AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Heterogeneous-Nuclear Ribonucleoprotein Group CHeterogeneous-Nuclear Ribonucleoprotein Group A-BHeterogeneous-Nuclear RibonucleoproteinsHeterogeneous-Nuclear Ribonucleoprotein KHeterogeneous-Nuclear Ribonucleoprotein Group MRibonucleoproteinsHeterogeneous-Nuclear Ribonucleoprotein Group F-HRNA, Heterogeneous NuclearHeterogeneous-Nuclear Ribonucleoprotein LHeterogeneous-Nuclear Ribonucleoprotein URibonucleoproteins, Small NuclearRNA-Binding ProteinsRibonucleoprotein, U1 Small NuclearHeterogeneous-Nuclear Ribonucleoprotein DRibonucleoprotein, U2 Small NuclearHeLa CellsRNA SplicingMolecular Sequence DataRNA PrecursorsBase SequenceProtein BindingSpliceosomesRibonucleoprotein, U4-U6 Small NuclearAlternative SplicingCell NucleusRNA, MessengerRNA, Small NuclearRNAsnRNP Core ProteinsRibonucleoprotein, U5 Small NuclearAmino Acid SequencePoly C3' Untranslated RegionsThymus HormonesNuclear ProteinsExonsNucleoproteinsPolypyrimidine Tract-Binding ProteinRibonucleoprotein, U7 Small NuclearCell LineTranscription, GeneticBinding SitesCytoplasmAutoantigensRNA TransportNucleic Acid ConformationElectrophoresis, Gel, Two-DimensionalProtein BiosynthesisProtein-Arginine N-MethyltransferasesRNA Processing, Post-Transcriptional5' Untranslated RegionsImmunoprecipitationRNA StabilityRecombinant ProteinsTwo-Hybrid System TechniquesProtein Structure, TertiaryCloning, MolecularPoly APrecipitin TestsRNA, Small InterferingChromatography, AffinityCross-Linking ReagentsIntronsGene Expression RegulationSequence Homology, Amino AcidNucleocytoplasmic Transport ProteinsMolecular WeightDNA-Binding ProteinsDNADNA, ComplementaryElectrophoresis, Polyacrylamide GelAutoantibodiesTransfectionDNA, Single-StrandedRecombinant Fusion ProteinsActive Transport, Cell NucleusMutationSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationDNA PrimersMultiprotein ComplexesRNA, ViralPromoter Regions, GeneticUltraviolet RaysMuscular Dystrophies, Limb-GirdleCell Line, TumorBlotting, WesternPhosphorylationMass SpectrometryMurine hepatitis virusProtein IsoformsOsteitis DeformansCoiled BodiesRNA InterferenceSaccharomyces cerevisiaeMyositis, Inclusion BodyCOS CellsDactinomycinGenes, ReporterPlasmidsTranscriptional Activation
HnRNPProgressionCellularCharacteristicsProteinTestAdditionA2B1RegulatesComplexesMRNALocalizationResearch
HnRNP2
  • The proteins involved in the hnRNP complexes are collectively known as heterogeneous ribonucleoproteins. (wikipedia.org)
  • However, fine control of splice site usage is orchestrated by a complex interplay between splicing regulator proteins such as the Serine Arginine (SR) class of splicing activators and the heterogeneous ribonucleoprotein (hnRNP) class of splicing repressors. (beds.ac.uk)
Progression2
  • Therefore, in the current study, we sought to investigate the role of immune regulation by elaborately characterize the heterogeneous of immune cells during the progression of IPF. (bvsalud.org)
  • ALS is heterogeneous in its presentation, course, and progression. (biomedcentral.com)
Cellular1
  • GBM originate from poorly differentiated glial cells and have the characteristics of nuclear atypia, cellular polymorphism, and a high degree of mitotic activity. (biomedcentral.com)
Characteristics1
  • These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin proteins. (biomedcentral.com)
Protein3
  • Heterogeneous nuclear ribonucleoproteins (hnRNPs) are complexes of RNA and protein present in the cell nucleus during gene transcription and subsequent post-transcriptional modification of the newly synthesized RNA (pre-mRNA). (wikipedia.org)
  • Since most mature RNA is exported from the nucleus relatively quickly, most RNA-binding protein in the nucleus exist as heterogeneous ribonucleoprotein particles. (wikipedia.org)
  • p53 regulates a large group of RNAs that are not translated into protein, called large intergenic noncoding RNAs (lincRNAs). (wikipedia.org)
Test2
  • Classic evolutionary theories only consider the functional consequence of missense mutations, and the synonymous mutations are regarded as neutral sites and are used as "control group" to test the selection force on missense mutations [ 3 , 4 , 5 ]. (biomedcentral.com)
  • The clinical presentations of ALS are heterogeneous and there is no single test or procedure to establish the diagnosis of ALS. (biomedcentral.com)
Addition1
  • The nucleotide building blocks of RNA contain pyrimidine or purine rings, and each position of these rings can be chemically altered by the addition of various chemical groups. (pharmaceuticalintelligence.com)
A2B12
  • Previously we demonstrated that expression of the RNA binding protein and N6-methyladenosine (m6A) reader HNRNPA2B1 (A2B1) is higher in LCC9 and LY2 tamoxifen (TAM)-resistant ERα breast cancer cells relative to parental TAM-sensitive MCF-7 cells. (nih.gov)
  • 6. Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 ( hn rnpa2 b1 ) in tumour tissue and blood samples from patients diagnosed with lung cancer . (nih.gov)
Regulates3
  • p53 regulates a large group of RNAs that are not translated into protein, called large intergenic noncoding RNAs (lincRNAs). (wikipedia.org)
  • HNRNPA2B1 regulates tamoxifen- and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells. (nih.gov)
  • 2. Heterogeneous nuclear ribonucleoprotein A2/B1 regulates the ERK and p53/HDM2 signaling pathways to promote the survival, proliferation and migration of non‑small cell lung cancer cells. (nih.gov)
Complexes1
MRNA1
  • N6-methyladenosine (m6A) was first discovered in eukaryotic messenger RNA (mRNA) [ 2 , 3 ] and viral nuclear RNA [ 4 , 5 ] in the 1970s and has been identified as one of the most common and abundant RNA modifications. (biomedcentral.com)
Localization2
  • However, hnRNPs also have their own nuclear localization sequences (NLS) and are therefore found mainly in the nucleus. (wikipedia.org)
  • Interestingly, several mutations genetically linked to ALS impair nuclear localization of RNA-binding proteins like FUS and TDP-43 causing them to accumulate in cytoplasmic stress granules and insoluble inclusions in patient neurons 11 . (nature.com)
Research1
  • An ever-increasing number of research groups report the presence of TDP-43-enriched cytoplasmic aggregates in diverse neuropathological conditions. (medscape.com)