• The PRH monomer has three functional domains: a 136 amino acid N-terminal glycine-, alanine- and proline-rich domain, a central 60 amino acid proline-rich homeodomain, and a 73 amino acid acidic C-terminal domain (Fig. 1 ). (beds.ac.uk)
  • To construct theΔ 1-5 -pacap1b mutant, site-directed mutagenesis was used to delete the cDNA nucleotides encoding amino acids 121-125 of the PACAP1b precursor protein. (biologists.org)
  • One of the principal differences between HTH motifs in these different proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the beta-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, whereas for many of the homeotic and other DNA-binding proteins the requirement is relaxed. (wikipedia.org)
  • The two are now checking to see if this new cell growth regulation mechanism they've discovered is conserved across different species, including mice, which have similar Hipk proteins to humans. (sfu.ca)