Hodgkin's DiseaseClassical HodgkinCalled Hodgkin's lymphomaClassic Hodgkin lymphomaPreceding Hodgkin lymphomaNodularThomas HodgkinPeople with Hodgkin lymphomaDiagnosed with Hodgkin lymphomaLymphomasType of lymphomaSymptomsMalignantLymphoma causesLymphatic systemChemotherapyLymphocyte-predominantCenters for DiseasAutologousLymphoproliferative DisordersLarge mediastinal adenopathyReed-SternIncidenceLymph nodeBoneLymphoidRadiationCancersAdolescents and young adultsCancerInfectionOncologyLymphocytesPainlessSubtypesCommon symptomSpleenImmune systemLesionsComputed TomographyStagingHistologicRelapseTumorsSpreads
Hodgkin's Disease53
- The authors report a 4-year-old male with Hodgkin's disease with atypical clinical presentation, laboratory data and imaging studies as well as an increased radiosensitivity. (hindawi.com)
- After partial resection of the tumor the histology indicated Hodgkin's disease-mixed cellularity. (hindawi.com)
- He suffered recurrent pulmonary infections and succumbed to severe pneumonia with respiratory failure and pulmonary hypertension five years after the diagnosis of malignant lymphoma without evidence of recurrence of Hodgkin's disease. (hindawi.com)
- C. Sandoval and M. Swift, "Hodgkin's disease in ataxia-telangiectasia patients with poor outcomes," Medical and Pediatric Oncology , vol. 40, no. 3, pp. 162-166, 2003. (hindawi.com)
- R. Y. J. Tamminga, W. V. Dolsma, J. A. Leeuw, and H. H. Kampinga, "Chemo- and radiosensitivity testing in a patient with ataxia telangiectasia and Hodgkin's disease," Pediatric Hematology and Oncology , vol. 19, no. 3, pp. 163-171, 2002. (hindawi.com)
- The concept of the GPOH-HD 2003 therapy study for pediatric Hodgkin's disease: evolution in the tradition of the DAL/GPOH studies," Klinische Pädiatrie , vol. 216, no. 3, pp. 150-156, 2004. (hindawi.com)
- Immunodeficiency and Hodgkin's disease: treatment and outcome in the DAL HD78-90 and GPOH HD95 studies," Klinische Pädiatrie , vol. 215, no. 6, pp. 315-320, 2003. (hindawi.com)
- In stage I and II treatment of Hodgkin's disease consists of local radiation, which can abort Hodgkin's disease with very good long-term survival rates. (nethealthbook.com)
- Stage III and IV patients of these patients with low-grade Hodgkin's disease were first treated with combination chemotherapy and then with radiotherapy, if indicated. (nethealthbook.com)
- Hodgkin's disease , like other medical conditions requiring intensive therapy, is dependent on clinical assessment and diagnostic imaging for careful follow-up. (oncolink.org)
- It is often used to assess and follow patients with Hodgkin's disease and Non-Hodgkin's lymphomas , as well as for monitoring various inflammatory processes. (oncolink.org)
- The article cited above was designed to evaluate the predictive value and usefulness of periodic gallium scans in the management of patients with Hodgkin's disease. (oncolink.org)
- 101 patients treated for Hodgkin's disease between 1990 and 1994 had a positive 67Ga at the time of diagnosis. (oncolink.org)
- The conclusion put forth by the authors was that most patients with Hodgkin's disease have a negative gallium scan after treatment, and that a positive gallium scan should be considered a manifestation of gross residual disease. (oncolink.org)
- A novel 160-kDa intermediate filament associated protein, named restin (Reed-Sternberg intermediate filament associated protein), is specifically expressed in the malignant cells of Hodgkin's disease and anaplastic large cell lym-phoma (Ki-1 lymphoma). (karger.com)
- Hodgkin's lymphoma (or Hodgkin's disease, lymphogranulomatosis) is a malignant tumour of the lymphatic system. (hyperthermia-centre-hannover.com)
- Hodgkin's disease mainly affects young to middle-aged adults. (hyperthermia-centre-hannover.com)
- There are two types of lymphomas known as Hodgkin's Disease and Non-Hodgkin Lymphoma. (bumperstickermagnet.com)
- Hodgkin's lymphoma (or Hodgkin's disease) is a type of cancer of the lymph nodes (lymph glands). (carle.org)
