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  • allele
  • In fact, the null allele of the HLA-DRB4 gene ( DRB4*0103102N ) is transcribed, but it is an aberrant protein due to the lack of splicing out of the first exon 11 . (dorak.info)
  • The null allele DRB4*0103102N has been found on HLA-DRB1*04:01, *04:02 and *04:04 haplotypes 13;14 . (dorak.info)
  • The first childhood leukaemia studies examined HLA class-II antigen frequencies found an increased allele frequency of DR7 in Switzerland where DR7 is the most common DR53 group antigen 8;9 . (dorak.info)
  • The increased HLA-DR53 allele frequency in adult ALL (66.7% vs 52.3%) could have been significant if homozygosity had been considered 11 . (dorak.info)
  • 7. A marker DNA sequence from the HLA DQ-beta allele associated with susceptibility to insulin-dependent diabetes mellitus, wherein said sequence can be used to detect either directly or indirectly the identity of the codon at position 57 of the DQ-beta protein sequence. (google.com.au)
  • For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B 57:01 ). (hindawi.com)
  • Members of this subtype contain alpha chains that are encoded by the HLA-A*01 allele family. (healthmatics.info)
  • In renal dialysis patients, HLA-A*02 was the most frequent allele in both carriers (25.5%) and non-carriers (21.2%) of S. aureus . (biomedcentral.com)
  • Regarding HLA-B and HLA-DRB1, no allele was shown to be involved in protection against or susceptibility to carriage of S. aureus . (biomedcentral.com)
  • Finally, case control analyses using imputed HLA types indicated that the DR10 allele of HLA-DRB1 was more frequent in individuals with SLI than population controls ( P = 0.004, relative risk = 2.575), as has been reported for individuals with attention deficit hyperactivity disorder (ADHD). (biomedcentral.com)
  • genotype
  • We published the first molecular HLA association study in childhood ALL and showed a convincing association for a homozygous genotype of the DQA1 locus by RFLP analysis 4 . (dorak.info)
  • This genotype more or less corresponds to homozygosity for HLA-DR53 and the current research specifically examined this genotype by PCR analysis against a newborn control group (as opposed to an adult control group in the previous RFLP study). (dorak.info)
  • Blood samples at diagnosis were analyzed to determine HLA genotype, islet autoantibodies and serum C-peptide. (pubmedcentralcanada.ca)
  • locus
  • The HLA-DRB4 promoter polymorphism is associated with differential expression of this locus 4 and this occurs at the level of mRNA production 3 . (dorak.info)
  • tephan V,Kuehr J,Seibt A,et al.Genetic linkage of HLA class locus to mite specific IgE immune responsiveness J .Clin Exp Allergy,1999,29(8):1049-54. (paperonce.org)
  • The HLA-C locus has been found only in humans, gorilla and chimpanzees but not in monkeys 17 . (tripod.com)
  • Gene
  • HLA-DR53 is not expressed on the HLA-B57DR7Dw11DQ9 (DQA1*02:01, DQB1*03:03) haplotype (as in the cell line DBB (IHW 9052) representing the conserved extended haplotype (CEH) 57.1) due to a base substitution at the 3' end of the first intron of the gene 9;10 . (dorak.info)
  • loci
  • However, to date, no studies have investigated the possible involvement of HLA loci in specific language impairment (SLI), a disorder that is defined primarily upon unexpected language impairment. (biomedcentral.com)
  • These preliminary data provide an intriguing link to those described by previous studies of other neurodevelopmental disorders and suggest a possible role for HLA loci in language disorders. (biomedcentral.com)
  • class
  • In this study, we identify monocytes as a primary target in HLA class II-induced TRALI. (bloodjournal.org)
  • In an ex vivo rodent model, HLA class II antibody-dependent monocyte activation leads to severe pulmonary edema in a relevant period of time, whenever neutrophils are present and the endothelium is preactivated. (bloodjournal.org)
  • Having identified the biologic mechanism of HLA class II antibody-induced TRALI, strategies to avoid plasma from immunized donors, such as women with a history of pregnancy, appear to be justified preventive measures. (bloodjournal.org)
