Hodgkin antigens cd30. Medical search. Frequent questions

Autologous T Cells Expressing CD30 Chimeric Antigen Receptors for Relapsed or Refractory Hodgkin Lymphoma: An Open-Label Phase I Trial. (qxmd.com)
Hodgkin lymphoma is a potentially curable lymphoma. (medscape.com)
Mixed cellularity Hodgkin lymphoma showing both mononucleate and binucleate Reed-Sternberg cells in a background of inflammatory cells (hematoxylin and eosin, original magnification x200). (medscape.com)
A histologic diagnosis of Hodgkin lymphoma is always required. (medscape.com)
See also the Medscape article Hodgkin Lymphoma Staging . (medscape.com)
See also Hodgkin Lymphoma Treatment Protocols . (medscape.com)
[ 6 ] provide consensus opinions from leading experts on evidence-based approaches to the diagnosis and treatment of Hodgkin lymphoma. (medscape.com)
AFM-13 is under development for the treatment of refractory and relapsed Hodgkin lymphoma, CD30+ lymphoma such as transformed mycosis fungoides, peripheral and cutaneous T-cell lymphoma, angioimmunoblastic T cell lymphoma, large B-cell lymphoma, B-cell non-Hodgkin lymphoma, Hodgkin lymphoma combination with check point inhibitors and Hodgkin lymphoma combination with lenalidomide. (pharmaceutical-technology.com)
The technique has also shown preliminarily promising outcomes in B cell acute lymphoblastic leukemia (B-ALL), B cell non-Hodgkin's lymphoma (B-NHL), chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma and multiple myeloma in clinical trials targeting CD19, CD20, CD22, CD30 and B-cell maturation antigen (BCMA), with many more under investigation. (bdbiosciences.com)
Wright CW, Rumble JM, Duckett CS: CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. (exbio.cz)
The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA. (lookformedical.com)
The research interests of Joo Song, M.D., are focused on the genomics, prognostication, and classification of aggressive lymphomas such as Hodgkin lymphoma and diffuse large B cell lymphoma. (cityofhope.org)
Coexisting and clonally identical classical Hodgkin lymphoma and nodular lymphocyte predominant Hodgkin lymphoma. (cityofhope.org)
Peripheral T-cell lymphoma with aberrant expression of CD30, CD15, and CD20. (cityofhope.org)
Nodal involvement by cutaneous CD30-positive T-cell lymphoma mimicking classical Hodgkin lymphoma. (cityofhope.org)
Aberrant T-Cell Antigen Expression in Classical Hodgkin Lymphoma is Associated with Decreased Event-Free Survival and Overall Survival. (cityofhope.org)
Coexpression of CD15 and CD30 (usually associated with classical Hodgkin's lymphoma) may be seen in some PTCL, NOS. (webpathology.com)
Hodgkin's lymphoma and anaplastic large cell lymphoma, especially relapsed or refractory diseases, could recently be cured by CD30-targeted immunotherapy. (bvsalud.org)
Therefore, the membrane epitope of CD30 (mCD30), left on the cancer cells, might be a prospective target for lymphoma treatment. (bvsalud.org)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
Recent reports have shown an increased incidence of Hodgkin lymphoma (HL) in patients treated with antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection. (amjcaserep.com)
This report is of a case of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) with a good outcome in a 58-year-old Nigerian HIV-positive man who was being treated with ART. (amjcaserep.com)
Hodgkin lymphoma (HL) is the most common acquired immune deficiency syndrome (AIDS)-defining malignancy in human immunodeficiency virus (HIV)-infected patients, usually presenting at an advanced stage and in unusual locations in individuals with HIV/AIDS [1]. (amjcaserep.com)
A literature review showed that the risk of developing Hodgkin lymphoma (HL) is about 10 times higher in HIV-positive patients compared to HIV-negative patients [2]. (amjcaserep.com)
TT11 is an autologous CD30 chimeric antigen receptor T-cell (CAR-T) therapy that harvests the patient's own T-cells and modifies them to target cancer cells expressing the CD30 protein, a well-validated lymphoma target. (newsasiatoday.com)
Collectively, CTCL is classified as a type of non-Hodgkin lymphoma (NHL). (medscape.com)
CD30 positivity may also be observed in large cell transformation in MF, Hodgkin lymphoma, and other reactive disorders. (aad.org)
Brentuximab vedotin (Adcetris ® ), an anti-CD30 antibody conjugated to a potent microtubule inhibitor for the treatment of Hodgkin's lymphoma and anaplastic large cell lymphomas, is the only marketed ADC today. (springer.com)
B cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) frequently express CD19, CD20 and CD22 on the cell surfaces. (biomedcentral.com)
Several antibody-drug conjugates (ADC) have been approved for clinical use (gemtuzumab ozogamicin in acute myeloid leukemia and brentuximab vedotin in Hodgkin lymphoma as well as CD30+ anaplastic large cell lymphoma). (biomedcentral.com)
Immune checkpoint inhibitors have also been approved for treatment of Hodgkin lymphoma [ 24 ]. (biomedcentral.com)
CD20, CD22, and CD30 are also targeted antigens of CAR T cells in ALL and lymphoma trials [ 26 ]. (biomedcentral.com)
The Adcetris clinical trial showed a clear effect of this ADC against Hodgkin lymphoma and ALCL with increased long-term survival rates. (adcreview.com)
Transient loss of detectable HIV-1 RNA following brentuximab vedotin anti-CD30 therapy for Hodgkin lymphoma. (ucsf.edu)
In addition, CD 22 and CD 30 antigens are being studied diligently in the preclinical trials with promising results for the treatment of B cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma, respectively. (credenceresearch.com)
For instance, the anterior mediastinum is the site of the thymus with its varied associated pathology from Hodgkin and non-Hodgkin lymphoma (NHL), to thymoma, to germ cell neoplasms. (basicmedicalkey.com)
Lymphoma is further grouped into Hodgkin Lymphoma and Non-Hodgkin Lymphoma. (lymphoma.org.au)
What is the difference between Hodgkin and Non-Hodgkin Lymphoma? (lymphoma.org.au)
Hodgkin Lymphoma - all Hodgkin Lymphomas are lymphomas of B-cell lymphocytes. (lymphoma.org.au)
Hodgkin Lymphoma is identified when the cancerous B-cells develop in a certain way and become Reed-Sternberg cells - which look very different from normal B-cells. (lymphoma.org.au)
Click here to learn more about Hodgkin lymphoma. (lymphoma.org.au)
Non-Hodgkin Lymphoma (NHL) - these are lymphomas of all other B-cells or T-cell lymphocytes, including NK cells. (lymphoma.org.au)

