Chemicals and DrugsPhenomena and Processes
HMGB1 ProteinHMGB2 ProteinHMGB3 ProteinHMGB ProteinsHMG-Box DomainsToll-Like Receptor 4
Recombinant ProteinsChromatin proteinsAntibodyHMGBInteractionsDifferentiationChromosomalRegulatesBiochemicalExpressionRedoxVIVOMoleculesEukaryoticCleavageRegulatorsNucleoprotein structuresPathwayKinaseRecombination signalAxisOnsetMiceHuman Protein AtlasVariantsCellsSequenceBindsVitroTranscriptionFlexibilitySearchStabilityDomainChromosomeHigh-mobilSequencesSourceSpecificVarietyResultsCellDatabase
Recombinant Proteins1
  • Western blot: 100 ng of HMGB1 and HMGB2 recombinant proteins stained with ARG66714 anti-HMGB1 Neutralizing antibody [SQab20175] (low endotoxin). (arigobio.cn)
Chromatin proteins1
  • Furthermore, AT-hook motifs are frequently associated with known functional domains seen in chromatin proteins and in DNA-binding proteins (e.g. histone folds, homeodomains and zinc fingers). (embl.de)
Antibody5
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig High Mobility Group Protein 1 (HMG1) in serum, plasma and other biological fluids. (orbitalbiosciences.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Pig High Mobility Group Protein 1 (HMG1) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (orbitalbiosciences.com)
  • Antibody Reactive against Recombinant Protein with GST tag on ELISA and Western Blot. (novusbio.com)
  • Western blot: 1) 50 ng of HMGB1 (Purified from E. coli) and 2) 100 ng of HMGB2 (Purified from E.coli) stained with ARG65863 anti-HMGB1 antibody [SQab1711] at 1:5000 dilution. (arigobio.cn)
  • This antibody could specifically neutralize HMGB1 induced pathway but not HMGB2 tested by TNF alpha releasing assay. (arigobio.cn)
HMGB4
  • High mobility group B (HMGB) proteins have been previously related to the onset and progressions of cancers of different origins. (hindawi.com)
  • This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
  • Eukaryotic High-Mobility Group B (HMGB) proteins alter DNA elasticity while facilitating transcription, replication and DNA repair. (shengsci.com)
  • We developed a new single-molecule method to probe non-specific DNA interactions for two HMGB homologs: the human HMGB2 box A domain and yeast Nhp6Ap, along with chimeric mutants replacin. (shengsci.com)
Interactions3
  • These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. (wikipedia.org)
  • MRPL17 has direct interactions with proteins and molecules. (creativebiomart.net)
  • High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. (embl.de)
Differentiation5
  • This review addressed HMGB2 expression patterns in MSC and its position in the course of differentiation. (cox-inhibitors.com)
  • HMGB2 was detected at higher levels in human MSC as in comparison with human articular chondrocytes and its expression declined during chondrogenic differentiation of MSC. (cox-inhibitors.com)
  • The expression of Runx2, which plays a significant part in late stage chondrocyte differentiation, was enhanced in Hmgb2 / MSC and HMGB2 negatively regulated the stimulatory result of Wnt/b catenin signaling around the Runx2 proximal promoter. (cox-inhibitors.com)
  • These effects demonstrate that HMGB2 expression is inversely correlated with all the differentiation status of MSC and that HMGB2 suppresses chondrogenic differentiation. (cox-inhibitors.com)
  • This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. (arigobio.cn)
Chromosomal3
  • This gene encodes a member of the non-histone chromosomal high-mobility group protein family. (wikipedia.org)
  • The AT-hook is a small DNA-binding protein motif which was first described in the high mobility group non-histone chromosomal protein HMG-I(Y). Since its discovery, this motif has been observed in other DNA-binding proteins from a wide range of organisms. (embl.de)
  • It is most interesting that this motif seems to be quite specific to known or predicted chromosomal/DNA-binding proteins, suggesting that it may act as a versatile minor groove tether. (embl.de)
Regulates1
  • The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. (arigobio.cn)
Biochemical2
  • MRPL17 has several biochemical functions, for example, protein domain specific binding, structural constituent of ribosome. (creativebiomart.net)
  • Biochemical analysis and comparative proteomics with 6AzGlcNAc, N-azidoacetyl-glucosamine (GlcNAz), and N-azidoacetyl-galactosamine (GalNAz) revealed that 6AzGlcNAc exclusively labels intracellular proteins, while GlcNAz and GalNAz are incorporated into a combination of intracellular and extracellular/lumenal glycoproteins. (mcw.edu)
