• Metazoan life is dependent upon the utilization of O(2) for essential metabolic processes and oxygen homeostasis is an organizing principle for understanding metazoan evolution, ontology, physiology, and pathology. (nih.gov)
  • Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mitochondrial physiology, which is also diminished during cellular senescence and normative physiological ageing. (mdpi.com)
  • Walter Cannon, a professor of physiology at Harvard University coined the commonly used term, homeostasis, in his book The Wisdom of the Body, 1932, from the Greek word homoios, meaning similar, and stasis, meaning position. (wikipedia.org)
  • Protein Homeostasis comprises all the cellular networks that maintain the proper structure and assembly of the cellular proteome, and it is essential to normal cell function. (umass.edu)
  • In the last decade an explosion of discoveries has indicated that imbalances in protein homeostasis are associated with many diseases, including neurodegenerative diseases like Alzheimer's, Parkinson's and Huntington's, as well as many forms of cancer, diabetes, cystic fibrosis, lysosomal storage diseases, and more. (umass.edu)
  • Improved understanding of protein homeostasis has promise of leading to new targets for small molecule modulators, and hence new therapeutic strategies against many of these diseases. (umass.edu)
  • Targeting protein homeostasis components also affords the opportunity to develop new antiinfectives, either by intervening with the protein homeostasis components of the pathogen, or targeting components of the host network that are hijacked by a pathogen. (umass.edu)
  • A protein involved in protein homeostasis limits the maturation of IGF1R and the overproduction of blood cells. (sciencemag.org)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers the entire spectrum of protein homeostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry. (cshlpress.com)
  • Including discussions of specific disorders such as Alzheimer's disease, Huntington's disease, and prion diseases, this book is an essential reference for not only molecular and cellular biologists but also medical scientists wishing to understand the pathological consequences of and potential therapies for protein homeostasis deficiencies in common human diseases. (cshlpress.com)
  • Biological stability, or 'homeostasis', where an organism works to maintain an internal 'steady state' in response to the environment, is a concept familiar to all modern biologists. (plos.org)
  • Homeostasis is to maintain and restore certain steady states or conditions of the organism. (smore.com)
  • When cells are in homeostasis, they work to help the organism function properly. (ehow.co.uk)
  • It is important for cells to maintain homeostasis for the organism to remain healthy. (ehow.co.uk)
  • Homeostasis can be defined as a property of an organism or system that helps it maintain its parameters within a normal range of values. (scirp.org)
  • By connecting information and catalysis, epigenesis coupled with homeostasis exemplifies the internal, directive capacities of the organism, linking information and behavior. (wikipedia.org)
  • This theory suggests that both homeostasis and allostasis are endogenous systems responsible for maintaining the internal stability of an organism. (wikipedia.org)
  • It's part of endocrinology, it's not really the crux of Neurobiology and so what we're gonna look at today is how the hypothalamus and other places in the nervous system contribute to homeostasis. (coursera.org)
  • And in fact, the hypothalamus is gonna use all of the outputs of the central nervous system in order to accomplish homeostasis. (coursera.org)
  • The hypothalamus is highly involved in maintaining homeostasis of the body, and the median preoptic nucleus is no exception, contributing to regulation of blood composition, body temperature, and non-REM sleep. (wikipedia.org)
  • Connectivity with other regions of the hypothalamus, such as the ventrolateral preoptic area (VLPO) and with regions of the brain stem also allow the median preoptic nucleus to be involved in other aspects of homeostasis. (wikipedia.org)
  • http://www.ehow.co.uk/about_6049897_homeostasis-diabetes.html. (ehow.co.uk)
  • Here, the principal genetic and biochemical processes that are responsible for membrane lipid homeostasis in bacteria are reviewed. (nih.gov)
  • Advances in understanding the molecular regulation of Ca(2+) homeostasis and how it is perturbed in neurological disorders may lead to therapeutic strategies that modulate neuronal Ca(2+) signaling to enhance function and counteract disease processes. (nih.gov)
  • The cell membrane maintains homeostasis through the processes of diffusion, osmosis and filtration, which are passive forms of transport. (ehow.co.uk)
  • The rapid expansion of multiple lineages building up to homeostasis in the adult parallels processes in the hematopoietic system where stem cells give rise to progenitor cells and finally terminally differentiated cells. (pnas.org)
  • Homeostasis imbalance results when the body's internal environment is unable to remain in equilibrium in the face of internal, external and environmental i. (reference.com)
  • Homeostasis is a state in which everything within the cell is in equilibrium and functioning properly. (ehow.co.uk)
  • Homeostasis is a fancy word meaning "equilibrium," and it entails many interwoven variables that are amazing to consider. (ehow.co.uk)
  • A new vision of immunity: homeostasis of the superorganism. (nih.gov)
  • In other diseases, temporary upsets in homeostasis may make us more susceptible to infectious agents. (hubpages.com)
  • The circulatory system includes the heart, blood vessels and blood, and is vital for fighting diseases and maintaining homeostasis (proper temperature and pH balance). (smore.com)
  • It is key to life, and failures in homeostasis can lead to diseases like hypertension and diabetes. (scirp.org)
