Hmox1 gene heme oxygenase 1. Medical search. Frequent questions

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. (nih.gov)
Heme oxygenase-1 deficiency Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, carbon monoxide, and ferrous iron. (wikipedia.org)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
The Special Issue will continue to focus on the most up-to-date knowledge concerning the pharmacology and clinical applications of the enzyme heme oxygenase-1 (HO-1) that plays a critical role in the catabolism of heme to the bile pigment bilirubin, generating carbon monoxide (CO) and releasing iron, which is sequestered by ferritin. (mdpi.com)
Heme oxygenases (HOs) act on heme degradation to produce carbon monoxide (CO), free iron, ferritin, and biliverdin. (encyclopedia.pub)
HOs are the key-limiting enzymes in heme degradation leading to carbon monoxide (CO), ferrous iron, and biliverdin products. (encyclopedia.pub)
Heme is degraded by heme oxygenases (HOs), generating biliverdin, carbon monoxide, and ferrous iron (Fe 2+ ). (encyclopedia.pub)
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. (research.com)
Heme oxygenase-1 (Hmox1) catalyzes the conversion of heme to biliverdin, carbon monoxide (CO), and ferrous iron (Fe 2+ ). (springer.com)

HMOX1 (heme oxygenase 1 gene) is a human gene that encodes for the enzyme heme oxygenase 1 (EC 1.14.99.3). (wikipedia.org)
The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. (nih.gov)

Heme covers Jawed Alam research in Heme oxygenase. (research.com)

Recombinant protein encompassing a sequence within the center region of human Heme Oxygenase 1. (genetex.com)
Heme Oxygenase 1 antibody detects Heme Oxygenase 1 protein at endoplasmic reticulum and nucleus by immunofluorescent analysis. (genetex.com)
Heme Oxygenase 1 antibody detects Heme Oxygenase 1 protein at cytoplasm on human renal carcinoma by immunohistochemical analysis. (genetex.com)
Heme Oxygenase 1 antibody detects Heme Oxygenase 1 protein at cytoplasm by immunohistochemical analysis. (genetex.com)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
HMOX2 is constitutively expressed to encode a 36 kDa HO-2 protein, mainly functioning to maintain the basal heme metabolism and may also play a role in inflammatory responses [ 4 ] . (encyclopedia.pub)
Vascular endothelial growth factor increases heme oxygenase-1 protein expression in the chick embryo chorioallantoic membrane. (wakehealth.edu)
Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin. (wakehealth.edu)
Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells. (wakehealth.edu)
His Regulation of gene expression research incorporates elements of Protease, Mutant, Proteasome, Kelch-Like ECH-Associated Protein 1 and Protein biosynthesis. (research.com)
He combines subjects such as Proteasome, Protein biosynthesis, Promoter, HMOX1 and Transcription with his study of Transcription factor. (research.com)
The scientist's investigation covers issues in Biochemistry, Heme oxygenase, Signal transduction, Protein kinase B and Heme. (research.com)
The mRNA and protein expression levels of Nrf2, the antioxidant gene heme oxygenase-1 (HO-1), osteogenic markers, including runt-related transcription factor 2 (Runx2) and bone morphogenetic protein 2 (BMP2), and Kelch-like ECH-associated protein 1 (Keap1) were also measured. (biomedcentral.com)
Recombinant protein of Mouse Heme Oxygenase 1. (arigobio.cn)
with Pubmed ID, gene symbol/accession number and viral interacting protein. (polygenicpathways.co.uk)
Heme oxygenase-1 (Hmox1) is a stress-inducible protein crucial in heme catabolism. (springer.com)
This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)
It varies from species to species whether it is the aromatase protein that has different activity at different temperatures or whether the amount of transcription undergone by the aromatase gene is what is temperature-sensitive, but in either case, differential development is observed at different temperatures. (wikidoc.org)