- one is called Hodgkin's disease and the other is called non-Hodgkin's lymphoma. (digitalnaturopath.com)
- In most cases of Hodgkin's disease , a particular cell known as the Reed-Sternberg cell is found in the biopsies. (digitalnaturopath.com)
- A case of benign fibrous histiocytoma in a patient with previous Hodgkin's disease is reported. (elsevierpure.com)
- Hodgkin's disease is considered a malignant disorder of the monocyte-histiocyte cell line but also includes benign inflammatory cells as part of its histological picture. (elsevierpure.com)
- The pathogenic relationship between both entities is discussed in the context of the immune dysregulation associated with Hodgkin's disease. (elsevierpure.com)
- What is Hodgkin's disease? (marystolfacancerfoundation.org)
- Hodgkin's disease is a type of lymphoma. (marystolfacancerfoundation.org)
- Because there is lymph tissue in many parts of the body, Hodgkin's disease can start in almost any part of the body. (marystolfacancerfoundation.org)
- Lymphomas are divided into two general types: Hodgkin's disease and non-Hodgkin's lymphomas. (marystolfacancerfoundation.org)
- The cancer cells in Hodgkin's disease look a certain way under a microscope. (marystolfacancerfoundation.org)
- Adult Hodgkin's disease most commonly affects young adults and people older than 55 years of age. (marystolfacancerfoundation.org)
- Hodgkin's disease can also occur in children and is treated differently from that in adults. (marystolfacancerfoundation.org)
- Refer to Childhood Hodgkin's Disease Treatment for more information. (marystolfacancerfoundation.org)
- Once Hodgkin's disease is found, more tests will be done to find out if the cancer has spread from where it started to other parts of the body. (marystolfacancerfoundation.org)
- Each stage for Hodgkin's disease is further divided by an "A" or "B," based on whether there are certain symptoms called B symptoms. (marystolfacancerfoundation.org)
- B symptoms include the following: loss of more than 10% of weight in the previous 6 months, fever without any known cause other than Hodgkin's disease, and night sweats that leave the body soaked. (marystolfacancerfoundation.org)
- An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. (lookformedical.com)
- The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
- Thyroid carcinoma and Hodgkin's disease. (elsevierpure.com)
- NSHD: Nodular sclerosing Hodgkin's disease, a lymphoma. (stylizedfacts.com)
- Hodgkin's disease is cancer of the lymph glands, which includes the lymph nodes and the pleen. (article1000.com)
- The cells they look for are Reed-Sternberg cells, a cell specific to Hodgkin's Disease. (lymphomainfo.net)
- Earlier application of transplantation or development of additional effective antineoplastic modalities will be required to improve the results of transplantation for patients with advanced Hodgkin's disease. (umn.edu)
- Krutchik, AN & Velasquez, W 1977, ' Campylobachter fetus Infection in a Patient With Hodgkin's Disease ', JAMA: The Journal of the American Medical Association , vol. 238, no. 17, pp. 1810-1811. (elsevierpure.com)
- The object of this study was to examine cases of Hodgkin's Disease (HD) for evidence of space-time clustering of onsets by age group, sex and disease subtype. (ncl.ac.uk)
- Eleven tumors from ten patients with Hodgkin's disease (HD) were characterized by histologic, cytogenetic, immunophenotypic, and genotypic studies. (elsevierpure.com)
- 6. Lymphomas (other than Hodgkin's disease). (cdc.gov)
- Highly active antiretroviral therapy (HAART) improves survival in HIV-associated Hodgkin's disease: results of a multicenter study. (medscape.com)
- Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. (medscape.com)
- Gutensohn N, Cole P. Childhood social environment and Hodgkin's disease. (medscape.com)
- Frequent detection in Hodgkin's disease. (medscape.com)
- Weiss LM, Chen YY, Liu XF, Shibata D. Epstein-Barr virus and Hodgkin's disease. (medscape.com)
- Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease. (medscape.com)
- Concordance for Hodgkin's disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease. (medscape.com)
Classical Hodgkin6
- Classical Hodgkin lymphoma (HL) accounts for approximately 95% of all HL cases, with the other 5% being nodular lymphocyte-predominant HL (NLP-HL). (medscape.com)
- The purpose of this study is to compare efficacy of coformulated favezelimab/pembrolizumab (MK-4280A) with physician's choice chemotherapy of bendamustine or gemcitabine in participants with PD-(L)1-refractory, relapsed or refractory classical Hodgkin Lymphoma. (merckclinicaltrials.com)
- Treatment protocols for classical Hodgkin lymphoma (HL) are provided below, including treatment for early-stage, advanced-stage, and relapsed/refractory disease. (medscape.com)
- Classical Hodgkin lymphoma is derived by malignant transformation of a mature B cell at the germinal center stage of differentiation and is characterized pathologically by multinucleated Hodgkin and Reed-Sternberg cells embedded in a mixed infiltrate of nonneoplastic cells. (mhmedical.com)
- Morphologic and immunophenotypic features distinguish the four subtypes of classical Hodgkin lymphoma (accounting for 95 percent of cases) from nodular lymphocyte predominance Hodgkin lymphoma (accounting for 5 percent of cases). (mhmedical.com)
- Classical Hodgkin lymphoma is treated with the intent to cure the disease in all stages, and long-term survival exceeds 85 percent. (mhmedical.com)
Called Hodgkin's lymphoma1
- Hodgkin lymphoma, also called Hodgkin's lymphoma and Hodgkin disease, is a cancer of the lymphoid system. (curesearch.org)
Classic Hodgkin lymphoma3
- The two major types of Hodgkin lymphoma are classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. (wikipedia.org)
- Classic Hodgkin lymphoma is the most common type. (uhhospitals.org)
- The combination of nivolumab and chemotherapy is potent and safe in patients with stage 3 or 4 classic Hodgkin lymphoma as an initial treatment," Herrera said. (iprsoftware.com)
Preceding Hodgkin lymphoma2
- We report a case of disseminated M. genavense infection preceding Hodgkin lymphoma in a patient without obvious risk factors for this infection. (cdc.gov)
- Clinical manifestations and radiologic findings in the course of disease in a 23-year-old woman with disseminated M. genavense infection preceding Hodgkin lymphoma, Germany. (cdc.gov)
Nodular3
- Nodular lymphocyte-predominant Hodgkin lymphoma is not as common. (uhhospitals.org)
- For therapeutic purposes, nodular lymphocyte-predominant HL is managed in the same way as indolent non-Hodgkin lymphoma (see Follicular Lymphoma [non-Hodgkin Lymphoma] ). (medscape.com)
- A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32. (medscape.com)
Thomas Hodgkin3
- Dr Thomas Hodgkin first described Hodgkin disease in 1832. (medscape.com)
- The disease was named after the English physician Thomas Hodgkin (1798-1866), who first described it in 1832. (hyperthermia-centre-hannover.com)
- The condition was named after the English physician Thomas Hodgkin, who first described it in 1832. (wikipedia.org)
People with Hodgkin lymphoma4
- People with Hodgkin lymphoma may present with these symptoms: Lymphadenopathy: The most common symptom of Hodgkin is the painless enlargement of one or more lymph nodes. (wikipedia.org)
- Splenomegaly: Enlargement of the spleen is often present in people with Hodgkin lymphoma. (wikipedia.org)
- Hepatomegaly: Enlargement of the liver, due to liver involvement, is infrequent in people with Hodgkin lymphoma. (wikipedia.org)
- Pain following alcohol consumption: Classically, involved nodes are painful after alcohol consumption, though this phenomenon is very uncommon, occurring in only two to three percent of people with Hodgkin lymphoma, thus having a low sensitivity. (wikipedia.org)
Diagnosed with Hodgkin lymphoma2