CD30 is also expressed on different non-Hodgkin's lymphomas, virus-infected T and B cells, and on normal T and B cells after activation. (rndsystems.com)
CD30 can act as a co-stimulatory molecule in thymic negative selection and may also play a critical role in the pathophysiology of Hodgkin's disease and other CD30 + lymphomas. (rndsystems.com)
Engineered chimeric antigen receptor (CAR) T cell therapies (CAR-T) are now commercially available to treat certain leukemias and lymphomas. (bdbiosciences.com)
CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. (exbio.cz)
In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. (exbio.cz)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. (lookformedical.com)
Purpose of review: This article reviews the current data and future directions of engineered T cell therapies in non-Hodgkin lymphomas. (pimac.org)
Thus the senile lymphoproliferations, as a result of this theses, can be considered as Hodgkin`s lymphomas in the elderly. (uni-wuerzburg.de)
In this respect, the comparison between EBV positive ans EBV negative Hodgkin`s Lymphomas showed no distinct result. (uni-wuerzburg.de)
Distinction between atypical lymphoid proliferations rich in Reed-Sternberg-like cells (reactive immunoblasts) and classic Hodgkin lymphomas. (medscape.com)
absence/loss of pan B-cell and pan T-cell antigens), reactive cell population of other lineage, aberrant antigen expression, gene rearrangement studies, lineage infidelity, dual clones, and composite lymphomas. (aad.org)
Anti-CD30 distinguishes large cell lymphomas derived from activated lymphoid cells from histocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. (biogenex.com)
Reed-Sternberg cells are not present in Non-Hodgkin Lymphomas. (lymphoma.org.au)

Of note, CD19, CD20, CD30, CD33, CD123, and CD269 as ideal targets have shown extraordinary potential for CAR-T cell therapy and other targets such as CD23 and SLAMF7 have brought promising future for clinical trials. (hindawi.com)

The Reed Sterberg cells also have with a specific protein called CD15 or CD30 on them. (lymphoma.org.au)

These initial results encouraged us to undertake preclinical investigations with immunotoxins directed against the B-cell restricted CD19 antigen for B-lymphoid tumors and against the CD38 molecule for multiple myeloma. (atsbio.com)
Currently, CD19 antigens have been approved by USFDA for the treatment of relapsed b-cell acute lymphocytic leukemia. (credenceresearch.com)

