Homolog tissues mammalian embryonic. Medical search. Frequent questions

FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. (wikipedia.org)

In this study, we identified both temporal and localization changes in expression of DmFKBP12, a translational and transcriptional regulator of Drosophila RyR (DmRyR) and FKBP12, through embryonic development. (biomedcentral.com)
Further study on the differences between mammalian RyR-FKBP12 and Drosophila DmRyR-FKBP12 can be exploited to develop safe pesticides. (biomedcentral.com)
rbf1 , the Drosophila homolog of Rb , also displays a pro- apoptotic activity in proliferative cells. (sdbonline.org)
Deformed epidermal autoregulatory factor-1 (DEAF-1) is a transcription factor that was originally shown to bind the autoregulatory enhancer of the Deformed ( Dfd ) Hox gene, which is activated in embryonic head segments of Drosophila (Gross, 1996). (sdbonline.org)
In 1993, Clifford Tabin and Andrew P. McMahon in the US and Philip W. Ingham in England published the DNA sequences of related genes, or homologs, to the Drosophila hh gene in several vertebrate families. (asu.edu)
To understand the role of autophagy in the pathogenesis of glial tumors in vivo, an established Drosophila melanogaster model of glioma was used based on overexpression in larval glial cells of an active human EGFR and of the PI3K homolog Pi3K92E /Dp110. (sdbonline.org)
Interestingly, the resulting hyperplastic glia express high levels of key components of the lysosomal-autophagic compartment, including vacuolar-type H(+)-ATPase (V-ATPase) subunits and ref(2)P (refractory to Sigma P), the Drosophila homolog of SQSTM1/p62. (sdbonline.org)
volume = {122}, number = {Pt 24}, pages = {4505--4515}, abstract = {In Drosophila, the humoral response characterised by the synthesis of antimicrobial peptides (AMPs) in the fat body (the equivalent of the mammalian liver) and the cellular response mediated by haemocytes (blood cells) engaged in phagocytosis represent two major reactions that counter pathogens. (cnrs.fr)

To elucidate the general importance of ADF/cofilin activity for apoptosis, we exposed mouse embryonic fibroblasts deficient for n-cofilin, ADF (actin depolymerizing factor), or all ADF/cofilin isoforms to well-characterized apoptosis inducers. (nature.com)
To test the relevance of ADF/cofilin activity for apoptotic processes, we here employed a genetically well-defined system of mouse embryonic fibroblasts (MEFs) devoid of any ADF/cofilin activity and challenged these cells with well-characterized apoptosis inducers. (nature.com)
Examples of a novel series of phenanthrolinones are shown to be potent competitive inhibitors of avian prolyl 4-hydroxylase, and of collagen hydroxylation, in embryonic chick tendon cells and human foreskin fibroblasts in vitro and in the oestradiol-stimulated rat uterus in vivo. (embl.de)
Primed hPSCs are treated with a mammalian target of rapamycin inhibitor (Torin1) for 3 h and dissociated to single cells, which are plated on mouse embryonic fibroblasts in 2iLI medium, a condition essentially the same for culturing mouse embryonic stem cells. (nature.com)
The aberrant chromatin adjustments in SIRT1 depleted fibroblasts are followed by chromosomal instability [8,9], as well as the phenotypes of conditional, tissue-specific deletion mutants implicate SIRT1 activity in the response to oxidative stress during embryonic tumorigenesis and hematopoiesis [10]. (monossabios.com)

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. (thermofisher.com)

Apoptosis is essential for many fundamental processes, such as embryogenesis and tissue homeostasis. (nature.com)
During oogenesis, spermatogenesis and embryogenesis cells initially proliferate then differentiate into specific tissues. (ecu.edu)
The hedgehog signaling pathway is a mechanism that regulates cell growth and differentiation during embryonic development, called embryogenesis, in animals. (asu.edu)
Hh proteins are secreted morphogens that play essential roles in regulation of embryogenesis, development, tissue homeostasis, regeneration and stem cell maintenance in a concentration-dependent manner [ 6 ]. (biomedcentral.com)
Thus, the extrinsic apoptosis pathway in zebrafish closely resembles its mammalian counterpart and cooperates with the intrinsic pathway to trigger tissue-specific apoptosis during embryogenesis in response to ectopic Apo2L/TRAIL expression. (deathbase.org)

