GenesProteinsProteinTranscriptionalInteractsGENETIC TRANSCRIPTIONGenePituitaryRolesFound primarilyDomainExpressionHumanFamilyProteinsOtx2Pax2Cell differentiationVERTEBRATEGenes encoding transcriptioMetabolismRegulateSignaling moleculesSubunitsRegulatesGene expressionMeshEnzymaticNeuralDifferentiationDevelopmentHormoneNuclearPlayImportantModelFunctionsGrowthNetworksRegionMajor
Genes6
- Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. (nih.gov)
- Identification of transcription and processing signals of ribosomal genes of D. melanogaster. (cnr.it)
- In the developing mouse embryo, both Otx genes are expressed in the rostral head region and in certain sense organs such as the inner ear. (biologists.com)
- Previous studies have demonstrated that transcription factors such as Pax genes play important roles during their development. (biomedcentral.com)
- Reprime la TRANSCRIPCIÓN GENÉTICA de los GENES diana y desempeña una función fundamental en la ODONTOGÉNESIS. (bvsalud.org)
- It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS. (bvsalud.org)
Proteins9
- The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. (nih.gov)
- It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. (nih.gov)
- It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions. (nih.gov)
- Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
- A family of double-stranded RNA-binding proteins that are related to NFATC TRANSCRIPTION FACTORS. (ouhsc.edu)
- In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
- This graph shows the total number of publications written about "Nuclear Factor 90 Proteins" by people in this website by year, and whether "Nuclear Factor 90 Proteins" was a major or minor topic of these publications. (ouhsc.edu)
- Below are the most recent publications written about "Nuclear Factor 90 Proteins" by people in Profiles. (ouhsc.edu)
- These proteins are transcription factors that control developmental pathways. (nih.gov)
Protein2
- OTX2 is a 289 amino acid containing protein encoding a member of the bicoid sub-family of homeodomain-containing transcription factors. (thermofisher.com)
- A homeodomain protein that interacts with TATA-BOX BINDING PROTEIN. (bvsalud.org)
Transcriptional1
- They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. (childrensmercy.org)
Interacts1
- 2000). "The leucine zipper of NRL interacts with the CRX homeodomain. (en-academic.com)
GENETIC TRANSCRIPTION1
- It regulates GENETIC TRANSCRIPTION involved in METABOLISM of AMINO ACIDS in response to the increased concentration of LEUCINE. (rush.edu)
Gene4
- Identification of an Otx gene-dosage dependent mechanism required for patterning of developing brain and proper positioning of midbrain-hindbrain isthmic organizer. (cnr.it)
- This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. (en-academic.com)
- Our results, along with those on Otx - and Hox -gene expression, demonstrate that the cephalopod condition is similar to that in mouse and fruit fly, with Otx being expressed in the anterior-most brain region (except for the vertical lobe) and a Pax2/5/8 expression domain separating the Otx -domain from a Hox -gene-expressing posterior brain region. (biomedcentral.com)
- NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription. (ouhsc.edu)
Pituitary2
- PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. (wikipedia.org)
- supplied by OMIM] Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2 and PITX1. (wikipedia.org)
Roles2
- For inferences concerning the evolutionary conservation versus plasticity of transcription factor expression patterns and their putative roles, a broad comparative approach is imperative. (biomedcentral.com)
- They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (umassmed.edu)
Found primarily1
- A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG. (ucdenver.edu)
Domain1
- POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone. (wikipedia.org)
Expression2
- Combined expression analysis of Otx, Emx, Dlx and Otp during development and definition of brain segmentary identities. (cnr.it)
- A coordinated tempo-spatial expression of transcription factors is required for cell type specification and the differentiation of the three germ layers into distinct organ systems during bilaterian ontogeny [ 1 ]. (biomedcentral.com)
Human3
- Real-world patient-reported outcomes and physician satisfaction with poly (ADP-ribose) polymerase inhibitors versus chemotherapy in patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2-negative advanced breast cancer from the United States, Europe, and Israel. (jefferson.edu)
- Real-World Study of Regional Differences in Patient Demographics, Clinical Characteristics, and BRCA1/2 Mutation Testing in Patients with Human Epidermal Growth Factor Receptor?2-Negative Advanced Breast Cancer in the United States, Europe, and Israel. (jefferson.edu)
- Real-world study of patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2?Negative advanced breast cancer: Patient demographics, treatment patterns, adverse events, and physician-reported satisfaction in the United States, Europe, and Israel. (jefferson.edu)
Family1
- Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in HEPATOCYTES. (umassmed.edu)
Proteins7
- Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2 Causes Subfertility in Mice via Distinct Mechanisms. (nih.gov)
- Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (homeodomains.com)
- A family of VERTEBRATE homeodomain proteins that share homology with orthodenticle protein, Drosophila. (bvsalud.org)
- Genes near these "CRX Dependent" sites code for proteins important for photoreceptor physiology and function, and their transcription is significantly reduced in Crx deficient retinas. (biomedcentral.com)
- Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (reference.md)
- HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
- This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. (wikidoc.org)
Otx22