Based on the transcriptomic analysis, both S and ORF-9B subunits dysregulated signaling pathways associated with metabolism and cardiomyopathy, including upregulated genes involved in HIF-signaling and downregulated genes involved in cholesterol biosynthetic processes. (bvsalud.org)
This Special Issue will highlight the wealth of research on the hereditary and acquired disorders of heme metabolism and the role of dietary regulation of heme-containing proteins via hormonal and chemical actions as well as on the genetic and acquired disorders associated with such diseases as neonatal jaundice and hemochromatosis. (mdpi.com)
Nrf2 target genes include those for enzymes involved in the production or metabolism of bilirubin, including heme oxygenase 1 (Hmox1) and CYP2A (mouse Cyp2a5 and human CYP2A6). (arizona.edu)
HO-1 and heme metabolism. (encyclopedia.pub)
Iron-regulatory proteins 1 and 2 (IRP1 and IRP2) regulate the expression of numerous proteins of iron metabolism. (nih.gov)
Heme metabolism in blood vessel wall - the influence on abdominal aortic aneurysm formation. (edu.pl)

Heme oxygenase 1 in erythropoiesis: an important regulator beyond catalyzing heme catabolism. (nih.gov)
Heme oxygenase (abbreviated HMOX or HO) mediates the first step of heme catabolism, it cleaves heme to form biliverdin. (wikipedia.org)

Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation. (nih.gov)
These findings indicate that the C allele of rs35652124 located in the promoter region of Nrf2 gene is associated with protective effect on vitiligo in a Han Chinese population. (nih.gov)
The mitophagy pathway was suppressed through loss of NRF-1 binding to proximal promoter sites on both genes. (jci.org)
These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. (molcells.org)
Upstream regulatory elements in chick heme oxygenase-1 promoter: a study in primary cultures of chick embryo liver cells. (wakehealth.edu)
Mapping of the chick heme oxygenase-1 proximal promoter for responsiveness to metalloporphyrins. (wakehealth.edu)

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
On the other hand, the only one that induced heme oxygenase-1 expression was sulforaphane, a known activator of a HMOX1 inducer-NRF2. (hindawi.com)
This study evaluated the association of the Nrf2 and HO-1 genes polymorphisms with vitiligo susceptibility. (nih.gov)
In this case-control study of 1136 Han Chinese vitiligo patients and 1200 controls, Nrf2 (rs35652124 and rs6721961) and HO-1 (rs2071746) genes were genotyped by PCR-restriction fragment length polymorphism analysis. (nih.gov)
Nrf2, a master regulator of the antioxidant response, enhances cellular protective mechanisms through the canonic pathway, leading to activation of many antioxidant and biotransformation genes. (arizona.edu)
Accordingly, the researchers believe that the disruptive events (studied in Project 1 - Diabetogenic Mine Tailings: Mechanistic Link Between Arsenic, NRF2, Autophagy, and Diabetes) and the protective mechanisms (this project) mediated by Nrf2 signaling are both important determinants of the diabetogenic risk of mine tailing arsenic metalloids. (arizona.edu)
These findings support the specific hypothesis that the induction of intestinal Hmox1 and hepatic CYP2A5/6 serves as an important counterbalance against the diabetogenic effects caused by chronic Nrf2 activation by mine tailing arsenic metalloids. (arizona.edu)
Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin. (wakehealth.edu)
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. (research.com)
PQS treatment reduced intracellular ROS production and significantly upregulated Nrf2 transcriptional activity and the expression of Nrf2 and its target antioxidant gene HO-1. (biomedcentral.com)
Taken together, these findings suggest that PQS could effectively inhibit VSMCs calcification by ameliorating oxidative stress and regulating osteogenic genes via the promotion of Nrf2 expression. (biomedcentral.com)

Gene ontology analysis of differentially expressed genes showed that genes encoding zinc-binding proteins are enriched after superparamagnetic iron oxide/PLL labeling relative to PLL only treatment, whereas members of the apoptosis/programmed cell death pathway did not display increased expression. (johnshopkins.edu)
The expression and cellular localisation of proteins encoded by selected candidate genes were confirmed by immunohistochemistry. (biomedcentral.com)
Previous research has found that these variants in the APOL1 gene increase the risk of developing preeclampsia when present in the fetus and also alter levels of certain proteins in cells when expressed. (preeclampsia.org)
A large genetic study of maternal and fetal determinants of preeclampsia, along with global profiling of associated gene transcripts, proteins, and metabolites, to identify the causal biologic pathways altered in pregnancy prior to clinically apparent preeclampsia. (preeclampsia.org)
HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells. (wakehealth.edu)
Genes encoding proteins involved in processing of drugs and other xenobiotics. (gsea-msigdb.org)

