)

In competent cells MreB was found in complex with several competence proteins by pull-down assays. (researchdataservice.com)

Recently new lysine modifications were detected in histones and other proteins. (cipsm.de)

Many food proteins can act as antigens in humans. (medscape.com)
Of the bacterial ATP/ADP translocases characterized thus far, all have been found in endosymbionts of protozoa or pathogens of higher order animals including humans. (usda.gov)

Anatomy19

Organisms27

Diseases1

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes67

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science5

Health Care1

Mammalian2

Recombination9

Eukaryotic9

Genes11

Genome9

Membrane transpor2

Escherichia2

Bacteria13

Structurally2

Biosynthesis1

Putative3

Mitochondria2

Extracellular4

Sequence11

Intracellular3

Homology2

Contributes4

Chromosomes1

Homologues1

Degradation4

Pathway2

Physico-chemical properties1

Strains2

Infections8

Pathogen3

Genomes1

Lysozyme1

Flagellar3

Molecular3

Transport proteins1

External identifiers for the protein1

Cas91

Sequences3

Adenylyl cyclase3

Species2

RecA2

Antigen2

Cell19

Soluble2

Transporters1

Superfamily1

Genetic2

Cellular1

Genomic3

Helices3

Receptors1

Structural5

Structures5

Mediate1

Cytoplasmic2

Cytosolic1

Peptidoglycan1

Double-strand breaks2

Bacterium2

Viral3

Assays1

Lysine1

Humans2