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  • motif
  • The PRD class comprises six families in Bilateria , and tinkers with four different motifs, i.e., the PAIRED domain, the Groucho-interacting motif EH1 (aka Octapeptide or TN), the homeodomain, and the OAR motif. (springer.com)
  • In addition, this motif might also regulate protein activity by alteration of the protein's DNA-binding affinity through changes in the phosphorylation state of two conserved tyrosine residues within the homeodomain. (biologists.org)
  • abstract
  • In his honor, we provide here an update of this review, although we will barely be able to scratch the surface, given that over 17,000 publications containing "homeobox," "homeodomain," or "Hox" in the title or abstract have appeared since the first publications. (springer.com)
  • TALE
  • This regulatory module appears to function broadly as we also identify Meis3 regulation of cell survival and PDK1 expression in ovarian carcinoma cells, suggesting a unique function for Meis3 beyond the traditional roles for TALE homeodomain factors during embryogenesis. (biomedsearch.com)
  • expression
  • In Drosophila and mammals, overlapping domains of expression of LIM subfamily homeodomain (HD) proteins, a 'LIM code', has been proposed to specify different neuron classes (for a review, see Shirasaki and Pfaff, 2002 ). (biologists.org)
  • class
  • Eyg also contains another DNA-binding domain, a Prd-class homeodomain (HD), whose palindromic binding site is similar to other Prd-class HDs. (pnas.org)
  • One of these corresponds to the LIM class homeodomain (HD) protein CEH-14/Lhx3, and the other two correspond to Paired-like HD proteins CEH-10/Chx10 and CEH-17/Phox2. (biologists.org)
  • domain
  • Export from donor nuclei can be saturated and is strongly reduced after deletion of a 11 amino acid-long (Δ)1 sequence present within a slightly larger domain that extends between helices 2 and 3 of the homeodomain and shows strong similarities with leucine-rich nuclear export signals (NES). (biologists.org)