SIRT1 substrates in the mammalian nucleus Potential SIRT1 substrates could be discovered by acquiring proteins that talk about the SIRT1 identification theme, bind overexpressed SIRT1 or display elevated degrees of acetylation in SIRT1-depleted cells. (monossabios.com)
Generally in most mammalian genomes, the WNT family members is normally made up of 19 associates that are seen as a an extremely conserved cysteine-rich secreted glycoproteins, which present the specialized challenges in effective creation, biochemical characterization and structural evaluation of WNT proteins 28, however the structure from the Xenopus WNT8 proteins as destined to Frizzled (FZD) was lately resolved 29. (icsv20.org)
If Extramacrochaetae par-ticipates in cell specification by dimerizing with basic-region-helix-loop-helix proteins, the variety of defects and tissues affected by the insufficiency of extramacrochaetae suggests that helix-loop-helix proteins are involved in many embryonic developmental processes. (biologists.com)

In embryonic avian tendon, cell density regulates collagen production. (embl.de)
An early on identified take a flight Wingless (Wg) gene, which regulates portion polarity during larval advancement 3, was discovered to be always a WNT1 homolog 4. (icsv20.org)
Sonic hedgehog (SHH) is a secreted morphogen that regulates the patterning and growth of many tissues in the developing mouse embryo, including the central nervous system (CNS). (silverchair.com)

Adult and embryonic Brugia malayi are shown to be susceptible to inhibitors of vertebrate prolyl 4-hydroxylase, with exposed parasites exhibiting pathologies consistent with a disruption in cuticle biosynthesis. (embl.de)
Cloning new vertebrate receptors offers the opportunity to use molecular genetic techniques, biochemistry and genomic technology to identify new hormones important in embryonic development and adult physiology. (uci.edu)
These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs, and our study suggests that the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution. (deathbase.org)

Loss of REV3L causes embryonic lethality in mice and leads to progressive chromosomal instability in Rev3L disrupted cell lines. (pitt.edu)
When SIRT1 is certainly depleted in mice, nearly all SIRT1 depleted mice display embryonic lethality. (monossabios.com)

Here, we demonstrate that ß-catenin targets vinculin to the apical AJs and the centrosome in the embryonic neural tube (NT). (bvsalud.org)
Although it is expressed broadly, FKBP8 is required to antagonize SHH signaling primarily in neural tissues, suggesting that hedgehog signal transduction is subject to cell-type specific modulation during mammalian development. (silverchair.com)

In addition, elucidating how Rev3L is expressed and regulated in mammalian cells will indicate what role it may play in tissues of the adult organism and why it is essential for life. (pitt.edu)
their post-translational modification, and tissue-specific expression pattern in the adult mouse. (pitt.edu)
In the last four decades, transgenic and knockout mouse models have helped to understand the mechanisms of mammalian sex determination, germ cell development, and adult gonad functions. (lidsen.com)
Central nervous system (CNS) of adult mammalian and, in particular of people, is a typical example of organs that are not restored. (kiev.ua)

Three mammalian Hh ligands have been identified, namely Sonic Hedgehog (SHH), Indian Hedgehog (IHH) and Desert Hedgehog (DHH) [ 3 ]. (biomedcentral.com)

The protocol is suitable for studying the development of hPSCs in mouse embryos and may facilitate the generation of human cells, tissues and organs in animals. (nature.com)
HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)
Essential for mesoderm formation and axial patterning during embryonic development. (cusabio.com)
However, the growing interest in the development of innovative treatments that are aimed at the regeneration damaged tissue CNS is based on the latest research in the field of stem cells and neurology. (kiev.ua)
Despite of the relevance of this issue, very little is known about the factors regulating the development of adipose tissue in fish, and the possible health alterations associated to an increased fat deposition. (biomedcentral.com)
In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
We have previously shown that fish primary preadipocytes differentiate into mature adipocytes in vitro and that these cells represent a very helpful model system to study adipose tissue development in fish [ 5 , 6 ]. (biomedcentral.com)
The first lineage specification during mammalian embryo development can be visually distinguished at the blastocyst stage. (bioone.org)

Because of the large size of the mammalian REV3L cDNA (10.6 kbp) and protein (353 kDa), work in this field has focused solely on functional genetic studies associated with disruption or knockdown of the gene. (pitt.edu)

Fertility and embryonic viability are measures of efficient germ cell growth and differentiation. (ecu.edu)

