The ALX3 protein is a transcription factor, which means that it attaches (binds) to DNA and controls the activity of certain genes. (medlineplus.gov)
Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific for the thyroid, lung, and diencephalon. (wikipedia.org)
To identify genes, signaling pathways and networks that are controlled by SRC-3 and potentially important for hormone-dependent decidualization, we performed RNA-sequencing on HESCs in which SRC-3 levels were significantly reduced at the time of administering the deciduogenic stimulus. (frontiersin.org)
Comparing HESC controls with HESCs deficient in SRC-3, gene enrichment analysis of the differentially expressed gene set revealed an overrepresentation of genes involved in chromatin remodeling, cell proliferation/motility, and programmed cell death. (frontiersin.org)
The rostral division of the neural tube into its 3 main sections falls under the control of homeobox (Hox) family of genes. (medscape.com)
[ 4 ] The Hox genes, well described as the master regulators of development, encode a set of transcription factors that specify the identity of particular segments during embryogenesis. (medscape.com)
Identification of transcription and processing signals of ribosomal genes of D. melanogaster. (cnr.it)
Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development. (cnr.it)
Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
FSHD is a gain-of-function disease characterized by the aberrant expression of the Double homeobox 4 (DUX4) transcription factor leading to altered pathogenic deregulation of multiple genes in muscles. (nih.gov)
The homeobox genes DLX4, HB24, MSX2 and MOX2 also likely play a role in devel opment at the epithelial-mesenchymal boundary. (eurekaselect.com)
Transcription factors such as TEF-5, Hand1, HEB, HASH-2 and two genes represented by ESTs may have regulatory roles in placental development. (eurekaselect.com)
Represses transcription of the dorsal genes gsc and otx2. (xenbase.org)
Previous researches have shown that LIM-homeobox genes are important transcription factors during diencephalon regionalization in mice. (ehu.eus)
Here we examined expression patterns of several chick orthologs of LIM-homeobox genes. (ehu.eus)
Our data suggest that the LIM-homeobox genes, Lhx1 and Lhx9 , regulated by ventral and/or dorsal signals, may play important roles in controlling regionalization of the diencephalon during chick development. (ehu.eus)
Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)
There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)
Reprime la TRANSCRIPCIÓN GENÉTICA de los GENES diana y desempeña una función fundamental en la ODONTOGÉNESIS. (bvsalud.org)
It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS. (bvsalud.org)
Protein8
The ALX3 gene provides instructions for making a protein that is a member of the homeobox protein family. (medlineplus.gov)
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene. (wikipedia.org)
The transcription factor FOSL1 (also known as Fra-1), which is found in basal-like breast cancers but not in the luminal subtype, stimulated the transcription of miR-221/222, and the abundance of these miRNAs decreased with inhibition of the epidermal growth factor receptor (EGFR) or MEK (mitogen-activated or extracellular signal-regulated protein kinase kinase), placing miR-221/222 downstream of the RAS pathway. (nih.gov)
also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). (cancerindex.org)
The leucine zipper domain forms a dimer that is essential for HD-Zip protein recognition of DNA [ 3 ]. (biomedcentral.com)
From a cDNA library of 3-day after-pollination (DAP) rice embryos we cloned a HAZ1 cDNA that encodes a protein with a PHD-finger domain and a homeodomain. (elsevierpure.com)
OTX2 is a 289 amino acid containing protein encoding a member of the bicoid sub-family of homeodomain-containing transcription factors. (thermofisher.com)
Recent studies have suggested that menin may act as a scaffold protein to coordinate gene transcription, and that menin is an oncogenic cofactor for homeobox (HOX) gene expression in hematopoietic cancer. (elsevierpure.com)
Factors9
It has been observed that a loss of Nkx2-1 allows for deregulation of transcription factors FOXA1/2 (by relaxing histone deacetylation and methylation-mediated repression of Foxa1/2 by Nkx2-1) causing reactivation of an embryonic gastric differentiation program in pulmonary cells. (wikipedia.org)
This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. (nih.gov)
Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. (nih.gov)
