AnatomyDiseasesChemicals and DrugsPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth Care
Heterogeneous-Nuclear Ribonucleoprotein Group A-BHeterogeneous-Nuclear RibonucleoproteinsMuscular Dystrophies, Limb-GirdleHealth PromotionOsteitis DeformansMyositis, Inclusion BodyAlternative SplicingRNA-Binding ProteinsEducation of Visually DisabledExonsRNA SplicingRNA, MessengerRNA, Small InterferingProtein BindingMolecular Sequence DataBase SequenceCell Line
HnRNPA1Heterogeneous nuclearRA33Multisystem proteinopathyMRNAKnockdownMiceBrainNuclearGeneAutoimmuneCell proliferationProtein
HnRNPA15
  • The entire length of intron/exon organization of HNRNPA2B1 is identical to that of the HNRNPA1 gene which indicates a common origin by gene duplication. (wikipedia.org)
  • Mutations in hnRNPA2B1 and hnRNPA1 cause of amyotrophic lateral sclerosis and multisystem proteinopathy. (wikipedia.org)
  • Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, et al.Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 causemultisystem proteinopathy and ALS. (wikipedia.org)
  • Available from: https://www.researchgate.net/publication/235770144_Mutations_in_prion-like_domains_in_hnRNPA2B1_and_hnRNPA1_cause_multisystem_proteinopathy_and_ALS [Retrieved 28 Mar 2017]. (wikipedia.org)
  • The identification of pathogenic mutations within prion-like domains (PrLDs) of the RNA-binding proteins hnRNPA2B1 and hnRNPA1 add to our understanding of how mutations in these proteins lead to degenerative disease, and highlight the potential importance of PrLDs in degenerative diseases of the nervous system, muscle and bone. (natureasia.com)
Heterogeneous nuclear1
  • Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein that in humans is encoded by the HNRNPA2B1 gene. (wikipedia.org)
RA331
  • When referred to as an autoantigen, hnRNPA2B1 is also known as RA33. (wikipedia.org)
Multisystem proteinopathy1
  • Gen. Mar 1;25(5):936-50, Genetic Interaction of hnRNPA2B1 and DnaJB6 in a Drosophila Model of Multisystem Proteinopathy. (umn.edu)
MRNA1
  • Jia C, Guo Y, Chen Y, Wang X, Xu Q, Zhang Y, Quan L. HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma. (biomedcentral.com)
Knockdown2
  • Function of HNRNPA2B1 gene can be effectively examined by siRNA knockdown based on an independent validation. (wikipedia.org)
  • Knockdown of HNRNPA2B1 prevents oTau or oTau-c from associating with m 6 A or from reducing protein synthesis and reduces oTau-induced neurodegeneration. (elsevierpure.com)
Mice1
  • Levels of m 6 A and the m 6 A-oTau-HNRNPA2B1 complex are increased up to 5-fold in the brains of Alzheimer subjects and P301S tau mice. (elsevierpure.com)
Brain1
  • The association of HNRNPA2B1 with endogenous oTau was verified in neurons, animal models, and human Alzheimer brain tissues. (elsevierpure.com)
Nuclear2
  • Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein that in humans is encoded by the HNRNPA2B1 gene. (wikipedia.org)
  • HNRNPA2B1 is a mediator of m 6 A-dependent nuclear RNA processing events. (nature.com)
Gene3
  • HNRNPA2B1 gene contains 12 exons, including a B1 protein specific 36-nucleotide mini-exon. (wikipedia.org)
  • Function of HNRNPA2B1 gene can be effectively examined by siRNA knockdown based on an independent validation. (wikipedia.org)
  • 6 disease terms (MeSH) has been reported with HNRNPA2B1 gene. (cdc.gov)
Autoimmune2
  • HnRNPA2B1 is an autoantigen in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and mixed connective tissue disease. (wikipedia.org)
  • ECH1 and HNRNPA2B1 are autoantigens that elicit autoimmune responses in LC and their autoantibody can be the potential biomarkers for the early detection of LC. (nih.gov)
Cell proliferation3
  • Previous research shows that hnRNPA2B1 has a positive correlation with breast cancer cell proliferation but with respect to breast cancer metastasis, research studies differ in the conclusion- positive correlation or negative correlation. (cmu.edu)
  • Since the previous research has focused on hnRNPA2B1 as a whole, here, we investigate the effect of each isoform of hnRNPA2B1 on both breast cancer cell proliferation and migration. (cmu.edu)
  • Our results showed that transfection with hnRNPA2B1 AMO led to a reduction in the cell proliferation and cell migration of MDAMB231 cells. (cmu.edu)
Protein1