- Approximately 1,180 children and adolescents each year are diagnosed with Hodgkin lymphoma in the United States. (curesearch.org)
- In the United States, 88% of people diagnosed with Hodgkin lymphoma survive for five years or longer. (wikipedia.org)
Lymphomas2
- Hodgkin lymphoma has an incidence of about 3 new cases per 100,000 individuals per year, making it one of the most common lymphomas. (medscape.com)
- Non-Hodgkin's lymphomas, like other cancers, are diseases of the body's cells. (digitalnaturopath.com)
Type of lymphoma2
- Hodgkin lymphoma (HL) is a type of lymphoma in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed-Sternberg cells (RS cells) are present in the patient's lymph nodes. (wikipedia.org)
- Hodgkin lymphoma is a type of lymphoma that involves one particular type of lymphocyte. (msdmanuals.com)
Symptoms6
- FDG/PET and MRI can identify involvement of bone marrow, and imaging can confirm poor prognostic indicators such as large mediastinal adenopathy, stage IV disease, systemic symptoms, and pleural effusion and pericardial effusion. (medscape.com)
- Certain symptoms relate to where the disease spreads. (carle.org)
- Systemic symptoms: About one-third of people with Hodgkin disease may also present with systemic symptoms, including: Itchy skin Night sweats Unexplained weight loss of at least 10% of the person's total body mass in six months or less Low-grade fever. (wikipedia.org)
- if the patient had stage I disease with B symptoms, then the patient would have stage IB disease. (marystolfacancerfoundation.org)
- What are the symptoms of Hodgkin lymphoma in a child? (uhhospitals.org)
- The symptoms of Hodgkin lymphoma are a lot like those of other health conditions. (uhhospitals.org)
Malignant3
- A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. (ucdenver.edu)
- Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
- Williams Hematology Malignant Lymphoid Diseases Press OW, Lichtman MA, Leonard JP. (mhmedical.com)
Lymphoma causes1
- Hodgkin lymphoma causes abnormal growth of the cells in the lymphatic system. (uhhospitals.org)
Chemotherapy5
- Hodgkin lymphoma may be treated with chemotherapy, radiation therapy, and stem-cell transplantation. (wikipedia.org)
- Radiation and some chemotherapy drugs, however, increase the risk of other cancers, heart disease, or lung disease over the subsequent decades. (wikipedia.org)
- Regimens that combine chemotherapy and radiation therapy (RT) have replaced RT alone for treatment of early-stage, favorable disease. (medscape.com)
- Doxorubicin-containing chemotherapy plays a major role in treatment of all stages of the disease, whereas radiotherapy is used selectively because of concerns for late toxicities. (mhmedical.com)
- An historic and groundbreaking clinical trial, which for the first time in the modern era included both adolescents and adults with advanced Hodgkin Lymphoma (HL), showed that 94% of the patients treated with an experimental immunotherapy plus chemotherapy were cancer-free or had no progression of disease after one year. (iprsoftware.com)
Lymphocyte-predominant2
- The lymphocytic and histiocytic (L&H) cells of lymphocyte predominant Hodgkin lymphoma (HL) originate from germinal centre B cells and carry mutated V gene rearrangements, usually with intraclonal diversity. (bmj.com)
- Hodgkin lymphoma (HL) is subdivided into classic forms and lymphocyte predominant HL. (bmj.com)
Centers for Diseas2
Autologous4
- 12 months after completion of therapy) may be cured with conventional therapy, those with progressive disease or early relapse (3-12 months) are considered candidates for autologous HSCT. (nih.gov)
- According to patient selection criteria, overall and disease-free survival rates after autologous HSCT are 43-95% and 31-70%, respectively. (nih.gov)
- Short time to relapse and refractory disease at the time of autologous HSCT remain the most important risk factors. (nih.gov)
