• Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
  • Furthermore, we demonstrated that these automatically isolated cells bear proliferation and differentiation capacities comparable to manually isolated cells in vitro. (biomedcentral.com)
  • Recently, several clinical trials showed an increased left ventricular ejection fraction (LVEF) and an improved regional perfusion following intramyocardial application of cluster of differentiation (CD) 133 + stem cells [ 5 - 9 ]. (biomedcentral.com)
  • The signaling network in the niche establishes the baseline for self-renewal, fate determination, proliferation, and differentiation of intestinal stem cells. (wjgnet.com)
  • The blood cell counts in TERT-depleted zebrafish embryos are markedly decreased and hematopoietic cell differentiation is impaired, whereas other somatic lineages remain morphologically unaffected. (harvard.edu)
  • Induced p53 deficiency, as well as overexpression of the anti-apoptotic proteins Bcl-2 and E1B-19K, significantly relieves the decreased blood cells numbers caused by zTERT knockdown, but not the impaired blood cell differentiation. (harvard.edu)
  • These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis. (harvard.edu)
  • Our research focuses on characterising the stem and progenitor cells that build the hypothalamus and characterising the molecular networks that direct hypothalamic morphogenesis, growth and differentiation. (sheffield.ac.uk)
  • Fu T, Towers M & Placzek M (2017) Fgf10(+) progenitors give rise to the chick hypothalamus by rostral and caudal growth and differentiation. . (sheffield.ac.uk)
  • WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
  • Using lineage tracing, transcriptional profiling and via assessment of energy metabolism in skeletal stem cells/progenitor cells and committed osteoblasts, we will elucidate the stage-specific action of GR on cellular differentiation and cell metabolism during bone regeneration after fracture in close cooperation with projects A09N, B03, B09, C03, C08 and Z02. (uni-ulm.de)
  • The peculiarity of the gastrointestinal epithelium is the presence of a proliferative compartment, where are located multipotent stem cells and progenitors which proliferate and are engaged in differentiation toward multiple lineages. (unica.it)
  • Several signaling pathways are involved in the control of the perpetual cell proliferation and differentiation of the stem and progenitor cells. (unica.it)
  • Progenitor cells, also known as precursor cells, are a type of cell that falls somewhere between stem cells and fully differentiated, specialized cells in terms of their differentiation potential. (thenoveldifference.com)
  • They have already committed to a particular differentiation pathway, meaning they are destined to become a specific type of cell, such as a red blood cell, white blood cell, or platelet in the case of hematopoietic progenitor cells. (thenoveldifference.com)
  • Moreover, the molecular signatures of tracheal embryonic E18.5 preBCs and adult TrBCs were generated through high-throughput profiling, which provided hints about the genetic regulation of airway BC maturation process and generated potential molecular landmarks for the in vitro ES/iPS cell differentiation towards airway BCs. (columbia.edu)
  • The Bayin Lab is interested in identifying the molecular mechanisms that regulate self-renewal, differentiation and plasticity of neural stem/progenitor populations during development and homeostasis, in order to discover how to stimulate repair of the brain upon injury. (jobs.ac.uk)
  • Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
  • During liver development, cytokines released from various cell types are critical for stem/progenitor cell differentiation and lineage expansions. (elsevierpure.com)
  • These studies showed signals emanating from fetal liver cells induced hepatic differentiation in stem cells. (elsevierpure.com)
  • We concluded that hepatic differentiation of pluripotent stem cells with metabolomics products will be significant for developing therapies. (elsevierpure.com)
  • The differentiation mechanisms involving metabolomics products could have an impact on advancing recruitment of stem/progenitor cells during tissue homeostasis. (elsevierpure.com)
  • Bandi, S , Tchaikovskaya, T & Gupta, S 2019, ' Hepatic differentiation of human pluripotent stem cells by developmental stage-related metabolomics products ', Differentiation , vol. 105, pp. 54-70. (elsevierpure.com)
  • We propose these results as a confirmation that apoptotic cells can control surrounding cells fate and as a reference database to explore novel apoptotic functions in animals, including those related to migration and differentiation. (biomedcentral.com)
  • Accumulating evidence in many metazoans suggest that apoptotic cells can emit caspase-dependent signals to their neighbours, modulating their fate (survival/death, differentiation or proliferation) or behaviour (migration) [ 12 , 13 ]. (biomedcentral.com)
  • The basal cells (BC) are the stem/progenitor cells of the SAE, responsible for the differentiation into intermediate cells and ciliated, club and mucous cells. (biomedcentral.com)