CD30 was originally identified as a cell surface antigen of Hodgkin's and Reed-Sternberg cells using the monoclonal antibody Ki-1. (rndsystems.com)
The earliest study was conducted by Falini and his associates3 in Italy and Germany utilizing a CD30 antibody coupled to saporin for the treatment of four patients with advanced Hodgkin's disease. (atsbio.com)
In Hodgkin's disease, the CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. (biogenex.com)

Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. (ijbs.com)

Visualising an antibody-antigen interaction can be accomplished in a number of ways, mainly either of the following: Chromogenic immunohistochemistry (CIH), wherein an antibody is conjugated to an enzyme, such as peroxidase (the combination being termed immunoperoxidase), that can catalyse a colour-producing reaction. (wikipedia.org)
Depending on the method of fixation and tissue preservation, the sample may require additional steps to make the epitopes available for antibody binding, including deparaffinization and antigen retrieval. (wikipedia.org)
Depending on the tissue type and the method of antigen detection, endogenous biotin or enzymes may need to be blocked or quenched, respectively, prior to antibody staining. (wikipedia.org)
Quality control should as a minimum include a tissue known to express the antigen as a positive control and negative controls of tissue known not to express the antigen, as well as the test tissue probed in the same way with omission of the primary antibody (or better, absorption of the primary antibody). (wikipedia.org)
Primary antibodies are raised against an antigen of interest and are typically unconjugated (unlabeled), while secondary antibodies are raised against immunoglobulins of the primary antibody species. (wikipedia.org)
AFM-13 is a bi-specific, tetravalent human antibody, it acts by targeting CD30/CD16A. (pharmaceutical-technology.com)
Rabbit polyclonal antibodies (pAb) were used for preparing a gold-pAb conjugate, and the rGroEL-specific mouse monoclonal antibody was used as the antigen detection reagent at the ICT test line. (bvsalud.org)
ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
CAR has scFv derived from antibody, containing CD3ζ and costimulatory domain(s), making engineered CAR able to recognize specific tumor associated antigens. (cip.com.cn)
Given the unique characteristic of high antigen-specificity of Monoclonal Antibodies or MAb(s) (which I touched upon briefly in the previous post ), it is expected that the practice of antibody therapeutics would embrace this technology. (inscientioveritas.org)
Customarily prepared antibody-drug conjugate (ADC) products refer to the conjugation of therapeutic antibodies against cancer surface antigens with different drug-linker complexes that serve the course of ADC development and evaluation. (adcreview.com)
Adcetris is formulated by the conjugation of brentuximab, an anti-CD30 (also known as TNFRSF8) monoclonal antibody with payload monomethyl auristatin E (MMAE) via a cleavable peptide linker. (adcreview.com)
Brentuximab is a chimeric IgG1 monoclonal antibody that is developed by grafting the mouse anti-CD30 antibody CDR onto a human Fc framework while the payload, MMAE, an antimitotic agent, is an auristatin derivative that inhibits mitosis by impeding tubulin polymerization. (adcreview.com)
Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)

Although antibodies show preferential avidity for specific epitopes, they may partially or weakly bind to sites on nonspecific proteins (also called reactive sites) that are similar to the cognate binding sites on the target antigen. (wikipedia.org)
A great amount of non-specific binding causes high background staining which will mask the detection of the target antigen. (wikipedia.org)
Even though clinical results are encouraging for both approaches, several major challenges have been identified, including: target antigen selection such as less tumor toxicity and antigen escape, T cell homing to the tumor, T cell infiltration into the tumor, T cell persistence, and local immunosuppression in the tumor microenvironment. (cip.com.cn)
Synthetic biology technologies have enabled flexible reprogramming of engineered T cells to overcome the aforementioned limitations, bringing new opportunities for improving their safety and effectiveness, but the choice of a suitable target antigen is still a key for success. (cip.com.cn)
In the following studies attributes of SAS1B are defined that support its candidacy like a tumor cell-specific target antigen, including tumor cell-surface convenience, immunogenicity, internalization of immune complexes into the endosomal-lysosomal system, and immunotoxin delivery resulting in tumor cell growth arrest = 4 experiments). (gasyblog.com)

Therefore, CAR has an ability to bind unprocessed tumor surface antigens without MHC processing, while TCR engages with both tumor intracellular and surface antigens embedded in MHC. (cip.com.cn)
As well as concerning the latency type of EBV, the expression of surface antigens and transcriptionfactors and the This work´s aime was to describe the EBV infected cell in infectious monunnocleosis, hodgkin`s disease, post-transplatation lymphoproliferations (PTLD) and senile lymphoproliferation. (uni-wuerzburg.de)
As well as concerning the latency type of EBV, the expression of surface antigens and transcriptionfactors and the missing immunoglobulin synthesis Hodgkin`s disease and senile lymphoproliferation were equivalent to each other. (uni-wuerzburg.de)