Biliverdin is then rapidly converted to bilirubin by biliverdin reductase ( Figure 1 ) [ 1 ] [ 2 ] . (encyclopedia.pub)

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. (arigobio.cn)

Both conditions can be accompanied by decreased levels of heme oxygenase-1 (HMOX1), cytoprotective, heme-degrading enzyme. (hindawi.com)
Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (arigobio.cn)

Number of polymorphisms tested per gene and per sample. (alzgene.org)

Haem oxygenase-1--a culprit in vascular and renal damage? (wikipedia.org)
Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH. (wakehealth.edu)
Effects of silymarin on hepatitis C virus and haem oxygenase-1 gene expression in human hepatoma cells. (wakehealth.edu)

His research in Heme intersects with topics in Oxygenase, Immunology, Bilirubin, Kidney and Pharmacology. (research.com)

Overview of all the structural information available in the PDB for UniProt: P09601 (Heme oxygenase 1) at the PDBe-KB. (wikipedia.org)

encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)

Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1. (wakehealth.edu)
The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes. (wakehealth.edu)

HO-1) pathway was tested for defense of mitochondrial quality control in cardiomyocyte-specific Hmox1 KO mice (HO-1[CM] -/- ) exposed to oxidative stress (100% O 2 ). (jci.org)
Currently, there are 171 genes in SZGR 2.0 (with evidence in schizophrenia) that are present at this pathway. (uth.edu)
The implementation of these functions relies on the complex multi-pathways network, especially TNF signaling pathway and HIF-1 signaling pathway. (biomedcentral.com)
Particularly, TNF signaling pathway and HIF-1 signaling pathway may play crucial roles in the protection of KYQG against oral ulcers. (biomedcentral.com)

Recent genetic studies have correlated human genes with severe malaria susceptibility, but there is little data on genetic variants that increase the risk of developing specific malaria clinical complications. (lshtm.ac.uk)
CONCLUSIONS/SIGNIFICANCE: These results represent the first report on CM genetic risk factors in Angolan children and suggest the novel hypothesis that genetic variants of the TGFB2 and HMOX1 genes may contribute to confer a specific risk of developing the CM syndrome in patients with severe P. falciparum malaria. (lshtm.ac.uk)
These results indicate that cardiac Hmox1 induction not only prevents heme toxicity, but also regulates the timing and registration of genetic programs for mitochondrial quality control that limit cell death, pathological remodeling, and cardiac fibrosis. (jci.org)
Genetic variations in heme oxygenase-1 and chronic hepatitis. (wakehealth.edu)
Genetic variation in heme oxygenase 1 (HMOX1) and the risk of recurrent venous thromboembolism. (cdc.gov)

Though these differentially expressed genes exhibited altered expression over time, the overall extent was limited. (johnshopkins.edu)
Overexpression of the differentially expressed genes Rnf138 and Abcc4 were confirmed by quantitative realtime polymerase chain reaction. (johnshopkins.edu)

HMOX1 and HMOX2 belong to the heme oxygenase family. (nih.gov)

Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. (nih.gov)
HO-1 is inducible, synthetically enhanced by pro-oxidant stimuli. (encyclopedia.pub)
Hmox1 ) enzyme system is among the most important inducible mechanisms for cell protection against oxidative damage in the cardiovascular system. (jci.org)

Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response. (wakehealth.edu)
Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. (wakehealth.edu)

After hyperoxia, HO-1(CM) -/- hearts showed suppression of the Pgc-1α/nuclear respiratory factor-1 (NRF-1) axis, swelling, low electron density mitochondria by electron microscopy (EM), increased cell death, and extensive collagen deposition. (jci.org)
[ 1 , 2 ] Loss of mitochondria occurs in many of these maladies, but defects in the remaining mitochondria are emerging as key players in diabetes [ 3 ] and aging-related dysfunctions. (medscape.com)