This spacer and the putative promoter 600 bp upstream from the hsa‐miR‐200c stem-loop contain six putative binding sequences for [zinc‐finger E‐box binding homeobox 1] ZEB1, two of which were restricted to ZEB factors (Z‐box 1 and 2, CAGGTA). (wikiversity.org)
HD-Zips (Homeodomain-Leucine Zippers) are a class of plant-specific transcription factors that play multiple roles in plant growth and development. (biomedcentral.com)
These 23 PpHDZ transcription factors all contained a homeomorphism box domain and a leucine zipper domain, were divided into 4 subfamilies(I-IV) according to the evolutionary analysis, and their promoters contained many different cis-acting elements. (biomedcentral.com)
Transcription factors and regulatory mechanisms are proposed for these altered biological functions. (biomedcentral.com)
SHOX interacts with the chondrogenic transcription factors SOX5 and SOX6 to activate the aggrecan enhancer. (cdc.gov)
Factor15
We then found that VGLUT3-persistent neurons express the runt domain transcription factor Runx1. (jneurosci.org)
Using bioinformatics, a luciferase reporter assay and western blot analyses, the current study identified that runt‑related transcription factor 2 (RUNX2) was a target of miR‑205 in PC and overexpression of miR‑205 suppressed the expression of RUNX2. (spandidos-publications.com)
Runt-related transcription factor 2 (RUNX2), a member of the RUNX family, functions as a critical regulator for osteoblast differentiation ( 14 ). (spandidos-publications.com)
To date, a homeobox transcription factor Hoxb4 has been only demonstrated to possess such an effect in mice. (ebiotrade.com)
Here, we show that HSC-like cells were efficiently induced from mouse ESCs by enforced expression of Lhx2, a LIM-homeobox transcription factor. (ebiotrade.com)
We have previously shown that the forkhead transcription factor FoxO1 is a prominent transcriptional effector of GLP-1 signaling in the β-cell. (diabetesjournals.org)
It also stimulates insulin gene expression and insulin biosynthesis ( 6 ), in part via increased expression and activity of the β-cell-specific transcription factor Pdx1 ( 7 , 8 ). (diabetesjournals.org)
We have previously shown that GLP-1 transactivates the epidermal growth factor receptor ( 12 ) to subsequently activate phosphatidylinositol-3 kinase and Akt signaling ( 7 , 11 ). (diabetesjournals.org)
Although some functions of HD-Zip transcription factor have been reported in several plants, it has not been comprehensively studied in peach, especially during adventitious root formation of peach cuttings. (biomedcentral.com)
As a unique transcription factor in plants, HD-Zip plays an important regulatory role in plant growth and development, environmental response, cell cycle and cell metabolism [ 9 ]. (biomedcentral.com)
The 4q25 genetic locus is adjacent to PITX2 , a transcription factor that determines left-right asymmetry of the heart [ 6 ]. (e-arrhythmia.org)
Those studies used mice lacking serotonergic neurons resulting from the loss of function mutations in the gene encoding the LIM homeobox transcription factor 1 ( Lmx1b ). (aspetjournals.org)
the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. (pharna.com)
For example, we have applied light-activatable cMOs to interrogate transcription factor function during zebrafish notochord, pancreas, and vascular patterning. (cdc.gov)
As the material increased in purity, there are more high-aspect-ratio particulates and a corresponding distinct increase in cytotoxicity, nuclear factor-B transcription, and inflammasome activation. (cdc.gov)
Zinc finger3
Furthermore, miR-221/222-mediated reduction in E-cadherin abundance depended on their targeting the 3' untranslated region of the GATA family transcriptional repressor TRPS1 (tricho-rhino-phalangeal syndrome type 1), which inhibited EMT by decreasing ZEB2 (zinc finger E-box-binding homeobox2) expression. (nih.gov)
In vivo SIP1, or Zinc finger E-box-binding homeobox 2 (ZEB2), binds "to potential SIP1-binding sites (Z-boxes) located in the vicinity of the cyclin D1 transcription start site. (wikiversity.org)
[ 2 ] The product of the WT1 gene has zinc finger arrays that bind to specific DNA sequences, whereas the amino terminus appears to regulate transcription. (medscape.com)
Mutations1
Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene. (medlineplus.gov)
Proteins1
Homeobox proteins direct the formation of body structures during early embryonic development. (medlineplus.gov)
Embryos1
Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp). (cnr.it)
Transcriptional2
MicroRNAs (miRNAs or miRs) are small non-coding RNAs that participate in diverse cellular processes and negatively regulate gene expression at the post-transcriptional level by binding with 3′-untranslated regions (3′-UTRs) ( 2 - 4 ). (spandidos-publications.com)