This gene displayed oncogenic transforming activity when transfected into mammalian cells. (wikipedia.org)
This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. (thermofisher.com)
SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. (thermofisher.com)
attract various forms of ECs from adjacent nontumorous tissues, circulating ECs, or bone marrow derived endothelial progenitor cells for the web site wherever neoangiogenesis happens. (fak-signal.com)
Here, we find that inhibitory SMAD6 functions in endothelial cells to negatively regulate ALK1-mediated responses, and it is required to prevent vessel dysmorphogenesis and hemorrhage in the embryonic liver vasculature. (bvsalud.org)
Reduced Alk1 gene dosage rescued embryonic hepatic hemorrhage and microvascular capillarization induced by Smad6 deletion in endothelial cells in vivo. (bvsalud.org)
Thus, we conclude that ADF/cofilin activity is not generally required for induction or progression of apoptosis in mammalian cells. (nature.com)
In summary, our work demonstrates that in mammalian cells ADF/cofilin activity is not generally required for efficient induction of apoptosis. (nature.com)
In mammalian cells, m6A modification is a reversible process regulated by m6A WERs (writers, erasers and readers). (biomedcentral.com)
Systematical profiling and comprehensive annotation of embryonic stem cells lincRNAs may not only bring a clearer big picture of these novel regulators but also shed light on their functionalities. (biomedcentral.com)
New cell lines from mouse epiblast share defining features with human embryonic stem cells. (nature.com)
Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells. (nature.com)
Derivation of naive human embryonic stem cells. (nature.com)
Interspecies chimerism with mammalian pluripotent stem cells. (nature.com)
Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. (nature.com)
Wang, Y. & Gao, S. Human naive embryonic stem cells: how full is the glass? (nature.com)
CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells. (nih.gov)
Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
The rising evidence signifies that WNT signaling performs an essential function in regulating many natural procedures, including embryonic advancement, tissues maintenance and homoeostasis of stem cells. (icsv20.org)
In this study, we found that LIM-only protein 3 (LMO3) is hypomethylated and overexpressed in glioma cells and tissues. (oncotarget.com)
Furthermore, we examined the function of zebrafish Casp8 protein in mammalian cells, and showed that it has pro-apoptotic activity when overexpressed. (deathbase.org)
In mouse embryos, cells seem prepatterned to become certain cell lineage because the first cleavage plane has been related with further embryonic-abembryonic axis at the blastocyst stage. (bioone.org)
Blastocysts were then classified according to the allocation of the labeled cells in the embryonic and/or abembryonic part of the blastocyst. (bioone.org)

Based on multiple RNA-Seq datasets, we systematically identified 300 human embryonic stem cell lincRNAs (hES lincRNAs). (biomedcentral.com)
As the first global profiling and annotating of human embryonic stem cell lincRNAs, this work aims to provide a valuable resource for both experimental biologists and bioinformaticians. (biomedcentral.com)
Combining a comprehensive collection of human embryonic stem cell RNA-Seq datasets with Human BodyMap 2, we validated that 295 previously annotated lincRNAs were expressed in multiple human embryonic stem cell samples and further identified five novel hES lincRNAs through de novo assembling. (biomedcentral.com)
Moreover, we surveyed and manually screened published hES RNA-Seq datasets in several public repositories, resulting in a list of 31 wild-type human embryonic stem cell samples. (biomedcentral.com)
After 3-4 d, bright, dome-shaped colonies with mouse embryonic stem cell morphology are passaged in 2iLI medium. (nature.com)
Embryonic stem cell lines derived from human blastocysts. (nature.com)
The ground state of embryonic stem cell self-renewal. (nature.com)
The structure and structure-based modulation of ADAM17 are also described for better understanding of the various ADAM17 regulatory pathways in different cell types or tissues. (frontiersin.org)
These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)
Generally in most cell/tissues contexts, WNTs become short-range signaling 23. (icsv20.org)
In our previous studies, EMSCs were obtained from rat embryonic facial process tissue by fluorescence p75 neurotrophin receptor (p75NTR) activated cell sorting, providing a good stem cell model for studies of dental mineralization. (researchsquare.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
We identified homologs of FasL and Apo2L/TRAIL, their receptors, and other components of the cell death machinery. (deathbase.org)
Two cell lineages are observed on the embryonic-abembryonic axis of the blastocyst: the inner cell mass and the trophectoderm. (bioone.org)

The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. (wikipedia.org)
Therefore, growth of adipose tissue includes the hypertrophy of already existing adipocytes and the proliferation and differentiation of new ones from MSCs. (biomedcentral.com)

The mammalian extrinsic apoptosis pathway is triggered by Fas ligand (FasL) and Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL). (deathbase.org)

In the developing mouse embryo, Rev3L transcript is found in all tissues. (pitt.edu)
Here we describe the cloning and characterization of the developmental expression pattern of two mouse cdc25 homologs. (biologists.com)

These sites of expression suggest that REV3L may be important for highly oxidative tissue compared to proliferative tissue. (pitt.edu)

