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  • protein
  • Putative genes that are regulated by NK-2 protein were cloned and were sequenced partially. (nih.gov)
  • A nuclear protein was found that binds to a novel trinucleotide repeat sequence in the 5'-upstream region of a rat brain voltage-sensitive calcium channel a1 subunit that activates an enhancerless chloramphenicol acetyltransferase reporter gene. (nih.gov)
  • genes
  • Four Pou-domain genes expressed in embryonic and adult mouse brain were cloned and sequenced: Brain-1, Brain-2, Brain-4, and Scip. (nih.gov)
  • homeobox gene
  • A mouse homeobox gene, mNK-1, was cloned and approximately 5.2 kb of DNA was sequenced. (nih.gov)
  • We have generated transgenic mice, using 5′- and/or 3′-flanking sequences from the mouse Crx homeobox gene fused to the β-galactosidase ( lacZ ) reporter gene, and we have investigated the promoter function of the cell-specific and developmentally regulated expression of Crx . (jneurosci.org)
  • Tinman
  • Of particular interest to cardiac studies is Tinman (Tin), an NK homeodomain-containing transcriptional factor that is the earliest cardiac lineage cell marker and is necessary for the early specification of the primordial heart ( 5 , 6 ). (pnas.org)
  • Molecular
  • To define gene expression changes associated with diabetic retinopathy in a mouse model using next generation sequencing, and to utilize transcriptome signatures to assess molecular pathways by which pharmacological agents inhibit diabetic retinopathy. (molvis.org)
  • transcripts
  • Transcripts of this gene give rise to four alternative splice products (Pax8a to Pax8d) which differ in their C‐terminal sequences while sharing common N‐terminal regions including the paired domain. (embopress.org)
  • Next generation sequencing-based RNA-seq profiles provided comprehensive signatures of transcripts that are altered in early stages of diabetic retinopathy. (molvis.org)
  • segmental
  • Another potential Tin target is dSUR , which has a heart-specific segmental expression pattern that is identical to the late cardiac-restricted expression of Tin ( 17 ) and is speculated to be an effector molecule for cardiac performance. (pnas.org)