  • The resulting cell line (hSABCi-NS1.1) was characterized by RNAseq, TaqMan PCR, protein immunofluorescence, differentiation capacity on an air-liquid interface (ALI) culture, transepithelial electrical resistance (TEER), airway region-associated features and response to genetic modification with SPDEF. (biomedcentral.com)
  • The immortalized hSABCi-NS1.1 cell line has diverse differentiation capacities and retains SAE features, which will be useful for understanding the biology of SAE, the pathogenesis of SAE-related diseases, and testing new pharmacologic agents. (biomedcentral.com)
  • However, variation in the mitochondrial content in stem cells and the implication, if any, on differentiation is poorly understood. (stanford.edu)
  • Cells bearing MSC characteristics differ in the facets of proliferation and differentiation, which results in their diverse biological potential and applications in tissue regeneration. (mdpi.com)
  • Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states. (digs-bb.de)
  • At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
  • In times of growth or regeneration, stem cells can also divide symmetrically, to produce two identical copies of the original cell. (wikipedia.org)
  • CD133 + stem cells represent a promising subpopulation for innovative cell-based therapies in cardiovascular regeneration. (biomedcentral.com)
  • Adult stem cells remain of particular interest as therapeutic agents for cardiac regeneration in ischemic heart disease [ 1 - 4 ]. (biomedcentral.com)
  • The regeneration potential of these cells is mainly based on their direct contribution to neovascularization and on their secretion of various paracrine factors activating pro-angiogenic mechanisms [ 13 - 16 ]. (biomedcentral.com)
  • According to the European Medicines Agency (EMA) BM-derived CD133 + stem cells intended for the regeneration of human ischemic heart tissue are classified as an advanced therapy medicinal product (ATMP) [ 17 ]. (biomedcentral.com)
  • We have strong evidence that GR deletion in skeletal stem cells/progenitor cells (SSPCs), positive for Sox9+, increases bone mass and regeneration, whereas GR deletion in Osterix (Osx, Sp7)-labeled committed osteogenic cells results in opposite effects.Beyond GR's role as a transcriptional activator, we discovered that it regulates cellular energy metabolism and, vice versa, energy metabolites influence GR activity. (uni-ulm.de)
  • However, cell proliferation is critical for renewal, repair and regeneration to maintain normal tissue homeostasis and functions. (umassmed.edu)
  • The genetic pathways that regulate the establishment of skeletal muscle in the embryo have been studied extensively, and many of the genes that govern muscle stem cell maintenance and commitment are redeployed during adult homeostasis and regeneration. (pasteur.fr)
  • However, there are some important distinctions between prenatal development and regeneration - in the context of the cells, niche, anatomy and the regulatory genes employed. (pasteur.fr)
  • Progenitor cells play a crucial role in tissue repair and regeneration. (thenoveldifference.com)
  • They are committed to a specific cell lineage but retain the ability to generate a limited range of related cell types, making them essential for tissue repair, regeneration, and potential medical interventions. (thenoveldifference.com)
  • Cell transplantation studies were performed in mice with drug-induced acute liver failure to elicit benefits in hepatic support and tissue regeneration. (elsevierpure.com)
  • During this rescue, paracrine factors from transplanted cells contributed in stimulating liver regeneration. (elsevierpure.com)
  • Apoptotic-induced proliferation was reported in several organisms, such as in the cnidarian Hydra , where apoptosis promotes proliferation of adjacent cells through emission of Wnt3 signalling in a caspase-dependant manner during head regeneration [ 14 ]. (biomedcentral.com)
  • In addition to the olfactory neurons, the epithelium is composed of supporting cells, Bowman glands and ducts unique to the olfactory epithelium, and basal cells that allow for the regeneration of the epithelium, including the olfactory sensory neurons. (medscape.com)
  • Together, our results demonstrate the active role of ECM remodelling in regulating tissue homeostasis and regeneration in planaria. (stanford.edu)
  • In summary, we show that low mitochondrial mass is a hallmark of PSCs in planaria and provide a mechanism to isolate live, functionally active, PSCs from different cell cycle stages (G0/G1 and S, G2/M). Our study demonstrates that the change in mitochondrial metabolism, a feature of PSCs is conserved in planaria and highlights its role in organismal regeneration. (stanford.edu)
  • The first Special Issue "Mesenchymal Stem/Progenitor Cells and Their Derivates in Tissue Regeneration" has been recognized by many scientific groups and was a successful endeavor. (mdpi.com)
  • Mesenchymal stem/progenitor cells (MSCs) reside in many human tissues and organs and play important roles in tissue regeneration and tissue homeostasis. (mdpi.com)
  • These cells can be isolated from different tissues in the adult human body, expanded in vitro and applied for the regeneration of tissues and organs damaged by age, disease or extensive injury. (mdpi.com)
  • Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
  • Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
  • 1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
  • Hematopoietic stem cells (HSCs) are a type of multipotent stem cell found primarily in the bone marrow and, to a lesser extent, in peripheral blood. (thenoveldifference.com)
  • Basal cells (BCs) are multipotent tissue-specific stem cells of a variety of organs including the skin, digestive and respiratory tract. (columbia.edu)
  • This thesis work showed the newly identified p63+ airway progenitors before E10.5 are multipotent for all lung epithelial lineages and this multipotency gets restricted to proximal fate at E10.5. (columbia.edu)
  • The cell biology of these events has been most studied in three animal models: the mouse, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster. (wikipedia.org)
  • However, the signaling pathways directly involved in the biology of the physiological and cancer stem cells, i.e. self-renewal and multi-potency, have not been identified yet. (unica.it)
  • Sirakov M, Skah M, Nadjar J, Plateroti M (2013) Thyroid hormone's action on progenitor/stem cell biology: new challenge for a classic hormone? (unica.it)
  • He received postdoctoral training at Stanford University School of Medicine, and joined the faculty in the Department of Cell Biology at University of Massachusetts Medical School in 2006. (umassmed.edu)
  • A variety of other projects on neural stem cell biology during brain development and pathologies are possible, depending on the candidate's interest and background. (jobs.ac.uk)
  • Applicants must have (or expect to obtain) a PhD (or equivalent) in biological sciences, preferably in cell, developmental biology or in genetics. (jobs.ac.uk)
  • To facilitate the study of the biology of the human SAE in health and disease, we immortalized and characterized a normal human SAE basal cell line. (biomedcentral.com)
  • In this context, if it is possible to immortalize normal human SAE BC that retain the capacity to differentiate to ciliated, secretory, and other differentiated cell types in vitro on air-liquid interface (ALI) culture, it would be very useful to the investigation of SAE biology in health and disease, and the assessment of pharmacologic agents targeted to modify dysregulated BC biology relevant to the pathogenesis of human lung disease. (biomedcentral.com)
  • However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)
  • Li, L. & Clevers, H. Coexistence of quiescent and active adult stem cells in mammals. (nature.com)
  • The mouse models we have generated to modulate senescence response in vivo are also used in our studies of senescence regulation in aging, with an emphasis on adult stem cells. (umassmed.edu)
  • However, the embryonic origin of these adult stem cells remains elusive. (columbia.edu)
  • Previous reports showed that p63+ cells appear early during airway development, but these do not express markers of adult BCs, raising the question whether these cells represent BC precursors. (columbia.edu)
  • Moreover, little was known whether embryonic BCs have an impact in the adult pool of progenitors that mediate responses of the lung to injury or pulmonary diseases. (columbia.edu)
  • However, as development proceeds, they underwent two sequential lineage segregation events to finally generate two regionally distinct adult stem cell pools. (columbia.edu)
  • In addition, single cell RNA-sequencing analyses revealed heterogeneity of adult BCs in the tracheal and esophageal epithelia. (columbia.edu)
  • In the adult injury-repair, this thesis work for the first time revealed that the H1N1-induced Krt5+ pods are generated by bronchial p63+ Krt5- progenitors, which originate from a subpopulation of E13.5 intrapulmonary p63+ progenitors. (columbia.edu)
  • Importantly, the regenerative potential of the neonatal cerebellum dramatically decreases once development ends, despite the presence of stem-like cells in the adult mouse cerebellum. (jobs.ac.uk)
  • Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles. (rupress.org)
  • Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • Mesenchymal stromal cells (MSCs) are cells of non-haematopoietic origin, with the capacity to differentiate into multiple lineages of the mesenchyme, that is, chondrocytes, osteoblasts and adipocytes. (bmj.com)
  • All blood cells originate from a population of relatively few haematopoietic stem cells residing in the bone marrow, which give rise to specific progenitors through different lineages. (lu.se)
  • Our ongoing studies have found that LT-HSC population, which give rise to all lineages of blood cells, increases in Smurf2-deficient mice, suggesting a beneficial effect of Smurf2 deficiency. (umassmed.edu)
  • Hematopoietic stem and progenitor cells (HSPCs) are crucial for the maintenance of homeostasis of all blood lineages in human. (stemcell-lab-mk1dresden.de)
  • Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)
  • To study how radiation affects neurogenesis, we combine phenotyping of subpopulations of hippocampal neural stem and progenitor cells with double- and triple S-phase labeling paradigms. (scite.ai)
  • Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
  • In aged mice, the self-renewal capacity of long-term hematopoietic stem cells (LT-HSC) diminishes. (umassmed.edu)
  • They produce a defined number of specialized cells and do not have the same capacity for self-renewal as stem cells. (thenoveldifference.com)
  • In vitro neurosphere assays revealed striking increases in the number of neurosphere forming cells from p107 −/− brains that exhibited enhanced capacity for self-renewal. (rupress.org)
  • The anterior pituitary is responsible for the continuous production of several hormones, secreted by specialised cell populations. (kcl.ac.uk)
  • During adulthood, there is a requirement to replenish hormone-producing cells and to expand the populations depending on hormonal demand e.g. during pregnancy. (kcl.ac.uk)
  • Cambuli FM, Rezza A, Nadjar J, Plateroti M (2013) Musashi1-eGFP mice, a new tool for differential isolation of the intestinal stem cell populations. (unica.it)
  • We isolated bone marrow from mice at 8 time points after transplantation and examined the reconstitution dynamics and transcriptional profiles of stem and progenitor populations. (lu.se)
  • Mature epithelial cells originate from the crypt and move up toward the villus tip. (wjgnet.com)
  • A tightly regulated balance of proliferation and cell death of intestinal epithelial cells (IECs) is essential for maintenance of gut homeostasis. (uea.ac.uk)
  • The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. (wjgnet.com)
  • Although the aetiology of these disorders remains unknown, in this review we analyse the pathogenic mechanisms by cell of interest (fibroblast, fibrocyte, myofibroblast, endothelial and alveolar epithelial cells and immune competent cells). (ersjournals.com)
  • Stem cells rely on extracellular signals produced by the niche, which dictate their ability to self-renew, expand and differentiate. (karger.com)
  • Notably, stem cells divide asymmetrically to give rise to two distinct daughter cells: one copy of the original stem cell as well as a second daughter programmed to differentiate into a non-stem cell fate. (wikipedia.org)
  • The crypts generate a constant stream of new cells that differentiate and migrate upward into the villi. (wjgnet.com)
  • We have previously shown that cells exclusively within the Sox2+ compartment of the mouse pituitary have progenitor/stem cell properties in culture where they can self-renew and terminally differentiate. (endocrine-abstracts.org)
  • They differentiate into very specific cells. (thenoveldifference.com)
  • HSCs have the remarkable ability to differentiate into a wide range of specialized blood cells. (thenoveldifference.com)
  • It has been shown that the early epidermal progenitors migrate outward from this region and progressively differentiate to maintain the terminal epidermis. (stanford.edu)
  • Convolutional neural networks (CNNs) have been successfully applied to object detection tasks, however, when applied to mitotic cell detection, most existing methods generate high false-positive rates due to the complex characteristics that differentiate normal cells from mitotic cells. (biomedcentral.com)
  • Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)
  • At distinct anatomical sites, bone tissue harbors multiple types of skeletal stem cells, which may independently supply osteogenic cells in a site-specific manner. (nature.com)
  • However, it remains unclear whether there is functional crosstalk between these two types of skeletal stem cells. (nature.com)
  • In endochondral bone formation, parathyroid hormone-related protein (PTHrP)-expressing RZSCs are the source of growth plate chondrocytes, which give rise to bone-forming osteoblasts as well as bone marrow skeletal stem cells 1 . (nature.com)
  • A recent study identified cathepsin K ( Ctsk )-Cre expressing PSCs as a unique class of skeletal stem cells residing in the periosteum 3 . (nature.com)
  • In particular, data have shown that TRα1 controls the epithelial progenitor proliferation via the regulation of key genes of the Wnt, BMP and Notch pathways, all involved in progenitor/stem cell physiopathology. (unica.it)
  • Using these 'senescence' mouse models, combined with different tumorigenesis models (for instance, p53 knockout, B cell lymphoma, skin cancer, colon cancer and liver cancer models), we hope to gain a better understanding of the regulation and contribution of senescence in tumor development. (umassmed.edu)
  • Lentivirus-mediated expression of SPDEF in hSABCi-NS1.1 cells induced secretory cell metaplasia, accompanied with characteristic COPD-associated SAE secretory cell changes, including up-regulation of MSMB, CEACAM5 and down-regulation of LTF. (biomedcentral.com)
  • Conclusions These findings provide insight into better understanding the role and complexity of myeloid cells in the brain, including their regulation of other CNS cells and functional outcomes. (scite.ai)
  • This regulation becomes important in the transplantation setting where HSCs undergo proliferation followed by a gradual transition to quiescence and homeostasis. (lu.se)
