In the course of our studies concerning the evolution of Hox gene regulation, we produced a transgenic mouse model expressing fish Hox genes, which displayed a reduced number of thoraco-lumbar vertebrae and concurrent sacral homeotic transformations. (nih.gov)
The tkv receptor is therefore involved in delimiting the expression domains of homeotic genes in the visceral mesoderm. (biologists.com)
Other genes whose mutation produces homeotic transformations were discovered and analysed by Edward Lewis in the United States using classical genetic techniques. (balzan.org)
Several other homeotic genes were then cloned by Gehring's and other groups. (balzan.org)
The ingenious scientist Walter Gehring then discovered (independently from Matthew Scott's group in the USA) that all homeotic genes have a 180 base pair sequence in common that he called the Homeobox. (balzan.org)
The Additional sex combs (Asx) gene of Drosophila is a member of the Polycomb group of genes, which are required for maintenance of stable repression of homeotic and other loci. (ox.ac.uk)
Copf T, Rabet N, Averof M. (2006) Knockdown of spalt function by RNAi causes de-repression of Hox genes and homeotic transformations in the crustacean Artemia franciscana. (forth.gr)
Interestingly, our results show that inactivation of dBRE1 produces trithorax-like related homeotic transformations, suggesting that dBRE1 functions in the regulation of homeotic genes expression. (qub.ac.uk)
The ABCE model, a broadly accepted model of flower development that was first proposed two decades ago, describes how the combinatorial activity of four classes of homeotic genes determines floral organ identity [ 1 - 5 ]. (biomedcentral.com)
One of the important groups of conserved developmental genes are the homeotic genes. (nih.gov)
In Drosophila , the homeotic genes specify cell identities at both embryonic and adult stages. (nih.gov)
The homeotic genes are expressed in precise spatial patterns that are crucial for the proper determination of cell fate. (nih.gov)
The changes provide powerful assays for identifying the trans -acting factors that regulate the homeotic genes and the cis -acting sequences through which they act. (nih.gov)
Assays in transgenes in Drosophila previously identified cis -acting transcriptional regulatory elements from homeotic genes. (nih.gov)
Hox genes encode for evolutionary conserved transcription factors that have long fascinated biologists since the observation of the first homeotic transformations in flies. (bvsalud.org)
Genes controlling floral organ identity have been identified through the genetic analysis of homeotic mutants, leading to the ABCDE model, in which five classes of regulatory genes (A, B, C, D and E) work in a combinatorial manner to confer the organ identities of the four whorls [ 10 ]. (biomedcentral.com)
2. Carpenter R,Coen E S. Floral homeotic mutations produced by transposon-mutagenesis in Antirrhinum majus [J].Genes Dev,1990,4(9):1483-1493. (nefu.edu.cn)
Analysis of the APETALA3- and PISTILLATA -like genes in Hedyosmum orientale (Chloranthaceae) provides insight into the evolution of the floral homeotic B-function in angiosperms[J].Ann Bot,2013,112(7):1239-5121. (nefu.edu.cn)
19. Mara C D,Huang T,Irish V F. The Arabidopsis floral homeotic proteins APETALA3 and PISTILLATA negatively regulate the BANQUO genes implicated in light signaling[J].Plant Cell,2010,22(3):690-702. (nefu.edu.cn)
Here, we describe a patient with AML that progressed from a myelodysplastic syndrome (MDS) with pathogenic mutations of the RUNX1 , SRSF2 , ASXL1 , and TET2 genes in association with development of 1q JTs, which supports that the formation of 1q JTs may involve multiple stages and that 1q JTs may represent a very high-risk cytogenetic abnormality with transformation to AML. (biomedcentral.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Domains of homeotic1
The initial domains of homeotic gene repression are set by the segmentation proteins, which also divide the embryo into segments. (nih.gov)
Analysis of homeotic phenotypes and post-translationally modified histones levels show that dRYBP antagonizes dKDM2 and dBRE1 functions by respectively preventing H3K36me2 demethylation and H2B monoubiquitylation. (qub.ac.uk)
Gene2
We used a large number of existing chromosomal aberrations in the Scr homeotic gene to investigate the functions of the cis -acting elements within the endogenous gene. (nih.gov)
Construction of Plant Expression Vector and Genetic Transformation Analysis of Arabidopsis thaliana AtPI Gene in Nicotiana tabacum [J]. Bulletin of Botanical Research, 2016, 36(3): 388-394. (nefu.edu.cn)
Mutants1
Complementation of plant mutants with large genomic DNA fragments by a transformation-competent artificial chromosome vector accelerates positional cloning[J].Proc Natl Acad Sci USA,1999,96(11):6535-6540. (nefu.edu.cn)