Methylation of mammalian DNA and histone residues are known to regulate transcription, and the discovery of demethylases that remove methylation in DNA and histones provide a basis for the understanding of dynamic regulation of mammalian gene expression. (cmbn.no)
Finally, REV3L expression in mice is highest in testis, cardiac tissue and the smooth musculature of lung and intestines and low in lymphoid tissues. (pitt.edu)
We sought to establish the effects of the loss of AND-34 expression in a mammalian organism. (molvis.org)

A small percentage of AND-34 −/− mice show distinctive small white eye lesions resulting from the migration of ruptured cortical lens tissue into the anterior chamber. (molvis.org)

Human REV3L was hypothesized to interact with REV1 and/or REV7 based on knowledge about te yeast homologs. (pitt.edu)
This Human NODAL ELISA Kit was designed for the quantitative measurement of Human NODAL protein in serum, plasma, tissue homogenates. (cusabio.com)

It was hypothesized that organs with highly proliferative tissue require REV3L. (pitt.edu)

It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological processes. (frontiersin.org)

Since the discovery of the yeast gene silencing modifier (Silent Information Modifier 2, SIR2) and its own function in maintaining genomic stability a lot more than 2 decades ago, SIR2 homologs (sirtuins) were identified in diverse species. (monossabios.com)
The zebrafish casp8 gene has a genomic organization similar to mammalian casp8 genes, consisting of 10 exons. (deathbase.org)

Our understanding of REV3L biochemistry stems predominantly from studies done with the budding yeast homolog, Rev3. (pitt.edu)

These results show that in larvae, integration of the two responses in a systemic reaction depend on the production of a cytokine (spz), a process that strongly parallels the mammalian immune response. (cnrs.fr)

Zygotic mutants develop to pupal stages, but do not eclose, whereas maternal mutants display severe defects in early embryonic patterning (Veraksa, 2002). (sdbonline.org)

Analyses of the hh DNA sequence data led researchers to discover gene homologs, or genetic sequences similar to those in fruit flies but in vertebrates, a result that revealed a high degree of genetic conservation between species. (asu.edu)

Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)

Meanwhile, ECs iso lated from HCC tissue enhance the angiogenesis exercise with larger resistance selelck kinase inhibitor to chemotherapeutic agents and inhibitors of angiogenesis,and are connected with a high chance for metastasis. (fak-signal.com)

In teleosts, studies of isotocin (IT), a homolog of OT, have been primarily focused on social behaviors, including social decision-making and anxiety behaviors in mosquitofish ( Gambusia affinis ) ( 6 ), paternal care and social class in cichlid fish species ( 7 - 9 ) and territory defense, egg care and courtship behaviors in three-spined stickleback ( Gasterosteus aculeatus ) ( 10 ). (frontiersin.org)
Our objective was to determine whether this would be the case in another mammalian species, the bovine. (bioone.org)

However, the mechanism of dental mineralization is still far from being revealed, which restricts the process of dental tissue engineering and tooth regeneration. (researchsquare.com)

Teeth, composed of three mineralized tissues (dentine, cementum, and enamel), constitute important models for gaining insight into the general processes of biological mineralization. (researchsquare.com)
They can diffuse from a source and penetrate to a target within tissues making them ideal candidates for developmental signals and an important model system to study the role of regulated transcription in fundamental biological processes. (uci.edu)

An interest in identifying novel morphogens led me to design a strategy where candidate nuclear hormone receptor homologs are first isolated from a developmental system and then used to identify the corresponding ligand. (uci.edu)

One receptor, now termed BXR for benzoate X receptor, was activated by embryonic extracts. (uci.edu)

In addition, ife-1 spermatocytes prematurely accumulated pro-apoptotic CED-4, homolog to mammalian Apaf-1, during spermatogenesis. (ecu.edu)

We found that, upon induction of apoptosis in control MEFs, n-cofilin, and its homolog ADF translocated to mitochondria together with actin. (nature.com)

Until recently, hardly any research explored the function of mammalian SIRT1 in modulating DNA replication. (monossabios.com)
Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. (nih.gov)

Anatomy32

Organisms25

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes94

Disciplines and Occupations2

Information Science4

Health Care1

Including embryonic development1

Drosophila8

Fibroblasts5

Tumorigenesis1

Embryogenesis5

Proteins3

Regulates3

Vertebrate3

Lethality2

Neural2

Adult4

Hedgehog1

Development8

CDNA1

Germ cell1

Cells23

Cell14

Differentiation2

Pathway1

Mouse2

Oxidative1

Expression3

Mice1

Human2

Organs1

Physiological1

Genomic2

Yeast1

Immune1

Defects1

Sequence data1

Vivo1

Kinase1

Species2

Regeneration1

Processes2

Ligand1

Receptor1

Apoptotic1

Apoptosis1

Function2