  • Jensen, K. B. & Watt, F. M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. (nature.com)
  • WNT, R-spondin, epidermal growth factor, and mammalian target of rapamycin are secreted by Paneth cells or mesenchymal cells. (wjgnet.com)
  • Human epidermal growth factor receptor 2 (HER2)-positive tumor cells (BT474 and SKOV3) formed spheroids of approximately 300-350 µm in diameter after 2 days in the 3DHSP. (bvsalud.org)
  • Smed-ETS-1 regulates cathepsin+ cell function and epidermal lineage landscape via basement membrane remodeling. (stanford.edu)
  • Furthermore, the absence of ets-1 led to a defective epidermal progenitor landscape, in spite of its lack of expression in those cell types. (stanford.edu)
  • This enabled them to identify a Zinc finger protein (ZNF) specifically expressed in humans and not chimpanzees and demonstrate that the human-specific ZNF (named ZNF558) is crucial for both mitochondrial homeostasis and early human brain development. (lu.se)
  • In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
  • In this review, we discuss the rationale for MSC-based cell therapy in COPD, the main findings from in vitro and in vivo preclinical COPD model studies, clinical trials in patients with COPD and directions for further research. (bmj.com)
  • You will work in the Bayin Lab to explore the molecular mechanisms that regulate the regenerative potential of stem cells in the brain during development and in adulthood using various techniques including but not limited to single cell genomics, and in vivo and in vitro stem cell assays, organoid models and mouse genetics. (jobs.ac.uk)
  • This project involves using in vivo and in vitro approaches to identify mechanisms that control the developmental and regenerative responses of cerebellar progenitors in neonates and determine how it differs in adults in order to understand how we can facilitate efficient repair after injury to the brain. (jobs.ac.uk)
  • Three-dimensional cell culture has become a reliable method for reproducing in vitro cellular growth in more realistic physiological conditions. (bvsalud.org)
  • Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
  • Further characterization demonstrated a p63 gene dosage dependency in the specification/maintenance of this rare progenitor pool. (columbia.edu)
  • Further molecular characterization and genetic manipulation of this rare progenitor pool may provide valuable cues to understand the pathogenesis about pulmonary disorders and to develop effective therapies. (columbia.edu)
  • Fixed single-cell transcriptomic characterization of human radial glial diversity. (digs-bb.de)
  • As ErbB-family ligands and receptors are highly expressed within the stem-cell niche 7 , we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. (nature.com)
  • Voog, J. & Jones, D. L. Stem cells and the niche: a dynamic duo. (nature.com)
  • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. (nature.com)
  • Many external insults and intrinsic defects can be deleterious to LSCs and their niche microenvironment, resulting in limbal stem cell dysfunction or deficiency (LSCD). (ca.gov)
  • The Wnt and Notch signaling exhibit high activity in the stem cell niche. (wjgnet.com)
  • In summary, Survivin is a key regulator of gut tissue integrity by regulating epithelial homeostasis in the stem cell niche. (uea.ac.uk)
  • Extracellular matrix (ECM) is an important component of stem cell niche. (stanford.edu)
  • However, the mechanisms that modulate the function of ECM regulators in the stem cell niche are understudied. (stanford.edu)
  • In planarians, the basement membrane around the gut/inner parenchyma is thought to act as a niche for pluripotent stem cells. (stanford.edu)
  • Stem cell niche. (bvsalud.org)
  • The data also provide insights into a non-canonical pathway by which TERT functions to modulate specification of hematopoietic stem/progenitor cells during vertebrate development. (harvard.edu)
  • Glucocorticoids (GCs) are a major pillar of the stress response upon bone fracture, but also modulate the immune response and shape bone tissue homeostasis. (uni-ulm.de)
  • Finally, apoptotic cells modulate death or survival balance, as was observed in the Drosophila imaginal disc, by producing the Tie ligand Pvf1, that induces death resistance of neighbouring cells [ 17 ]. (biomedcentral.com)
  • Hematopoietic stem cells (HSCs) adapt their metabolism to maintenance and proliferation, but the mechanism remains incompletely understood. (sdsc.edu)
  • Overall, our study uncovers the direct links between metabolic alterations and translation control in HSCs during homeostasis and proliferation. (sdsc.edu)
  • We found that regenerating HSCs initially produced rapidly expanding progenitors and displayed distinct changes in fatty acid metabolism and glycolysis. (lu.se)
  • Moreover, we observed molecular changes in cell cycle, MYC and mTOR signaling in both HSCs, and progenitor subsets. (lu.se)
  • Progenitor cells are often located within specific tissues, close to where they will ultimately function. (thenoveldifference.com)