The specific receptor for CD30L is CD30/TNFRSF8, a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. (rndsystems.com)
CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. (exbio.cz)

Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia[J]. The New England Journal of Medicine , 2013 , 368 (16): 1509-1518. (cip.com.cn)
Atypical molluscum contagiosum accompanied by CD30-positive lymphoid infiltrates. (harvard.edu)

CD30 ligand (CD30L)/TNFSF8 is a type II membrane protein belonging to the TNF superfamily. (rndsystems.com)
CD30 ligation by CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation and cell death by apoptosis. (rndsystems.com)
The ligand for CD30 is CD30L (CD153). (exbio.cz)
The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. (exbio.cz)
In reactive conditions, CD30 receptor and ligand (CD30L, CD153) expression is normally seen on activated T-immunoblasts and B-immunoblasts. (aad.org)
CD30 functions as a receptor for TNFSF8/CD30L and may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. (biogenex.com)

The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)
About 30% to 40% of PTCL, NOS, express markers of cytotoxic T-cells such as T-cell intracellular antigen-1 (TIA-1). (webpathology.com)
A poignant reminder here was the disastrous peripheral nerve damage experienced by women with breast cancer treated with a ricin A chain-based immunotoxin which unexpectedly also targeted nervous tissue.4 The most sensitive in vitro method for determining the selective cytotoxic potency of saporin-based immunotoxins is by measuring their ability to selectively inhibit protein synthesis in antigen-expressing cell lines in a dose-dependent manner. (atsbio.com)

CD30 is a transmembrane glycoprotein receptor of the tumor necrosis factor receptor super family 8 (TNFRSF8), mediating its effects through a number of signaling pathways that produce a survival advantage to the cells on which the protein is overexpressed. (aad.org)

It involves the process of selectively identifying antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. (wikipedia.org)
Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
Among T cells, CD30 is preferentially expressed on a subset of T cells producing Th2-type cytokines and on CD4 + /CD8 + thymocytes that co-express CD45RO and IL-4 receptor. (rndsystems.com)
1 T cells are engineered to express CARs through viral vectors, enabling them to recognize specific target antigens. (bdbiosciences.com)
In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. (exbio.cz)
Zeiser R, Nguyen VH, Hou JZ, Beilhack A, Zambricki E, Buess M, Contag CH, Negrin RS: Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease. (exbio.cz)
Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE. (lookformedical.com)
Expression of the activation marker CD30 may be seen in occasional tumor cells. (webpathology.com)
The cytotoxicity assay of anti-mCD30-H4CART cells showed significant eradication of the CD30-expressing cell line, K562 (p = 0.0378). (bvsalud.org)
These ITs, BB10.dgA (CD2S), HRS3.dgA (CD30), and IRac.dgA (70 kDa), strongly inhibited the growth of L540Cy H‐RS cells in vitro. (elsevierpure.com)
This was at least in part due to the non‐homogeneous distribution of CD25, CD30 or IRac on the L540Cy H‐RS target cells and to the fact that sub‐populations deficient in one antigen nevertheless expressed appreciable levels of the other target antigens. (elsevierpure.com)
Analysis of 7 L540Cy sub‐lines re‐established ex vivo from mice that relapsed after having achieved complete remission (CR) after therapy with a single IT showed that the surviving tumor cells were antigen‐deficient variants which were resistant to the original IT, but which could be killed by ITs directed against other target antigens. (elsevierpure.com)
The gene encodes a chimaeric antigen receptor (CAR) that targets leukaemia cells. (wikimili.com)
Due to their structure difference, TCR-T and CAR-T cells show different characteristics in signal activation and antigen recognition. (cip.com.cn)
As a side observeration the examined Hodgkin`s cells presented themselfs as CD27 negative. (uni-wuerzburg.de)
However, targeting solid tumors is more challenging than targeting B-cell malignancies with CAR-T cells because of the histopathological structure features, specific antigens shortage and strong immunosuppressive environment of solid tumors. (ijbs.com)
Advances in our understanding on the interaction between the immune system and tumor cells have contributed to the rapid development of novel therapeutic strategies based on chimeric antigen receptor (CAR) or T cell receptor (TCR) modified T cells. (ijbs.com)
Immunotherapeutic agents including antibodies and chimeric antigen receptor T cells are widely studied in clinical trials. (biomedcentral.com)
Sorrento Therapeutics through its wholly-owned subsidiary TNK Therapeutics is developing CEA CAR T. It is a CAR T-cells targeting carcinoembryonic antigen (CEA). (thesunshinereporter.com)
Descartes-011 are autologous CD8+ T-cells expressing an anti-BCMA chimeric antigen receptor. (thesunshinereporter.com)
Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30. (ucsf.edu)

