Homeostasis model. Medical search. Frequent questions

The estimate of deficient beta-cell function obtained by homeostasis model assessment correlated with that derived using the hyperglycaemic clamp (Rs = 0.61, p less than 0.01) and with the estimate from the intravenous glucose tolerance test (Rs = 0.64, p less than 0.05). (nih.gov)
The low precision of the estimates from the model (coefficients of variation: 31% for insulin resistance and 32% for beta-cell deficit) limits its use, but the correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop. (nih.gov)
Therefore, the aim of this meta-analysis was to compare the effect of the Paleolithic diet with other types of diets on glucose and insulin homeostasis in subjects with altered glucose metabolism. (mdpi.com)
We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and decrease risk of type 2 diabetes (T2D). (nature.com)
Functional studies in Angptl4 -deficient mice confirm improved insulin sensitivity and glucose homeostasis. (nature.com)
Together, these observations suggest that genetic inhibition of ANGPTL4 function might have a favorable impact on glucose homeostasis in humans and reduce risk of type 2 diabetes. (nature.com)
It is not yet known whether p.E40K affects glucose homeostasis in non-diabetics, whether other variants that abolish ANGPTL4 function modify type 2 diabetes risk, or how loss of ANGPTL4 function modifies glucose homeostasis and type 2 diabetes risk. (nature.com)
There are conflicting published reports of the relationship between ANGPTL4 function and glucose homeostasis in animal models. (nature.com)
We also evaluate the functional consequences of rare and novel genetic variants identified by exome sequencing, as well as the effect of Angptl4 deletion on insulin sensitivity and glucose homeostasis. (nature.com)
Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis? (jci.org)
BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in mice. (jci.org)
The pathophysiology of diabetes as a disease is characterised by an inability to maintain normal glucose homeostasis. (endocrinology-journals.org)
Animal models, in particular genetically modified mice, are increasingly being used to elucidate the mechanisms underlying both type 1 and type 2 diabetes, and as such the ability to study glucose homeostasis in vivo has become an essential tool. (endocrinology-journals.org)
Representative scenarios illustrating some of the practical considerations of designing in vivo experiments for the measurement of glucose homeostasis are also discussed. (endocrinology-journals.org)
We accessed the literature regarding atypical antipsychotics and glucose homeostasis using PubMed. (psychiatrist.com)
In addition, insulin is the most important factor in the regulation of plasma glucose homeostasis, as it counteracts glucagon and other catabolic hormones-epinephrine, glucocorticoid, and growth hormone. (medscape.com)
We show how this model can respond to an ATPase load as well as to the glucose supply. (ebi.ac.uk)
Glucagon and insulin respectively secreted from the pancreatic islet α-cells and β-cells are main hormones for regulating glucose homeostasis. (researchsquare.com)
So in response to high glucose level or in type 2 diabetes, how 25(OH)D impact glucagon secretion from islet α-cells as well as the islet function homeostasis between islet α-cells and β-cells should be elucidated, which can provide new strategies for treating glucose metabolism disorders. (researchsquare.com)
Understanding these factors, interactions and extent they contribute to the preservation of glucose homeostasis and psychosocial functioning is important for the development of preventive and therapeutic measures promoting healthy and active ageing. (europa.eu)
By identifying biological and psychosocial determinants of the GPA and characterising metabolic and epigenetic factors, whilst quantifying the impact of exposure to an optimal lifelong GPA, DynaHEALTH will influence weight gain, glucose homeostasis, employability, health deterioration and disease accumulation as individuals age. (europa.eu)
We show that derangements in energy homeostasis are causally associated with increased risk of cardiometabolic outcomes and that early intervention on perturbed glucose control and excess adiposity may help prevent these adverse health outcomes. (lu.se)

Spike pattern structure influences synaptic efficacy variability under STDP and synaptic homeostasis. (edu.hk)
In this paper, we try to understand this influence under pair-wise additive spike-timing dependent plasticity (STDP) when the mean strength of plastic synapses into a neuron is bounded (synaptic homeostasis). (edu.hk)
Dive into the research topics of 'Spike pattern structure influences synaptic efficacy variability under STDP and synaptic homeostasis. (edu.hk)
In model neurons, such changes of the weight dependence of heterosynaptic plasticity shifted their operating point between regimes dominated by associative plasticity or by synaptic homeostasis. (jneurosci.org)
Whereas both REM sleep and SWS have been proposed to play an important role in memory consolidation ( Diekelmann and Born, 2010 ), SWS has been proposed to be specifically involved in maintaining synaptic homeostasis in mammals ( Tononi and Cirelli, 2003 , 2006 ). (jneurosci.org)