- We have studied 3 different homeodomain genes Otx2, Vax1, and Six3 and found that the deletion of one allele for any of these genes in mice produces subfertility or infertility in one or both sexes, despite the presence of one intact allele. (nih.gov)
- 9 ]). The homeodomain (HD) TF OTX2 specifies the photoreceptor lineage by turning on the expression of cone rod homeobox (CRX) and its downstream TFs. (biomedcentral.com)
Pax22
- Subsequently, a series of transcription factors including Pax2 , Pax5 , Pax8 , En1 , En2 are expressed at the Otx 2- Gbx 2 boundary that are required for maintenance of the MHB organizer and specification of the midbrain territory. (biomedcentral.com)
- Our results, along with those on Otx - and Hox -gene expression, demonstrate that the cephalopod condition is similar to that in mouse and fruit fly, with Otx being expressed in the anterior-most brain region (except for the vertical lobe) and a Pax2/5/8 expression domain separating the Otx -domain from a Hox -gene-expressing posterior brain region. (biomedcentral.com)
Cell differentiation2
- Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression. (umassmed.edu)
- They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (childrensmercy.org)
VERTEBRATE1
- In this Review, we outline the signaling and transcription factors that drive vertebrate photoreceptor development and discuss how these function together in gene regulatory networks to control photoreceptor cell fate specification. (biologists.com)
Genes encoding transcriptio1
- This view reflects the amazing conservation of genetic apparatus that has been discovered across the Bilateria, particularly of genes encoding transcription factors and signaling molecules. (silverchair.com)
Metabolism1
- Here, we show that fibroblast growth factor 21 (FGF21), a lipid metabolism-related hormone, may play a role in this relationship. (tokushima-u.ac.jp)
Regulate2
- They regulate GENETIC TRANSCRIPTION and play an important role in EMBRYONIC DEVELOPMENT of the BRAIN . (bvsalud.org)
- Using plasmid- and bacterial artificial chromosome-based transgenic reporter assays, we identified key cis -regulatory elements (CREs) and transcription factor inputs that regulate Sp-kirrelL , including direct, positive inputs from two key transcription factors in the skeletogenic GRN, Alx1 and Ets1. (elifesciences.org)
Signaling molecules2
- By using a combination of in situ hybridization screening, overexpression of mRNA, recombinant ligand treatments, and morpholino-based loss-of-function studies, we identified a cohort of transcription factors and signaling molecules expressed in the ventral ectoderm , dorsal ectoderm , and interposed neurogenic ("ciliary band") region in response to the known key signaling molecules Nodal and BMP2/4 and defined the epistatic relationships between the most important genes. (echinobase.org)
- Gene expression profiles of transcription factors and signaling molecules analyzed in this study. (echinobase.org)
Subunits3
- Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. (homeodomains.com)
- NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. (homeodomains.com)
- Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. (umassmed.edu)
Regulates1
- HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
Gene expression2
- To address these questions, we focused on CRX, a disease-associated homeodomain TF required for photoreceptor gene expression and development. (biomedcentral.com)
- Rod gene expression is tightly regulated by a number of transcription factors (TFs), acting in a cascade during development [(Reviewed by Swaroop et al. (biomedcentral.com)
Mesh2
- Core Binding Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- Hepatocyte Nuclear Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Enzymatic1
- The coactivators may act through an enzymatic process that affects the rate of transcription or the structure of chromatin. (nih.gov)
Neural2
- However, it is known that the specification and subsequent patterning of the neural tube uses hierarchies of transcription factors working in combination with the activity of signalling centres located at discrete AP positions. (biomedcentral.com)
- They therefore provide an excellent model for exploring the factors and mechanisms that drive neural progenitors into a differentiated cell fate in the nervous system. (biologists.com)
Differentiation1
- Second, goosecoid was identified as a central player in a regulatory sub-circuit controlling mouth formation, while tbx2/3 emerged as a critical factor for differentiation of the dorsal ectoderm . (echinobase.org)
Development1
- Previous studies have demonstrated that transcription factors such as Pax genes play important roles during their development. (biomedcentral.com)
Hormone1
- POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone. (wikipedia.org)
Nuclear1
- Below are the most recent publications written about "Hepatocyte Nuclear Factors" by people in Profiles. (childrensmercy.org)
Play1
- Signaling ligand binding transcription factors play an important role in transduction cascades. (homeodomains.com)
Important1
- Recent technological advances have delivered the genome-wide targets of many important transcription factors (TFs). (biomedcentral.com)
Model1
- In this study, we sought to address these questions using the retinal and disease relevant homeodomain TF CRX as a model. (biomedcentral.com)
Functions1
- Transcriptions are key functions in signal transduction pathways. (homeodomains.com)
Growth1
- The TX-HYB Hybridoma Growth Supplement replaces feeder layers or other conditioned media and growth factors used in hybridoma production. (homeodomains.com)
Networks1
- This is directed by transcription factor (TF) networks and their target DNA elements across the genome. (biomedcentral.com)
Region1
- STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION . (nih.gov)
Major1
- This graph shows the total number of publications written about "Core Binding Factors" by people in this website by year, and whether "Core Binding Factors" was a major or minor topic of these publications. (umassmed.edu)