- Data suggest that young patients with recurring disease following autologous HSCT, as well as some patients with multiple relapses and selected patients with refractory lymphoma, might benefit from allogeneic HSCT, but relapse remains the major challenge. (nih.gov)
Lymphoproliferative Disorders1
Large mediastinal adenopathy1
- Prognostic value of chest x-ray- and CT-defined large mediastinal adenopathy in high-risk pediatric Hodgkin lymphoma: A report from the Children's Oncology Group Study AHOD0831. (ucdenver.edu)
Reed-Stern4
- Hodgkin disease (lymphoma) is a cancer of the lymph system that is characterized by the presence of large, abnormal Reed-Sternberg cells in a background of lymphocytes, macrophages, fibroblasts, and granulocytes. (medscape.com)
- Hodgkin and Reed-Sternberg cells contain monoclonal immunoglobulin gene rearrangements but have lost most of the B-cell-specific expression program. (mhmedical.com)
- The inflammatory microenvironment promotes survival and allows escape of Hodgkin and Reed-Sternberg cells from immune attack. (mhmedical.com)
- Thomas RK, Re D, Wolf J, Diehl V. Part I: Hodgkin's lymphoma--molecular biology of Hodgkin and Reed-Sternberg cells. (medscape.com)
Incidence3
- 0.05), as did the incidence of anal cancer, lung cancer and Hodgkin lymphoma in all age groups. (aidsmap.com)
- The incidence of invasive disease ranges from 3.8 per 100,000 among persons aged 18-34 years to 36.4 per 100,000 among those aged ≥65 years ( 4 ). (cdc.gov)
- ORRHES) requested that the Agency for Toxic Substances and Disease Registry (ATSDR) and the Tennessee Cancer Registry (TCR) of the Tennessee Department of Health assess the incidence of cancer in this area. (cdc.gov)
Lymph node5
- Hodgkin lymphoma must be distinguished from noncancerous causes of lymph node swelling (such as various infections) and from other types of cancer. (wikipedia.org)
- The first sign of Hodgkin disease is often an enlarged lymph node. (aidsmap.com)
- A lymph node biopsy is needed to diagnose Hodgkin lymphoma. (uhhospitals.org)
- The Cotswolds modification maintains the original 4-stage clinical and pathologic staging framework of the Ann Arbor staging system but also adds information regarding the prognostic significance of bulky disease (denoted by an X designation) and regions of lymph node involvement (denoted by an E designation). (medscape.com)
- Hodgkin Lymphoma, formerly known as Hodgkin disease, is a cancer of the lymph node(s). (thismedicallife.com.au)
Bone3
- Bone scanning is useful for evaluating bone involvement in Hodgkin disease. (medscape.com)
- Severe or recurrent disease may need a bone marrow transplant. (carle.org)
- The disease can spread to nearby lymph nodes, the lungs, liver, or bone marrow. (aidsmap.com)
Lymphoid1
- A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
Radiation2
- Involved-site radiation therapy (ISRT) is typically recommended, because high-dose, large-field radiation therapy (LFRT) increases risk for heart disease, pulmonary dysfunction, and secondary cancers. (medscape.com)
- Radiation therapy for the lymphoma halted the progression of her neurological disease. (jamanetwork.com)
Cancers1
- The projected changes in cancer diagnoses are a consequence of the ageing of people living with HIV and the success of antiretroviral therapy in preventing immunosuppression that leaves people vulnerable to AIDS-defining cancers such as Kaposi's sarcoma and non-Hodgkin lymphoma. (aidsmap.com)
Adolescents and young adults1
- Concerns regarding late treatment effects guide therapy and followup decisions in Hodgkin lymphoma, which disproportionately affects adolescents and young adults. (mhmedical.com)
Cancer7
- Hodgkin lymphoma is the most common cancer of teenagers and young adults. (curesearch.org)
- The many types of non-Hodgkin lymphoma (NHL) are classified according to how fast the cancer spreads. (aidsmap.com)
- But Hodgkin lymphoma is the most common cancer diagnosed in teens ages 15 to 19. (uhhospitals.org)
- It depends on twhere the Hodgkin lymphoma starts and the size of the cancer. (uhhospitals.org)