The model consisted of ordinary differential equations and included negative feedback regulation. (lu.se)
Homeostasis is the property of an open system, especially living organisms, to regulate its internal environment to maintain a stable, constant condition, by means of multiple dynamic equilibrium adjustments, controlled by interrelated regulation mechanisms. (dadamo.com)
The goal of this minireview is to provide an update on the regulation of bile acid (BA) homeostasis by the nuclear receptor Farnesoid X receptor (FXR) and the effects on this regulation by exposure to environmental or therapeutic agents. (aspetjournals.org)
The hypothalamic-pituitary-gonadal (HPG) axis plays a crucial and integrative role in the mammalian endocrine regulation to maintain homeostasis. (intechopen.com)
Following crises, tthe family can foresee the future by building on its historic legacy model, by replicating emotional regulation patterns rather than reproducting past mistakes. (edhec.edu)
As a result, self-regulation helps reaching family homeostasis, described by Donald de Avila Jackson as the ability to migrate from one stable state to another, so as to obtain an equilibrium in terms of relations. (edhec.edu)

As an attempt to bridge between molecular mechanisms and their cellular relevance, we explain here the model of local axon homeostasis, based on our own experiments in Drosophila and published data primarily from vertebrates/mammals as well as C. elegans. (manchester.ac.uk)
However, the effects and the mechanisms by which environmental chemicals interact with FXR to affect BA homeostasis are only emerging. (aspetjournals.org)
OBJECTIVE: Knowledge of the cellular mechanisms involved in homeostasis of human squamous oesophagus in the steady state and following chronic injury is limited. (who.int)

Dr. Orosz has a diverse portfolio that overarches a broad range of alcohol induced pathologies including the cardiovascular system, proteostasis (protein homeostasis) pathways, alcoholic liver disease, epigenetics, mitochondrial dysfunction and apoptosis, and identification and validation of alcohol biomarker signatures. (nih.gov)
In the present work, the molecular effects of the aromatic short-chain fatty acid 4-phenylbutyric acid (4-PBA) and the medium-chain fatty acid caprylic acid (CA) on proteostasis and mitochondrial homeostasis were investigated using the transgenic Caenorhabditis elegans strain GMC101, expressing human Aβ1-42 in body wall muscle cells. (uni-giessen.de)
In mice PD models that were deficient in IFNβ signaling, the investigators showed that neuronal IFNβ is required to maintain mitochondrial homeostasis and metabolism. (medscape.com)

We aimed to investigate the association between 25(OH)D and islet function homeostasis in type 2 diabetes (T2D) patients. (researchsquare.com)

Methods: Murine tracheal smooth muscle cells (MTSMC) from T- bet KO mice and human bronchial smooth muscle cells (HBSMC) incubated with IL-13 and IL-4 served as asthma models. (uni-muenchen.de)
In this study, all parameters governing these processes were estimated in a computational model to describe the haematopoietic hierarchy in adult mice. (lu.se)
Using Ptpn22 −/− mice we demonstrate that the phosphatase PTPN22 is a highly selective, negative regulator of cDC2 homeostasis, preventing excessive population expansion from as early as 3 weeks of age. (frontiersin.org)
Alessa Wagner from the University of Ulm with the project "Glucocorticoid treatment in mice disrupts liver iron homeostasis" for a research stay at the Ludwig-Maximilians-University Munich, Gen-Zentrum. (uni-ulm.de)
As proof of principle, we applied DUCT to a mouse model for Alagille syndrome ( Jag1 Ndr/Ndr mice), characterized by intrahepatic bile duct paucity, that can spontaneously generate a biliary system in adulthood. (elifesciences.org)
Fate-mapping studies in inbred mice: A model for understanding macrophage development and homeostasis? (bvsalud.org)