Expression9
  • https://doi.org/10.1083/jcb.201608026 ) describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin spreading. (rupress.org)
  • The superficial zone of articular cartilage is vital in maintaining tissue function and homeostasis and represents the website from the earliest Figure 1 HMGB2 expression in the course of chondrogenesis of human MSC. (cox-inhibitors.com)
  • Immunohistochemistry demonstrates that HMGB2 is expressed at days 1 and 3, but that expression is diminished at days 7, 14 upon induction of chondrogenesis. (cox-inhibitors.com)
  • The expression of chromatin protein HMGB2 is limited to your SZ, which consists of cells expressing mesenchymal stem cell markers. (cox-inhibitors.com)
  • Lentiviral HMGB2 transduction Fingolimod supplier of MSC suppressed chondrogenesis as reflected by an inhibition of Col2a1 and Col10a1 expression. (cox-inhibitors.com)
  • Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer. (gzsys.org.cn)
  • Recombinant Human High Mobility Group Protein B1 is produced by our Mammalian expression system and the target gene encoding Gly2-Glu215 is expressed with a 6His tag at the C-terminus. (assaygenie.com)
  • Many of these proteins are regulators of gene expression. (embl.de)
  • Demethylating the hypermethylated REC8 gene restored its expression in thyroid cancer cells in which the PI3K pathway was genetically over-activated and induced expression of REC8 protein inhibited the proliferation and colony formation of these cells. (oncotarget.com)
Redox3
  • The protein HMGB1 behaves as a redox sensor and its structural changes, which are conditioned by the oxidative environment, are associated with different functions of the protein. (hindawi.com)
  • Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
  • HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
VIVO2
  • This can be constant with in vivo results from mouse growth plates exhibiting that Hmgb2 is expressed in proliferating and prehypertrophic zones but not in hypertrophic cartilage wherever Col10a1 is strongly expressed. (cox-inhibitors.com)
  • All proteins are LPS free, so they are suitable for in vitro and in vivo researches. (hmgbiotech.eu)
Molecules2
  • We selected proteins and molecules interacted with MRPL17 here. (creativebiomart.net)
  • Deep sequencing of RNA molecules cross-linked to immunoprecipitated protein particles (CLIP-seq) revealed. (shengsci.com)
Eukaryotic2
  • The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. (wikipedia.org)
  • We have classified these motifs into three types according to their sequence similarity and have found that they are prevalent in many eukaryotic nuclear proteins in single or multiple copies. (embl.de)
Cleavage1
  • Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). (arigobio.cn)
Regulators1
  • Muscleblind-like proteins (MBNLs) are regulators of RNA metabolism. (shengsci.com)
Nucleoprotein structures1
  • HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. (embl.de)
Pathway2
  • Also, other proteins which involved in the same pathway with MRPL17 were listed below. (creativebiomart.net)
  • Functional assays confirmed impaired DNA binding of mutated RBPJ, placing it among other notch-pathway Selleckchem Galardin proteins altered in human genetic syndromes. (phosphorylase-signal.com)
Kinase2
Recombination signal1
  • Through exome resequencing, we identified two unique mutations in recombination signal binding protein for immunoglobulin kappa J (RBPJ) in two independent families affected by Adams-Oliver syndrome (AOS), a rare multiple-malformation disorder consisting primarily of aplasia cutis congenita of the vertex scalp and transverse terminal limb defects. (phosphorylase-signal.com)
Axis1
  • CXCR4 is the receptor of CXCL12 chemokine protein: theese proteins create an axis which plays a relevant role in shaping the tumor microenvironment (TME), mainly against dampening immune responses. (hmgbiotech.eu)
Onset1
  • Aging associated loss of HMGB2 and gene deletion are associated with lowered SZ cellularity and early onset OA. (cox-inhibitors.com)
Mice1
  • Conversely, in bone marrow MSC from Hmgb2 / mice, Col10a1 was much more strongly expressed than in wildtype MSC. (cox-inhibitors.com)
Human Protein Atlas1
