It is the full-length product of the alternatively-spliced HMGA1 gene and may function as an architectural chromatin binding protein that is involved in transcriptional regulation. (nih.gov)
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. (embl.de)
Chromatin target of Prmt1 (Chtop) is a vertebrate-specific chromatin-bound protein that plays an important role in transcriptional regulation. (embl.de)
HMGA chromatin binding proteins get excited about diverse biological procedures by virtue of their capability to regulate gene appearance (11C33). (eyesoftheelephants.com)
Since phosphorylation of HMGA proteins significantly reduces their binding affinity for A/T-rich DNA [109,136], hyper-phosphorylation likely results in partial displacement of HMGA proteins from DNA and the formation of a less condensed chromatin structure that is more easily digested by nucleases. (mg132.com)
Hypo-phosphorylated HMGA proteins, on the other hand, have an increased overall positive change that facilitates tighter DNA binding, chromatin condensation and placement of HMGA:DNA complexes into apoptotic bodies [41]. (mg132.com)
HMGA Proteins8
The expression of HMGA proteins is high in early developmental stages in embryos and mesenchymal stem cells, whilst it is almost absent or very low in adult tissues. (biomedcentral.com)
For example, the early stages of apoptosis are first accompanied by a global hyper-phosphorylation, which is quickly followed by a massive de-phosphorylation, of the total population of cellular HMGA proteins [41]. (mg132.com)
Other site-specific PTMs of HMGA proteins, such as acetylation of K60 of HMGA1b [50] and methylation of R25 of HMGA1a [146-148], have also been reported to occur during apoptosis but the function(s) of such modifications in the death process is unknown. (mg132.com)
In contrast to induction of apoptosis in normal cells, overexpression of HMGA proteins in some "pre-disposed" normal cells, as well as in immortalized cell lines that have already breached the senescence barrier, often has anti-apoptotic affects [85-87] and frequently induces overt cancerous transformation [34,72,168,169]. (mg132.com)
HMGA proteins have recently been directly implicated in the process of senescence, or aging, of normal cells. (mg132.com)
HMGA Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "HMGA Proteins" by people in this website by year, and whether "HMGA Proteins" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "HMGA Proteins" by people in Profiles. (uchicago.edu)
HMGA23
HMGA2 gene encodes for the HMGA2 protein, member of the "high-mobility group AT-hook" (HMGA) family. (biomedcentral.com)
We lately reported high degrees of (gene encodes the HMGA1a and HMGA1b proteins isoforms that derive from additionally spliced RNA and differ by an interior 11 proteins, present just in the HMGA1a isoform (11C13), while HMGA2 is certainly encoded by another gene (13, 16, 24, 27, 32C33). (eyesoftheelephants.com)
And, importantly for the present discussion, SAHFs are depleted in linker histone H1 and enriched for HMGA1 and HMGA2, proteins which have been demonstrated to be essential components of these heterochromatin structures [56,107,176]. (mg132.com)
TRANSCRIPTION FACTORS1
These proteins act as architectural transcription factors that regulate the trascriptional activity of several genes. (biomedcentral.com)
NUCLEOPROTEINS1
Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)
MOTIFS2
An 11-kDa AT-hook motif-containing ( AT-HOOK MOTIFS ) protein that binds to the minor grove of AT-rich regions of DNA . (nih.gov)
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
Gene5
miRNAs base-pair to complementary sequences in mRNA molecules, then gene silence said mRNA molecules by one or more of the following processes: Cleavage of mRNA strand into two pieces, Destabilization of mRNA by shortening its poly(A) tail, or Translation of mRNA into proteins. (wikipedia.org)
Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. (embl.de)
Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
HMGA protein are AT-hook protein that bind towards the minimal groove of DNA at AT wealthy locations (11C13, 33C35), recruit extra transcription elements, and in collaboration with these elements, alter gene appearance (11). (eyesoftheelephants.com)
MRNA3
isolated the lin-4 miRNA, they found that instead of producing an mRNA encoding a protein, it produced short non-coding RNAs, one of which was a ~22-nucleotide RNA that contained sequences partially complementary to multiple sequences in the 3' UTR of the lin-14 mRNA. (wikipedia.org)
This complementarity was proposed to inhibit the translation of the lin-14 mRNA into the LIN-14 protein. (wikipedia.org)
proteins and mRNA had been elevated in the cells transduced using the HMGA1a lentivirus as proven by quantitative, change transcriptase real-time PCR (qRT-PCR) and Traditional western evaluation (Fig. 1A). (eyesoftheelephants.com)
Architectural1
The assembly of PRMT6 protein network allowed us to formulate functional hypotheses which led to the discovery of new molecular partners for the architectural transcription factor HMGA1a, a known substrate for PRMT6, and to provide evidences for a modulatory role of HMGA1a on the methyltransferase activity of PRMT6. (embl.de)
Methylation3
To test our hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, H4R3 and H3R17 protein arginine (R) methyltransferases 1 and 4 (PRMT1 and PRMT4) were investigated. (embl.de)
We describe the residue-specific methylation of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetric dimethylating PRMT5 and relate the marks to different functional consequences of E2F-1 activity. (embl.de)
The Tudor domain protein p100-TSN reads the symmetric methylation mark, and binding of p100-TSN downregulates E2F-1 apoptotic activity. (embl.de)
Condensates1
In this study, we demonstrate that formation and regulation of PRC1 condensates are consistent with the scaffold-client model, where the Chromobox 2 (CBX2) protein behaves as the scaffold while the other PRC1 proteins are clients. (bvsalud.org)
Arginine2
Identification and characterization of new molecular partners for the protein arginine methyltransferase 6 (PRMT6). (embl.de)
PRMT6 is a protein arginine methyltransferase that has been implicated in transcriptional regulation, DNA repair, and human immunodeficiency virus pathogenesis. (embl.de)
GENES2
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
Cellular1
We propose that sorbitol is a mechanosensitive metabolite enabling protein condensation to control mechano-regulated cellular functions. (bvsalud.org)
Species2
Proteins that originate from insect species belonging to the genus DROSOPHILA. (lookformedical.com)
The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (lookformedical.com)
Family1
The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)
Variant1
SAHFs also contain heterochromatin protein 1 (HP1) and the transcriptionally repressive histone variant macroH2A [56,106,176]. (mg132.com)
Network1
This network included the abundant pattern recognition proteins, signal transduction compo nents involved with Toll, Imd and JAK/STAT pathways, modulation molecules in proPO activating cascade and immune responsive effectors. (cox2-inhibitors.com)
Control1
The Traditional western blot displays Pexacerfont the elevated HMGA1 proteins in the HPNE-K-RAS-HMGA1 cells (denoted HMGA1) set alongside the control HPNE-K-RAS cells (denoted control). (eyesoftheelephants.com)
Formation1
Phase separation plays an important role in the formation of membraneless compartments within the cell and intrinsically disordered proteins with low-complexity sequences can drive this compartmentalisation. (bvsalud.org)
Results1
PPI (protein-protein interaction) results are shown above. (ihb.ac.cn)
Function1
Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)