An old paper revisited: ''A mathematical model of carbohydrate energy metabolism. (ebi.ac.uk)
We revisit an old Russian paper by V.V. Dynnik, R. Heinrich and E.E. Sel'kov (1980a, b) describing: ''A mathematical model of carbohydrate energy metabolism. (ebi.ac.uk)
We also show how this simple model can help in understanding the articulation between the major blocks of energetic metabolism, i.e. glycolysis, the Krebs cycle and the H-transporting shuttles. (ebi.ac.uk)

These cells provide several important physiological functions during homeostasis (Figure 1 ). (hindawi.com)
Tissue microenvironment plays critical roles in maintaining homeostasis and physiological functions of organ systems. (cdc.gov)

Thus, our results indicate that PFOS worsens inflammation-induced intestinal damage with disruption of T-cell homeostasis beyond the gut and provides a novel in vivo toolbox to screen for pollutants affecting intestinal homeostasis. (lu.se)
BAs are critical molecules for life, and disruption of BA homeostasis has been closely linked to hepatic, intestinal, and systemic diseases, including cholestasis, fatty liver diseases, and hepatic and colon tumors. (aspetjournals.org)

Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model. (oregonstate.edu)

A computer-solved model has been used to predict the homeostatic concentrations which arise from varying degrees beta-cell deficiency and insulin resistance. (nih.gov)
This creates a situation of "metastability", in which homeostatic conditions are maintained within fixed limits, but once these limits are exceeded, the system can shift wildly to a wholly new (and possibly less desirable) situation of homeostasis. (dadamo.com)

This is an important development in the field of glycan modeling, which revealed biological insights about the glycosylation machinery in altered cellular states. (york.ac.uk)
The term is most often used in the sense of biological homeostasis. (dadamo.com)

Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for regulating immune responses, with changes in numbers sufficient to break immune tolerance. (frontiersin.org)

A classification that sufficiently covers their phenotypic heterogeneity and plasticity during homeostasis and disease does not yet exist because cell culture-based phenotypes often do not match those found in vivo . (hindawi.com)
Using model simulations, we found that the strength of weight dependence determines the ability of heterosynaptic plasticity to prevent runaway dynamics of synaptic weights imposed by Hebbian-type learning. (jneurosci.org)

ABSTRACT: A mathematical model of calcium homeostasis is presented in which the controlling factors are the plasma concentrations of calcium, PTH, and calcitriol, and the effector organs are the parathyroids, bone, kidney, and intestine. (cellml.org)
Block diagram of calcium homeostasis. (cellml.org)
Using cellular disease models for ADTKD-SEC61A1, we identified an impaired protein transport of the renal secretory protein renin and a reduced abundance of regulatory calcium transporters, including SERCA2. (amrita.edu)
Treatment with the molecular chaperone phenylbutyrate reversed the defective protein transport of renin and the imbalanced calcium homeostasis. (amrita.edu)

However, there is still a huge gap in understanding how these chemicals contribute to the dysregulation of BA homeostasis and how this dysregulation may promote NASH development. (aspetjournals.org)

Our model can provide detailed information on altered biosynthetic paths, with potential for advancing treatments for glycosylation-related diseases and glyco-engineering of cells. (york.ac.uk)

Comparison of a patient's fasting values with the model's predictions allows a quantitative assessment of the contributions of insulin resistance and deficient beta-cell function to the fasting hyperglycaemia (homeostasis model assessment, HOMA). (nih.gov)
The estimate of insulin resistance obtained by homeostasis model assessment correlated with estimates obtained by use of the euglycaemic clamp (Rs = 0.88, p less than 0.0001), the fasting insulin concentration (Rs = 0.81, p less than 0.0001), and the hyperglycaemic clamp, (Rs = 0.69, p less than 0.01). (nih.gov)
Erosion of bone at ligament entheses was evident by 12 weeks of age, by both histologic and micro-CT assessment.Conclusion MIG-6 expression in chondrocytes is important for the maintenance of cartilage and joint homeostasis. (bepress.com)
Interventions Comparative risk assessment models were used to estimate the effects of a nationwide intervention to replace discretionary dietary salt with potassium enriched salt substitutes (20-30% potassium chloride). (bmj.com)
At the end of the study significant reductions in fasting blood sugar (FBS), the homeostasis model assessment insulin resistance (HOMA-IR), triglyceride (TG), alkaline phosphatase (ALP), and Omentin level were found in groups 3 and 4 in comparison with group 2. (researchgate.net)