Intestinal expression of genes involved in iron absorption in humans. (wakehealth.edu)
[ 11 ] In the CALERIE phase 1 study, however, we demonstrated that 6 months of 25% CR in healthy human s increased the expression of genes involved in mitochondrial biogenesis and mitochondrial DNA (mtDNA) copy number. (medscape.com)

HO-1 and their products exert beneficial effects through the protection against oxidative injury, regulation of apoptosis, modulation of inflammation as well as contribution to angiogenesis. (springer.com)
Jawed Alam has included themes like Inflammation, Proinflammatory cytokine, Apoptosis and Gene expression in his Signal transduction study. (research.com)

The HMOX gene is located on the long (q) arm of chromosome 22 at position 12.3, from base pair 34,101,636 to base pair 34,114,748. (wikipedia.org)
L‟hémophilie A est une maladie hémorragique rare liée au chromosome X qui se traduit par un déficit en facteur VIII (FVIII) fonctionnel. (123dok.net)
[2] In humans, the gene CYP19, located on chromosome 15q 21.1, encodes the aromatase enzyme. (wikidoc.org)

Subcellular traffics of HO-1 to different organelles constitute a network of interactions compromising a variety of effectors such as pro-oxidants, ROS, mitochondrial enzymes, and nucleic transcription factors. (encyclopedia.pub)
Jawed Alam focuses on Heme oxygenase, Biochemistry, Molecular biology, Regulation of gene expression and Transcription factor. (research.com)
His study looks at the intersection of Signal transduction and topics like Gene expression with HMOX1, Activator, Transcription and Proinflammatory cytokine. (research.com)
How Many Transcription Factors Does It Take to Turn On the Heme Oxygenase-1 Gene? (research.com)
The various areas that Jawed Alam examines in his Gene expression study include HMOX1, Transcription factor, Transcription and Activator. (research.com)

Wild-type (WT) and Heme Oxygenase 1 knockout (KO) HeLa cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Heme Oxygenase 1 antibody (GTX101147) diluted at 1:500. (genetex.com)
Hmox1 knockout (Hmox1 −/− ) and wild-type (WT, Hmox1 +/+ ) mice were subjected to a permanent ligation of the left anterior descending coronary artery. (springer.com)

Differential Effects of Arsenic in Drinking Water on Mouse Hepatic and Intestinal Heme Oxygenase-1 Expression. (arizona.edu)
Heme status affects human hepatic messenger RNA and microRNA expression. (wakehealth.edu)

The HO-1 system plays an important role in cellular defense in the context of several diseases or physiological processes, including cardiovascular disease, diabetes, obesity, inflammation, neurodegeneration and ageing, and transplantation, among many others. (mdpi.com)
Upregulation of cellular HO-1 levels is signature of oxidative stress for its downstream effects particularly under pro-oxidative status. (encyclopedia.pub)
Through the first two compounds Hmox1 mitigates cellular injury. (springer.com)

8(1): 109, 2023 03 09. (bvsalud.org)
HO-1 in Cancer Cell Survival" Encyclopedia , https://encyclopedia.pub/entry/14608 (accessed December 06, 2023). (encyclopedia.pub)

Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells. (wakehealth.edu)
Basic Scientific Calorie (BSC): This is the one one that increases the temperature of 1g of water by 1 degree Celsius. (blogspot.com)

Hypoxia-induced oxidative stress promotes therapy resistance via upregulation of heme oxygenase-1 in multiple myeloma. (nih.gov)
In recent years, the discovery of non-heme-containing inducers of HO-1 has resulted in new discoveries regarding the metabolic and cardiovascular effects of the upregulation of HO activity. (mdpi.com)

He interconnects Regulation of gene expression, Mutant, Gene, Enhancer and Angiotensin II in the investigation of issues within Molecular biology. (research.com)
Heme oxygenase, Biochemistry, Molecular biology, Angiotensin II and Signal transduction are his primary areas of study. (research.com)