  • They offer the potential to replace damaged or dysfunctional cells in specific tissues or organs. (thenoveldifference.com)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • This thesis showed that this rare progenitor pool is established during embryonic development when airways are still branching. (columbia.edu)
  • When is specialized mechanosignaling necessary for successful embryonic development and organism homeostasis? (digs-bb.de)
  • It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
  • HYPOTHESIS: Do LRIG Proteins Regulate Stem Cell Quiescence by Promoting BMP Signaling? (nature.com)
  • The mechanisms that regulate the size of the stem cell pool and instruct proliferation and commitment are poorly understood. (kcl.ac.uk)
  • Endogenous cell signals regulate tissue homeostasis and are significant for directing the fate of stem cells. (elsevierpure.com)
  • In addition, the regenerative potential of purified stem cells was assessed 3 weeks after transplantation in immunodeficient mice which had been subjected to experimental myocardial infarction. (biomedcentral.com)
  • Hematopoietic stem cells are widely used in medical treatments, particularly in bone marrow transplantation for individuals with hematological disorders like leukemia or aplastic anemia. (thenoveldifference.com)
  • The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
  • Effect of Laptm4b Deletion on Hematopoietic Stem and Progenitor Cells Homeostasis in Mice]. (nih.gov)
  • No significant alteration of hematopoietic homeostasis and HSC function is observed in young Pus10-/- mice, while aged Pus10-/- mice exhibit mild alteration of hematopoietic homeostasis and HSC function. (haematologica.org)
  • The extent of metabolic and synthetic functions in stem cell-derived hepatocytes was sufficient for providing hepatic support along with promotion of tissue repair to rescue mice in acute liver failure. (elsevierpure.com)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • The biological activity of automatically isolated CD133 + cells was evaluated and compared to manually isolated CD133 + cells via functional assays as well as immunofluorescence microscopy. (biomedcentral.com)
  • For identifying lineage conversion and maturation, we utilized conventional assays of cell morphology, gene expression analysis and lineage markers. (elsevierpure.com)
  • Tumor spheroids, however, can recapitulate the TME and have been used for cytotoxicity assays of CAR T cells. (bvsalud.org)
  • But a major obstacle to the use of tumor spheroids for cytotoxicity assays is the difficulty in separating unbound CAR T and dead tumor cells from spheroids. (bvsalud.org)
  • Here, we present a three-dimensional hanging spheroid plate (3DHSP), which facilitates the formation of spheroids and the separation of unbound and dead cells from spheroids during cytotoxicity assays. (bvsalud.org)
  • Here we show a novel function for Retinoblastoma family member, p107 in controlling stem cell expansion in the mammalian brain. (rupress.org)
  • In this work, surfaces at different wettability have been compared to observe their influence on the growth and promotion of aggregates of representative mammalian cell lines, both tumoral and non-tumoral (3T3, HaCat and MCF-7 cell lines). (bvsalud.org)
  • Wan LQ, Ronaldson K, Park M, Taylor G , Zhang Y, Gimble JM, Vunjak-Novakovic G. Micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry . (ny.gov)
  • Cells in living organisms are surrounded by physical cues, such as mechanical forces, material properties and electrical cues. (digs-bb.de)
  • These cues vary depending on their location in the body, so that different cells experience a variety of types, magnitudes, and dynamics of mechanical input. (digs-bb.de)
  • The ability of cells to take reliable decisions about cell behavior based on local physical cues is a key component of equilibrium in living organisms. (digs-bb.de)
  • How do stem cells and other progenitor cells determine how to respond to physical cues in site-appropriate ways? (digs-bb.de)
  • Our group studies how stem cells learn to respond to mechanical forces and electrical cues during the development and maintenance of the nervous and cardiovascular organ systems. (digs-bb.de)
  • We investigate these circuits in the cardiovascular system and nervous system to determine how specialized responses to mechanical forces and physical cues are encoded in cells. (digs-bb.de)
  • Periosteal stem cells (PSCs) and growth plate resting zone stem cells (RZSCs) critically contribute to intramembranous and endochondral bone formation, respectively. (nature.com)
  • CD133 + stem cells were purified from patient-derived sternal bone marrow using the recently developed automatic CliniMACS Prodigy® BM-133 System (Prodigy). (biomedcentral.com)
  • 2 MSCs were first described in the bone marrow where they constitute a small fraction of cells (0.001%-0.01%) that closely interact with haematopoietic cells to support haematopoiesis and skeletal homeostasis. (bmj.com)
  • The bone marrow serves as the primary residence for hematopoietic stem cells. (thenoveldifference.com)
  • For example, hematopoietic progenitor cells are found in the bone marrow, as this is where blood cell production occurs. (thenoveldifference.com)
  • Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