- Data are included from 3 organizations, including the German Study Hodgkin Lymphoma Study Group (GSHG), European Organization for Research and Treatment of Cancer (EORTC), and the National Cancer Institute of Canada (NCIC). (medscape.com)
- A risk factor is anything that affects your chance of getting a disease such as cancer. (cancer.org)
- 3. Breastfeeding reduces the mother's risk of ovarian and breast cancer, heart disease, and osteoporosis. (jamaica-gleaner.com)
Infection3
- These organs produce, store and carry white blood cells to fight infection and disease. (curesearch.org)
- Mycobacterium genavense infection, a rare nontuberculous mycobacteria infection, occurs in heavily immunocompromised patients (i.e., those with advanced HIV disease, genetic disorders, or acquired immunologic disorders and those undergoing immunosuppressive therapy). (cdc.gov)
- Lymph glands and lymph vessels are part of the immune system that filter infection and other diseases from the body. (carle.org)
Oncology1
- Guideline] NCCN Clinical Practice Guidelines in Oncology: Hodgkin Lymphoma. (medscape.com)
Lymphocytes1
- Lymphocytes and other white blood cells help your body fight disease. (msdmanuals.com)
Painless2
- The disease becomes evident through a painless swelling of lymph nodes, which patients typically notice by chance. (hyperthermia-centre-hannover.com)
- Doctors suspect Hodgkin lymphoma when you have enlarged, painless lymph nodes that don't go away after a few weeks. (msdmanuals.com)
Subtypes1
- The proportion of SCR and DR subsets did not differ by histological subtypes, disease stage or age groups. (bmj.com)
Common symptom2
- The most common symptom of Hodgkin lymphoma is swelling of the lymph nodes, a condition called lymphadenopathy. (curesearch.org)
- Swollen lymph nodes are a common symptom of colds and flus, but in Hodgkin disease, the lymph nodes are usually larger than those that occur with common infections, and they do not shrink when treated with standard medications like antibiotics. (curesearch.org)
Spleen3
- An enlargement of the liver and/or spleen can be signs of the disease. (hyperthermia-centre-hannover.com)
- The disease usually affects lymph glands, white blood cells, and the spleen. (carle.org)
- Hepatosplenomegaly: The enlargement of both the liver and spleen can be caused by the same disease. (wikipedia.org)
Immune system2
- These findings add to the growing evidence that immune system malfunction, following allergic disease or immunosuppression, is central to HL development. (ucl.ac.uk)
- Having a weak immune system and some viral infections may increase a child's risk of having Hodgkin lymphoma. (uhhospitals.org)
Lesions1
- Multiple signaling pathways and transcription factors are deregulated in Hodgkin lymphoma, and genetic lesions involving the JAK-STAT and nuclear factor- κ B pathways are commonly identified. (mhmedical.com)
Computed Tomography1
- Computed tomography (CT) scans, which rely on anatomic evaluation, are invaluable for determining the extent of disease involvement at diagnosis. (oncolink.org)
Staging4
- CT, MRI, PET/CT, and PET/MRI play a major role in the diagnosis, staging, and response to therapy of Hodgkin lymphoma. (medscape.com)
- Other tests may in some cases include laparotomy, which is surgery on the abdomen (belly) for disease staging. (carle.org)
- Staging shows how far the disease has spread. (carle.org)
- Exploratory surgery (staging laparotomy) to determine the extent of the disease. (lymphomainfo.net)
Histologic1
- Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE. (lookformedical.com)
Relapse1
- Positron emission tomography (PET) scanning with fluorodeoxyglucose (FDG) is most useful for detecting disease relapse. (medscape.com)
Tumors1
- Familial aggregation of Hodgkin lymphoma and related tumors. (medscape.com)
Spreads1
- Hodgkin lymphoma spreads in a predictable, contiguous manner and is classified into four stages, I to IV. (mhmedical.com)