• The Bacillus subtilis φ29 Holin (φ29 Holin) Family (TC# 1.E.10) is a group of transporters belonging to the Holin Superfamily IV. (wikipedia.org)
  • Thus, GP14 is a nonspecific holin in the cytoplasmic membrane of B. subtilis. (wikipedia.org)
  • Portal: Biology As of this edit, this article uses content from "1.E.10 The Bacillus subtilis φ29 Holin (φ29 Holin) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. (wikipedia.org)
  • Phage was discovered from a soil sample in Philadelphia at 25 degrees Celcius. (phagesdb.org)
  • A representative list of members belonging to the φ29 holin family can be found in the Transporter Classification Database. (wikipedia.org)
  • The phage φ29 gene 14 encodes the protein GP14 (TC# 1.E.10.1.1) which is required for phage φ29-promoted host cell lysis. (wikipedia.org)
  • The phage φ29 gene 14 encodes the protein GP14 (TC# 1.E.10.1.1) which is required for phage φ29-promoted host cell lysis. (wikipedia.org)
  • When expressed together with phage φ29 lysozyme or an unrelated murein-degrading enzyme, cell lysis is also observed. (wikipedia.org)
  • It is identical to the phage PZA lysis protein and nearly identical to the phage B103 lysis protein. (wikipedia.org)
  • Production of infective virions is induced upon DNA damage (SOS conditions), and is accompanied by bacterial lysis, driven by the phage-encoded holin and endolysin. (tau.ac.il)
  • Prophage excision was highly induced when bacteria were located within the macrophage phagosomes, yet, unlike in classic phage induction, this did not lead to the production of progeny virions and bacterial lysis. (tau.ac.il)
  • functional analysis of the lysis genes of staphylococcus aureus phage p68 in escherichia coli. (liverpool.ac.uk)
  • double-stranded dna phages of both gram-positive and gram-negative bacteria typically use a holin-endolysin system to achieve lysis of their host. (liverpool.ac.uk)
  • in this study, the lysis genes of staphylococcus aureus phage p68 were characterized. (liverpool.ac.uk)
  • These Listeria-specific phages are known to reproduce through both lysogenic and lytic cycles. (tau.ac.il)
  • We termed this type of phage behaviour active lysogeny, representing cases where prophages control bacterial gene expression via genomic excision, without triggering the lytic cycle (Nature Reviews Microbiology, Feiner et al. (tau.ac.il)
  • Biotechnological advances have further expanded the repertoire of potential phage therapeutics to include novel strategies using bioengineered phages and purified phage lytic proteins. (wjgnet.com)
  • Current research on the use of phages and their lytic proteins against multidrug-resistant bacterial infections, suggests phage therapy has the potential to be used as either an alternative or a supplement to antibiotic treatments. (wjgnet.com)
  • Most bacterial pathogens are lysogens, namely carry DNA of infective and cryptic phage elements within their genome (in many cases more than one), yet the impact of this phenomenon on their behaviour during mammalian infection is not well understood. (tau.ac.il)
  • The practice of phage therapy, which uses bacterial viruses (phages) to treat bacterial infections, has been around for almost a century. (wjgnet.com)
  • The phenomenon by which a temperate phage incorporates itself into the DNA of a bacterial host, establishing a kind of symbiotic relation between PROPHAGE and bacterium which results in the perpetuation of the prophage in all the descendants of the bacterium. (lookformedical.com)
  • BACTERIOPHAGE T4), and T6, and the phage T5 are called "autonomously virulent" because they cause cessation of all bacterial metabolism on infection. (lookformedical.com)
  • Conventionally, phage therapy relies on the use of naturally-occurring phages to infect and lyse bacteria at the site of infection. (wjgnet.com)
  • All RNA phages infect their host bacteria via the host's surface pili. (lookformedical.com)
  • The S. mutans LrgA/B holin-like proteins have been shown to affect biofilm formation and oxidative stress tolerance, and are regulated by oxygenation, glucose levels, and by the LytST two-component system. (biomedcentral.com)
  • a phage lambda vector with a q(-) mutation was used to enhance the expression of the lambda system. (liverpool.ac.uk)
  • red/et recombination, a powerful homologous recombination system based on the red operon of lambda phage or rece/ rect from rac phage, provides an innovative approach for dna engineering. (liverpool.ac.uk)
  • Virulent bacteriophage and type species of the genus T4-like phages, in the family MYOVIRIDAE. (lookformedical.com)
  • Virulent bacteriophage and type species of the genus T7-like phages, in the family PODOVIRIDAE, that infects E. coli. (lookformedical.com)
  • Bacteriophages whose genetic material is RNA, which is single-stranded in all except the Pseudomonas phage phi 6 (BACTERIOPHAGE PHI 6). (lookformedical.com)
  • Adsorption: the phage attaches to target cell through its tail fibers. (expasy.org)
  • A representative list of members belonging to the φ29 holin family can be found in the Transporter Classification Database. (wikipedia.org)
  • Upon induction (VIRUS ACTIVATION) by various agents, such as ultraviolet radiation, the phage is released, which then becomes virulent and lyses the bacterium. (lookformedical.com)