  • The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
  • Methods Using whole body irradiation, bone marrow transplant, and colony-stimulating factor 1 receptor inhibition, we achieve long-term and brain-wide (~ 80%) engraftment and colonization of peripheral bone marrow-derived myeloid cells (i.e. monocytes) in the brain parenchyma and evaluated the long-term effects of their colonization in the CNS. (scite.ai)
  • These cells are committed to developing into a specific type of cell but still retain the capacity to proliferate and generate a limited range of related cell types. (thenoveldifference.com)
  • When specific tissue or organ damage occurs, these cells can rapidly generate new cells of the desired type to facilitate the healing process. (thenoveldifference.com)
  • Surprisingly, lineage analysis showed that early in development these cells were able to generate all epithelial cell types of the airways and alveolar compartment. (columbia.edu)
  • Hematopoietic stem cells (HSC) generate all of the blood cells throughout their life-span. (haematologica.org)
  • that is, they have the ability to generate other stem cells and perpetuate themselves. (bvsalud.org)
  • In an attempt to answer that, they used induced pluripotent stem cells (iPSCs) to generate neural progenitors from both humans and chimpanzees, which is our closest living relative in evolutionary terms. (lu.se)
  • In one, the daughter cells are initially equivalent but a difference is induced by signaling between the cells, from surrounding cells, or from the precursor cell. (wikipedia.org)
  • In line with these studies, we observe a signi cant decrease in doublecortin, a marker for neuronal precursor cells/neurogenesis, in the subgranular zone in the dentate gyrus of the hippocampus, a major site of neurogenesis in the mouse brain, following irradiation, which remains reduced following monocyte in ltration ( Fig. (scite.ai)
  • Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)
  • 11 12 MSCs furthermore contribute to tissue homeostasis through anti-apoptotic and regenerative properties. (bmj.com)
  • Our laboratory is studying since several years the importance of the thyroid hormone signaling through its nuclear receptor TRα1 in intestinal development, homeostasis and tumorigenesis. (unica.it)
  • A recent study demonstrated that the first event of the intestinal tumorigenesis involves the transformation of the physiological stem cells. (unica.it)
  • Rezza A, Skah S, Roche C, Nadjar J, Samarut J, Plateroti M (2010) The overexpression of the putative gut stem cell marker Musashi1 induces tumorigenesis through Wnt and Notch activation. (unica.it)
  • By limiting cell proliferation, senescence impedes the accumulation of multiple mutations that are necessary for tumorigenesis. (umassmed.edu)
  • Extensive research has shown that OC cells undergo significant metabolic alterations during tumorigenesis. (stanford.edu)
  • Although it is clear that telomerase expression is crucial for the maintenance of telomere homeostasis, there is increasing evidence that the TERT protein can have physiological roles that are independent of this central function. (harvard.edu)
  • These remarkable cells play a crucial role in the production and maintenance of the body's blood and immune cell supply. (thenoveldifference.com)
  • Embryonic precursors of Rathke's pouch, the primordium of the anterior pituitary, give rise to all of the hormone-producing cell types in this tissue. (kcl.ac.uk)
  • Conversely, an over-proliferation of cells in the pituitary gland leads to tumours, which in turn can damage healthy pituitary tissue. (kcl.ac.uk)
  • The function of stem cells in the anterior pituitary gland, their role in homeostasis during life and possible involvement in pituitary tumours remain largely unknown. (endocrine-abstracts.org)
  • We performed differential transcriptomic analysis between control metamorphosing larvae and larvae treated with the pan-caspase inhibitor Z-VAD-fmk in order to explore the transcriptional control of apoptotic cells on neighbouring cells that survive and migrate. (biomedcentral.com)
  • A very high number of different types of blood cells must be generated daily through a process called haematopoiesis in order to meet the physiological requirements of the organism. (lu.se)
  • On the other hand, the "exosome vesicle " is an extracellular particle released from the endosomal compartment of most eukaryotic cells. (frontiersin.org)
  • Limbal stem cell diseases. (ca.gov)
  • This review article pretends to highlight the importance of using the new non-invasive imaging tests to confirm the diagnosis and stage limbal stem cell deficiency characterized by the loss or disfunction of the limbal stem cell population of the cornea. (ca.gov)
  • The function of limbal stem/progenitor cells (LSCs) is critical to maintain corneal epithelial homeostasis. (ca.gov)
  • In order for asymmetric division to take place the mother cell must be polarized, and the mitotic spindle must be aligned with the axis of polarity. (wikipedia.org)
  • The mitotic spindle must be oriented correctly to ensure that the proper cell fate determinants are distributed appropriately to the daughter cells. (wikipedia.org)