  • The HLA complex is divided into three regions: class I, II, and III regions as first proposed by Jan Klein in 1977 57 . (dorak.info)
  • The classical HLA antigens encoded in each region are HLA-A, -B, and -C in the class I region, and HLA-DR, -DQ and -DP in the class II region. (dorak.info)
  • This was done to clarify the role of the HLA class II antigens in patients positive for anticardiolipin antibody who repeatedly have fetal miscarriages. (healthdocbox.com)
  • these women were examined for HLA class II s after informed consent was obtained. (healthdocbox.com)
  • Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes. (healthmatics.info)
  • DR53
  • An exception has been reported as an unexpected expression of HLA-DR53 in a DR7 (Dw11) : DQ9 - positive leukemia patient 12 . (dorak.info)
  • Two British studies examined HLA-DR antigens in adult leukaemias and reported the involvement of HLA-DR53 or its members in adult ALL 11 and chronic lymphoid leukaemia (CLL) 12 . (dorak.info)
  • Dausset
  • The workshop was convened for the purpose of comparing the different in vitro assay systems used at the time to define antigens which were described as Hu-1 (Dausset and Ivanyi), LA (Payne and Bodmer), and Four (van Rood). (ihiws.org)
  • frequencies
  • The very first paper which studied HLA-A, and -B frequencies in childhood leukaemia found a significant increase in HLA-A2B12 (Ref.3). (dorak.info)
  • genotypes
  • oung R P,Dekker J W,Wordsworth B P,et al.HLA DR and HLA DP genotypes and immunoglobulin E responses to common major allergens J .Clin Exp Allergy,1994,24(5):431-9. (paperonce.org)
  • glycoprotein
  • It was found that of the structural proteins, El glycoprotein was the dominant antigen recognized by the study population sampled from normal individuals with no history of rubella associated conditions. (ubc.ca)
  • frequency
  • In this study, the frequency of s of HLA-DR, HLA-DQ, and HLA-DP antigens was evaluated by means of the PCR- RFLP method. (healthdocbox.com)
  • Intensity (concentration) and duration of exposure to the antigen, frequency of exposure, particle size, and antigen solubility may influence disease latency, prevalence, severity and course [6, (worldallergy.org)
  • responses
  • An effective tumor vaccine may be required to induce both CTLs and T-helper (Th) responses against tumor-associated antigens. (aacrjournals.org)
  • In addition, exposure to airborne endotoxins, which is common in workplaces associated with HP, potentiates antigen-specific airway inflammation and allergen responses . (worldallergy.org)
  • These results indicate that keratinocyte expression of HLA-DR enhances inflammatory skin responses to SAg's. (smokershistory.com)
  • donors
  • they are also critical in the field of transplant surgery where the donors and the recipients must be HLA-compatible [ 3 ]. (hindawi.com)
  • sequences
  • For the alignment of DRB4 allelic sequences, see the IMGT/HLA Sequence Database alignment page . (dorak.info)
  • exposure
  • In general, there appears to be a direct relationship between the intensity of antigen exposure and the development of HP. (worldallergy.org)
  • It is believed that acute HP usually results from intense intermittent exposure to inhaled antigens and that subacute HP results from a less intense but more persistent exposure. (worldallergy.org)
  • adjuvant
  • Antigens that cause HP also have adjuvant properties that enable them to activate complement and release cytokines directly which also may be relevant [6, (worldallergy.org)
  • several
  • The first HLA workshop involved scientists from several countries and proved to be a seminal event, an impetus for more extensive collaborations in the following years. (ihiws.org)
  • Several of these antigens (e.g. (healthmatics.info)
  • 6 - 8 A non-HLA B-cell antigen known as D8/17 has been investigated in several population groups. (mja.com.au)
  • assay
  • The B-cell antigen D8/17 accurately identifies Australians with a past history of RF, and the assay is feasible in remote settings with access to facilities capable of performing D8/17 staining within half a day of sample collection. (mja.com.au)
  • separately
  • In a meta-analysis of published reports, HLA-A2 and -B12 are separately associated with childhood ALL 7 . (dorak.info)