Notably, the HMOX1-associated haplotype conferred increased HMOX1 mRNA expression in peripheral blood cells of CM patients (P = 0.012). (lshtm.ac.uk)

The study is designed to potentially accelerate discovery of therapies for preeclampsia by designing placental cell lines that express variants of the APOL1 gene for drug screening. (preeclampsia.org)
The gene expresses two transcript variants. (wikidoc.org)

In conclusion, Hmox1 deficiency has divergent consequences in MI. (springer.com)

Green: Heme Oxygenase 1 stained by Heme Oxygenase 1 antibody (GTX101147) diluted at 1:500. (genetex.com)
Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Heme Oxygenase 1 antibody (GTX101147) diluted at 1:1500. (genetex.com)
Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG43341 anti-Heme Oxygenase 1 antibody at 1:50 dilution. (arigobio.cn)
Western blot: A549 cell lysate stained with ARG43341 anti-Heme Oxygenase 1 antibody at 1:500 dilution. (arigobio.cn)

HO-1: a new marker for predicting postoperative recurrence of CRSwNP. (nih.gov)

HO-1 and HO-2 are identified in human and rats. (encyclopedia.pub)
Regulation of expression of the human heme oxygenase-1 gene in transfected chick embryo liver cell cultures. (wakehealth.edu)
Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS. (wakehealth.edu)
Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes. (wakehealth.edu)

However, the role of HO-1 in tumorigenesis has not been systematically addressed. (encyclopedia.pub)

He has researched Heme in several fields, including Superoxide dismutase, Reductase, Catalase and Bovine serum albumin. (research.com)

Such myeloid angiogenic cells (MAC) [ 1 ] of bone marrow origin were known as endothelial progenitor cells (EPCs). (hindawi.com)
912, 2202, and 1227 genes were significantly differentially expressed between cases with self-reported T2D and controls in neurones, astrocytes, and endothelial cells respectively. (biomedcentral.com)

METHODS: In this phase 3, double-blind, randomized trial, we assigned patients with hereditary, also known as variant, or wild-type ATTR cardiac amyloidosis, in a 1:1 ratio, to receive patisiran (0.3 mg per kilogram of body weight) or placebo once every 3 weeks for 12 months. (bvsalud.org)
The aim of this study was to determine the role of Hmox1 in the monocyte/macrophage-mediated cardiac remodeling in a mouse model of MI. (springer.com)
Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)

Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC). (wakehealth.edu)

acyl-CoA oxidase 1 [Source:HGNC Symbol. (gsea-msigdb.org)
acid phosphatase 1 [Source:HGNC Symbol. (gsea-msigdb.org)
arginase 1 [Source:HGNC Symbol;Acc:HGN. (gsea-msigdb.org)
carboxylesterase 1 [Source:HGNC Symbol. (gsea-msigdb.org)

This work may provide motivation for future studies aiming to replicate our findings in larger populations and to confirm a role for these genes in determining the clinical course of malaria. (lshtm.ac.uk)
We analyze the results of sequencing TTR gene, the differential characteristics and their clinical implications. (bvsalud.org)
This is especially relevant to a wide variety of natural product HO-1 inducers, which have the potential for important pharmaceutical and clinical applications, all of which will be highlighted in this Special Issue. (mdpi.com)

Anatomy5

Organisms4

Diseases2

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes16

Information Science3

Carbon monoxide9

Enzyme heme2

Research in Heme Oxygenase1

Protein18

Metabolism6

Catabolism2

Promoter6

Nrf214

Proteins6

Biliverdin reductase1

Cleaves1

Cytoprotective2

Polymorphisms1

Haem3

Bilirubin1

P096011

Antioxidant1

Bach12

Pathway4

Genetic5

Differentially expressed genes2

HMOX21

Inducible3

Induction2

Mitochondria2

Expression of genes invol2

Apoptosis2

Chromosome3

Transcription5

Knockout2

Hepatic2

Cellular3

20232

Increases2

Upregulation2

Molecular2

MRNA1

Variants2

Deficiency1

Antibody4

Recurrence1

Human4

Systematically1

Superoxide Dismutase1

Endothelial2

Cardiac4

Primary1

Symbol4

Clinical3