  • The ability to detection mitotic cells is a fundamental step in diagnosing cell-related diseases. (biomedcentral.com)
  • Cell size and orientation variations in each stage make detecting mitotic cells difficult in 2D approaches. (biomedcentral.com)
  • The conventional techniques for detecting and counting mitotic cells are performed manually by specialists. (biomedcentral.com)
  • Although various methods have been proposed to solve mitotic cell detection problems [ 5 , 6 ], a cell may freely perform mitosis in any orientation. (biomedcentral.com)
  • Thus, capturing mitotic cells in 2D images may lead to a loss of spatial features due to different cell orientations. (biomedcentral.com)
  • Augmenting the information by using 4D data reduces the resources and time needed to detect mitotic cells but also increases the required effort. (biomedcentral.com)
  • Fig. 1 depicts cell images at various slice indexes \(\{s-1,s,s+1\}\) (spatial information) and time frames \(\{t-1,t,t+1\}\) (temporal information) from a 4D microscopic image (the mitotic cells are indicated by the bounding boxes). (biomedcentral.com)
  • Manually detecting mitotic cells in 4D microscopic images is a labour-and time-intensive task, which makes the ability to perform automatic cell detection in 4D microscopic images desirable. (biomedcentral.com)
  • In stem cells exposed to signals from fetal cells, mechanistic gene networks of upstream regulators decreased pluripotency, while simultaneously inducing mesenchymal and epithelial properties. (elsevierpure.com)
  • Remodelling of ECM mediated by ECM regulators such as MMPs plays a vital role in stem cell function. (stanford.edu)
  • New insights into the complex cellular contributions and interactions will be provided, comparing the role of cell subsets in the pathogenesis of IPF and systemic sclerosis. (ersjournals.com)
  • These Lgr5+ intestinal stem cells reside at the bottom of the crypts and are wedged between Paneth cells, which protect and nurture stem cells. (wjgnet.com)
  • Here, they reside in specialized niches where they remain quiescent until needed to replenish and repair the blood cell population. (thenoveldifference.com)
  • It is largely responsible for maintaining homeostasis and can play a significant part in supporting healthy brain function and a normal immune response. (analyticalcannabis.com)
  • Background Microglia, the primary resident myeloid cells of brain, play critical roles in immune defense by maintaining tissue homeostasis and responding to injury or disease. (scite.ai)
  • Consequently, induced deletion of Survivin in Lgr5(+) stem cells led to cell death. (uea.ac.uk)
  • Small airway basal cells were purified from brushed SAE of a healthy nonsmoker donor with a characteristic normal SAE transcriptome. (biomedcentral.com)
  • Because this latter mechanism does not depend on interactions of cells with each other or with their environment, it must rely on intrinsic asymmetry. (wikipedia.org)
  • The term asymmetric cell division usually refers to such intrinsic asymmetric divisions. (wikipedia.org)
  • Moreover, Survivin-deficient animals showed induced phosphorylation of p53 and H2AX and increased levels of cell-intrinsic apoptosis in IECs. (uea.ac.uk)
  • While irradiation can effectively treat brain tumors, this therapy also causes cognitive impairments, some of which may stem from the disruption of hippocampal neurogenesis. (scite.ai)
  • Numb is a suppressor of Notch, therefore the asymmetric segregation of Numb to the basal cortex biases the response of the daughter cells to Notch signaling, resulting in two distinct cell fates. (wikipedia.org)
  • Lysosomal function is critical for organismal homeostasis-mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome. (stanford.edu)
  • When caspase activity was impaired, genes known to be involved in metamorphosis were downregulated along with other implicated in cell migration and survival molecular pathways. (biomedcentral.com)
  • While caspase-dependent signals emitted by apoptotic cells start to be characterised, almost no target genes are identified in receptor cells. (biomedcentral.com)
  • Compared to the large airway cell line BCi-NS1.1, differentiated of hSABCi-NS1.1 cells on ALI were enriched with small airway epithelial genes, including surfactant protein genes, LTF and small airway development relevant transcription factors NKX2-1, GATA6, SOX9, HOPX, ID2 and ETV5. (biomedcentral.com)
  • Mitochondrial state changes were shown to be critical for stem cell function. (stanford.edu)
  • Noncanonical WNT signals are transduced through Frizzled family receptors and ROR2/RYK coreceptors to the Dishevelled-dependent (Rho family GTPases and c-jun NH 2 -terminal kinase) or the Ca 2+ -dependent (NLK and nuclear factor of activated T cells) signaling cascades. (aacrjournals.org)
  • Breakage of the stem cell signaling network leads to carcinogenesis. (aacrjournals.org)
  • Senescence, a process by which cells enter an irreversible growth arrest state, is activated by many stimuli, including telomere attrition, aberrant oncogenic signaling, DNA damage or oxidative stress. (umassmed.edu)