All animals are composed of distinct body parts and organs, many of which are specified by particular combinations of `selector' genes that control cell and tissue behavior by regulating downstream `realisator' genes( Garcia-Bellido, 1975 ). (biologists.com)
Drosophila3
We have used Drosophila melanogaster (a.k.a, fruit fly) eye as our model organ as 75% of genetic machinery is conserved between fruit flies and humans and have identified defective proventriculus (dve, a Homeobox gene), an ortholog of SATB-homeobox-1 (special AT-rich sequence binding protein-1 in humans), as a new member of DV- patterning genes hierarchy. (udayton.edu)
Mutations in genes like human-Fused in Sarcoma (h-FUS) or cabeza (caz) in Drosophila, have been known to cause ALS in flies. (udayton.edu)
The Drosophila wing primordium is defined by expression of the selector gene vestigial ( vg ) in a discrete subpopulation of cells within the wing imaginal disc. (biologists.com)
Organ2
DV patterning marks first lineage restriction event during eye development, any deviation during this event during development results in defective organ formation. (udayton.edu)
Despite the importance of compartment-specific selector genes, it is now apparent that they constitute a special class, and that most other selector genes are expressed in discrete `organ' domains that are defined by active signaling rather than by epigenetic inheritance( Mann and Morata, 2000 ). (biologists.com)