The objective of this study was to determine the role of LXR during development using the zebrafish model. (scirp.org)

In the conscious canine model, some atypical antipsychotics cause adiposity, including visceral obesity, a strong risk factor for the metabolic syndrome. (psychiatrist.com)
Thus even in homeostasis, body temperature, blood pressure, heart rate and most metabolic indicators are not always at a constant level, but vary predictably over time. (dadamo.com)

L. Wang, G. U. Schuster, K. Hultenby, Q. Zhang, S. Andersson and J. A. Gustafsson, "Liver X Receptors in the Central Nervous System: From Lipid Homeostasis to Neuronal Degeneration," Proceedings of the National Acadamy of Sciences of the USA, 15 October 2002, pp. 13878-13883. (scirp.org)
DUCT is thus a powerful new technology for 3D analysis, which can reveal novel phenotypes and provide a standardized method of defining liver architecture in mouse models. (elifesciences.org)
A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450s. (cdc.gov)

Many cigarette smoke-associated airway diseases involve alterations in mucin homeostasis. (cdc.gov)

Acetylcholine- induced changes in the cytoplasmic Ca(2+) concentration were recorded using fluorescence microscopy and the expression of Ca(2+) homeostasis regulating proteins was investigated with Western blot analysis. (uni-muenchen.de)

Here, to overcome the lack of in vivo models suitable for screening of environmental factors, we used zebrafish reporters of intestinal inflammation. (lu.se)

Maintaining bile acid (BA) homeostasis is important and regulated by BA activated receptors and signaling pathways. (aspetjournals.org)

Title : Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis Personal Author(s) : Baur, Rachel;Kashon, Michael;Lukomska, Ewa;Weatherly, Lisa M.;Shane, Hillary L.;Anderson, Stacey E. (cdc.gov)

Maintaining brain homeostasis function is essential. (news-medical.net)

Furthermore, environmental estrogens, such as Bisphenol A, activate MCs in preclinical models but their impact on pain pathways or migraine is understudied. (frontiersin.org)

Accumulating mechanistic understanding of CNT lung pathology at the systemic, cellular, and molecular levels has demonstrated the potential of using CNT-exposed animals as a new disease model for the studies on inflammation, fibrosis, and the interactions between these two disease states. (cdc.gov)

Duration of diabetes influence the effect of 25(OH)D on the ratio of glucagon/C-p, on behalf of islet function homeostasis, in T2D patients with abdominal obesity. (researchsquare.com)

Where a value for a variable is unknown it has been defined as 1.000 in this CellML model (these added values are distinct from any value which is definitely known to be 1 by including 3 decimal places). (cellml.org)

Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo- p -dioxin evaluated with a multicompartment geometric model of hepatic zonation. (cdc.gov)

A tissue-centric view assumes that changing tissue microenvironments shape the phenotypes of their resident and infiltrating mononuclear phagocytes to fulfill the tissue's need to maintain or regain homeostasis. (hindawi.com)
A more tissue-centric view of these processes, claiming that the tissues define phenotype and function of resident and infiltrating immune cells to meet tissues needs during homeostasis and disease, seems provocative [ 4 , 5 ]. (hindawi.com)
We examine tissue needs to maintain homeostasis and how to regain homeostasis upon tissue injury. (hindawi.com)
With the rationale that relevant tissue responses can be measured to evaluate the adverse health effects of tobacco products, we assessed changes in mucin secretion and the density and size of goblet cells in an in vitro human air-liquid-interface (ALI) airway tissue model after exposure to a tobacco smoke solution. (cdc.gov)

Our data show that lxr is an important component of the regulatory network governing the lipid homeostasis during zebrafish development, which in turn may support a role of lxr for normal development of the central nervous sytem, including the retina. (scirp.org)
DynaHEALTH will contribute to implementing a dynamic model for early GPA risk identification and validation, allowing development of risk-based prevention tools and policies that will help to inform policy makers on the best periods to invest in cost-effective and sustainable healthcare strategies. (europa.eu)
This analysis would provide new insights into the mechanistic understanding of lung inflammation and fibrosis induced by CNTs, as well as the development of CNT-exposed animals as a new model for human lung diseases. (cdc.gov)