Mutation3
A homozygous HOXD13 missense mutation causes a severe form of synpolydactyly with metacarpal to carpal transformation. (mpg.de)
As he was working on his doctorate, he isolated a new mutation in Drosophila causing the transformation of the antennae into legs, a mutation which is called Antennapedia. (balzan.org)
A homeotic mutation mixes up body parts, so that a fly grows a leg on its head or antennae on its mouth. (rickilewis.com)
Developmental1
To anyone familiar with developmental biology, a body part in the wrong place evokes one word: HOMEOTIC. (rickilewis.com)
Organs2
Structural Requirements of the Phytoplasma Effector Protein SAP54 for Causing Homeotic Transformation of Floral Organs. (leibniz-fli.de)
In the ranunculid, Thalictrum thalictroides , down-regulation of the AG homolog ThtAG1 has been shown to result in homeotic conversion of stamens and carpels into sepaloid organs, as well as a loss of flower determinacy. (biomedcentral.com)
Petal2
4) In the third whorl the stamens have petal oid cells on their filaments and no homeotic transformation is observed. (bdword.com)
Deficiens is a member of the B class of floral homeotic regulators that have been shown to specify petal and stamen identity according to the ABC model of floral development. (isenseo.com)
Large1
Furthermore, I shall argue that this non-equivalence cannot be repaired by means of large symmetry transformations. (isenseo.com)
Drosophila2
The study of homeotic-transformation mutants in model organisms such as Drosophila revolutionized the field of developmental biology, but how these mutants relate to human developmental defects remains to be elucidated. (nih.gov)
4. Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton. (nih.gov)
About 50% of homozygous null mice die perinatally while the remaining 50% become runted and die within two weeks of birth with severe defects of the axial skeleton, including anterior homeotic transformation of the cervical and thoracic regions, a deformed atlas and an extra cervical vertebra. (jax.org)
Embryonic2
This embryonic function of Tsh is characterized as homeotic since loss of embryonic Tsh activity leads to transformation of trunk segments toward head identity. (ua.edu)
In addition to this embryonic homeotic role, Tsh also performs vital Hox-independent functions through patterning numerous embryonic, larval and adult structures. (ua.edu)
Skeletal1
Interestingly, Gdf8 -/- /Gdf11 -/- mice have exaggerated homeotic axial transformations compared to Gdf11 -/- mice, suggesting that GDF8 and GDF11 have redundant functions in skeletal patterning [ 13 ]. (biomedcentral.com)
Gene expression1
With the exception of the Dfd gene, the anterior limit of homeotic gene expression in the CNS is always parasegmental (Hirth, 1998). (sdbonline.org)
Cervical vertebrae1
12. Böhmer C , Amson, E, Arnold P, van Heteren A H and Nyakatura J ( 2018 ) Homeotic transformations reflect departure from the mammalian 'rule of seven' cervical vertebrae in sloths: inference on the Hox code and morphological modularity of the mammalian neck. (vertevo.de)
Anterior1
Evidence is provided that loss of abd-A function causes a transformation of the heart into aorta, whereas ectopic expression of abd-A in more anterior cardioblasts causes the aorta to assume heart-like features. (sdbonline.org)
Positional1
A shift in antero-posterior positional information may contribute to the fin-to-limb transformation. (elifesciences.org)
Homologous1
Floral homeotic gene encoding a MADS domain protein homologous to AP1. (or.jp)
Defect1
In situ hybridizations with Wnt7b , a marker of the metanephric kidney , show that the branching defect was not simply the result of homeotic transformation of metanephros to mesonephros . (xenbase.org)
Proteins1
We show that Tsh is expressed throughout the developing abdomen and that this expression is dependent on the three Bithorax Hox proteins Ultrabithorax, Abdominal-A and Abdominal-B. Conditional reduction of Tsh activity during pupation reveals broad homeotic roles for this transcription factor throughout the adult abdomen. (ua.edu)
Floral homeotic gene encoding a MADS domain transcription factor. (or.jp)
Floral1
An apparent reversal in floral symmetry in the legume Cadia is a homeotic transformation. (wikidot.com)
Development1
Here we address whether the homeotic function of Tsh is maintained throughout development by investigating its contribution to patterning the adult abdomen. (ua.edu)
Role1
Additionally we show that, as during embryogenesis, the tsh paralog tiptop (tio) plays a partially redundant role in this homeotic activity. (ua.edu)
Features1
Here, we show that Liebenberg syndrome, an autosomal-dominant upper-limb malformation, shows features of a homeotic limb transformation in which the arms have acquired morphological characteristics of a leg. (nih.gov)