  • The GSE13861 and GSE54129 cohorts, single-cell dataset GSE134520, and The Human Protein Atlas (THPA) database were utilized for localization of the key senescence-related genes. (impactaging.com)
Variants1
  • Alternative splicing results in multiple transcript variants that encode the same protein. (arigobio.cn)
Cells4
  • The C protein has been purified from cells carrying the Ptrp-C plasmid, and a preliminary study of C protein-DNA binding properties has been carried out. (shengsci.com)
  • Cells continuously monitor protein synthesis to prevent accumulation of aberrant polypeptides. (shengsci.com)
  • In contrast to the endogenous modification N-acetyl-glucosamine (GlcNAc), we find that 2AzGlc is not dynamically removed from protein substrates and that treatment with higher concentrations of per-acetylated 2AzGlc is toxic to cells. (mcw.edu)
  • Senescence-related secretory phenotype (SASP) refers to the ability of senescent tumor cells to actively produce a wide variety of proteins, many of which are pro-inflammatory cytokines or pro-inflammatory substances in themselves [ 10 , 11 ]. (impactaging.com)
Sequence3
  • Using pattern searches and position-dependent matrices, we have extracted the AT-hook motifs present in a non-redundant protein sequence database. (embl.de)
  • The HMG family of proteins comprises members with multiple HMG domains that bind DNA with low sequence specificity, and members with single HMG domains that recognize specific nucleotide sequences. (embl.de)
  • The miniF plasmid C protein: sequence, purification and DNA binding. (shengsci.com)
Binds1
  • C protein binds strongly to pifO, and weakly to sequences in the ori-1 region. (shengsci.com)
Vitro1
  • In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. (wikipedia.org)
Transcription1
  • HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. (embl.de)
Flexibility1
  • Single-molecule kinetics reveal microscopic mechanism by which High-Mobility Group B proteins alter DNA flexibility. (shengsci.com)
Search1
  • Creative BioMart supplied nearly all the proteins listed, you can search them on our site. (creativebiomart.net)
Stability1
  • Furthermore, CECR7 enhanced the stability of EXO1 mRNA by recruiting RNA binding protein U2AF2. (bvsalud.org)
Domain3
  • Taxonomic distribution of proteins containing HMG domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with HMG domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing HMG domain in the selected taxonomic class. (embl.de)
Chromosome1
  • Etiology HCHWA-D is due to a mutation in the APP gene on chromosome 21q21.2, encoding the beta-amyloid precursor protein. (findzebra.com)
High-mobil5
  • High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene. (wikipedia.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat High Mobility Group Protein 1 (HMG1) in samples from serum, plasma, tissue homogenates or other biological fluids. (orbitalbiosciences.com)
  • High-mobility group protein box 1 (HMGB1) is overexpressed and reported to be a prognostic factor in patients with non-small-cell lung cancer (NSCLC). (jcancer.org)
  • HMGB1 is a protein that belongs to the High Mobility Group-box superfamily. (arigobio.cn)
  • High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell. (gzsys.org.cn)
Sequences1
  • Large international consortiums such as ENCODE (The Encyclopedia of DNA Elements) has shown that up to 80% of the genome is transcribed while only 1,5% of it is protein -coding sequences [ 1 ]. (biomedcentral.com)
Source6
Specific1
  • We demonstrate here that 6-azido-6-deoxy-N-acetyl-glucosamine (6AzGlcNAc) is a specific MCR for O -GlcNAcylated proteins. (mcw.edu)
Variety2
  • In the central dogma RNA acts as a simple intermediary between the DNA that carries the genetic information and the proteins that define the whole variety of biological processes in the cell. (biomedcentral.com)
  • AT-hook motifs identified in a wide variety of DNA-binding proteins. (embl.de)
Results1
  • Finally, we demonstrate that this toxicity is an inherent property of the small-molecule, as removal of the 6-acetyl-group renders the corresponding reporter nontoxic but still results in protein labeling. (mcw.edu)
Cell1
  • Subsequent characterization of 6AlkGlcNAc shows that this probe is selectively incorporated into O -GlcNAcylated proteins over cell-surface glycoproteins. (mcw.edu)
Database1
  • There are 46627 HMG domains in 39088 proteins in SMART's nrdb database. (embl.de)