Nevertheless, targeting solid tumors is more challenging than targeting hematological malignancies because of tumor histopathological characteristics, shortage of specific antigens and local strong immunosuppressive microenvironment [ 4 ]. (ijbs.com)
Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)

AFM-26, targeting B-cell maturation antigen to treat multiple myeloma. (pharmaceutical-technology.com)

Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. (lookformedical.com)

Detects human CD30 ligand/TNFSF8 in direct ELISAs. (rndsystems.com)
Mouse myeloma cell line NS0-derived human CD30 Ligand/TNFSF8. (rndsystems.com)
Human and mouse CD30 ligand cDNAs share 70% sequence homology. (rndsystems.com)

This combination is expected to bring together the benefits of highly potent drugs on the one hand and selective binders of specific tumor antigens on the other hand. (springer.com)

Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)

Other compounds, such as CMC-544, SAR3419, CDX-011, PSMA-ADC, BT-062, and IMGN901 currently in clinical trials, targeting varied antigens and bearing different linker and drugs, contribute to the learning curve of ADC, as do the discontinued ADC. (springer.com)

Hodgkin disease. (lookformedical.com)
PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
This work´s aime was to describe the EBV infected cell in infectious monunnocleosis, hodgkin`s disease, post-transplatation lymphoproliferations (PTLD) and senile lymphoproliferation. (uni-wuerzburg.de)
Therefore immunhistochemical stainigs were made to examin the relation between senile lymphoproliferations and PTLD and Hodgkin`s disease, respectively. (uni-wuerzburg.de)

We generated chimeric antigen receptor-modified T lymphocytes using HuscFv #A4 as an antigen detection part (anti-mCD30-H4CART). (bvsalud.org)

Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response. (exbio.cz)
However, the CD30 antigen releases the soluble ectodomain of CD30, which might obscure the targeted therapy. (bvsalud.org)

In this study, an immunochromatographic antigen detection test kit (ICT AgTK) that targets the highly conserved O. tsutsugamushi 60 kDa GroEL chaperonin (heat shock protein 60) was developed. (bvsalud.org)
Stimulation of CD30 leads signal mediation through tumor necrosis factor receptor-associated proteins (TRAF), thereby stimulating the nuclear factor-kappa B (NFkB) pathway and the mitogen-activated protein kinase (MAPK) pathways. (aad.org)

In recent years, engineering T cell therapy has made great progress in tumor immunotherapy, which mainly includes T-cell receptor-engineered T cell (TCR-T) therapy and chimeric antigen receptor T cell (CAR-T) therapy. (cip.com.cn)

Recent findings: Currently, four chimeric antigen receptor (CAR) T cell products are approved: axicabtagene ciloleucel, tisagenlecleucel, lisocabtagene maraleucel, and brexucabtagene autoleucel. (pimac.org)
This is a unexpected difference to the CD27 and CD30 positive memory cell which was postulated as the corresponding regular cell. (uni-wuerzburg.de)
Therefore the CD27 negativity of the Hodgkin`s cell is not an EBV specific phenomenon and requires further investigation. (uni-wuerzburg.de)
Also called chimeric antigen receptor T-cell therapy. (thesunshinereporter.com)

CD30 acts as a costimulatory molecule in thymic negative selection. (exbio.cz)

Xu et al state that "there is no standardized or validated form of performing the interpretation of CD30 expression. (aad.org)

We systematically examined and proved that our HuscFv #A4 could specifically eradicate CD30-expressing cancers. (bvsalud.org)

Anatomy29

Organisms8

Diseases13

Chemicals and Drugs151

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes28

Disciplines and Occupations1

Information Science4

Health Care5

Lymphoma44

Lymphomas14

CD201

CD151

CD192

Hodgkin's3

Chimeric Antigen Receptors1

Antibody14

Target antigen5

Surface antigens3

Type I transmembrane glycoprotein2

Lymphoid4

CD30L6

Cytotoxic3

Transmembrane glycoprotein1

Cells21

Tumors2

Maturation antigen1

Hematopoietic1

Ligand3

Specific tumor1

CD45RO1

Clinical trials1

Disease4

Receptor-modified1

Soluble2

Protein2

Immunotherapy1

Cell4

Molecule1

Expression1

Cancers1