Exposure to perfluorooctanesulfonic acid (PFOS) during 2,4,6-trinitro-benzene sulfonic acid (TNBS)-induced inflammation enhanced the expression of proinflammatory cytokines as well as neutrophil recruitment to the intestine of zebrafish larvae, which was validated in the TNBS-induced colitis mouse model. (lu.se)

Deficiency of 25(OH)D has been confirmed to affect the synthesis and secretion of insulin in both animal models and human studies 4− [4]. (researchsquare.com)

In this minireview, our focus is to provide evidence from reports that determine the effects of environmental or therapeutic exposure on altering homeostasis and functions of BAs and FXR. (aspetjournals.org)

This question has become increasingly relevant since Drosophila became a model of choice for investigating molecular processes associated with sleep in health and disease ( van Alphen and van Swinderen, 2013 ). (jneurosci.org)

Here, we develop and validate a computational model for glycan biosynthesis to probe how the biosynthetic machinery creates different glycan profiles. (york.ac.uk)

We analyse the model mathematically and calculate the control coefficients as a function of ATPase loads. (ebi.ac.uk)

Complex systems, such as a human body, must have homeostasis to maintain stability and to survive. (dadamo.com)

In conclusion, both 4-PBA as well as CA attenuate Aβ proteotoxicity in an AD model of the nematode C. elegans. (uni-giessen.de)

Mechanistically, PTPN22 mediates cDC2 homeostasis in a cell intrinsic manner by restricting cDC2 proliferation. (frontiersin.org)
This control of cDC homeostasis is mediated by a number of factors that drive cDC differentiation, proliferation, and survival or apoptosis ( 4 ). (frontiersin.org)

Our results show that the NADPH oxidase RBOHD is essential for microbiota homeostasis and emphasizes the importance of the plant immune system in controlling the leaf microbiota. (nature.com)

Their self-renewing potential was investigated by colony forming cells assays and in vitro organotypic culture models. (who.int)

While studies in healthy subjects are limited and inconclusive, studies in animal models are more revealing. (psychiatrist.com)
The effect of these drugs on fat distribution has been clearly shown in animal models. (psychiatrist.com)
11 (5 with animal and 6 with human models) were eligible. (bvsalud.org)

Conclusions: We conclude that in the murine asthma model the SR Ca(2+) buffer capacity is increased, while in the human asthma model the expression of SR Ca(2+) channels is altered. (uni-muenchen.de)

The steady state solution of the Daisyworld model of Watson and Lovelock (1983) is examined in de. (knmi.nl)

The models incorporated existing data and corresponding uncertainties from randomised trials, the China National Survey of Chronic Kidney Disease, the Global Burden of Disease Study, and the Chronic Kidney Disease Prognosis Consortium. (bmj.com)
In deterministic sensitivity analyses, with changes to key model inputs and assumptions, net benefits were consistent in the total population and in individuals with chronic kidney disease, with averted deaths outweighing additional deaths. (bmj.com)
The host-pathogen interactions that define a disease are homeostasis. (cdc.gov)

The model was able to recapitulate the fundamental steady-state features of haematopoiesis and simulate the re-establishment of steady-state conditions after haemorrhage and bone marrow transplantation. (lu.se)

Anatomy24

Organisms5

Diseases36

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment62

Psychiatry and Psychology3

Phenomena and Processes75

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture4

Information Science4

Named Groups8

Health Care37

Geographicals7

Glucose22

Synaptic homeostasis5

Regulation6

Mechanisms3

Mitochondrial3

Type 2 diabet1

Mice6

Metabolism3

Physiological functions2

Disruption2

Embryonic1

Homeostatic2

Biological2

Dendritic cells1

Plasticity2

Calcium4

Dysregulation1

Glycosylation1

Assessment5

Zebrafish model1

Metabolic2

Liver3

Alterations1

Proteins1

Intestinal1

Receptors1

Disrupts1

Maintaining1

Pathways1

Systemic1

Glucagon1

Distinct1

Hepatic1

Tissue4

Development3

Inflammation1

Synthesis1

Exposure1

Drosophila1

Computational model1

Function1

Maintain1

Conclusion1

Proliferation2

Essential1

Vitro1

Animal3

Human1

Watson1

Disease3

Steady1