SIP1 represses cyclin D1 transcriptional activity via direct interaction with Z-boxes 1-3 in the cyclin D1 promoter. (wikiversity.org)
Activates2
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. (pharna.com)
Activates the head organizer gene cer1 by acting synergistically with siamois and mix-A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. (xenbase.org)
Amino1
The homeodomain domain is generally composed of about 60 amino acids encoded homeobox, which form three alpha helices. (biomedcentral.com)
Tumor1
The identification of the gene responsible for Wilms tumor did not occur until 1990, when 3 groups independently identified the WT1 gene on band 11p13. (medscape.com)
Regulation1
Particularly involved in glucose-dependent regulation of insulin gene transcription. (pharna.com)
Embryonic1
The mouse small intestine is formed at embryonic day 10 when a sheet of endoderm closes and seals to form a tube of epithelium surrounded by mesenchymal cells 3 . (jove.com)
Metabolism2
Alveolar type II (ATII) epithelial cells synthesize, secrete and recycle all components of surfactant and dysfunction in surfactant metabolism can result in a variety of pediatric lung diseases including respiratory distress syndrome and interstitial lung disease 3 . (nature.com)
The Journal of clinical endocrinology and metabolism 2002 Mar 87 (3): 1402-6. (cdc.gov)
MRNA3
Defects in mRNA 3'end formation have been described to alter transcription termination, transport of the mRNA from the nucleus to the cytoplasm, stability of the mRNA and translation efficiency. (nih.gov)
Here, we choose facioscapulohumeral dystrophy (FSHD) as a model to determine whether or not targeting key 3' end elements involved in mRNA processing using antisense oligonucleotide drugs can be used as a strategy for gene silencing within a potentially therapeutic context. (nih.gov)
We conclude that targeting key functional 3' end elements involved in pre-mRNA to mRNA maturation with antisense drugs can lead to efficient gene silencing and is thus a potentially effective therapeutic strategy for at least FSHD. (nih.gov)
Complex3
They are 3-dimensional, complex, multicellular structures that can be derived from patient specific human induced pluripotent stem cells (hiPSCs). (nature.com)
Isolation and identification of the structural organization of the human homeobox gene family (HOX Complex). (cnr.it)
Polycomb Repressive Complex 2 (PRC2), a component of the Polycomb machinery, is responsible for the methylation of histone H3 lysine 27 (H3K27me2/3). (sdbonline.org)
Important2
Collectively, our results support SRC-3 as an important coregulator in HESC decidualization. (frontiersin.org)
Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature. (cdc.gov)
Cytoplasmic1
The cell surface immune receptors (CSIRs) and intracellular immune receptors (IIRs) directly or indirectly recognize apoplastic or cytoplasmic "invasion molecules" to induce weak or strong immune responses [ 3 ]. (researchsquare.com)
Human1
We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)
Epithelial1
As most malignant ovarian tumors are epithelial in origin, most studies of ovarian malignancy do not include GCTs [3]. (cancerhugs.com)
Represses1
Represses transcription of the dorsal. (xenbase.org)
Diencephalon1
The diencephalon is the caudal part of the developing forebrain, which corresponds to prosomeres 1 to 3. (ehu.eus)
Function1
[ 3 ] Loss of function of the BDNF gene in some patients with WAGR syndrome may produce obesity and hyperphagia. (medscape.com)
Involves1
This approach involves the intramolecular cross-linking of 5′ amine- and 3′ disulfide-modified MO oligonucleotides using appropriately functionalized tethers, generating macrocyclic structures that conformationally resist RNA hybridization. (cdc.gov)
Expression1
We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)
Markedly1
These molecular findings are supported at the cellular level by the inability of HESCs to morphologically transform from a stromal fibroblastoid cell to an epithelioid decidual cell when endogenous SRC-3 levels are markedly reduced. (frontiersin.org)
Development1
Although it may seem daunting to the casual reader, revisiting cranial embryology allows for a more comprehensive understanding of the final 3-dimensional structure of the nerve, as well as the inherent logic in its development. (medscape.com)
Genome1
Recently, genome-wide association studies (GWAS) performed in populations of European-descent have identified several genetic variants associated with AF [ 3 ]. (e-arrhythmia.org)