  • To independently assess the extent to which c-myb is required for colonic crypt homeostasis we also generated a novel tissue-specific mouse model to allow the deletion of c-myb in adult colon, and using these mice we show that c-Myb is required for crypt integrity, normal differentiation, and steady-state proliferation. (pnas.org)
  • Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (nih.gov)
  • Precise control of cell cycle regulators is critical for normal development and tissue homeostasis. (nih.gov)
  • The role of cell death is the maintenance of tissue and organ homeostasis , for example, the regular loss of skin cells or a more active role seen in involuting tissues like the thymus. (wikipedia.org)
  • The fact that the function and viability of nonadipocytes is compromised when their TG content rises above or falls below the normal range suggests that normal homeostasis of their intracellular TG is critical for optimal function and to prevent lipoapoptosis. (pnas.org)
  • Several factors can disrupt homeostasis, including viruses and other microorganisms that induce fevers, raise blood pressure and alter blood pH. (reference.com)
  • Homeostasis is an almost exclusively biological term, referring to the concepts described by Bernard and Cannon, concerning the constancy of the internal environment in which the cells of the body live and survive. (wikipedia.org)
  • Cells are complex genetic systems, having evolved compensatory molecular networks that provide growth homeostasis (robustness). (pnas.org)
  • Detailed information about the properties of multiple antiporters in individual strains is starting to explain how specific monovalent cation/proton antiporters play dominant roles in alkaline pH homeostasis in cells that have several additional antiporters catalyzing ostensibly similar reactions. (nih.gov)
  • In this Review, we discuss the role of IL-7 in the survival and homeostasis of naive and memory T cells and how that role is regulated by other factors. (nih.gov)
  • E) Quantification by flow cytometry of RFP-positive G1 cells from trypsin-dissociated en-Gal4, UAS-RFP wing discs expressing GFP or the indicated GFP-E2f1 fusion proteins. (nih.gov)
  • Osmosis Ion Homeostasis Immune Response Growth Higher levels of potassium in the roots creates a greater amount of photosynthesis in the leaves by helping to control osmosis occurring throughout the cells. (wikipedia.org)
  • The low-density lipoprotein receptor (LDLR) regulates cholesterol homeostasis in mammalian cells. (wikipedia.org)
  • Homeostasis is the active process by which our nervous system regulates internal conditions, such as blood pressure and temperature. (coursera.org)
  • Inducible neuron inhibition reveals essential roles for serotonergic neurons in respiratory and body temperature homeostasis. (sciencemag.org)
  • Homeostasis is not always in the context of body temperature but we will use that as an example to illustrate its importance. (ehow.co.uk)
  • If your temperature is too low, normal events can't work, including homeostasis. (ehow.co.uk)
  • A temperature due to fever is a type of homeostasis failure. (wisegeek.com)
  • Remarkably, all of these iar4 mutant phenotypes were rescued when endogenous indole-3-acetic acid (IAA) levels were increased by growth at high temperature or overexpression of the YUCCA1 IAA biosynthetic enzyme, suggesting that iar4 mutations may alter IAA homeostasis rather than auxin response. (nih.gov)
  • The integumentary system maintains homeostasis by protecting the body, regulating temperature, absorbing materials and synthesizing vitamins and minerals. (reference.com)
  • Recent evidence suggests that other cytokines, including IL-2, IL-10, IL-12, interferons and TGF-beta, as well as the transcription factors T-bet and eomesodermin all play important but different roles at distinct stages of T-cell homeostasis. (nih.gov)
  • Less energetically expensive, but no less important, roles in the maintenance of homeostasis include the lymphatic system's ability to fight infection, the respiratory system's maintenance of oxygen and proper pH levels, and the urinary system's removal of toxins from the blood. (ehow.co.uk)
  • Membrane lipid homeostasis in bacteria. (nih.gov)
  • Alkaline pH homeostasis in bacteria: new insights. (nih.gov)
  • This review highlights the approaches, major findings and unresolved problems in alkaline pH homeostasis, focusing on the small number of well-characterized alkali-tolerant and extremely alkaliphilic bacteria. (nih.gov)
  • Helpful bacteria also are integral to maintaining homeostasis in the digestive system. (ehow.co.uk)
  • The strict homeostasis of iron leads to a free concentration of about 10āˆ’24 mol Lāˆ’1, hence there are great evolutionary pressures put on pathogenic bacteria to obtain this metal. (wikipedia.org)
  • When the human body is in a state of homeostasis, all functions and chemicals are balanced and the body functions normally. (ehow.co.uk)
  • In short, a state of homeostasis is never achieved. (ehow.co.uk)
  • The state of homeostasis keeps the cell constant with what it needs to function. (ehow.co.uk)
  • The word homeostasis is derived from the Greek, homeo or "same", and stasis or "stable" and means remaining stable or remaining the same. (hubpages.com)
  • Homeostasis is the property of a system in which variables are regulated so that internal conditions remain stable and relatively constant. (smore.com)
  • Homeostasis keeps the cell stable. (ehow.co.uk)
  • Building upon this empirical work, Turner has argued that the principle of homeostasis is a fundamental property of living systems that accounts for, among other things, the phenomenon of biological design. (wikipedia.org)
  • Homeostasis controls respiratory rate through the area of the brain known as the medulla, according to Florida International University. (reference.com)
  • Systems of the body decline at different points, causing homeostasis failure as result of decreased nerve functioning and that of other organs. (wisegeek.com)
  • Here I consider the role of oxysterols as intermediates in different catabolic pathways, and I weigh the evidence for and against the "oxysterol hypothesis" of cholesterol homeostasis. (jci.org)